Construction of a bidirectional medical evaluation system using quantitative evaluation (micro TDM and DBS) and ICT
Project/Area Number |
19K07193
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 47060:Clinical pharmacy-related
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Research Institution | Hiroshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
猪川 和朗 広島大学, 医系科学研究科(薬), 准教授 (40363048)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 臨床 / 感染症 / 抗菌剤 / PK/PD / PK/PD |
Outline of Research at the Start |
我々は、マイクロTDMを提案し、最近6年間での健康チェック時の 13,000人以上の健常一般人の生体情報とPOCT (Point OF Care Testing) を用いた血液生化学測定値を集積した。他方、入院患者3,000人以上30種類以上の血漿中および臓器内の組織内濃度測定値から、日本人の母集団薬物動態パラメータと組織内薬物動態を報告してきた。 この両実績を日本人の基準値とし、未病、予防、医療間のシームレスな医療モニタリングシステムを構築する。そのために、在宅でのPOCTを用いたリアルタイム生化学測定とDBS (Dried blood spot)法を用いた薬物濃度測定法を構築する。
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Outline of Final Research Achievements |
We proposed micro TDM and collected biometric information of more than 13,000 healthy ordinary people and blood biochemical measurements using POCT (Point OF Care Testing) at the time of health check in the last 6 years. On the other hand, we have reported the pharmacokinetic parameters of the Japanese population and the pharmacokinetics in tissues from the plasma and tissue concentration measurements of more than 30 kinds of drugs in more than 3,000 inpatients. In this study, we will build a seamless medical monitoring system between pre-illness, prevention, and medical care, using both of these achievements as standard values for Japanese people. To this end, we constructed a real-time biochemical measurement using POCT at home and a drug concentration measurement method using the DBS (Dried blood spot) method.
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Academic Significance and Societal Importance of the Research Achievements |
最近6年間での健康チェック時に13,000人以上の健常一般人の生体情報とPOCT (Point OF Care Testing) を用いた血液生化学測定値を集積した。この集積結果を基に、性差、年齢別に測定値を検討する。入院患者3,000人以上、30種類以上の薬剤(抗菌剤、抗てんかん剤)の日本人の血漿中および臓器内(腹水、胆汁、膵液、尿、前立腺組織、精巣、肺胞液、人工透析液、人工心肺還流液、等)の組織内濃度測定値から、日本人の母集団薬物動態パラメータと組織内薬物動態を報告した。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Pharmacokinetic/pharmacodynamic evaluation of teicoplanin against Staphylococcus aureus in murine thigh infection model.2021
Author(s)
Watanabe E, Matsumoto K, Ikawa K, Yokoyama Y, Shigemi A, Enoki Y, Umezaki Y, Nakamura K, Ueno K, Terazono H, Morikawa N, Takeda Y.
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Journal Title
J. Glob. Antimicrob. Resist.
Volume: 24
Pages: 83-87
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dosing optimization of ampicillin-sulbactam based on cystatin C in elderly patients with pneumonia.2021
Author(s)
Matsubara K, Matsumoto K, Yokoyama Y, Watanabe E, Enoki Y, Shigemi A, Ikawa K, Terazono H, Morikawa N, Ohshige T, Takeda Y.
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Journal Title
Biol. Pharm. Bull.
Volume: 44
Pages: 732-736
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical pharmacokinetics of flomoxef in prostate tissue and dosing considerations for prostatitis based on site-specific pharmacodynamic target attainment.2020
Author(s)
Nakamura K, Ikawa K, Nishikawa G, Kobayashi I, Tobiume M, Sugie M, Muramatsu H, Morinaga S, Kajikawa K, Watanabe M, Kanao K, Onita T, Morikawa N.
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Journal Title
J. Infect. Chemother.
Volume: 26
Issue: 2
Pages: 236-241
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The pharmacokinetics of oral metronidazole in patients with metronidazole-induced encephalopathy undergoing maintenance hemodialysis.2020
Author(s)
Mimura Y, Yahiro M, Masumoto M, Fukui R, Okamoto R, Aichi M, Mihara Y, Ueda T, Takesue Y, Ikawa K, Morikawa N, Kuragano T.
