• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Chemical identification of activation factors in mitochondrial DAMPs and their regulatory mechanisms in innate immunity

Research Project

Project/Area Number 19K05853
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38040:Bioorganic chemistry-related
Research InstitutionNagahama Institute of Bio-Science and Technology

Principal Investigator

Mukai Hidehito  長浜バイオ大学, バイオサイエンス学部, 教授 (20251027)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsクリプタイド / 生体機能物質 / 自然免疫機構 / 好中球 / 肝傷害モデル / エンドトキシン / 炎症 / 活性発現の分子機構
Outline of Research at the Start

現在までのmtDAMPsに関する研究と申請者らの研究の結果を総合すると、未だ明らかでないmtDAMPs中の自然免疫応答誘導因子群の多くは、申請者らの同定した一群の新規好中球活性化ペプチド、MCTsである可能性が高いと考えられるようになった。そこで本研究では、MCTsを中心として、mtDAMPsを構成する自然免疫応答誘導因子の詳細な化学構造を分析・決定すること、さらにはそれらが関与する自然免疫機構を解析し、同定した活性化因子の存在意義を解明する。そして、得られた結果をもとに、虚血性疾患やリウマチなど、好中球の組織浸潤をともなう疾病の発症原因の解明と治療法や治療薬の開発に結びつける研究を行う。

Outline of Final Research Achievements

Mitocryptides (MCTs) including mitocryptide-1 (MCT-1), mitocryptide-2 (MCT-2) and mitocryptide-3 (MCT-3) are a family of novel neutrophil-activating peptides derived from various mitochondrial proteins. Here we suggested the novel mechanisms that initiate innate immune responses. Indeed, the receptor molecule for MCT-2 was shifted from formyl-peptide receptor-2 to formyl-peptide receptor-1 depending on the truncation of MCT-2 from C-terminus. It was also suggested that MCT-3 as well as MCT-1 directly activated Gαi2 protein that was located at the surface of neutrophilic plasma membrane. We also demonstrated that intravenous pre-injection of neutralizing antibodies against MCT-2 suppressed neutrophil infiltration and promoted recovery of the tissue in the mouse hepatic injury model caused by lipopolysaccharide (LPS), indicating that MCT-2 involves not only in the tissue damage mechanisms induced by LPS but also in recovery from the damage.

Academic Significance and Societal Importance of the Research Achievements

本研究では、我々が世界に先駆けて発見した、ミトコンドリアタンパク質由来の一群の新規好中球活性化ペプチド、「マイトクリプタイド」(MCTs)の生体における役割を解明するため、まずMCTsとmtDAMPsとの関連を検討した。その結果、実際にmtDMPs中にMCT-2およびMCT-3が存在していることが明らかになった。また、LPSにより実験的に誘導した肝傷害モデルにおいて、MCT-2がその増悪および再生、両者に関わる可能性を世界で初めて示すことに成功した。この研究成果は、多臓器不全や虚血傷害といった未だ有効な治療法が確立されていない炎症性疾病の治療に道を開く画期的成果であると考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (55 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 5 results) Presentation (29 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (1 results) Remarks (6 results)

  • [Int'l Joint Research] University of Goteborg(スウェーデン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of Goteborg(スウェーデン)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Physiological roles of mitocryptide-3 and its derivatives in mitochondrial damage associated molecular patterns2022

    • Author(s)
      Yoshinori Sugimoto, Hiroki Morikawa, Takayuki Marutani, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2021 Pages: 49-50

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signaling mechanisms for mitocryptides derived from mitochondrial transit sequences in neutrophilic cells2022

    • Author(s)
      Koji Ohura, Takayuki Marutani, Ryota Tanemura, Takumi Sasaki, Shinichiro Tamura, Kenta Nakashima, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2021 Pages: 59-60

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of mitocryptide-2 and its derivatives with formyl peptide receptor-2 for neutrophilic activation2022

    • Author(s)
      Hiroki Hirai, Takayuki Marutani, Kodai Nishino, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2021 Pages: 61-62

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological significance of different receptor selectivities between FPR2 and FPR1 for mitocryptide-2 and its derivatives depending on their molecular forms2022

    • Author(s)
      Tomoyuki Miyaji, Takayuki Marutani, Kodai Nishino, Yoshito Takamuro, Takenori Yamada, Hiroki Morikawa, Tatsuya Hattori, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2021 Pages: 71-72

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation mechanisms of neutrophils stimulated by mitochondrial transit signal sequences including mitocryptide-32022

    • Author(s)
      Ryota Tanemura, Takayuki Marutani, Koji Ohura, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2021 Pages: 73-74

