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Elucidation of neural mechanism for adapting flexibly to temporally uncertain future rewards

Research Project

Project/Area Number 19K06892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

Miyazaki Katsuhiko  沖縄科学技術大学院大学, 神経計算ユニット, グループリーダー (10426570)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsセロトニン / 光遺伝学 / 時間的不確実性 / 報酬待機行動 / 前頭眼窩野 / 内側前頭前野 / 時間的不確実 / 意思決定 / オプトロード
Outline of Research at the Start

将来の報酬がいつ獲得できるかを予測することができれば(時間的不確実性の減少)、動物が報酬獲得行動を持続する際に利点となる。それに対し、獲得できるのはかなり確実だがいつかが予測困難な場合(時間的不確実性の増大)は、予測できる場合に比べてより柔軟に適応することが要求される。本研究は、将来獲得できる報酬を辛抱強く待つことに関わるセロトニン神経系は、時間的に不確実な将来報酬獲得のための適応的な行動制御に関与するとの仮説を検証する。

Outline of Final Research Achievements

We revealed that there is causal relationship between dorsal raphe serotonin neural activity and patience to wait for delayed rewards. In this study, we found that only optogenetic activation of serotonin in the orbitofrontal cortex promoted waiting when the delay time is constant and the timing to obtain rewards was predictable (low timing uncertainty). We also found that activation of serotonin not only in the orbitofrontal cortex but also in the medial prefrontal cortex promoted waiting when the timing to obtain rewards was unpredictable (low timing uncertainty).(with high temporal uncertainty) . This result suggests that the serotonergic system acts on higher brain regions to produce flexible adaptive behaviors to changes in the timing uncertainty of future rewards.

Academic Significance and Societal Importance of the Research Achievements

セロトニンはうつ病や注意欠陥多動性障害などの衝動性を伴う精神疾患と深く関わっていいるが、セロトニン神経活動がどのように神経疾患と関連しているのかについては未だ謎が多い。本研究では、セロトニンが脳の高次領域で異なって働くことが明らかになった。脳の様々な領域でセロトニンがどのように働くかについての知識を増やすことで、将来の医薬品開発等への貢献が期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2021 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Serotonergic Modulation of Cognitive Computations2021

    • Author(s)
      Kenji Doya, Kayoko W. Miyazaki, Katsuhiko Miyazaki
    • Journal Title

      Current opinion of Behavioral Sciences

      Volume: Volume 38, April 2021 Pages: 116-123

    • DOI

      10.1016/j.cobeha.2021.02.003

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards2020

    • Author(s)
      Miyazaki K, Miyazaki KW, Sivori G, Yamanaka A, Tanaka KF, Doya K
    • Journal Title

      Science Advances

      Volume: 6 Issue: 48 Pages: 7246-7246

    • DOI

      10.1126/sciadv.abc7246

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The orbitofrontal and medial prefrontal cortices differentially calculate the posterior probability of reward delivery to modulate waiting for future rewards2020

    • Author(s)
      Miyazaki K, Miyazaki KW, Doya K
    • Organizer
      12th Forum of European Neuroscience
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Stimulation of serotonergic terminals in the orbitofrontal and medial prefrontal cortices differentially affects waiting for the future rewards2019

    • Author(s)
      Miyazaki KW, Miyazaki K, Yamanaka A, Tanaka KF, Doya, K
    • Organizer
      49th Annual Meeting of the Society for Neuroscience
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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