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Analysis of the hindbrain and spinal circuits controlling the speed-dependent change of locomotor patterns using small fish

Research Project

Project/Area Number 19K06897
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionCenter for Novel Science Initatives, National Institutes of Natural Sciences

Principal Investigator

Kimura Yukiko  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 助教 (70581122)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsゼブラフィッシュ / 遊泳運動 / 移動運動 / 神経回路
Outline of Research at the Start

脊椎動物の移動運動では速度変化にともない、ウマの常歩、襲歩のように運動パターンが変化することがある。異なる速度の異なる運動パターンは、特定の速度で特定の脊髄ニューロンが選択的に活動して作られると考えられるが、その具体的なメカニズムは明らかでない。本研究では、ゼブラフィッシュ幼魚を材料に、特定の運動パターン生成に関わる脊髄ニューロンが速度依存的発火パターンを示す機構を解明するために、そのニューロンが様々な速度の運動で脊髄および後脳のニューロンから受ける入力を調べる。本研究によって、速度依存的移動運動パターン変化を制御する後脳・脊髄神経回路を明らかにする。

Outline of Final Research Achievements

This study aims to clarify how spinal circuits control the change of locomotor patterns depending on speed by using zebrafish larvae. In order to clear the mechanism, revealing the speed-dependent change of synaptic inputs is critical. In this study, recordings of the synaptic inputs received by different types of spinal neurons showing speed-dependent firing patterns revealed that the balance of excitatory and inhibitory inputs changed depending on swimming speed. The changing patterns of synaptic inputs and the mechanisms regulating them were variables between cell types.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、速度依存的な運動を制御する脊髄神経回路の理解を進展させたことである。ゼブラフィッシュ仔魚の小型で単純な神経回路を遺伝学的解析と電気生理学的解析を組み合わせて解析することで、哺乳類など大型の脊椎動物では容易ではない解析を行えた。また社会的意義として、本研究による脊髄の運動系神経回路の動作原理の解明は、脊椎・脊髄疾患の理解や治療法の開発に将来的につながる可能性がある。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2022 2020 2019

All Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 4 results)

  • [Journal Article] Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish2022

    • Author(s)
      Kawano Kohei、Kato Kagayaki、Sugioka Takumi、Kimura Yukiko、Tanimoto Masashi、Higashijima Shin-ichi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4348-4348

    • DOI

      10.1038/s41598-022-08283-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents2020

    • Author(s)
      Liu Zhikai、Kimura Yukiko、Higashijima Shin-ichi、Hildebrand David G.C.、Morgan Joshua L.、Bagnall Martha W.
    • Journal Title

      Neuron

      Volume: 108 Issue: 4 Pages: 748-762.e4

    • DOI

      10.1016/j.neuron.2020.08.019

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuronal Circuits That Control Rhythmic Pectoral Fin Movements in Zebrafish2020

    • Author(s)
      Uemura Yuto、Kato Kagayaki、Kawakami Koichi、Kimura Yukiko、Oda Yoichi、Higashijima Shin-ichi
    • Journal Title

      The Journal of Neuroscience

      Volume: 40 Issue: 35 Pages: 6678-6690

    • DOI

      10.1523/jneurosci.1484-20.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional Diversity of Glycinergic Commissural Inhibitory Neurons in Larval Zebrafish2020

    • Author(s)
      Satou Chie、Sugioka Takumi、Uemura Yuto、Shimazaki Takashi、Zmarz Pawel、Kimura Yukiko、Higashijima Shin-ichi
    • Journal Title

      Cell Reports

      Volume: 30 Issue: 9 Pages: 3036-3050

    • DOI

      10.1016/j.celrep.2020.02.015

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of locomotor speed and selection of active sets of neurons by V1 neurons2019

    • Author(s)
      Kimura Yukiko、Higashijima Shin-ichi
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2268-2268

    • DOI

      10.1038/s41467-019-09871-x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control2019

    • Author(s)
      Callahan Rebecca A、Roberts Richard、Sengupta Mohini、Kimura Yukiko、Higashijima Shin-ichi、Bagnall Martha W
    • Journal Title

      eLife

      Volume: 8

    • DOI

      10.7554/elife.47837

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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