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 一群の自然免疫イニシエーションファクター、マイトクリプタイド -効率的中和抗体獲得法の開発と炎症性疾患治療を目指したアプローチ-2022

    • Author(s)
      向井秀仁、木曽良明
    • Journal Title

      月刊BIOINDUSTRY

      Volume: 39 Pages: 2-14

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitocryptide-2: identification of its minimum structure for specific activation of FPR2 - possible receptor switching from FPR2 to FPR1 by its physiological C-terminal cleavages2021

    • Author(s)
      Takayuki Marutani, Kodai Nishino, Tomoyuki Miyaji, Keisuke Kamada, Koji Ohura, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 8 Pages: 4084-4084

    • DOI

      10.3390/ijms22084084

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitocryptides: presence and molecular forms in mitochondrial damage associated molecular patterns2021

    • Author(s)
      Yoshinori Sugimoto, Hiroki Morikawa, Tatsuya Ojima, Takayuki Marutani, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2020 Pages: 39-40

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recognition mechanisms of mitocryptide-2 by formyl-peptide receptor 22021

    • Author(s)
      Keisuke Kamada, Takayuki Marutani, Kodai Nishino, Koji Ohura, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2020 Pages: 75-76

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mitocryptide-2: alteration of its molecular forms in serum2021

    • Author(s)
      Tomoyuki Miyaji, Yoshito Takamuro, Takenori Yamada, Hiroki Morikawa, Kodai Nishino, Tatsuya Hattori, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2020 Pages: 97-98

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] An interacting mechanism between mitocryptide-3 and its receptor molecule2021

    • Author(s)
      Koji Ohura, Takayuki Marutani, Shinichiro Tamura, Kenta Nakashima, Hiroki Morikawa, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2020 Pages: 99-100

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cellular functions of mitocryptide-3-binding proteins in neutrophilic cells2021

    • Author(s)
      Ryota Tanemura, Takayuki Marutani, Kohei Sakuma, Koji Ohura, Shinichiro Tamura, Kenta Nakashima, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2020 Pages: 105-106

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mitocryptides: A novel family of bioactive regulatory peptides produced from various mitochondrial proteins that induce innate immune responses2020

    • Author(s)
      向井秀仁
    • Journal Title

      Hikaku seiri seikagaku(Comparative Physiology and Biochemistry)

      Volume: 37 Issue: 3 Pages: 189-196

    • DOI

      10.3330/hikakuseiriseika.37.189

    • NAID

      130007959721

    • ISSN
      0916-3786, 1881-9346
    • Year and Date
      2020-12-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitocryptide-2: investigation of its pathophysiological roles utilizing a specific neutralizing monoclonal antibody2020

    • Author(s)
      Yoshito Takamuro, Takenori Yamada, Hiroki Morikawa, Naoyuki Tamura, Tatsuya Hattori, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2019 Pages: 95-96

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitocryptides: investigation of signaling mechanisms induced by novel neutrophil-activating peptides derived from mitochondrial transit signal sequences2020

    • Author(s)
      Takayuki Marutani, Koji Ohura, Shinichiro Tamura, Kenta Nakashima, Hiroki Morikawa, Tatsuya Hattori, Yoshiaki Kiso, and Hidehito Mukai
    • Journal Title

      Peptide Science

      Volume: 2019 Pages: 147-148

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of residues critical for FPR2 activation by the cryptic peptide mitocryptide-2 originating from the mitochondrial DNA-encoded cytochrome b2019

    • Author(s)
      Simon Lind, Michael Gabl, Andre Holdfeldt, Jonas Martensson, Martina Sundqvist, Kodai Nishino, Claes Dahlgren, Hidehito Mukai and Huamei Forsman
    • Journal Title

      The Journal of Immunology

      Volume: 202 Issue: 9 Pages: 2710-2719

    • DOI

      10.4049/jimmunol.1900060

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Mitocryptide-3をはじめとしたミトコンドリア移行シグナル配列由来のmitocryptidesによる好中球活性化機序2021

    • Author(s)
      種村亮太、丸谷飛之、大浦紘嗣、木曽良明、向井秀仁
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイトクリプタイド-2およびその誘導体における分子形態の相違による受容体選択性変化の生理的意義2021

    • Author(s)
      宮地智之、丸谷飛之、西野弘大、高室義人、山田武慶、森川広樹、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 好中球様細胞活性化におけるmitocryptide-2およびその誘導体とformyl peptide receptor 2との相互作用の解析2021

    • Author(s)
      平井大貴、丸谷飛之、西野弘大、木曽良明、向井秀仁
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ミトコンドリア傷害関連分子パターンに存在するmitocryptide-3およびその誘導体の生理的役割の解析2021

