• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Spot measurement of alanine radicals produced by irradiation and application of sugar radial to dosimeter

Research Project

Project/Area Number 19K05343
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 31010:Nuclear engineering-related
Research InstitutionTokyo Metropolitan Industrial Technology Research Institute

Principal Investigator

Nakagawa Seiko  地方独立行政法人東京都立産業技術研究センター, 事業化支援本部技術開発支援部計測分析技術グループ, 主任研究員 (30462980)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsESR / ラジカル / アラニン / 糖 / 生成機構 / 線量評価 / 電子スピン共鳴 / 線量測定
Outline of Research at the Start

放射線の線量を評価する固体線量計の一つとして、アラニンから生成するラジカルの生成量を測定する方法が用いられている。近年、医療分野への放射線利用の拡大により、低線量を正確に評価する需要が増加している。そこで、アラニンより低線量の評価が可能と考えられる、糖から生成するラジカルを用いた線量計の開発を目指す。さらに、Sping-8での軟X線照射でアラニンから生成するラジカル種のその場での時間分解観察を行い、ラジカルの生成機構および反応機構を明らかにする。本研究の成果は、放射線計測の幅を広げ、精度の高い線量評価方法の確立に貢献できる。

Outline of Final Research Achievements

ESR spectral change of alanine radicals produced by soft X-ray irradiation was observed for the first time by spot measurement. The efficiency of the radical yield by the soft X-ray irradiation was much loser relative to that by gamma irradiation and the product formed by the radical recombination was observed. It means that the soft X-ray irradiation is a high-LET irradiation. The radicla yield efficiency decreased with decreasing the energy of soft X-ray.
The dose response and time dependence of radicals produced in fructose, mixed glucose, alpha-glucose, beta-glucose and sucrose were investigated in detail. It was found that beta-glucose is the best substance for the dosimeter.

Academic Significance and Societal Importance of the Research Achievements

線量計として広く使用されているアラニンへの軟X線照射により、軟X線のエネルギー低下に伴い、高LET照射である事が判明した。これは、放射線照射の生物効果への軟X線の影響に関する示唆を与えるのみならず、軟X線リソグラフィーなど産業利用においても新たな知見を与える。
スクロースのラジカルの線量計への応用は、原子力施設の事故の際の線量評価などが期待されている。本研究で、βグルコースが、より線量応答性や安定性で優れている事が判明し、新たな線量計開発の可能性が開けた。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2022 2021 2020 2019

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Dense radical formation in L-alanine-3,3,3-d3 and L-alanine-d4 by 1.5keV soft X-ray irradiation2022

    • Author(s)
      Nakagawa Seiko、Oka Toshitaka、Fujii Kentaro、Yokoya Akinari
    • Journal Title

      Radiation Physics and Chemistry

      Volume: 192 Pages: 109884-109884

    • DOI

      10.1016/j.radphyschem.2021.109884

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of radicals in irradiated maltose ? the role of hydrogen bonding with water2022

    • Author(s)
      Nakagawa Seiko
    • Journal Title

      Free Radical Research

      Volume: 56 Issue: 2 Pages: 201-206

    • DOI

      10.1080/10715762.2022.2071267

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ESR spectral change of radicals produced in L-alanine-3,3,3-d3 and L-alanine-d4. -A new pathway to produce the de-hydrogen radical and the hydrogen exchange reactions of the de-amino radical-2019

    • Author(s)
      Seiko Nakagawa
    • Journal Title

      Radiation Physics and Chemistry

      Volume: 165 Pages: 108406-108406

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 糖類から生成するラジカル量を利用した線量評価の検討2022

    • Author(s)
      中川清子
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 1.5keV軟X線照射した重水素化アラニン中での高密度ラジカル生成2021

    • Author(s)
      中川清子、岡 壽崇、藤井健太郎、横谷明徳
    • Organizer
      第64回放射線化学討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Radicals produced in irradiated maltose2021

    • Author(s)
      中川清子
    • Organizer
      ISMAR-APNMR2021
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射線照射により糖類から生成するラジカル量の評価(2)2020

    • Author(s)
      中川清子
    • Organizer
      スピンサイエンス学会(SEST2020)
    • Related Report
      2020 Research-status Report
  • [Presentation] ESR spectral change of radicals produced in Deuterated Alanines.2020

    • Author(s)
      中川清子
    • Organizer
      APSRC2020(誌上発表)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] ESR spectral change of radicals produced in Deuterated Alanines.2020

    • Author(s)
      Seiko Nakagawa
    • Organizer
      APSRC2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi