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Clinicopathological significance of T-UCR and molecular classification in gastrointestinal cancer

Research Project

Project/Area Number 19K07434
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionHiroshima University

Principal Investigator

Sentani Kazuhiro  広島大学, 医系科学研究科(医), 講師 (30508164)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsT-UCR / claspin / 分子分類 / 腫瘍内多様性 / 癌幹細胞
Outline of Research at the Start

消化管癌は近年、包括的ゲノム解析に基づく分子分類が提唱され、個別化医療の発展に大きく寄与している。一方で、生物種を超えて相同配列を示すT-UCRの中に抗癌剤耐性に関わるものが存在することが明らかとなり、抗癌剤抵抗性を制御する重要な分子であることが想定されるが、現在のところ癌における解析は十分ではない。本研究では、消化管癌の各々のmolecular subtype別のT-UCRの特徴を明らかにし、癌幹細胞マーカーを含めた制御機構や、腫瘍内局在や組織型別・臓器別相違を明らかにすることで、治療抵抗性を示す消化管癌の進展転移の解明や治療や予後予測、鑑別診断マーカーなどの臨床応用を目指す。

Outline of Final Research Achievements

This study includes the clinicopathological and biological analysis of T-UCR in urothelial carcinoma. We clarified that increased expression of Uc.63+ enhanced proliferation activity, and its decrease lead to cisplatin sensitivity. And we analyzed the relationship between intratumoral heterogeneity and molecular classification in gastric cancer (GC). GC cases with more histological numbers or mixed types in invasive areas showed significantly higher T grade and staging, poorer prognosis and characteristically expressed cancer stem cell-related molecules (CD44, CD133 or ALDH1) and receptor tyrosine kinase molecules (HER2, EGFR or c-MET) as well as chromosomal instability subtype of GC. In addition, we demonstrated the clinicopathological significance of claspin and intelectin-1 in gastrointestinal and urological organs.

Academic Significance and Societal Importance of the Research Achievements

本研究では、消化管癌および泌尿器系癌のT-UCRs発現解析に基づいて得られるデータを基盤として、対象とするT-UCRsの発現を制御するmicroRNAや標的とする分子に焦点を当てて解析を行った。得られたデータにより抗がん剤抵抗性を促進する機構など予後不良あるいは治療抵抗性を示す癌のメカニズムの一部を明らかにした。一方で癌の治療抵抗性の原因の一つである腫瘍内不均一性と分子分類との関係を調べるとともに、複数の癌関連分子の臨床病理学的特徴を明らかにした。これらの成果は今後さらなる診断、治療への応用が期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (59 results)

All 2022 2021 2020 2019 Other

All Journal Article (49 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 49 results,  Open Access: 31 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] Protocadherin B9 Is Associated with Human Esophageal Squamous Cell Carcinoma Progression2022

    • Author(s)
      Fujiki Yuto、Ishikawa Akira、Akabane Shintaro、Mukai Shoichiro、Maruyama Ryota、Yamamoto Yuji、Kido Aya、Katsuya Narutaka、Taniyama Daiki、Sentani Kazuhiro、Oue Naohide、Yasui Wataru
    • Journal Title

      Pathobiology

      Volume: - Issue: 1 Pages: 1-9

    • DOI

      10.1159/000523817

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of endoscopic findings in nine cases of Helicobacter suis‐infected gastritis complicated by gastric mucosa‐associated lymphoid tissue lymphoma2022

    • Author(s)
      Kadota Hiroki、Yuge Ryo、Miyamoto Ryo、Otani Rina、Takigawa Hidehiko、Hayashi Ryohei、Urabe Yuji、Oka Shiro、Sentani Kazuhiro、Oue Naohide、Kitadai Yasuhiko、Tanaka Shinji
    • Journal Title

      Helicobacter

      Volume: - Issue: 3 Pages: 12887-12887

    • DOI

      10.1111/hel.12887

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of aldolase, fructose‐bisphosphate C and its association with spheroid formation in colorectal cancer2022

    • Author(s)
      Maruyama Ryota、Nagaoka Yuma、Ishikawa Akira、Akabane Shintaro、Fujiki Yuto、Taniyama Daiki、Sentani Kazuhiro、Oue Naohide
    • Journal Title

      Pathology International

      Volume: 72 Issue: 3 Pages: 176-186

    • DOI

      10.1111/pin.13200

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytological and histological findings of upper tract mucinous urothelial carcinoma with clear cell component: A case report and review of literature2021

