Functional differentiation and interaction of AM and AM2 in metabolic regulation
Project/Area Number |
19K07317
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 48030:Pharmacology-related
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Research Institution | Shinshu University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | アドレノメデュリン / アドレノメデュリン2 |
Outline of Research at the Start |
アドレノメデュリン(AM)は生理活性ペプチドであり、これまでに脂肪細胞の分化、糖脂質代謝およびエネルギー代謝を制御していることを明らかとしてきたが、アドレノメデュリン2(AM2)の代謝制御における意義は明らかでない。本研究では、脂肪細胞の分化や代謝制御における、AMとAM2の機能分化と相互作用、メタボリックシンドロームにおける病態生理学的意義を解明し、メタボリックシンドロームにおいてAMとAM2が治療標的となりうるかを検討する。
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Outline of Final Research Achievements |
We elucidated that adrenomedullin (AM) which is biologically active peptide controls adipocyte differentiation and energy metabolism so far. Whereas adrenomedullin 2 (AM2) has effects similar to AM in the cardiovascular regulation, but the role in the metabolic regulation is not clear. In this study, we established AM2 knockout mice (AM2-/-) to elucidate functional differentiation and interaction of AM and AM2 in the metabolic regulation and analyzed pathophysiological significance in the metabolic syndrome. We showed the possibility that AM2 was involved in energy metabolic regulation similar to AM.
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Academic Significance and Societal Importance of the Research Achievements |
AMとAM2は、血管拡張作用などの循環調節作用を有するなど、共通の作用を持つ反面、両者の分布や発現量は組織により異なっている。これまでにAMの生理作用については多く報告されているが、AM2の生理作用については不明な点が多い。両者は受容体活性調節タンパクRAMPを共有することから、代謝関連組織におけるAMとAM2の機能分化と相互作用を明らかにすることにより、メタボリックシンドロームの治療法開発に展開することが期待される。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-b-Smads signaling and myofibroblast differentiation2021
Author(s)
Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T
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Journal Title
Endocrinology
Volume: 162(8)
Issue: 8
Pages: 1-22
DOI
Related Report
Peer Reviewed
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[Journal Article] Adrenomedullin-receptor activity-modifying protein 2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration2021
Author(s)
Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T
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Journal Title
Am J Pathol
Volume: 191(4)
Issue: 4
Pages: 652-668
DOI
Related Report
Peer Reviewed
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[Journal Article] Adrenomedullin-RAMP2 and -RAMP3 systems regulate cardiac homeostasis during cardiovascular stress2021
Author(s)
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T
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Journal Title
Endocrinology
Volume: 162(3)
Issue: 3
Pages: 0-0
DOI
Related Report
Peer Reviewed
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[Journal Article] Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts2020
Author(s)
Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T
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Journal Title
Oncogene
Volume: 39(9)
Issue: 9
Pages: 1914-1930
DOI
Related Report
Peer Reviewed
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[Journal Article] Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation2019
Author(s)
Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T
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Journal Title
Am J Pathol
Volume: 189(12)
Issue: 12
Pages: 2487-2502
DOI
Related Report
Peer Reviewed
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