Elucidation of tumor immune mechanisms aimed at establishing new immunotherapy for castration-resistant prostate cancer

• Project/Area Number: 19K07486
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49030:Experimental pathology-related
• Research Institution: Nagoya City University
• Principal Investigator: Takahashi Satoru 名古屋市立大学, 医薬学総合研究院(医学), 教授 (60254281)
• Co-Investigator(Kenkyū-buntansha): 内木 綾 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (20509236) ; 加藤 寛之 名古屋市立大学, 医薬学総合研究院(医学), 講師 (80791293)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 前立腺癌 / 腫瘍免疫 / 去勢抵抗生 / 去勢抵抗性前立腺癌 / 免疫回避

Outline of Research at the Start

免疫機構が保持されたF344ラットに生着可能な去勢抵抗性ラット前立腺癌細胞PLS10における免疫回避機構に関わる責任分子として同定することを目的に、F344ラットに生着しないPLS20あるいはPLS30にPLS10 cDNAライブラリーを遺伝子導入し、F344ラットに生着可能となった形質転換細胞から免疫回避機構に関わる責任遺伝子をfunctional cloningする。ラットにおいて確認された免疫回避機構がヒト去勢抵抗性前立腺癌においても機能しているかを検証し、新規免疫療法の標的候補分子を明らかにする。

Outline of Final Research Achievements

The aim is to discover a new tumor immune evasion mechanism in castration-resistant prostate cancer (CRPC). Through microarray analysis, we extracted five genes, CD81, Ccl2, Cx3cl1, Nradd, and Tmem252, highly expressed in rat CRPC PLS10 cells, that can be engrafted in normal immunocompetent rats. Among these, CD81, Ccl2, and Cx3cl1 were transfected into rat CRPC PLS30 cells, which cannot survive in normal immunocompetent rats and orthotopically transplanted, but no tumor formation was observed in any of them. Next, we performed spatial transcriptome gene expression analysis in vivo and confirmed that Pmepa1 was highly expressed in PLS10. We have established the Pmepa1-introduced PLS30 strain and are conducting orthotopic transplant experiments in rats.

Academic Significance and Societal Importance of the Research Achievements

去勢抵抗性前立腺癌(CRPC)に対する有効な治療法は未だ確立されてはいない。我々はラットCRPC細胞株を樹立し、正常免疫能ラットに同所移植するとPLS10は生着する一方で、PLS30では腫瘍形成はみられないことから、PLS10における腫瘍免疫回避機構を明らかにできれば、CRPCの治療法開発に繋がる基礎的データになると考えた。種々の解析により、PLS10で高発現している6遺伝子を抽出し、このうち3遺伝子についてPLS30に遺伝子導入して同所移植を行ったが、いずれも形質転換はなく腫瘍形成は得られなかった。他の遺伝子については遺伝子導入PLS30株を作成し、ラット同所移植実験を進めている。

Research Products

• [Journal Article] Switching mechanism from AR to EGFR signaling via-3-O-sulfated heparan sulfate in castration-resistant prostate cancer (2023)
  • Author(s): 10.Ota, H., Sato, H., Mizumoto, S., Wakai, K., Yoneda, K., Yamamoto, K., Nakanishi, H., Ikeda, J-I., Sakamoto, S., Ichikawa, T., Yamada, S., Takahashi, S., Ikehara, Y., Nishihara, S.
