Elucidation of disease control mechanism by intestinal bacteria-host interactions through extracellular phospholipid metabolism

• Project/Area Number: 19K07042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: The University of Tokyo
• Principal Investigator: MIKI Yoshimi 東京大学, 大学院医学系研究科(医学部), 特任研究員 (00632499)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脂質 / ホスホリパーゼA2 / 腸内細菌 / 免疫 / がん / アレルギー / 炎症 / リポクオリティ / PLA2 / 癌 / 腸内細菌叢

Outline of Research at the Start

本研究では、細胞外のリン脂質代謝を担う分泌性ホスホリパーゼA2(sPLA2)に関して、腸管上皮固有に発現しているsPLA2-IIAによる脂質代謝が微生物叢と宿主の相互作用に与える影響を定量的・定性的に捉え、微生物叢の維持と変容ならびにそれに基づく全身組織の恒常性の維持や疾患発症の新規メカニズムを解明することで、sPLA2の新しい動作原理を基盤とした新たな創薬・健康シーズ創出のための土台を築く。

Outline of Final Research Achievements

Secretory phospholipase A2 (sPLA2) is the enzyme that has various physiological functions by metabolizing phospholipids in microenvironment of tissue where characteristically expressed in vivo. In this study, we focused on sPLA2-IIA, and attempted to elucidate the mechanism that sPLA2-IIA-deficient mice show exceptional phenotypes of cancer and allergy in remote tissues (skin) rather than in the site of expression (intestinal tract). Then, we found that sPLA2-IIA directly affected intestinal microbiota, the source of phospholipids in the intestinal tract, and altered the composition of intestinal microbiota and bacteria-specific lipid metabolites. These results elucidate a novel disease control mechanism via regulation of the intestinal microbiome by sPLA2, and expected to be applied to novel therapeutic and preventive strategies for various immune-related diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、従来の脂質メディエーター動員酵素としてのPLA2の概念とは一線を画す脂質代謝酵素の新しい動作原理を提示したとともに、腸内細菌叢の研究領域にPLA2という新しい概念を導入した点で、独創的かつ創造的であると考えられる。sPLA2-IIAによる腸内細菌と細菌由来の代謝物の変化を定性的・定量的に捉えることに成功した本研究成果は、将来的に癌やアレルギー性疾患の発症や予後を予測するための新規診断法の開発や、当該代謝物を利用した創薬への展開も期待できる。

Research Products

• [Int'l Joint Research] University of Chicago/University of Illinois at Chicago(米国)
• [Int'l Joint Research] Harvard Medical School(カナダ)
• [Int'l Joint Research] Centre de Recherche du CHU de Quebec(米国)
• [Int'l Joint Research] Centre de Recherche du CHU de Quebec(カナダ)
• [Journal Article] Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation (2023)
  • Author(s): Plaster M, Richey G, Pandey S, Cheronis K, Ueda T, Gruenbaum A, Dudek SM, Stephens M, Murakami M, Chevrier N.
  • Journal Title: bioRxiv Volume: 2023.01.30 Pages: 526342-526342
  • DOI: 10.1101/2023.01.30.526342
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups (2023)
  • Author(s): Hirabayashi T, Kawaguchi M, Harada S, Mouri M, Takamiya R, Miki Y, Sato H, Taketomi Y, Yokoyama K, Kobayashi T, Tokuoka SM, Kita Y, Yoda E, Hara S, Mikami K, Nishito Y, Kikuchi N, Nakata R, Kaneko M, Kiyonari H, Kasahara K, Aiba T, Ikeda K, Soga T, Kurano M, Yatomi Y, Murakami M
  • Journal Title: Cell Rep Volume: 42 Issue: 2 Pages: 111940-111940
  • DOI: 10.1016/j.celrep.2022.111940
  • Peer Reviewed / Open Access
• [Journal Article] Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice (2022)
  • Author(s): Tsukayama Izumi、Kawakami Yuki、Tamenobu Asako、Toda Keisuke、Maruoka Saya、Nagasaki Yuki、Mori Yoshiko、Sawazumi Risa、Okamoto Kensuke、Kanzaki Keita、Ito Hideyuki、Takahashi Yoshitaka、Miki Yoshimi、Yamamoto Kei、Murakami Makoto、Suzuki-Yamamoto Toshiko
  • Journal Title: Free Radical Biology and Medicine Volume: 193 Pages: 1-8
  • DOI: 10.1016/j.freeradbiomed.2022.09.028
  • Peer Reviewed / Open Access
• [Journal Article] Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects (2022)
  • Author(s): Nagasaki Yuki、Kawai Erika、Maruoka Saya、Osumi Miho、Tsukayama Izumi、Kawakami Yuki、Takahashi Yoshitaka、Okazaki Yuka、Miki Yoshimi、Taketomi Yoshitaka、Yamamoto Kei、Murakami Makoto、Suzuki-Yamamoto Toshiko
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 630 Pages: 84-91
  • DOI: 10.1016/j.bbrc.2022.09.051
  • Peer Reviewed / Open Access
• [Journal Article] Segregated functions of two cytosolic phospholipase A2 isoforms (cPLA2α and cPLA2ε) in lipid mediator generation (2022)
  • Author(s): Murakami M, Takamiya R, Miki Y, Sugimoto N, Nagasaki Y, Suzuki-Yamamoto T, Taketomi Y.
  • Journal Title: Biochemical Pharmacology Volume: 203 Pages: 115176-115176
  • DOI: 10.1016/j.bcp.2022.115176
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Group IVE cytosolic phospholipase A2 limits psoriatic inflammation by mobilizing the anti‐inflammatory lipid N‐acylethanolamine. (2022)
  • Author(s): Liang Luyiyun、Takamiya Rina、Miki Yoshimi、Heike Kanako、Taketomi Yoshitaka、Sugimoto Nao、Yamaguchi Midori、Shitara Hiroshi、Nishito Yasumasa、Kobayashi Tetsuyuki、Hirabayashi Tetsuya、Murakami Makoto
  • Journal Title: The FASEB Journal Volume: 36 Issue: 5
  • DOI: 10.1096/fj.202101958r
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma (2022)
  • Author(s): Kudo Kai、Miki Yoshimi、Carreras Joaquim、Nakayama Shunya、Nakamoto Yasushi、Ito Masatoshi、Nagashima Etsuko、Yamamoto Kei、Higuchi Hiroshi、Morita Shin-ya、Inoue Asuka、Aoki Junken、Ando Kiyoshi、Nakamura Naoya、Murakami Makoto、Kotani Ai
  • Journal Title: Cell Metabolism Volume: 34 Issue: 4 Pages: 615-633
  • DOI: 10.1016/j.cmet.2022.02.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota (2022)
  • Author(s): Miki Yoshimi、Taketomi Yoshitaka、Kidoguchi Yuh、Yamamoto Kei、Muramatsu Kazuaki、Nishito Yasumasa、Park Jonguk、Hosomi Koji、Mizuguchi Kenji、Kunisawa Jun、Soga Tomoyoshi、Boilard Eric、B. Gowda Siddabasave Gowda、Ikeda Kazutaka、Arita Makoto、Murakami Makoto
  • Journal Title: JCI Insight Volume: 7 Issue: 2
  • DOI: 10.1172/jci.insight.152611
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagy is required for maturation of surfactant-containing lamellar bodies in the lung and swim bladder (2020)
  • Author(s): Hideaki Morishita, Yuki Kanda, Takeshi Kaizuka, Haruka Chino, Kazuki Nakao, Yoshimi Miki, Yoshitaka Taketomi, Jun-Lin Guan, Makoto Murakami, Atsu Aiba, Noboru Mizushima
  • Journal Title: Cell Reports Volume: 33 Issue: 10 Pages: 108477-108477
  • DOI: 10.1016/j.celrep.2020.108477
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Group V secreted phospholipase A2 plays a protective role against aortic dissection (2020)
  • Author(s): Kazuhiro Watanabe, Yoshitaka Taketomi, Yoshimi Miki, Kiyotaka Kugiyama, Makoto Murakami
  • Journal Title: Journal of Biological Chemistry Volume: 295 Issue: 30 Pages: 10092-10111
  • DOI: 10.1074/jbc.ra120.013753
  • Peer Reviewed / Open Access
• [Journal Article] Secreted phospholipase PLA2G2D contributes to metabolic health by mobilizing omega3 polyunsaturated fatty acids in WAT (2020)
  • Author(s): Sato H, Taketomi Y, Miki Y, Murase R, Yamamoto K, Murakami M.
  • Journal Title: Cell Reports Volume: 31 Issue: 5 Pages: 107579-107579
  • DOI: 10.1016/j.celrep.2020.107579
  • Peer Reviewed / Open Access
• [Journal Article] Activation of inflammation and resolution pathways of lipid mediators in synovial fluid from patients with severe rheumatoid arthritis compared with severe osteoarthritis (2020)
  • Author(s): Yutaka Sano, Shota Toyoshima, Yoshimi Miki, Yoshitaka Taketomi, Mana Ito, Hyunho Lee, Shu Saito, Makoto Murakami, Yoshimichi Okayama
  • Journal Title: Asia Pacific Allergy Volume: 10 Issue: 2 Pages: e21-e21
  • DOI: 10.5415/apallergy.2020.10.e21
  • Peer Reviewed / Open Access
• [Journal Article] Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation (2020)
  • Author(s): Toda Keisuke、Tsukayama Izumi、Nagasaki Yuki、Konoike Yuka、Tamenobu Asako、Ganeko Natsuki、Ito Hideyuki、Kawakami Yuki、Takahashi Yoshitaka、Miki Yoshimi、Yamamoto Kei、Murakami Makoto、Suzuki-Yamamoto Toshiko
  • Journal Title: Archives of Biochemistry and Biophysics Volume: - Pages: 108307-108307
  • DOI: 10.1016/j.abb.2020.108307
  • Peer Reviewed / Open Access
• [Journal Article] Parkinson's disease-associated iPLA2-VIA/PLA2G6 regulates neuronal functions and α-synuclein stability through membrane remodeling. (2019)
  • Author(s): Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo SI, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, Imai Y, Hattori N.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 116(41) Issue: 41 Pages: 20689-20699
  • DOI: 10.1073/pnas.1902958116
  • NAID: 120007132272
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 乳汁のリピドミクス解析と乳腺発達における生理活性脂質合成系酵素の発現動態 (2023)
  • Author(s): 日本農芸化学2022年度大会
  • Organizer: 丸岡 紗也, 長崎 祐樹, 大角 美穂, 津嘉山 泉, 三木 寿美, 山本 圭, 村上 誠, 山本 登志子
• [Presentation] Comparative profile of free fatty acids and the metabolites between different species and search for the critical enzymes to the lipid composition (2022)
  • Author(s): Saya Maruoka, Yuki Nagasaki, Erika Kawai, Miho Oosumi, Izumi Tsukayama, Yoshimi Miki, Makoto Murakami, Kei Yamamoto, Toshiko Suzuki-Yamamoto
  • Organizer: 22nd IUNS-ICN International Congress of Nutrition
  • Int'l Joint Research
• [Presentation] 乾癬時増加する生理活性脂質(NAE)の産生機構と乾癬炎症抑制効果 (2022)
  • Author(s): 高宮 里奈, 三木 寿美, 梁 陸伊韻, 村上 誠
  • Organizer: 第95回日本生化学会大会
• [Presentation] 細胞質型ホスホリパーゼ cPLA2ζは皮膚の適応修復に関わる (2022)
  • Author(s): 長崎 祐樹, 武富 芳隆, 三木 寿美, 安川 賢, 佐伯 和子, 横溝 岳彦, 山本 登志子, 村上 誠
  • Organizer: 第95回日本生化学会大会
• [Presentation] sPLA2-Xは腸内細菌叢の調節を介してメタボリックシンドロームを制御する (2022)
  • Author(s): 佐藤 弘泰, 武富 芳隆, 村瀬 礼美, 三木 寿美, 原 俊太郎, 細見 晃司, 朴 鐘旭, 水口 賢司, 國澤 純, 村上 誠
  • Organizer: 第95回日本生化学会大会
• [Presentation] sPLA2による修飾による細胞外小胞の新機能とリンパ腫発生における意義 (2022)
  • Author(s): 幸谷 愛, 工藤 海, 三木 寿美, 村上 誠
  • Organizer: 第95回日本生化学会大会
• [Presentation] 肝細胞由来細胞外小胞はリゾリン脂質を介して炎症収束を誘導する (2022)