    • Author(s)
      杉本佳宣、森川広樹、丸谷飛之、木曽良明、向井秀仁
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 好中球様細胞におけるミトコンドリア移行配列に由来するmitocryptidesの情報伝達機構の解析2021

    • Author(s)
      大浦紘嗣、丸谷飛之、種村亮太、鷦鷯匠、中島健太、木曽良明、向井秀仁
    • Organizer
      第58回ペプチド討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイトクリプタイド:新しい自然免疫調節因子と炎症性疾患2021

    • Author(s)
      向井秀仁
    • Organizer
      第94回日本生化学会大会 シンポジウム2S09a 「生理活性ペプチドと中分子創薬~新たな創薬ブレイクスルーを目指して」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Mitocryptide-3による好中球様細胞活性化におけるGi2タンパク質の役割2021

    • Author(s)
      種村亮太、丸谷飛之、大浦絋嗣、佐久間康平、田村慎一郎、中島健太、木曽良明、向井秀仁
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイトクリプタイド-3とGi2タンパク質との相互作用機構の解明2021

    • Author(s)
      大浦紘嗣、丸谷飛之、種村亮太、田村慎一郎、中島健太、森川広樹、木曽良明、向井秀仁
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイトクリプタイド-2およびその誘導体によるホルミルペプチド受容体選択多様性の生理的意義の検討2021

    • Author(s)
      宮地智之、丸谷飛之、西野弘大、鎌田恵輔、大浦絋嗣、木曽良明、向井秀仁
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ミトコンドリアDAMPsにおけるマイトクリプタイド-3関連ペプチドの存在および分子形態の解析2021

    • Author(s)
      杉本佳宣、森川広樹、丸谷飛之、木曽良明、向井秀仁
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Mitocryptides: physiological and pathophysiological roles in innate immune systems2021

    • Author(s)
      Yoshito Takamuro, Takayuki Marutani, Hiroki Morikawa, Tatsuya Ojima, Tatsuya Hattori, Yoshiaki Kiso, and Hidehito Mukai
    • Organizer
      18th Japanese-German Symposium on Peptide Science
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mitocryptide-3に対する受容体におけるリガンド結合部位の解析2020

    • Author(s)
      大浦紘嗣、丸谷飛之、田村慎一郎、中島健太、森川広樹、木曽良明、向井秀仁
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 好中球様細胞活性化におけるマイトクリプタイド-2およびその誘導体のホルミルペプチド受容体選択性の検討2020

    • Author(s)
      鎌田恵輔、丸谷飛之、西野弘大、大浦紘嗣、木曽良明、向井秀仁
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] リポポリサッカライド誘導エンドトキシンショックモデルにおけるマイトクリプタイド-2の病態的機能の検討2020

    • Author(s)
      宮地智之、高室義人、山田武慶、森川広樹、田村直之、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 好中球におけるマイトクリプタイド-3結合タンパク質の役割2020

    • Author(s)
      種村亮太、丸谷飛之、佐久間康平、大浦紘嗣、田村慎一朗、中島健太、木曽良明、向井秀仁
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Mitochondrial damage-associated molecular patternsにおけるマイトクリプタイドの存在および分子形態の解析2020

    • Author(s)
      杉本佳宣、森川広樹、小島達也、丸谷飛之、木曽良明、向井秀仁
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] マイトクリプタイド-2:リポポリサッカライド誘導性炎症における病態生理学的メカニズムの検討2020

    • Author(s)
      宮地智之、高室義人、山田武慶、森川広樹、西野弘大、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] マイトクリプタイド-3とその受容体分子との相互作用機構の解明2020

    • Author(s)
      大浦紘嗣、丸谷飛之、田村慎一朗、中島健太、森川広樹、木曽良明、向井秀仁
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] Formyl peptide receptor 2によるmitocryptide-2の認識機構2020

    • Author(s)
      鎌田恵輔、丸谷飛之、西野弘大、大浦紘嗣、木曽良明、向井秀仁
    • Organizer
      第57回ペプチド討論会
    • Related Report
      2020 Research-status Report
  • [Presentation] 新規好中球活性化ペプチド、mitocryptide-2の病態生理学的役割の解析2019

    • Author(s)
      高室義人、山田武慶、服部竜弥、森川広樹、田村直之、木曽良明、向井秀仁
    • Organizer
      第51回若手ペプチド夏の勉強会
    • Related Report
      2019 Research-status Report
  • [Presentation] ミトコンドリア移行配列由来のmitocryptidesによる好中球活性化機序の解析2019