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 11618-11618
  • DOI: 10.1038/s41598-023-38746-x
  • Peer Reviewed / Open Access
• [Journal Article] Identification of microRNA-96-5p as a postoperative, prognostic microRNA predictor in non-viral hepatocellular carcinoma (2022)
  • Author(s): Matsui T, Hamada TS, Naito Y, Nojima M, Iio E, Tamori A, Kubo S, Ide T, Kondo Y, Eguchi Y, Komori A, Morine Y, Shimada M, Utsunomiya T, Kimura K, Hiasa Y, Ochiya T, Naiki A, Takahashi S, Tanaka Y
  • Journal Title: Hepatol Res. Volume: 52(1) Issue: 1 Pages: 93-104
  • DOI: 10.1111/hepr.13674
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Discovering novel mechanisms of taxane resistance in human breast cancer by whole-exome sequencing (2022)
  • Author(s): Yumi Wanifuchi-Endo, Naoto Kondo, Yu Dong, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Yasuaki Uemoto, Sayaka Nishikawa, Yusuke Katagiri, Akiko Kato, Mitsuo Terada, Hiroshi Sugiura, Katsuhiro Okuda, Hiroyuki Kato, Satoru Takahashi, Tatsuya Toyama
  • Journal Title: Oncology letters Volume: 23 Issue: 2 Pages: 60-60
  • DOI: 10.3892/ol.2021.13178
  • Peer Reviewed / Open Access
• [Journal Article] PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer (2022)
  • Author(s): Koshino Akira、Nagano Aya、Ota Akinobu、Hyodo Toshinori、Ueki Akane、Komura Masayuki、Sugimura-Nagata Akane、Ebi Masahide、Ogasawara Naotaka、Kasai Kenji、Hosokawa Yoshitaka、Kasugai Kunio、Takahashi Satoru、Inaguma Shingo
  • Journal Title: Frontiers in Pharmacology Volume: 12 Pages: 772926-772935
  • DOI: 10.3389/fphar.2021.772926
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relevance of gene mutations and methylation to the growth of pancreatic intraductal papillary mucinous neoplasms based on pyrosequencing. (2022)
  • Author(s): Asano, G., Miyabe, K., Kato, H., Yoshida, M., Sawada, T., Okamoto, Y., Sahashi, H., Atsuta, N., Kachi, K., Kato, A., Jinno, N., Natsume, M., Hori, Y., Naitoh, I., Hayashi, K., Matsuo, Y., Takahashi, S., Suzuki, H., Kataoka, H.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 419-419
  • DOI: 10.1038/s41598-021-04335-z
  • Peer Reviewed / Open Access
• [Journal Article] Exercise-induced extracellular vesicles delay the progression of prostate cancer. (2022)
  • Author(s): Sadovska, L., Auders, J., Keisa, L., Romanchikova, N., Silamikele, L., Kreismane, M., Zayakin, P., Takahashi, S., Kalnina, Z., Line, A.
  • Journal Title: Frontiers in Molecular Biosciences Volume: 8 Pages: 784080-784080
  • DOI: 10.3389/fmolb.2021.784080
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Risk Analyses of Lymph Node Metastasis and Recurrence for Submucosal Invasive Colorectal Cancer: Novel Criteria to Skip Completion Surgery (2022)
  • Author(s): Ozeki T, Shimura T, Ozeki T, Ebi M, Iwasaki H, Kato H, Inaguma S, Okuda Y, Katano T, Nishie H, Takahashi S, Kataoka H
  • Journal Title: Cancers Volume: 14 Issue: 3 Pages: 822-822
  • DOI: 10.3390/cancers14030822
  • Peer Reviewed / Open Access
• [Journal Article] Peripheral neuropathy in the pre-diabetic state of the type 2 diabetes mouse model (TSOD mice) involves TRPV1 expression in dorsal root ganglions (2022)
  • Author(s): Shida Kyoko、Ohsawa Masahiro、Takahashi Satoru、Ota Haruko、Tamura Tetsuya、Kusama Nobuyoshi、Nakasone Mina、Yamazaki Hisaaki、Sobue Kazuya
  • Journal Title: IBRO Neuroscience Reports Volume: 12 Pages: 163
  • DOI: 10.1016/j.ibneur.2022.02.001
  • URL: https://localhost/en/publications/29f47334-4d84-4fc1-be22-499e7b18ee78
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SPATA18 expression predicts favorable clinical outcome in colorectal cancer. (2022)
  • Author(s): Sugimura-Nagata, A., Koshino, A., Nagao, K., Nagano, A., Komura, M., Ueki, A., Ebi, M., Ogasawara, N., Tsuzuki, T., Kasai, K., Takahashi, S., Kasugai, K., Inaguma, S.
  • Journal Title: International Journal of Molecular Science Volume: 23 Issue: 5 Pages: 2753-2753
  • DOI: 10.3390/ijms23052753
  • Peer Reviewed / Open Access
• [Journal Article] The complete loss of p53 expression uniquely predicts worse prognosis in colorectal cancer. (2022)
  • Author(s): Nagao, K., Koshino, A., Sugimura-Nagata, A., Nagano, A., Komura, M., Ueki, A., Ebi, M., Ogasawara, N., Tsuzuki, T., Kasai, K., Takahashi, S., Kasugai, K., Inaguma, S.
  • Journal Title: International Journal of Molecular Science Volume: 23 Issue: 6 Pages: 3252-3252
  • DOI: 10.3390/ijms23063252
  • Peer Reviewed / Open Access
• [Journal Article] Alterations in key signaling pathways in sinonasal tract melanoma. A molecular genetics and immunohistochemical study of 90 cases and comprehensive review of the literature (2022)
  • Author(s): Cholopek M, Lasota J, Thompson LDR, Szczepaniak M, Kuzniacka A, Hincza K, Kubicka K, Kaczorowski M, Newford M, Liu Y, Agaimy A, Biernat W, Durzynska M, Dziuba I, Hartmann A, Inaguma S, Izycka-Swieszewska E, Kato H, Kopczynski J, Michal M, Michal M, Peksa R, Prochorec-Sobieszek M, Starzynska A, Takahashi S, et al.
  • Journal Title: Modern Pathology Volume: 35 Issue: 11 Pages: 1609-1617
  • DOI: 10.1038/s41379-022-01122-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Determining Infected Aortic Aneurysm Treatment Using Focused Detection of Helicobacter cinaedi (2022)
  • Author(s): Jien Saito、Emiko Rimbara、Shingo Inaguma、Chihiro Hasegawa、Shinji Kamiya、Akihiro Mizuno、Yoshiaki Sone、Tatsuhito Ogawa、Yukihide Numata、Satoru Takahashi、Miki Asano
  • Journal Title: Emerging Infectious Diseases Volume: 28 Issue: 7 Pages: 1494-1498
  • DOI: 10.3201/eid2807.212505
  • Peer Reviewed / Open Access
• [Journal Article] Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer (2022)
  • Author(s): Uemoto Y, Katsuta E, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, Hisada T, Terada M, Kato A, Okuda K, Sugiura H, Komura M, Kato H, Osaga S, Takahashi S, Toyama T.
  • Journal Title: American Journal of Cancer Research Volume: 12 Pages: 1593-1605
  • Peer Reviewed / Open Access
• [Journal Article] Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer (2022)
  • Author(s): Hisada T, Kondo N, Wanifuchi-Endo Y, Osaga S, Fujita T, Asano T, Uemoto Y, Nishikawa S, Katagiri Y, Terada M, Kato A, Sugiura H, Okuda K, Kato H, Komura M, Morita S, Takahashi S, Toyama T.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 16515-16515
  • DOI: 10.1038/s41598-022-20225-4
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of the toxicity and carcinogenicity of double-walled carbon nanotubes in the rat lung after intratracheal instillation: a two-year study. (2022)
  • Author(s): Saleh, D.M., Luo, S., Ahmed, O.H.M., Alexander, D.B., Alexander, W.T., Gunasekaran, S., El-Gazzar, A.M., Abdelgied, M., Numano, T., Takase, H., Ohnishi, M., Tomono, S., El Hadi, R.H.A., Fukamachi, K., Kanno, J., Hirose, A., Xu, J., Suzuki, S., Naiki-Ito, A., Takahashi, S., Tsuda, H.
  • Journal Title: Particle abd Fibre Toxicology Volume: 19 Issue: 1 Pages: 1-21
  • DOI: 10.1186/s12989-022-00469-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serous Cystic Neoplasm With Typical Clinical Findings and Perineural Invasion (2022)
  • Author(s): Hirokawa T, Kobayashi M, Ueda G, Shamoto T, Mitsui A, Kuwabara Y, Ogawa R, Takahashi H, Matsuo Y, Takahashi S, Takiguchi S.
  • Journal Title: Pancreas Volume: 51 Issue: 4 Pages: e69-e71
  • DOI: 10.1097/mpa.0000000000002038
  • Peer Reviewed / Open Access
• [Journal Article] Potential Role of TRPV4 in Stretch-Induced Ghrelin Secretion and Obesity (2022)
  • Author(s): Hayakawa S, Tanaka T, Ogawa R, Ito S, Ueno S, Koyama H, Tomotaka O, Sagawa H, Tanaka T, Iwakura H, Takahashi H, Matsuo Y, Mitsui A, Kimura M, Takahashi S, Takiguchi S.