    • Author(s)
      Kobayashi Go、Uraoka Naohiro、Sentani Kazuhiro、Shibata Jun、Nobuhiro Ryosuke、Saito Yoichi、Taniyama Daiki、Hanamoto Masanori、Nose Hiroyuki、Oue Naohide
    • Journal Title

      Diagnostic Cytopathology

      Volume: 50 Issue: 5

    • DOI

      10.1002/dc.24921

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological significance of claspin overexpression and its efficacy as a novel biomarker for the diagnosis of urothelial carcinoma2021

    • Author(s)
      Kobayashi Go、Hayashi Tetsutaro、Sentani Kazuhiro、Babasaki Takashi、Sekino Yohei、Inoue Shogo、Uraoka Naohiro、Hanamoto Masanori、Nose Hiroyuki、Teishima Jun、Oue Naohide、Matsubara Akio、Sasaki Naomi、Yasui Wataru
    • Journal Title

      Virchows Archiv

      Volume: 480 Issue: 3 Pages: 621-633

    • DOI

      10.1007/s00428-021-03239-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of Schlafen 11 in bladder cancer patients treated with platinum‐based chemotherapy2021

    • Author(s)
      Taniyama Daiki、Sakamoto Naoya、Takashima Tsuyoshi、Takeda Masahiko、Pham Quoc Thang、Ukai Shoichi、Maruyama Ryota、Harada Kenji、Babasaki Takashi、Sekino Yohei、Hayashi Tetsutaro、Sentani Kazuhiro、Pommier Yves、Murai Junko、Yasui Wataru
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 2 Pages: 784-795

    • DOI

      10.1111/cas.15207

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KIFC1 Is Associated with Basal Type, Cisplatin Resistance, PD-L1 Expression and Poor Prognosis in Bladder Cancer2021

    • Author(s)
      Sekino Yohei、Pham Quoc Thang、Kobatake Kohei、Kitano Hiroyuki、Ikeda Kenichiro、Goto Keisuke、Hayashi Tetsutaro、Nakahara Hikaru、Sentani Kazuhiro、Oue Naohide、Yasui Wataru、Teishima Jun、Hinata Nobuyuki
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 21 Pages: 4837-4837

    • DOI

      10.3390/jcm10214837

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD44 Is Involved in Sunitinib Resistance and Poor Progression-free Survival After Sunitinib Treatment of Renal Cell Carcinoma2021

    • Author(s)
      SEKINO YOHEI、TAKEMOTO KENSHIRO、MURATA DAIKI、BABASAKI TAKASHI、KOBATAKE KOHEI、KITANO HIROYUKI、IKEDA KENICHIRO、GOTO KEISUKE、INOUE SHOGO、HAYASHI TETSUTARO、TANIYAMA DAIKI、SHIGETA MASANOBU、KURAOKA KAZUYA、MITA KOJI、KANEKO MAYUMI、SENTANI KAZUHIRO、OUE NAOHIDE、TEISHIMA JUN
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 10 Pages: 4875-4883

    • DOI

      10.21873/anticanres.15301

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P53 Is Involved in Sunitinib Resistance and Poor Progression-free Survival After Sunitinib Treatment of Renal Cell Carcinoma2021

    • Author(s)
      SEKINO YOHEI、TAKEMOTO KENSHIRO、MURATA DAIKI、BABASAKI TAKASHI、KOBATAKE KOHEI、KITANO HIROYUKI、IKEDA KENICHIRO、GOTO KEISUKE、INOUE SHOGO、HAYASHI TETSUTARO、TANIYAMA DAIKI、SHIGETA MASANOBU、KURAOKA KAZUYA、MITA KOJI、KANEKO MAYUMI、SENTANI KAZUHIRO、OUE NAOHIDE、TEISHIMA JUN
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 9 Pages: 4287-4294

    • DOI

      10.21873/anticanres.15233

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of claspin promotes docetaxel resistance and is associated with prostate‐specific antigen recurrence in prostate cancer2021

    • Author(s)
      Babasaki Takashi、Sentani Kazuhiro、Sekino Yohei、Kobayashi Go、Thang Pham Quoc、Katsuya Narutaka、Akabane Shintaro、Taniyama Daiki、Hayashi Tetsutaro、Shiota Masaki、Oue Naohide、Teishima Jun、Matsubara Akio、Yasui Wataru
    • Journal Title