    • Author(s)
      大浦紘嗣、丸谷飛之、田村慎一朗、中島健太、西野弘大、森川広樹、木曽良明、向井秀仁
    • Organizer
      第51回若手ペプチド夏の勉強会
    • Related Report
      2019 Research-status Report
  • [Presentation] Mitocryptide-3:mitochondrial damage associated molecular patternsにおける存在ならびに分子形態の解析2019

    • Author(s)
      杉本佳宣、小島達也、森川広樹、木曽良明、向井秀仁
    • Organizer
      第51回若手ペプチド夏の勉強会
    • Related Report
      2019 Research-status Report
  • [Presentation] ミトコンドリアチトクロームb由来の新規好中球活性化ペプチド、マイトクリプタイド-2の病態生理学的機能解析2019

    • Author(s)
      高室義人、山田武慶、服部竜弥、森川広樹、田村直之、木曽良明、向井秀仁
    • Organizer
      第92回日本生化学大会
    • Related Report
      2019 Research-status Report
  • [Presentation] マイトクリプタイド-2:特異的中和モノクローナル抗体を用いた病態生理学的役割の検討2019

    • Author(s)
      高室義人、山田武慶、森川広樹、田村直之、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第56回ペプチド討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] マイトクリプタイド:ミトコンドリア移行配列に由来する新規好中球活性化ペプチドによる情報伝達機構の検討2019

    • Author(s)
      丸谷飛之、大浦紘嗣、田村慎一朗、中島健太、森川弘樹、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第56回ペプチド討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Mitocryptides and inflammatory diseases: mitocryptides as a novel family of activating factors in innate immune systems2019

    • Author(s)
      Hidehito Mukai, Yoshito Takamuro, Takayuki Marutani, Hiroki Morikawa, Tatsuya Ojima, Tatsuya Hattori, and Yoshiaki Kiso
    • Organizer
      9th International DAMPs and Alarmins Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pathophysiological functions of mitocryptide-2 in the inflammation induced by lipopolysaccharide2019

    • Author(s)
      Yoshito Takamuro, Takenori Yamada, Hiroki Morikawa, Naoyuki Tamura, Tatsuya Hattori, Yoshiaki Kiso, and Hidehito Mukai
    • Organizer
      9th International DAMPs and Alarmins Symposium
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] リポポリサッカライド誘導エンドトキシンショックモデルにおけるマイトクリプタイド-2の病態生理学的機能解析2019

    • Author(s)
      高室義人、山田武慶、森川広樹、田村直之、服部竜弥、木曽良明、向井秀仁
    • Organizer
      第36回関西地区ペプチドセミナー
    • Related Report
      2019 Research-status Report
  • [Presentation] ホルミルペプチド受容体FPR1およびFPR2に対する阻害剤を用いたマイトクリプタイド-2ならびにその誘導体の受容体選択性の解析2019

    • Author(s)
      鎌田恵輔、西野弘大、大浦紘嗣、丸谷飛之、木曽良明、向井秀仁
    • Organizer
      第36回関西地区ペプチドセミナー
    • Related Report
      2019 Research-status Report
  • [Book] ペプチド創薬の最前線2019

    • Author(s)
      丸谷飛之、木曽良明、向井秀仁
    • Total Pages
      265
    • Publisher
      シーエムシー出版
    • ISBN
      9784781314174
    • Related Report
      2019 Research-status Report
  • [Remarks] 長浜バイオ大学ペプチド科学研究室

    • URL

      http://b-lab.nagahama-i-bio.ac.jp/~h_mukai/

    • Related Report
      2021 Annual Research Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] 長浜バイオ大学教員紹介

    • URL

      https://www.nagahama-i-bio.ac.jp/research/%e6%95%99%e5%93%a1%e3%81%ae%e7%b4%b9%e4%bb%8b%ef%bc%88%e5%90%91%e4%ba%95-%e7%a7%80%e4%bb%81%ef%bc%89/

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
  • [Remarks] 長浜バイオ大学ペプチド科学研究室・研究紹介動画

    • URL

      https://www.youtube.com/watch?v=ZOcEJi3TPfE

    • Related Report
      2021 Annual Research Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] 第50回若手ペプチド夏の勉強会

    • URL

      https://wwp.shizuoka.ac.jp/peptide-summer50/2018/07/24/

    • Related Report
      2021 Annual Research Report 2020 Research-status Report 2019 Research-status Report
  • [Remarks] 月刊BIOINDUSTRY

    • URL

      https://www.cmcbooks.co.jp/products/detail.php?product_id=8554

    • Related Report
      2021 Annual Research Report
  • [Remarks] 長浜バイオ大学教員紹介

    • URL

      http://www.nagahama-i-bio.ac.jp/research/

    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi