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Analysis of the molecular basis for stem cell differentiation

Research Project

Project/Area Number 19K05943
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38060:Applied molecular and cellular biology-related
Research InstitutionNagoya University (2022)
The University of Tokyo (2019-2020)

Principal Investigator

Shimotohno Akie  名古屋大学, トランスフォーマティブ生命分子研究所, 特任講師 (70647544)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords幹細胞 / 発生・分化 / 植物ホルモン / 低分子タンパク質 / 転写因子 / 複合体 / 発現制御 / 植物 / シグナル伝達 / 環境 / 生理学 / 分子生物学 / 応用分子細胞生物学
Outline of Research at the Start

本研究では、植物の幹細胞の維持に関わる因子群の分子ネットワークを詳細に明らかにすることにより、動植物の幹細胞維持過程における相違や植物幹細胞の独自性を明らかにすることを目的とする。さらに、環境刺激に応答した幹細胞形成に関わる新規制御因子の同定を目指す。本研究で得られる知見は、変動する環境下で幹細胞を永続的に維持する植物において、その生存戦略を支える、根源的な分子メカニズムの解明につながると期待される。

Outline of Final Research Achievements

The aim of this study was to identify a new component of regulatory factors regulating stem cell differentiation. Unexpectively, due to the COVID-19 outbreak, our activities were unexpectedly limited. We nonetheless managed to complete the MS analysis and identify several novel regulatory factors that interact with key transcription factor components. In addition, we successfully established a tool for live cell imaging of protein dynamics in plants, thus mainly fulfilling our objectives.

Academic Significance and Societal Importance of the Research Achievements

本研究は、植物の幹細胞化に必要不可欠な転写因子群が、生体内でどのような制御を受けているのかを示すことに成功した。今後は、これらの制御因子機能の発揮に至る分子機序を詳らかにすることによって、植物がもつ永続的な幹細胞能力の謎の解明につなげることが期待できる。

Report

(3 results)
  • 2022 Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (8 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Correction to: CLE2 regulates light-dependent carbohydrate metabolism in Arabidopsis shoots2021

    • Author(s)
      Ma Dichao、Endo Satoshi、Betsuyaku Shigeyuki、Shimotohno Akie、Fukuda Hiroo
    • Journal Title

      Plant Molecular Biology

      Volume: 106 Issue: 1-2 Pages: 221-221

    • DOI

      10.1007/s11103-021-01144-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of the Plant Cell Cycle in Response to Hormones and the Environment2021

    • Author(s)
      Shimotohno Akie、Aki Shiori S.、Takahashi Naoki、Umeda Masaaki
    • Journal Title

      Annual Review of Plant Biology

      Volume: 72 Issue: 1 Pages: 72-78

    • DOI

      10.1146/annurev-arplant-080720-103739

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] CLE2 regulates light-dependent carbohydrate metabolism in Arabidopsis shoots2020

    • Author(s)
      Ma Dichao、Endo Satoshi、Betsuyaku Shigeyuki、Shimotohno Akie、Fukuda Hiroo
    • Journal Title

      Plant Molecular Biology

      Volume: 104 Issue: 6 Pages: 561-574

    • DOI

      10.1007/s11103-020-01059-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Topology of Regulatory Networks That Guide Plant Meristem Activity: Similarities and Differences2019

    • Author(s)
      Akie Shimotohno and Ben Scheres
    • Journal Title

      Curr Opin Plant Biol

      Volume: 51 Pages: 74-80

    • DOI

      10.1016/j.pbi.2019.04.006

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 環境ストレスに呼応した CLEペプチドの新たな役割2021

    • Author(s)
      下遠野明恵・福田裕穂
    • Organizer
      第62回日本植物生理学会年会
    • Related Report
      2020 Research-status Report
  • [Presentation] A novel strategy for sensing and survival against environmental stresses in plants2019

    • Author(s)
      Shimotohno A et al.,
    • Organizer
      Frontiers in plant environmental response research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Roles of CLE peptide signaling in response to environmental stimuli2019

    • Author(s)
      Shimotohno A et al.,
    • Organizer
      The 60th Annual Meeting of the JSPP,
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Book] 植物の生きる知恵 5 植物の情報を伝える経路-環境メディエータとシグナル伝達の秘密に迫る2020

    • Author(s)
      福田裕穂, 下遠野明恵, 遠藤暁詩
    • Total Pages
      6
    • Publisher
      生物の科学 遺伝
    • Related Report
      2020 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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