      Cancer Medicine

      Volume: 10 Issue: 16 Pages: 5574-5588

    • DOI

      10.1002/cam4.4113

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathologic features of TDO2 overexpression in renal cell carcinoma2021

    • Author(s)
      Pham Quoc Thang、Taniyama Daiki、Sekino Yohei、Akabane Shintaro、Babasaki Takashi、Kobayashi Go、Sakamoto Naoya、Sentani Kazuhiro、Oue Naohide、Yasui Wataru
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1 Pages: 737-737

    • DOI

      10.1186/s12885-021-08477-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TDO2 overexpression correlates with poor prognosis, cancer stemness, and resistance to cetuximab in bladder cancer2021

    • Author(s)
      Pham Quoc Thang、Taniyama Daiki、Akabane Shintaro、Harada Kenji、Babasaki Takashi、Sekino Yohei、Hayashi Tetsuraro、Sakamoto Naoya、Sentani Kazuhiro、Oue Naohide、Yasui Wataru
    • Journal Title

      Cancer Reports

      Volume: 4 Issue: 6

    • DOI

      10.1002/cnr2.1417

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor budding as a predictive marker for 5-fluorouracil response in adjuvant-treated stage III colorectal cancer2021

    • Author(s)
      Akabane Shintaro、Shimizu Wataru、Takakura Yuji、Kochi Masatoshi、Taguchi Kazuhiro、Nakashima Ikki、Sato Koki、Hattori Minoru、Egi Hiroyuki、Sentani Kazuhiro、Yasui Wataru、Ohdan Hideki
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 7 Pages: 1285-1292

    • DOI

      10.1007/s10147-021-01917-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer2021

    • Author(s)
      Akabane Shintaro、Oue Naohide、Sekino Yohei、Asai Ryuichi、Thang Pham Quoc、Taniyama Daiki、Sentani Kazuhiro、Yukawa Masashi、Toda Takashi、Kimura Ken‐ichi、Egi Hiroyuki、Shimizu Wataru、Ohdan Hideki、Yasui Wataru
    • Journal Title

      Pathology International

      Volume: 71 Issue: 7 Pages: 441-452

    • DOI

      10.1111/pin.13098

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peritoneal lavage with hydrogen-rich saline can be an effective and practical procedure for acute peritonitis.2021

    • Author(s)
      Sada H, Egi H, Ide K, Sawada H, Sumi Y, Hattori M, Sentani K, Oue N, Yasui W, Ohdan H
    • Journal Title

      Surg Today

      Volume: - Issue: 11 Pages: 1860-1871

    • DOI

      10.1007/s00595-021-02271-z

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] BUB1B Overexpression Is an Independent Prognostic Marker and Associated with CD44, p53, and PD-L1 in Renal Cell Carcinoma.2021

    • Author(s)
      Sekino Y, Han X, Kobayashi G, Babasaki T, Miyamoto S, Kobatake K, Kitano H, Ikeda K, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A
    • Journal Title

      Oncology

      Volume: - Issue: 4 Pages: 240-250

    • DOI

      10.1159/000512446

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis2021

    • Author(s)
      Nishimichi Norihisa、Tsujino Kazuyuki、Kanno Keishi、Sentani Kazuhiro、Kobayashi Tsuyoshi、Chayama Kazuaki、Sheppard Dean、Yokosaki Yasuyuki
    • Journal Title

      The Journal of Pathology

      Volume: 253 Issue: 4 Pages: 366-373

    • DOI

      10.1002/path.5618

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastric mucosa-associated lymphoid tissue lymphoma in conjunction with multiple lymphomatous polyposis in the context of Helicobacter pylori and Helicobacter suis superinfection2021

    • Author(s)
      Naito Toshikatsu、Yuge Ryo、Tanaka Shinji、Otani Rina、Kadota Hiroki、Takigawa Hidehiko、Tamura Tadamasa、Sentani Kazuhiro、Yasui Wataru、Kitadai Yasuhiko、Chayama Kazuaki
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 14 Issue: 2 Pages: 478-483

    • DOI

      10.1007/s12328-020-01310-5

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Histological diversity and molecular characteristics in gastric cancer: relation of cancer stem cell-related molecules and receptor tyrosine kinase molecules to mixed histological type and more histological patterns2021

    • Author(s)
      Sentani K, Imai T, Kobayashi G, Hayashi T, Sasaki N, Oue N, Yasui W
    • Journal Title

      Gastric Cancer

      Volume: 24 Issue: 2 Pages: 368-381

    • DOI

      10.1007/s10120-020-01133-w

    • NAID

      40022501535

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between interleukin-1β gene expression in epicardial adipose tissue and coronary atherosclerosis based on computed tomographic analysis2021

    • Author(s)
      Kitagawa Toshiro、Hattori Takuya、Sentani Kazuhiro、Senoo Atsuhiro、Fujii Yuto、Takahashi Shinya、Yasui Wataru、Nakano Yukiko、Kihara Yasuki
    • Journal Title

      Journal of Cardiovascular Computed Tomography

      Volume: 15 Issue: 2 Pages: 175-179

    • DOI

      10.1016/j.jcct.2020.06.199

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrence- and progression-free survival in intermediate-risk non-muscle-invasive bladder cancer: the impact of conditional evaluation and subclassification2020

    • Author(s)
      Kohada Yuki、Hayashi Tetsutaro、Hsi Ryan S.、Yukihiro Kazuma、Sentani Kazuhiro、Goto Keisuke、Inoue Shogo、Ohara Shinya、Teishima Jun、Kajiwara Mitsuru、Nishisaka Takashi、Yasui Wataru、Black Peter C.、Matsubara Akio
    • Journal Title

      BJU International

      Volume: - Issue: 4 Pages: 473-485

    • DOI

      10.1111/bju.15209

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinicopathological significance of intelectin‐1 in colorectal cancer: Intelectin‐1 participates in tumor suppression and favorable progress2020

    • Author(s)
      Katsuya Narutaka、Sentani Kazuhiro、Sekino Yohei、Yamamoto Yuji、Kobayashi Go、Babasaki Takashi、Oue Naohide、Amatya Vishwa Jeet、Takeshima Yukio、Yasui Wataru
    • Journal Title

      Pathology International

      Volume: 70 Issue: 12 Pages: 943-952

    • DOI

      10.1111/pin.13027

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary adenocarcinoma of the rete testis with elevated serum CA19-9 antigen levels2020

    • Author(s)
      Kitano Hiroyuki、Sentani Kazuhiro、Goto Keisuke、Sekino Yohei、Yamanaka Ryoken、Nagasaka Keiji、Shigematsu Yoshinori、Kobayashi Kanao、Hayashi Tetsutaro、Yasui Wataru、Teishima Jun
    • Journal Title

      International Cancer Conference Journal

      Volume: 9 Issue: 4 Pages: 240-243

    • DOI

      10.1007/s13691-020-00437-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oncogenic mutation in RAS‐RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer2020

    • Author(s)
      Kochi Masatoshi、Hinoi Takao、Niitsu Hiroaki、Miguchi Masashi、Saito Yasufumi、Sada Haruki、Sentani Kazuhiro、Sakamoto Naoya、Oue Naohide、Tashiro Hirotaka、Sotomaru Yusuke、Yasui Wataru、Ohdan Hideki
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 10 Pages: 3540-3549

    • DOI

      10.1111/cas.14558

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TUBB3 Is Associated with High-Grade Histology, Poor Prognosis, p53 Expression, and Cancer Stem Cell Markers in Clear Cell Renal Cell Carcinoma2020

    • Author(s)
      Sekino Yohei、Han Xiangrui、Babasaki Takashi、Miyamoto Shunsuke、Kitano Hiroyuki、Kobayashi Go、Goto Keisuke、Inoue Shogo、Hayashi Tetsutaro、Teishima Jun、Sakamoto Naoya、Sentani Kazuhiro、Oue Naohide、Yasui Wataru、Matsubara Akio
    • Journal Title

      Oncology

      Volume: 98 Issue: 10 Pages: 689-698

    • DOI

      10.1159/000506775

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal metastasis from primary hepatocellular carcinoma: a case report2020

    • Author(s)
      Yamanaka Ryoken、Sekino Yohei、Babasaki Takashi、Kitano Hiroyuki、Ikeda Kenichiro、Goto Keisuke、Hieda Keisuke、Inoue Shogo、Hayashi Tetsutaro、Teishima Jun、Aikata Hiroshi、Chayama Kazuaki、Sentani Kazuhiro、Yasui Wataru、Matsubara Akio
    • Journal Title

