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Elucidation of the neural mechanisms that show activity correlated with pleasant and unpleasant taste responses and induce these responses

Research Project

Project/Area Number 19K06938
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Tanaka Daisuke  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (90456921)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords感情 / 快 / 不快 / 嫌悪 / 味覚 / 不快反応 / 嫌悪反応 / 快反応 / 情動 / 化学遺伝学 / カルシウムイメージング / 光シート顕微鏡 / 透明化 / 快情動 / 不快情動 / TRAP / 意識内容
Outline of Research at the Start

神経活動の分子マーカーである最初期遺伝子の転写機構に基づいた遺伝子組換え法を用いて、マウスにおける快反応もしくは不快反応と相関のある活動を示す神経細胞を、脳全域に亘って単細胞レベルの解像度で同定する。さらに、同定された神経細胞に加え、申請者らがこれまでに同定した不快反応と相関のある活動を示す前交連後脚介在核の神経細胞について、化学遺伝学的手法を用いて、それら神経細胞の活動の、快・不快反応に対する因果的効果を明らかにする。

Outline of Final Research Achievements

By using methods to specifically label active neurons with fluorescent proteins and by making the brain transparent to facilitate observation of their fluorescence, I identified neurons with activity closely related to pleasant or unpleasant sensations at the single-cell level of resolution across the entire mouse brain. I also found that artificially activating those cells using an injected compound or a technique in which they are activated by light emitted from an LED light induced some behaviors that indicate pleasantness and unpleasantness in mice.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、一般に「心脳問題」や「意識のハードプロブレム」として知られている、「意識経験と神経機構の関係性の問題」の解明に寄与する可能性がある。また、快・不快の情動的意識経験(快・不快経験)は、近年増加傾向にある統合失調症やうつ病、麻薬中毒などの様々な精神疾患において異常を呈していることが知られている。本研究の成果は、それら意識経験の異常に対する治療法の開発に貢献できる可能性がある。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (4 results)

All 2022 2021 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Genetic recombination in disgust-associated bitter taste-responsive neurons of the central nucleus of amygdala in male mice2021

    • Author(s)
      Tanaka Daisuke H.、Li Shusheng、Mukae Shiori、Tanabe Tsutomu
    • Journal Title

      Neuroscience Letters

      Volume: 742 Pages: 135456-135456

    • DOI

      10.1016/j.neulet.2020.135456

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic Access to Gustatory Disgust-Associated Neurons in the Interstitial Nucleus of the Posterior Limb of the Anterior Commissure in Male Mice2019

    • Author(s)
      Tanaka Daisuke H.、Li Shusheng、Mukae Shiori、Tanabe Tsutomu
    • Journal Title

      Neuroscience

      Volume: 413 Pages: 45-63

    • DOI

      10.1016/j.neuroscience.2019.06.021

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] CHANging Consciousness Epistemically (CHANCE): An empirical method to convert the subjective content of consciousness into scientific data2019

    • Author(s)
      Tanaka Daisuke H.、Tanabe Tsutomu
    • Journal Title

      J. Mind Behav.

      Volume: 40 (3/4) Pages: 177-190

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Water deprivation-active neurons in the hypothalamus induce hedonic “liking” reactions for water2022

    • Author(s)
      Tanaka DH, Mukae S, Han I, Nonaka S, Tanabe T and Uesaka N
    • Organizer
      2022年度 日本味と匂学会 第56回大会
    • Related Report
      2022 Annual Research Report
    • Invited

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Published: 2019-04-18   Modified: 2024-01-30  

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