  • Journal Title: International Journal of Endocrinology Volume: 2022 Pages: 7241275-7241275
  • DOI: 10.1155/2022/7241275
  • Peer Reviewed / Open Access
• [Journal Article] Use of Endoscopic Scraper and Cell Block Technique as a Replacement for Conventional Brush for Diagnosing Malignant Biliary Strictures (2022)
  • Author(s): Kato A, Kato H, Naitoh I, Hayashi K, Yoshida M, Hori Y, Kachi K, Asano G, Sahashi H, Toyohara T, Kuno K, Kito Y, Takahashi S, Kataoka H.
  • Journal Title: Cancers Volume: 14 Issue: 17 Pages: 4147-4147
  • DOI: 10.3390/cancers14174147
  • Peer Reviewed / Open Access
• [Journal Article] Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer (2022)
  • Author(s): Kato A, Naitoh I, Naiki-Ito A, Hayashi K, Okumura F, Fujita Y, Sano H, Nishi Y, Miyabe K, Inoue T, Hirano A, Takada H, Yoshida M, Hori Y, Natsume M, Kato H, Takahashi S, Kataoka H.
  • Journal Title: Pancreas Volume: 51 Issue: 4 Pages: 372-379
  • DOI: 10.1097/mpa.0000000000002032
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage (2022)
  • Author(s): Matsumoto Y, Shinjo K, Mase S, Fukuyo M, Aoki K, Ozawa F, Yoshihara H, Goto S, Kitaori T, Ozaki Y, Takahashi S, Kaneda A, Sugiura-Ogasawara M, Kondo Y.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 11673-11673
  • DOI: 10.1038/s41598-022-15656-y
  • Peer Reviewed / Open Access
• [Journal Article] Protective effects of tadalafil on damaged podocytes in an adriamycin-induced nephrotic syndrome model. (2022)
  • Author(s): Tomita N, Hotta Y, Naiki-Ito A, Sanagawa A, Kataoka T, Furukawa-Hibi Y, Takahashi S, Kimura K.
  • Journal Title: J Pharmacol Sci. Volume: 149 Issue: 2 Pages: 53-59
  • DOI: 10.1016/j.jphs.2022.03.003
  • Peer Reviewed / Open Access
• [Journal Article] Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial cellular respiratory function in breast cancer. (2022)
  • Author(s): Uemoto, Y., Katsuta, E., Kondo, N., Wanifuchi-Endo, Y., Fujita, T., Asano, T., Hisada, T., Terada, M., Kato, A., Okuda, K., Sugiura, H., Kato, H., Osaga, S., Takahashi, S., Toyma, T.
  • Journal Title: American Journal of Cancer Research Volume: 12 Pages: 1593-1605
  • Peer Reviewed / Open Access
• [Journal Article] Lactoferrin Prevents Hepatic Injury and Fibrosis via the Inhibition of NF-κB Signaling in a Rat Non-Alcoholic Steatohepatitis Model (2021)
  • Author(s): Aoyama Yoshinaga、Naiki-Ito Aya、Xiaochen Kuang、Komura Masayuki、Kato Hiroyuki、Nagayasu Yuko、Inaguma Shingo、Tsuda Hiroyuki、Tomita Mamoru、Matsuo Yoichi、Takiguchi Shuji、Takahashi Satoru
  • Journal Title: Nutrients Volume: 14 Issue: 1 Pages: 42-42
  • DOI: 10.3390/nu14010042
  • Peer Reviewed / Open Access
• [Journal Article] PBK expression predicts favorable survival in colorectal cancer patients (2021)
  • Author(s): Nagano-Matsuo A, Inoue S, Koshino A, Ota A, Nakao K, Komura M, Kato H, Naiki-Ito A, Watanabe K, Nagayasu Y, Hosokawa Y, Takiguchi S, Kasugai K, Kasai K, Inaguma S, Takahashi S
  • Journal Title: Virchows Archiv Volume: - Issue: 2 Pages: 277-284
  • DOI: 10.1007/s00428-021-03062-0
  • Peer Reviewed / Open Access
• [Journal Article] Anti-Allergic Drug Suppressed Pancreatic Carcinogenesis via Down-Regulation of Cellular Proliferation (2021)
  • Author(s): Kachi Kenta、Kato Hiroyuki、Naiki-Ito Aya、Komura Masayuki、Nagano-Matsuo Aya、Naitoh Itaru、Hayashi Kazuki、Kataoka Hiromi、Inaguma Shingo、Takahashi Satoru
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 14 Pages: 7444-7444
  • DOI: 10.3390/ijms22147444
  • Peer Reviewed / Open Access
• [Journal Article] Suppressive Effect and Molecular Mechanism of Houttuynia cordata Thunb. Extract against Prostate Carcinogenesis and Castration-Resistant Prostate Cancer (2021)
  • Author(s): Subhawa Subhawat、Naiki-Ito Aya、Kato Hiroyuki、Naiki Taku、Komura Masayuki、Nagano-Matsuo Aya、Yeewa Ranchana、Inaguma Shingo、Chewonarin Teera、Banjerdpongchai Ratana、Takahashi Satoru
  • Journal Title: Cancers Volume: 13 Issue: 14 Pages: 3403-3403
  • DOI: 10.3390/cancers13143403
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer (2021)
  • Author(s): Kato H, Naiki-Ito A, Suzuki S, Inaguma S, Komura M, Nakao K, Naiki T, Kachi K, Kato A, Matsuo Y, Takahashi S.