      International Cancer Conference Journal

      Volume: 9 Issue: 3 Pages: 141-145

    • DOI

      10.1007/s13691-020-00409-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma2020

    • Author(s)
      Yamamoto Yuji、Oue Naohide、Asai Ryuichi、Katsuya Narutaka、Uraoka Naohiro、Sakamoto Naoya、Sentani Kazuhiro、Tanabe Kazuaki、Ohdan Hideki、Yasui Wataru
    • Journal Title

      Pathobiology

      Volume: 87 Issue: 4 Pages: 254-261

    • DOI

      10.1159/000506956

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] PTEN Is Involved in Sunitinib and Sorafenib Resistance in Renal Cell Carcinoma.2020

    • Author(s)
      Sekino Y, Hagura T, Han X, Babasaki T, Goto K, Inoue S, Hayashi T, Teishima J, Shigeta M, Taniyama D, Kuraoka K, Sentani K, Yasui W, Matsubara A.
    • Journal Title

      Anticancer Res.

      Volume: 40 Issue: 4 Pages: 1943-1951

    • DOI

      10.21873/anticanres.14149

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma.2020

    • Author(s)
      Han X, Sekino Y, Babasaki T, Goto K, Inoue S, Hayashi T, Teishima J, Sakamoto N, Sentani K, Oue N, Yasui W, Matsubara A.
    • Journal Title

      Urol Oncol.

      Volume: - Issue: 6 Pages: 9-17

    • DOI

      10.1016/j.urolonc.2020.02.010

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of radiological morphology of clinical T1 renal cell carcinoma on the prediction of upstaging to pathological T3.2020

    • Author(s)
      Teishima J, Hayashi T, Kitano H, Sadahide K, Sekino Y, Goto K, Inoue S, Honda Y, Sentani K, Awai K, Yasui W, Matsubara A.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 50(4) Issue: 4 Pages: 473-478

    • DOI

      10.1093/jjco/hyz154

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction2020

    • Author(s)
      Kobatake Kohei et al., Honda Zen-ichiro et al. and Honda Hiroaki
    • Journal Title

      Clinical Cancer Research

      Volume: 26 Issue: 8 Pages: 2065-2079

    • DOI

      10.1158/1078-0432.ccr-19-2230

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Claspin overexpression is associated with high-grade histology and poor prognosis in renal cell carcinoma.2020

    • Author(s)
      Kobayashi G, Sentani K, Babasaki T, Sekino Y, Shigematsu Y, Hayashi T, Oue N, Teishima J, Matsubara A, Sasaki N, Yasui W.
    • Journal Title

      Cancer Sci.

      Volume: 111(3) Issue: 3 Pages: 1020-1027

    • DOI

      10.1111/cas.14299

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Annexin A10 Is Involved in the Induction of Pancreatic Duodenal homeobox in Gastric Cancer Tissue, Cells and Organoids2020

    • Author(s)
      Ishikawa A, Sakamoto N, Honma R, Taniyama D, Fukada K, Hattori T, Sentani K, Oue N, Yanagihara K, Tanabe K, Ohdan H, Yasui W.
    • Journal Title

      Oncol Rep

      Volume: 43 Pages: 581-590

    • DOI

      10.3892/or.2019.7422

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance imaging/transrectal ultrasonography fusion targeted prostate biopsy finds more significant prostate cancer in biopsy-naive Japanese men compared with the standard biopsy.2020

    • Author(s)
      Fujii S, Hayashi T, Honda Y, Terada H, Akita R, Kitamura N, Ueda E, Han X, Ueno T, Miyamoto S, Kitano H, Inoue S, Teishima J, Abdi H, Awai K, Takeshima Y, Sentani K, Yasui W, Matsubara A.
    • Journal Title

      Int J Urol.

      Volume: 27 Issue: 2 Pages: 140-146

    • DOI

      10.1111/iju.14149

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 卵巣内に巨大嚢胞性変化を来たした卵黄嚢腫瘍の1例2020

    • Author(s)
      城戸 綾、仙谷和弘、大上直秀、安井 弥
    • Journal Title

      広島医学

      Volume: 73 Pages: 639-642

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical staging of upper urinary tract urothelial carcinoma for T staging: Review and pictorial essay.2019

    • Author(s)
      Honda Y, Nakamura Y, Teishima J, Goto K, Higaki T, Narita K, Akagi M, Terada H, Kaichi Y, Fujii S, Hayashi T, Matsubara A, Sentani K, Yasui W, Iida M, Awai K.
    • Journal Title

      Int J Urol.

