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Causal role of novel oscillatory activity in the thalamic reticular nucleus in fluctuating neural responses to sensory stimulation.

Research Project

Project/Area Number 19K06944
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionKeio University

Principal Investigator

TAKATA Norio  慶應義塾大学, 医学部(信濃町), 講師 (50415212)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords視床網様核 / 光ファイバー測光装置 / カルシウム / ヒゲ刺激 / マウス / ゆらぎ / シリコンプローブ / 遺伝子改変マウス / 光ファイバー蛍光観察 / 電気生理学
Outline of Research at the Start

脳神経細胞の活動応答は、同一の感覚刺激に対しても試行毎にゆらぐ。このゆらぎは情報処理の効率を低下させる「ノイズ」だと想定されている。神経応答のゆらぎはどのように生じるているのだろうか?本研究では、マウスのヒゲ刺激に対して大脳皮質神経細胞が示す応答振幅のゆらぎが「ノイズ」ではなく、申請者が発見した視床網様核(TRN)の新規集団振動活動によって能動的に生み出されている可能性を検証する。

Outline of Final Research Achievements

The responses of neuronal activity fluctuate from trial to trial, even for the same sensory stimulus. This fluctuation is assumed to be "noise" that reduces the efficiency of information processing. In this study, we investigated the possibility that the fluctuations in the response amplitude in cortical neurons to whisker stimulation in mice are not "noise" but actually are actively modulated by the novel collective oscillatory activity of the thalamic reticular nucleus (TRN), which we discovered. We developed a "fiber-optic fluorescence measurement system" and applied it to genetically modified mice in which Ca2+-sensitive fluorescent protein was expressed in the TRN. We found that TRN oscillates at low frequencies correlated with fluctuating activity in specific cortical regions.

Academic Significance and Societal Importance of the Research Achievements

脳情報処理の効率を低下させると言われる神経活動応答のゆらぎを、実は脳がTRNを介して積極的に作り出しているとの仮説検証に取り組んだ。得られた結果は仮説を支持するものであり、ゆらぎを能動的に活用する新しい情報処理機構を示唆して脳理論研究への波及効果を期待できる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (24 results)

All 2022 2021 2020 2019

All Journal Article (17 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 11 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Journal Article] Dysfunction of parvalbumin-expressing cells in the thalamic reticular nucleus induces cortical spike-and-wave discharges and an unconscious state2022

    • Author(s)
      Abdelaal Manal S.、Midorikawa Mitsuharu、Suzuki Toru、Kobayashi Kenta、Takata Norio、Miyata Mariko、Mimura Masaru、Tanaka Kenji F.
    • Journal Title

      Brain Communications

      Volume: 4 Issue: 2 Pages: 1-17

    • DOI

      10.1093/braincomms/fcac010

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rhythmic activation of excitatory neurons in the mouse frontal cortex improves the prefrontal cortex mediated cognitive function2022

    • Author(s)
      Hazra Debabrata、Yoshinaga Satoshi、Yoshida Keitaro、Takata Norio、Tanaka Kenji F、Kubo Ken-ichiro、Nakajima Kazunori
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 23 Pages: 5243-5258

    • DOI

      10.1093/cercor/bhac011

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic social defeat stress impairs goal-directed behavior through dysregulation of ventral hippocampal activity in male mice2021

    • Author(s)
      Yoshida Keitaro、Drew Michael R.、Kono Anna、Mimura Masaru、Takata Norio、Tanaka Kenji F.
    • Journal Title

      Neuropsychopharmacology

      Volume: 46 Issue: 9 Pages: 1606-1616

    • DOI

      10.1038/s41386-021-00990-y

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy2021

    • Author(s)
      Takata Norio、Sato Nobuhiko、Komaki Yuji、Okano Hideyuki、Tanaka Kenji F.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 6234-6234

    • DOI

      10.1038/s41598-021-85807-0

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optical manipulation of local cerebral blood flow in the deep brain of freely moving mice2021

    • Author(s)
      Abe Yoshifumi、Kwon Soojin、Oishi Mitsuhiro、Unekawa Miyuki、Takata Norio、Seki Fumiko、Koyama Ryuta、Abe Manabu、Sakimura Kenji、Masamoto Kazuto、Tomita Yutaka、Okano Hideyuki、Mushiake Hajime、Tanaka Kenji F.
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 4 Pages: 109427-109427

    • DOI

      10.1016/j.celrep.2021.109427

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The dopamine dip amplitude is a quantitative measure of disappointment2021

    • Author(s)
      Shikano Yu、Yagishita Sho、Tanaka Kenji F.、Takata Norio
    • Journal Title

      bioRxiv

      Volume: 20210723 Pages: 1-53

    • DOI

      10.1101/2021.07.23.453499

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oscillatory population-level activity of dorsal raphe serotonergic neurons sculpts sleep structure2021