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Journal Title
Hemodial. Int.
Volume: 24
Issue: 4
Pages: 528-533
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical pharmacokinetics of oral azithromycin in epididymal tissue.2019
Author(s)
Sadahira T, Wada K, Ikawa K, Morikawa N, Mitsui M, Araki M, Fujiyoshi M, Ishii A, Watanabe M, Watanabe T, Nasu Y.
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Journal Title
J. Infect. Chemother.
Volume: 25
Issue: 10
Pages: 832-834
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] セファゾリン予防投与における血管手術患者での薬物動態解析と投与法評価.2022
Author(s)
大内香乃, 猪川和朗, 大谷英里香, 鷹取健太, 青木陽平, 有吉映, 岩下麻理, 隠澤和恭, 新畑知子, 川井和美, 森川則文
Organizer
日本薬学会第 142 年会 (名古屋)
Related Report
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[Presentation] Clinical pharmacokinetics of intravenous metronidazole in plasma, peritoneal fluid, peritoneum and adipose tissue.2020
Author(s)
Taogoshi H, Ohge H, Ikawa K, Watadani Y, Uegami S, Shigemoto N, Shimada N, Omori K, Kitano H, Kuroo Y, Kitagawa H, Yoshimura K, Uemura K, Murakami Y, Morikawa N, Takahashi S.
Organizer
Digestive Disease Week 2020 (Chicago, USA)
Related Report
Int'l Joint Research
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[Presentation] Clinical pharmacokinetics of beta-lactam and quinolone antibiotics in prostate tissue, and dosing considerations for prostatitis based on site-specific pharmacodynamics.2019
Author(s)
Nakamura K, Ikawa K, Nishikawa G, Kobayashi I, Sugie M, Muramatsu H, Morinaga S, Kajikawa K, Watanabe M, Kanao K, Morikawa N.
Organizer
34th Annual Congress of the European Association of Urology (Barcelona, Spain),
Related Report
Int'l Joint Research
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[Presentation] Clinical population pharmacokinetics of ampicillin-sulbactam in plasma and prostate.2019
Author(s)
Onita T, Ikawa K, Ishihara N, Nakamura K, Nishikawa G, Kobayashi I, Tamaki H, Yano T, Naora K, Morikawa N.
Organizer
40th Annual Meeting of the American College of Clinical Pharmacy (New York, USA),
Related Report
Int'l Joint Research
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[Presentation] Intraventricular administration of etoposide in a 3-year-old patient with meningeal recurrent AT/RT: the pharmacokinetics of etoposide in the cerebrospinal fluid.2019
Author(s)
Matsui M, Saito Y, Yokokawa Y, Tsuda K, Ihara S, Ayuta R, Ikawa K, Morikawa N, Makimoto A, Yuza Y.
Organizer
第 61 回日本小児血液・がん学会学術集会 (広島),
Related Report
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[Presentation] 結腸直腸手術患者におけるメトロニダゾール静注の血漿・腹水・腹部組織中濃度推移.2019
Author(s)
垰越宏幸, 大毛宏喜, 猪川和朗, 渡谷祐介, 上神慎之介, 繁本憲文, 嶋田徳光, 大森慶太郎, 北野弘之, 黒尾優太, 北川浩樹, 吉村幸祐, 森川則文.
Organizer
第 32 回日本外科感染症学会総会学術集会 (岐阜),
Related Report
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[Presentation] 前立腺組織における ampicillin/sulbactam 配合剤の母集団薬物動態解析.2019
Author(s)
大仁田哲修, 猪川和朗, 石原慎之, 中村小源太, 西川源也, 小林郁生, 玉木宏樹, 矢野貴久, 直良浩司, 森川則文.
Organizer
第 40 回日本臨床薬理学会年会 (東京),
Related Report