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Regulation of TE-derived non-coding RNAs in plant genomes

Research Project

Project/Area Number 19K06619
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 43050:Genome biology-related
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

Hidetoshi Saze  沖縄科学技術大学院大学, 植物エピジェネティクスユニット, 准教授 (70510006)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsエピジェネティクス / トランスポゾン / 植物ゲノム / トランスポソン / エピゲノム / シロイヌナズナ / 非コードRNA / 転移因子 / RNA
Outline of Research at the Start

植物のゲノムでは遺伝子内部の非翻訳領域に転移因子(トランスポゾン)が大量に蓄積している。本研究は植物ゲノムの遺伝子内部に存在する転移因子由来の潜在的プロモーターから転写されるRNAの転写制御メカニズムをエピジェネティック制御の観点から明らかにすることを目的とする。

Outline of Final Research Achievements

In plant genomes, many transposable elements (TEs) are accumulated in genic regions including intron and untranslated regions (UTR) of genes. In this study, we investigated cryptic promoters that are regulated by epigenetic modifications. In Arabidopsis thaliana, we identified more than 3000 novel transcription start sites (TSS) that are epigenetically regulated, most of which are derived from TE sequences.

Academic Significance and Societal Importance of the Research Achievements

これまで理解されていなかった植物ゲノムにおける遺伝子の転写開始点制御と転移因子配列のエピジェネティック制御について本研究成果から明らかになった。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2021 2020

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 3 results)

  • [Journal Article] Epigenetic regulation of spurious transcription initiation in Arabidopsis2020

    • Author(s)
      Le NT, Harukawa Y, Miura S, Boer D, Kawabe A, Saze H.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 3224-3224

    • DOI

      10.1038/s41467-020-16951-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 植物における環境要因におけるエピゲノム変化と継世代伝達の可能性2021

    • Author(s)
      佐瀬英俊
    • Organizer
      日本遺伝学会第93回大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Epigenetic regulation of intragenic transposons and gene transcription in plant genomes2021

    • Author(s)
      Hidetoshi Saze
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 植物における遺伝子内トランスポゾン配列の抑制的クロマチン修飾の維持機構2020

    • Author(s)
      佐瀬英俊
    • Organizer
      日本植物学会
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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