    • Author(s)
      Kato Tomonobu、Mitsukura Yasue、Yoshida Keitaro、Mimura Masaru、Takata Norio、Tanaka Kenji F.
    • Journal Title

      bioRxiv

      Volume: 20211120 Pages: 1-45

    • DOI

      10.1101/2021.11.19.469231

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 増大特集 脳の発振現象-基礎から臨床へ 視床を介した脳のグローバルな回路2020

    • Author(s)
      高田 則雄
    • Journal Title

      BRAIN and NERVE

      Volume: 72 Issue: 11 Pages: 1195-1205

    • DOI

      10.11477/mf.1416201672

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2020-11-01
    • Related Report
      2020 Research-status Report
  • [Journal Article] Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain2020

    • Author(s)
      Kawamura Atsuki、Abe Yoshifumi、Seki Fumiko、Katayama Yuta、Nishiyama Masaaki、Takata Norio、Tanaka Kenji F.、Okano Hideyuki、Nakayama Keiichi I.
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 160-160

    • DOI

      10.1186/s13041-020-00699-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diffusion functional MRI reveals global brain network functional abnormalities driven by targeted local activity in a neuropsychiatric disease mouse model2020

    • Author(s)
      Abe Yoshifumi、Takata Norio、Sakai Yuki、Hamada Hiro Taiyo、Hiraoka Yuichi、Aida Tomomi、Tanaka Kohichi、Bihan Denis Le、Doya Kenji、Tanaka Kenji F
    • Journal Title

      NeuroImage

      Volume: 223 Pages: 117318-117318

    • DOI

      10.1016/j.neuroimage.2020.117318

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states2020

    • Author(s)
      A. Natsubori, T. Tsunematsu, A. Karashima, H. Imamura, N. Kabe, A. Trevisiol, J. Hirrlinger, T. Kodama, T. Sanagi, K. Masamoto, N. Takata, K-A Nave, K. Matsui, K.F. Tanaka, M. Honda
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 491-491

    • DOI

      10.1038/s42003-020-01215-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thalamic reticular nucleus in the thalamocortical loop2020

    • Author(s)
      Norio Takata
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 32-40

    • DOI

      10.1016/j.neures.2019.12.004

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI2020

    • Author(s)
      Joanes Grandjean et al. (48名、23番目)
    • Journal Title

      NeuroImage

      Volume: 205

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Flexible annotation atlas of the mouse brain: combining and dividing brain structures of the Allen Brain Atlas while maintaining anatomical hierarchy2020

    • Author(s)
      Norio Takata, Nobuhiko Sato, Yuji Komaki, Hideyuki Okano, Kenji F. Tanaka
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2020.02.17.953547

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] 動物のDefault mode network2019

    • Author(s)
      高田則雄
    • Journal Title

      Clinical Neuroscience

      Volume: 37 Pages: 185-188

    • Related Report
      2019 Research-status Report
  • [Journal Article] マイネルト基底核2019

    • Author(s)
      高田則雄
    • Journal Title

      脳科学辞典

      Volume: -

    • DOI

      10.14931/bsd.3497

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] グリア活動を反映するBOLD-fMRI信号2019

    • Author(s)
      高田則雄
    • Journal Title

      実験医学

      Volume: 37 Pages: 196-201

    • Related Report
      2019 Research-status Report
  • [Presentation] A novel oscillatory activity of the thalamic reticular nucleus and its relation to resting state networks of the brain2021

    • Author(s)
      Norio Takata
    • Organizer
      ISMRM 28th annual meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] GRABセンサーを用いたオペラント条件付け中の腹外側線条体ドーパミン濃度変化の解析2021

    • Author(s)
      鹿野悠、田中謙二、高田則雄
    • Organizer
      第44回日本神経科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 全脳と微小神経核の活動同時可視化による脳領域間機能的結合性の解析2021

    • Author(s)
      高田則雄、小牧裕司、三村將、岡野栄之、田中謙二
    • Organizer
      第49回可視化情報シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Flexible annotation atlas of the mouse brain using the Allen Brain Atlas2020

    • Author(s)
      Norio Takata, Nobuhiko Sato, Yuji Komaki, Hideyuki Okano, Kenji F. Tanaka
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Causal evidence of BOLD-fMRI signal generation by astrocytes without neuronal activation2019

    • Author(s)
      Norio Takata
    • Organizer
      The 2nd FRIS-TFC Joint Symposium
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] A novel oscillatory activity of the thalamic reticular nucleus specifies resting state networks in the brain2019

    • Author(s)
      Norio Takata
    • Organizer
      Neuro2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel oscillatory activity of the thalamic reticular nucleus and its relation to whole-brain activity2019

    • Author(s)
      Norio Takata
    • Organizer
      第26回日本時間生物学会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-04-18   Modified: 2023-01-30  

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