Development of Self-regenerating type Silk Vascular Graft for Artery and Vein
| Project/Area Number |
19K05609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 35020:Polymer materials-related
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Asakura Tetsuo 東京農工大学, 工学(系)研究科(研究院), 名誉教授 (30139208)
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| Co-Investigator(Kenkyū-buntansha) |
田中 綾 東京農工大学, (連合)農学研究科(研究院), 教授 (70334480)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 絹人工血管 / 高機能化絹 / 絹多孔質コーティング / ダブルラッセル編み / 動物移植評価実験 / 動脈・静脈用人工血管 / 動脈・静脈用絹人工血管 / 高分子 / 人工血管 |
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| Outline of Research at the Start |
高強度または高弾性を有する絹人工血管基盤を、各々、“編み”の技術を駆使して作製する。そして、生分解性の高い人工血管用に改変した高機能化絹多孔質スポンジで基盤へのコーティングを行い、動物移植実験による評価を行う。それを3年間にわたって繰り返すことによって、動脈用および静脈用の小口径絹人工血管を開発、本研究課題を達成する
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| Outline of Final Research Achievements |
By combination of double-raschel knitting and several sponge coating, silk artificial vascular grafts with small diameter were prepared and implanted the grafts into artery and vein of rat. Especially, preparation of several coating was optimized by monitoring with sold-state NMR methods. After implantation of the silk artificial vascular grafts into artery and vein of rat, it was confirmed that some of blood vessels were regenerated. Thus, development of self-renewal silk artificial vascular grafts with small diameter for artery with high strength and vein with high elasticity has progressed.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会や社会習慣病の増加を受け、需要が高まっているが未だ市販品のない小口径動脈用人工血管や市販品では閉塞しやすい静脈用人工血管について、問題点を克服した絹人工血管を開発した社会的意義は大きい。
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Bio-functionalized titanium surfaces with modified silk fibroin carrying titanium binding motif to enhance the ossific differentiation of MC3T3-E12021
Author(s)
M. Watanabe, U.K. Bhawal, S. Takemoto, N. Nishiyama, Y. Nakahara, K. Tatematsu, H. Sezutsu, N. Kuwabara, T. Minamisawa, K. Shiba, T. Asakura
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Journal Title
Biotechnol. Bioeng.
Volume: 118
Issue: 7
Pages: 2585-2596
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice2020
Author(s)
Tanaka, K.; Fukuda, D.; Higashikuni, Y.; Hirata, Y.; Komuro, I.; Saotome, T.; Yamashita, Y.; Asakura, T.; Sata, M.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 27
Issue: 12
Pages: 1299-1309
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2020-12-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Silk fibroin vascular graft: a promising tissue-engineered scaffold material for abdominal venous system replacement2020
Author(s)
S. Kiritani, J. Kaneko, D. Ito, M. Morito, T. Ishizawa, N. Akamatsu, M. Tanaka, T. Iida, T. Tanaka, R. Tanaka, T. Asakura, J. Arita, K. Hasegawa
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Journal Title
Sci. Rep.
Volume: 10
Issue: 1
Pages: 21041-21041
DOI
Related Report
Peer Reviewed / Open Access
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