  • Journal Title: Carcinogenesis Volume: - Issue: 7 Pages: 940-950
  • DOI: 10.1093/carcin/bgab017
  • Peer Reviewed / Open Access
• [Journal Article] Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer (2021)
  • Author(s): Tasaki Y, Suzuki M, Katsushima K, Shinjo K, Iijima K, Murofushi Y, Naiki-Ito A, Hayashi K, Qiu C, Takahashi A, Tanaka Y, Kawaguchi T, Sugawara M, Kataoka T, Naito M, Miyata K, Kataoka K, Noda T, Gao W, Kataoka H, Takahashi S, Kimura K, Kondo Y.
  • Journal Title: Cancer Research Volume: - Issue: 7 Pages: 1654-1666
  • DOI: 10.1158/0008-5472.can-20-3021
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• [Journal Article] Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p (2021)
  • Author(s): Yoshihiro Araki, Hisaki Aiba, Takeshi Yoshida, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Tuan D. Nguyen, Kiyo-aki Ishii, Takayuki Nojima, Satoru Takahashi, Hideki Murakami, Hiroyuki Tsuchiya and Rikinari Hanayama
  • Journal Title: Frontiers in Oncology Volume: 11 Pages: 667109-667109
  • DOI: 10.3389/fonc.2021.667109
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression and Prognostic Significance of CD47-SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer (2021)
  • Author(s): Sugimura-Nagata A, Koshino A, Inoue S, Matsuo-Nagano A, Komura M, Riku M, Ito H, Inoko A, Murakami H, Ebi M, Ogasawara N, Tsuzuki T, Takahashi S, Kasugai K, Kasai K, Inaguma S
  • Journal Title: International Journal of Molecular Science Volume: 22 Issue: 5 Pages: 2690-2690
  • DOI: 10.3390/ijms22052690
  • Peer Reviewed / Open Access
• [Journal Article] Low RAI2 expression is a marker of poor prognosis in breast cancer (2021)
  • Author(s): Nishikawa S, Uemoto Y, Kim TS, Hisada T, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, Katagiri Y, Terada M, Kato A, Dong Y, Sugiura H, Okuda K, Kato H, Osaga S, Takahashi S, Toyama T.
  • Journal Title: Breast Cancer Research and Treatment Volume: 187 Issue: 1 Pages: 81-93
  • DOI: 10.1007/s10549-021-06176-w
  • Peer Reviewed / Open Access
• [Journal Article] Cell proliferation of rat bladder urothelium induced by nicotine is suppressed by the NADPH oxidase inhibitor, apocynin (2021)
  • Author(s): Suzuki S, Cohen SM, Arnold LL, Pennington KL, Gi M, Kato H, Naiki T, Naiki-Ito A, Wanibuchi H, Takahashi S.
  • Journal Title: Toxicology Letters Volume: 336 Pages: 32-38
  • DOI: 10.1016/j.toxlet.2020.11.005
  • NAID: 120007181781
  • URL: https://ocu-omu.repo.nii.ac.jp/records/2020538
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats (2020)
  • Author(s): Suzuki S, Gi M, Toyoda T, Kato H, Naiki-Ito A, Kakehashi A, Ogawa K, Takahashi S, Wanibuchi H.
  • Journal Title: Journal of Toxicologic Pathology Volume: 33 Issue: 4 Pages: 279-285
  • DOI: 10.1293/tox.2020-0038
  • NAID: 130007931389
  • ISSN: 0914-9198, 1881-915X
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat (2020)
  • Author(s): Saleh DM, Alexander WT, Numano T, Ahmed OHM, Gunasekaran S, Alexander DB, Abdelgied M, El-Gazzar AM, Takase H, Xu J, Naiki-Ito A, Takahashi S, Hirose A, Ohnishi M, Kanno J, Tsuda H.
  • Journal Title: Particle and Fibre Toxicology Volume: 17 Issue: 1 Pages: 48-48
  • DOI: 10.1186/s12989-020-00382-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The phosphodiesterase 5 inhibitor tadalafil has renoprotective effects in a rat model of chronic kidney disease (2020)
  • Author(s): Tomita N, Hotta Y, Naiki-Ito A, Hirano K, Kataoka T, Maeda Y, Takahashi S, Kimura K.
  • Journal Title: Physiological reports Volume: 8 Issue: 17
  • DOI: 10.14814/phy2.14556
  • Peer Reviewed / Open Access
• [Journal Article] Sentinel lymph node biopsy may be unnecessary for ductal carcinoma in situ of the breast that is small and diagnosed by preoperative biopsy (2020)
  • Author(s): Uemoto Y, Kondo N, Wanifuchi-Endo Y, Asano T, Hisada T, Nishikawa S, Katagiri Y, Terada M, Kato A, Okuda K, Sugiura H, Kato H, Takahashi S, Toyama T.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 50 Issue: 12 Pages: 1364-1369
  • DOI: 10.1093/jjco/hyaa151
  • Peer Reviewed
• [Journal Article] A novel model of non-alcoholic steatohepatitis with fibrosis and carcinogenesis in connexin 32 dominant-negative transgenic rats (2020)
  • Author(s): Naiki-Ito A, Kato H, Naiki T, Yeewa R, Aoyama Y, Nagayasu Y, Suzuki S, Inaguma S, Takahashi S.
  • Journal Title: Archives of Toxicology Volume: 94 Issue: 12 Pages: 4085-4097
  • DOI: 10.1007/s00204-020-02873-5
  • Peer Reviewed / Open Access
• [Journal Article] The standard form of CD44 as a marker for invasion of encapsulated papillary carcinoma of the breast (2020)
  • Author(s): Kato H, Naiki-Ito A, Yamada T, Suzuki S, Yamashita Y, Inaguma S, Kondo N, Wanifuchi-Endo Y, Toyama T, Takahashi S.
  • Journal Title: Pathology International Volume: 70 Issue: 11 Pages: 835-843
  • DOI: 10.1111/pin.13001
  • Peer Reviewed
• [Journal Article] Anagliptin, a dipeptidyl peptidase‐4 inhibitor, improved bladder function and hemodynamics in rats with bilateral internal iliac artery ligation (2020)
  • Author(s): Hotta Yuji、Takahashi Sena、Tokoro Misato、Naiki‐Ito Aya、Maeda Kotomi、Kawata Ryoya、Kataoka Tomoya、Ohta Yuya、Hamakawa Takashi、Takahashi Satoru、Yasui Takahiro、Kimura Kazunori
  • Journal Title: Neurourology and Urodynamics Volume: 39 Issue: 7 Pages: 1922-1929
  • DOI: 10.1002/nau.24449
  • Peer Reviewed
• [Journal Article] Selective lysine-specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis (2020)
  • Author(s): Nozaki S, Naiki T, Naiki-Ito A, Iwatsuki S, Takeda T, Etani T, Nagai T, Iida K, Kato H, Suzuki T, Takahashi S, Umemoto Y, Yasui T.
  • Journal Title: Andrology Volume: 8 Issue: 6 Pages: 1895-1906
  • DOI: 10.1111/andr.12846
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dehydrozingerone, a Curcumin Analog, as a Potential Anti-Prostate Cancer Inhibitor In Vitro and In Vivo (2020)
  • Author(s): Mapoung S, Suzuki S, Fuji S, Naiki-Ito A, Kato H, Yodkeeree S, Sakorn N, Ovatlarnporn C, Takahashi S, Limtrakul Dejkriengkraikul P.