      Volume: 26 Issue: 11 Pages: 1024-1032

    • DOI

      10.1111/iju.14068

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synbiotics Suppress Colitis-Induced Tumorigenesis in a Colon-Specific Cancer Mouse Model2019

    • Author(s)
      Saito Y, Hinoi T, Adachi T, Miguchi M, Niitsu H, Kochi M, Sada H, Sotomaru Y, Sakamoto N, Sentani K, Oue N, Yasui W, Tashiro H, Ohdan H.
    • Journal Title

      PLoS One

      Volume: 14 Issue: 6 Pages: 0216393-0216393

    • DOI

      10.1371/journal.pone.0216393

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter suis infection is associated with nodular gastritis-like appearance of gastric mucosa-associated lymphoid tissue lymphoma.2019

    • Author(s)
      Takigawa H, Masaki S, Naito T, Yuge R, Urabe Y, Tanaka S, Sentani K, Matsuo T, Matsuo K, Chayama K, Kitadai Y.
    • Journal Title

      Cancer Med.

      Volume: 8 Issue: 9 Pages: 4370-4379

    • DOI

      10.1002/cam4.2314

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] miR-130b Promotes Sunitinib Resistance through Regulation of PTEN in Renal Cell Carcinoma2019

    • Author(s)
      Sekino Yohei、Sakamoto Naoya、Sentani Kazuhiro、Oue Naohide、Teishima Jun、Matsubara Akio、Yasui Wataru
    • Journal Title

      Oncology

      Volume: 97 Issue: 3 Pages: 164-172

    • DOI

      10.1159/000500605

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma2019

    • Author(s)
      TANIYAMA DAIKI、TANIYAMA KIYOMI、KURAOKA KAZUYA、YAMAMOTO HIDEKI、ZAITSU JUNICHI、SAITO AKIHISA、SAKAMOTO NAOYA、SENTANI KAZUHIRO、OUE NAOHIDE、YASUI WATARU
    • Journal Title

      Anticancer Research

      Volume: 39 Issue: 6 Pages: 2767-2775

    • DOI

      10.21873/anticanres.13403

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival2019

    • Author(s)
      Shigematsu Yoshinori、Oue Naohide、Sekino Yohei、Sakamoto Naoya、Sentani Kazuhiro、Uraoka Naohiro、Hayashi Tetsutaro、Teishima Jun、Matsubara Akio、Yasui Wataru
    • Journal Title

      Pathobiology

      Volume: 86 Issue: 4 Pages: 208-216

    • DOI

      10.1159/000497206

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of 5015 Salivary Gland Neoplasms Registered in the Hiroshima Tumor Tissue Registry over a Period of 39 Years.2019

    • Author(s)
      Sentani K, Ogawa I, Ozasa K, Sadakane A, Utada M, Tsuya T, Kajihara H, Yonehara S, Takeshima Y, Yasui W.
    • Journal Title

      J Clin Med.

      Volume: 8 Issue: 5 Pages: 566-566

    • DOI

      10.3390/jcm8050566

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular carcinogenesis of gastric cancer: Lauren classification, mucin phenotype expression, and cancer stem cells.2019

    • Author(s)
      Oue N, Sentani K, Sakamoto N, Uraoka N, Yasui W.
    • Journal Title

      Int J Clin Oncol.

      Volume: 印刷中 Issue: 7 Pages: 771-778

    • DOI

      10.1007/s10147-019-01443-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection2019

    • Author(s)
      Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Oshima M, Yasui W, Tamura A, Tsukita S.
    • Journal Title

      Cell Mol Gastroenterol Hepatol.

      Volume: 8 Issue: 1 Pages: 119

    • DOI

      10.1016/j.jcmgh.2019.03.003

    • URL

      https://pure.teikyo.jp/en/publications/db6be6d6-389a-4856-aabd-67eee5f17638

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcribed ultraconserved region Uc.63+ promotes resistance to cisplatin through regulation of androgen receptor signaling in bladder cancer.2019

    • Author(s)
      Sekino Y, Sakamoto N, Ishikawa A, Honma R, Shigematsu Y, Hayashi T, Sentani K, Oue N, Teishima J, Matsubara A, Yasui W.
    • Journal Title

      Oncol Rep.