  • Author(s): 中山 駿矢, 中本 泰, 紙屋 光佑, 三木 寿美, 白石 良樹, 伊藤 洋子, 浅野 浩一郎, 村上 誠, 幸谷 愛
  • Organizer: 第95回日本生化学会大会
• [Presentation] EBV陽性リンパ腫における細胞外小胞脂質の修飾を介した新規発がん機序の解明 (2022)
  • Author(s): 工藤 海, 三木 寿美, 村上 誠, 幸谷 愛
  • Organizer: 第95回日本生化学会大会
• [Presentation] 表皮分泌性ホスホリパーゼA2代謝経路は創傷治癒を改善する (2022)
  • Author(s): 谷口 晴菜, 重永 章, 福田 朱里, 犬伏 穂南, 天野 智仁, 箱井 春香, 三木 寿美, 村上 誠, 山本 圭
  • Organizer: 第95回日本生化学会大会
• [Presentation] Lipid profiling reveals the presence of unique lipid mediators in human milk from healthy and mastitic subjects (2022)
  • Author(s): Yuki Nagasaki, Erika Kawai, Saya Marukoka, Miho Osumi, Izumi Tsukayama, Yuka Okazaki, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
  • Organizer: 17th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases 2022
  • Int'l Joint Research
• [Presentation] Inhibition of arachidonate 5-lipoxygenase and amelioration of psoriasis-like skin symptoms by malabaricone C derived from nutmeg (2022)
  • Author(s): Izumi Tsukayama, Yuki Kawakami, Asako Tamenobu, Saya Maruoka, Yoshimi Miki, Makoto Murakami, Toshiko Suzuki-Yamamoto
  • Organizer: 17th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases 2022
  • Int'l Joint Research
• [Presentation] Loss of MPAN-associated C19orf12 causes alteration of lipid metabolism and autophagosome-lysosome trafficking in Drosophila (2022)
  • Author(s): Kenta Shiina，Akio Mori，Yoshimi Miki，Makoto Murakami，Noriko Ueno，Yoshiki Miura， Taku Hatano， Yuzuru Imai， Nobutaka Hattori
  • Organizer: 8th International Symposium on NBIA(Neurodegeneration with Brain Iron Accumulation)
  • Int'l Joint Research
• [Presentation] sPLA2-IIF の二次産物であるアセタール型リゾプラズマローゲンは創傷治癒を改善する (2022)
  • Author(s): 福田 朱里, 重永 章, 谷口 晴菜, 犬伏 穂南, 天野 智仁, 三木 寿美, 村上 誠, 山本 圭
  • Organizer: 第64回日本脂質生化学会
• [Presentation] PLAAT1 Deficiency Alleviates High Fat Diet-Induced Hepatic Lipid Accumulation in Mice (2022)
  • Author(s): S.M. Khaledur Rahman, Toru Uyama, Zahir Hussain, Mohammad Mamun Sikder, Hiroyuki Saiga, Kenichi Ota, Katsuaki Hoshino, Masaki Ueno, Yoshimi Miki, Makoto Murakami, Natsuo Ueda
  • Organizer: 第68回日本生化学会中国・四国支部例会_香川大・宇山
• [Presentation] cPLA2εは複数組織において抗炎症性脂質NAEの産生に関わる. (2021)
  • Author(s): 杉本 奈央, 高宮 里奈, 三木 寿美, 宇山 徹, 上田 夏生, 李 賢哲, 横溝 岳彦, 村上 誠.
  • Organizer: 第94回日本生化学大会
• [Presentation] 皮膚バリア形成におけるリゾプラズマローゲンの機能解析. (2021)
  • Author(s): 福田 朱里, 谷口 晴菜, 犬伏 穂南, 天野 智仁, 三木 寿美, 村上 誠, 山本 圭.
  • Organizer: 第94回日本生化学大会
• [Presentation] 慢性皮膚炎症疾患におけるリゾプラズマローゲンの機能解析. (2021)
  • Author(s): 犬伏 穂南, 天野 智仁, 三木 寿美, 村上 誠, 山本 圭.
  • Organizer: 第94回日本生化学大会
• [Presentation] ナツメグ含有成分Malabaricone Cによる5-リポキシゲナーゼ活性阻害と乾癬予防効果. (2021)
  • Author(s): 津嘉山 泉，爲延 麻子，川上 祐生，戸田 圭祐，長崎 祐樹，丸岡 紗也，高橋 吉孝，三木 寿美，村上 誠，山本 登志子.
  • Organizer: 第62回日本生化学会中国・四国支部会
• [Presentation] ヒトとウシの乳汁中脂質メディエータープロファイル. (2021)
  • Author(s): 長崎 祐樹, 丸岡 紗也, 大角 美穂, 津嘉山 泉, 川上 祐生, 高橋 吉孝, 岡﨑 愉加, 三木 寿美, 山本 圭, 村上 誠, 山本 登志子.