  • Journal Title: Molecules Volume: 25 Issue: 12 Pages: 2737-2737
  • DOI: 10.3390/molecules25122737
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel sensitive detection method for DNA methylation in circulating free DNA of pancreatic cancer (2020)
  • Author(s): Shinjo K, Hara K, Nagae G, Umeda T, Katsushima K, Suzuki M, Murofushi Y, Umezu Y, Takeuchi I, Takahashi S, Okuno Y, Matsuo K, Ito H, Tajima S, Aburatani H, Yamao K, Kondo Y.
  • Journal Title: PLoS One Volume: 15 Issue: 6 Pages: 0233782-0233782
  • DOI: 10.1371/journal.pone.0233782
  • Peer Reviewed / Open Access
• [Journal Article] Omental adipocytes promote peritoneal metastasis of gastric cancer through the CXCL2-VEGFA axis (2020)
  • Author(s): Natsume M, Shimura T, Iwasaki H, Okuda Y, Hayashi K, Takahashi S, Kataoka H.
  • Journal Title: British Journal of Cancer Volume: 123 Issue: 3 Pages: 459-470
  • DOI: 10.1038/s41416-020-0898-3
  • Peer Reviewed
• [Journal Article] Comparison of real-time virtual sonography navigation versus BioJet navigation on magnetic resonance imaging guided prostate needle biopsy: a single institutional analysis (2020)
  • Author(s): Takashi Nagai, Taku Naiki, Shuzo Hamamoto, Toshiki Etani, Aya Naiki-Ito, Motoo Nakagawa, Keitaro Iida, Shoichiro Iwatsuki, Kazumi Taguchi, Tetsuji Maruyama, Noriyasu Kawai, Satoru Takahashi, Takahiro Yasui
  • Journal Title: Journal of Endourology Volume: オンライン Issue: 7 Pages: 739-745
  • DOI: 10.1089/end.2020.0042
  • Peer Reviewed
• [Journal Article] Luteolin suppresses bladder cancer growth via regulation of mechanistic target of rapamycin pathway (2020)
  • Author(s): Iida Keitaro、Naiki Taku、Naiki‐Ito Aya、Suzuki Shugo、Kato Hiroyuki、Nozaki Satoshi、Nagai Takashi、Etani Toshiki、Nagayasu Yuko、Ando Ryosuke、Kawai Noriyasu、Yasui Takahiro、Takahashi Satoru
  • Journal Title: Cancer Science Volume: 111 Issue: 4 Pages: 1165-1179
  • DOI: 10.1111/cas.14334
  • Peer Reviewed / Open Access
• [Journal Article] Hexane insoluble fraction from purple rice extract retards carcinogenesis and castration-resistant cancer growth of prostate through suppression of androgen receptor mediated cell proliferation and metabolism. (2020)
  • Author(s): 5.Yeewa, R., Naiki-Ito, A., Naiki, T., Kato, H., Suzuki, S., Chewonarin, T., Takahashi, S.
  • Journal Title: Nutrients Volume: 12 Issue: 2 Pages: 558-558
  • DOI: 10.3390/nu12020558
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer. (2019)
  • Author(s): Naiki-Ito A, Naiki T, Kato H, Iida K, Etani T, Nagayasu Y, Suzuki S, Yamashita Y, Inaguma S, Onishi M, Tanaka Y, Yasui T, Takahashi S.