      Volume: 41 Pages: 3111-3118

    • DOI

      10.3892/or.2019.7039

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.2019

    • Author(s)
      Sekino Y, Oue N, Koike Y, Shigematsu Y, Sakamoto N, Sentani K, Teishima J, Shiota M, Matsubara A, Yasui W.
    • Journal Title

      J Clin Med.

      Volume: 8 Issue: 2 Pages: 225-225

    • DOI

      10.3390/jcm8020225

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocadherin B9 promotes resistance to bicalutamide and is associated with the survival of prostate cancer patients.2019

    • Author(s)
      Sekino Y, Oue N, Mukai S, Shigematsu Y, Goto K, Sakamoto N, Sentani K, Hayashi T, Teishima J, Matsubara A, Yasui W.
    • Journal Title

      Prostate

      Volume: 79 Issue: 2 Pages: 234-242

    • DOI

      10.1002/pros.23728

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological significance of RCAN2 production in gastric carcinoma.2019

    • Author(s)
      Hattori Y, Sentani K, Shinmei S, Oo HZ, Hattori T, Imai T, Sekino Y, Sakamoto N, Oue N, Niitsu H, Hinoi T, Ohdan H, Yasui W.
    • Journal Title

      Histopathology

      Volume: 74 Issue: 3 Pages: 430-442

    • DOI

      10.1111/his.13764

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinicopathological significance of claspin overexpression and its association with spheroid formation in gastric cancer.2019

    • Author(s)
      Kobayashi G, Sentani K, Hattori T, Yamamoto Y, Imai T, Sakamoto N, Kuraoka K, Oue N, Sasaki N, Taniyama K, Yasui W.
    • Journal Title

      Hum Pathol

      Volume: 84 Pages: 8-17

    • DOI

      10.1016/j.humpath.2018.09.001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 胃癌の組織学的多様性と臨床病理学的意義2021

    • Author(s)
      仙谷和弘、今井健晴、小林 剛、佐々木なおみ、大上直秀、安井 弥
    • Organizer
      第110回日本病理学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 胃癌の組織学的多様性の臨床病理学的意義と癌関連分子との相関2020

    • Author(s)
      仙谷和弘,今井健晴,小林 剛,勝矢脩嵩,谷山大樹,浦岡直礼,坂本直也,佐々木なおみ,大上直秀,安井 弥
    • Organizer
      第109回日本病理学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 胃癌の組織学的多様性の臨床病理学的意義と癌関連分子との相関2020

    • Author(s)
      仙谷和弘,今井健晴,小林 剛,勝矢脩嵩,城戸 綾,藤木佑斗,谷山大樹,林哲太郎,佐々木なおみ,大上直秀,安井 弥
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 消化管癌における新しい癌幹細胞のバイオマーカー2020

    • Author(s)
      大上直秀,山本悠司,赤羽慎太郎,大島 貴,仙谷和弘,安井 弥
    • Organizer
      第40回日本分子腫瘍マーカー研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] Clinicopathological significance of claspin overexpression and its association with spheroid formation in gastric cancer.2019

    • Author(s)
      Sentani K, Kobayashi G, Imai T, Sakamoto N, Kuraoka K, Oue N, Sasaki N, Taniyama K and Yasui W
    • Organizer
      The 31st European Congress of Pathology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 広島県腫瘍登録事業に基づく5015例の唾液腺腫瘍の臨床病理学的特徴.2019

    • Author(s)
      仙谷和弘、小川郁子、梶原博毅、米原修治、武島幸男、安井 弥
    • Organizer
      第108回日本病理学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 広島県腫瘍登録事業に基づく5015例の唾液腺腫瘍の臨床病理学的特徴.2019

    • Author(s)
      仙谷和弘、小川郁子、梶原博毅、武島幸男、安井 弥
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Remarks]

    • URL

      https://byori1.hiroshima-u.ac.jp

    • Related Report
      2021 Annual Research Report
  • [Remarks]

    • URL

      https://byori1.hiroshima-u.ac.jp/

    • Related Report
      2020 Research-status Report
  • [Remarks] 広島大学大学院医系科学研究科分子病理学

    • URL

      https://home.hiroshima-u.ac.jp/byori1/

    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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