  • Organizer: 第75回日本栄養・食糧学会大会
• [Presentation] ヒトとウシの乳汁中脂質プロファイル比較. (2021)
  • Author(s): 長崎 祐樹, 川井 恵梨佳, 田中 充樹, 戸田 圭祐, 津嘉山 泉, 川上 祐生, 高橋 吉孝, 岡﨑 愉加, 三木 寿美, 山本 圭, 村上 誠, 山本 登志子.
  • Organizer: 第63回脂質生化学会
• [Presentation] 分泌性ホスホリパーゼA2はエクソソームのリン脂質を分解する (2020)
  • Author(s): 三木 寿美, 山本 圭, 工藤 海, 幸谷 愛, 武富 芳隆, 村上 誠
  • Organizer: 第93回日本生化学会大会
• [Presentation] 肺胞微石症IIb型ナトリウムリン酸共輸送体 (Npt2b) 欠損マウスを用いた臨床応用に向けた肺胞微石症の病態解析 (2020)
  • Author(s): 高宮 里奈, 三木 寿美, 村上 誠, 高橋 弘毅, 齋藤 充史
  • Organizer: 第93回日本生化学会大会
• [Presentation] 新規細胞質型ホスホリパーゼA2 (cPLA2δ) の機能解析 (2020)
  • Author(s): 杉本 奈央, 高宮 里奈, 梁 陸伊韻, 三木 寿美, 村上 誠
  • Organizer: 第93回日本生化学会大会
• [Presentation] 皮膚における新規細胞質型ホスホリパーゼA2 (cPLA2δ, cPLA2ε) の機能解析 (2019)
  • Author(s): 梁陸伊韻, 三木寿美, 平林哲也, 平家圭奈子, 小林哲幸, 山本圭, 武富芳隆, 高宮里奈, 村上誠
  • Organizer: 第92回日本生化学会大会
• [Presentation] 脂肪細胞のベージュ化に関わる2種類のThermogenic sPLA2sの同定 (2019)
  • Author(s): 佐藤弘泰, 武富芳隆, 三木寿美, 村上誠
  • Organizer: 第92回日本生化学会大会
• [Presentation] ヒトとウシの乳汁中脂質プロファイル解析 (2019)
  • Author(s): 長崎祐樹, 川井恵梨佳, 田中充樹, 戸田圭祐, 津嘉山泉, 川上祐生, 高橋吉孝, 岡﨑愉加, 三木寿美, 山本圭, 村上誠, 山本登志子
  • Organizer: 第92回日本生化学会大会
• [Presentation] IIF型分泌性ホスホリパーゼA2/リゾプラズマローゲン経路は表皮肥厚性疾患の新規創薬ターゲットである (2019)
  • Author(s): 山本圭, 箱井春香, 三木寿美, 村上誠
  • Organizer: 第61回日本脂質生化学会
• [Presentation] 赤米由来プロアントシアニジンによる5-リポキシゲナーゼ阻害と乾癬予防効果 (2019)
  • Author(s): 戸田圭祐, 津嘉山泉, 長崎祐樹, 爲延麻子, 鴻池優佳, 我如古菜月, 伊東秀之, 川上祐生, 高橋吉孝, 三木寿美, 山本圭, 村上誠, 山本登志子
  • Organizer: 第61回日本脂質生化学会
• [Presentation] Group IIA phospholipase A2 regulates gut microbiome (2019)
  • Author(s): Yoshimi Miki, Yoshitaka Taketomi, Kei Yamamoto, Koji Hosomi, Jun Kunisawa, Siddabasave Gowda B. Gowda, Kazutaka Ikeda, Makoto Arita, Makoto Murakami
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] The phosphate binder ferric citrate attenuates microlith formation and COX-2 induction in a mouse model of pulmonary alveolar microlithiasis (2019)
  • Author(s): Rina Takamiya, Yoshimi Miki, Makoto Murakami, Hiroki Takahashi, Atsushi Saito
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Group IID phospholipase A2 promotes browning of white adipose tissue and limits diet-induced obesity (2019)
  • Author(s): Hiroyasu Sato, Yoshitaka Taketomi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Distinct roles of phospholipase A2s in colitis and colonic cancer (2019)
  • Author(s): Remi Murase, Yoshitaka Taketomi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Group III phospholipase A2 promotes atherosclerosis (2019)
  • Author(s): Yoshitaka Taketomi, Takuro Miyazaki, Hiroyasu Sato, Yoshimi Miki, Makoto Murakami
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Group IVE phospholipase A2 (cPLA2ε) mobilizes the non-canonical lipid mediator N-acylethanolamine in mouse skin (2019)
  • Author(s): Luiyun Liang, Kanako Heike, Tetsuyuki Kobayashi, Tetsuya Hirabayashi, Yoshimi Miki, Kei Yamamoto, Yoshitaka Taketomi, Makoto Murakami
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Inhibition of arachidonate 5-lipoxygenase and improvement in psoriasis by red rice proanthocyanidin (2019)
  • Author(s): Keisuke Toda, Yuki Nagasaki, Izumi Tsukayama, Asako Tamenobu, Yuka Konoike, Natsuki Ganeko, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Lipocalin-type prostaglandin D synthase as a potential biomarker of bovine mastitis (2019)
  • Author(s): Yuki Nagasaki, Erika Kawai, Mitsuki Tanaka, Keisuke Toda, Izumi Tsukayama, Yuki Kawakami, Yoshitaka Takahashi, Masumi Kimoto, Yuka Okazaki, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] Exosome could be the source of lipid mediator in cancer platform (2019)
  • Author(s): Kai Kudou, Yoshimi Miki, Hiroshi Higuchi, Kei Yamamoto, Makoto Murakami, Ai Kotani
  • Organizer: 60th International Conference on the Bioscience of Lipids
  • Int'l Joint Research
• [Presentation] 慢性特発性蕁麻疹、アトピー性皮膚炎患者血漿を用いた脂質分子の網羅的解析 (2019)
  • Author(s): 伊東真奈, 遠藤嵩大, 豊島翔太, 三木寿美, 武富芳隆, 葉山惟大, 坂本朋美, 村上誠, 照井正, 岡山吉道
  • Organizer: 第68回日本アレルギー学会学術大会
• [Remarks] ホームページ: 東京大学大学院医学系研究科 疾患生命工学センター 健康環境医工学部門 (村上研)
  • URL: https://lmmhs.m.u-tokyo.ac.jp/
• [Remarks] 腸と皮膚の新たなクロストーク：腸内細菌叢を変えて皮膚の健康に影響を及ぼす脂質分解酵素の発見
  • URL: https://www.m.u-tokyo.ac.jp/news/press.html#20220126
• [Remarks] 腸と皮膚の新たなクロストーク：腸内細菌叢を変えて皮膚の健康に影響を及ぼす脂質分解酵素の発見
  • URL: https://www.amed.go.jp/news/release_20220126-02.html
• [Remarks] リンパ腫における細胞外小胞を介した新規発がんメカニズムを発見：脂質を軸とした新たな治療法の開発に期待
  • URL: https://www.tokai.ac.jp/news/detail/post_375.html
• [Remarks] リンパ腫における細胞外小胞を介した新規発がんメカニズムを発見：脂質を軸とした新たな治療法の開発に期待
  • URL: https://www.jst.go.jp/pr/announce/20220316/index.html
• [Remarks] プレス発表: オリーブ油の成分が大動脈を守る～オレイン酸を動かし大動脈解離を抑える脂質代謝酵素の同定
  • URL: https://www.m.u-tokyo.ac.jp/news/press.html#20200708
• [Remarks] プレス発表: オリーブ油の成分が大動脈を守る：オレイン酸を動かし大動脈解離を抑える脂質代謝酵素の同定
  • URL: https://www.amed.go.jp/news/seika/kenkyu/20200715.html
• [Remarks] プレス発表: オリーブ油に富む地中海食が血管に良い影響を及ぼす分子機序の一端を解明
  • URL: http://www.qlifepro.com/news/20200709/olive-oil.html
• [Remarks] プレス発表: 体に優しいオメガ3脂肪酸を動かし肥満を抑える新しい脂質代謝酵素の発見 (AMED)
  • URL: https://www.amed.go.jp/news/release_20200506.html
• [Remarks] 東京大学大学院医学系研究科 疾患生命工学センター 健康環境医工学部門 (村上研) ホームページ
  • URL: https://lmmhs.m.u-tokyo.ac.jp/
• [Remarks] プレスリリース: 脳内の脂質変化がパーキンソン病の原因となるメカニズムを解明
  • URL: https://www.amed.go.jp/news/release_20190927-01.html