  • Journal Title: Carcinogenesis Volume: 193 Issue: 8 Pages: 00-00
  • DOI: 10.1093/carcin/bgz193
  • Peer Reviewed / Open Access
• [Presentation] 膵癌におけるLuteolinの5-FU併用投与による効果の検討とDPYD抑制効果の意義 (2023)
  • Author(s): 加藤寛之、内木綾、小村理行、高橋智
  • Organizer: 第39回日本毒性病理学会総会および学術集会
• [Presentation] The lung carcinogenicity of single-walled carbon nanotube in male Fischer F344 rats (2023)
  • Author(s): Sheema Asraful Nahar, Aya Naiki-Ito, Hiroyuki Kato, Anna Kakehashi, Hiroyuki Tsuda, Satoru Takahashi
  • Organizer: 第39回日本毒性病理学会総会および学術集会
• [Presentation] 多層カーボンナノチューブおよびフラーレンウィスカーの肺発がん性の比較 (2023)
  • Author(s): 内木綾、加藤寛之、梯アンナ、津田洋幸、高橋智
  • Organizer: 第39回日本毒性病理学会総会および学術集会
• [Presentation] Chemopreventive effects of angiotensin-II receptor blocker on rat non-alcoholic steatohepatitis and fibrosis (2023)
  • Author(s): Xiaochen Kuang, Aya Naiki-Ito, Masayuki Komura, Hiroyuki Kato, Satoru Takahashi
  • Organizer: 第39回日本毒性病理学会総会および学術集会
• [Presentation] 非アルコール性脂肪肝炎および肝線維化に対する紫米抽出物の抑制効果 (2022)
  • Author(s): 内木綾、加藤寛之、小村理行、長野愛矢、稲熊真悟、高橋智
  • Organizer: 第111回日本病理学会総会
• [Presentation] 難治性食道狭窄に対する食道切除術中に見つかった十二指腸球部ガストリノーマの一例 (2022)
  • Author(s): 小村理行、加藤寛之、長野愛矢、内木綾、稲熊真悟、高橋智
  • Organizer: 第111回日本病理学会総会
• [Presentation] 全身性ヘモクロマトーシスを伴う有口赤血球症の1剖検例 (2022)
  • Author(s): 加藤寛之、小村理行、内木綾、稲熊真悟、高橋智
  • Organizer: 第111回日本病理学会総会
• [Presentation] 膵内副脾に発生した類表皮嚢胞の2例 (2022)
  • Author(s): 小林瑞穂、中尾健寿、長野愛矢、小村理行、稲熊真悟、高橋智
  • Organizer: 第111回日本病理学会総会
• [Presentation] 破骨型多核巨細胞を伴う膵未分化癌の一例 (2022)
  • Author(s): 中尾健寿、小林瑞穂、高橋智
  • Organizer: 第111回日本病理学会総会
• [Presentation] カーボンナノチューブ発癌を規定する要因の探求 (2022)
  • Author(s): 内木綾、津田洋幸、高橋智
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] PD-L1陽性大腸癌細胞は高悪性形質、幹細胞様表現型と特異な遺伝子発現を示す (2022)
  • Author(s): 稲熊真悟、上木あかね、小村理行、加藤寛之、内木綾、高橋智
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] 膵癌におけるdipyrimidine dehydrogenaseの役割 (2022)
  • Author(s): 加藤寛之、内木綾、稲熊真悟、小村理行、高橋智
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] ラット非アルコール性脂肪肝炎に対する紫米抽出物の化学予防効果 (2022)
  • Author(s): 内木綾、加藤寛之、小村理行、高橋智
  • Organizer: 第38回日本毒性病理学会総会および学術集会
• [Presentation] 膵癌におけるDPYD発現の寄与と発現抑制貴女の検討 (2022)
  • Author(s): 加藤寛之、内木綾、小村理行、高橋智
  • Organizer: 第38回日本毒性病理学会総会および学術集会
• [Presentation] Short term pulmonary toxicity study of carbon nano-horns (CNH) and carbon nano-brushes (CNB) using intratracheal method. (2022)
  • Author(s): Saleh Dina, Ahmed Omnia, Alexander David, Alexander William, Gunasekaran Sivagami, Takamasa Numano, Hiroshi Takase, Makoto Ohnishi, Satoru Takahashi, Masako Yudasaka, Hiroyuki Tsuda
  • Organizer: 第38回日本毒性病理学会総会および学術集会
• [Presentation] Evaluation of lung carcinogenicity of single-walled carbon nanotube (SWCNT) compared with MWCNT-7 and MWCNT-N. (2022)
  • Author(s): Sheema Asraful Nahar, Aya Naiki-Ito, Hiroyuki Kato, Masayuki Komura, Hiroyuki Tsuda, Satoru Takahashi
  • Organizer: The 1st Meeting of Asian Union of Toxicologic Pathology
  • Int'l Joint Research
• [Presentation] LuteolinはmTORシグナルとp21発現の制御により膀胱発がんを抑制する (2021)
  • Author(s): 内木綾、加藤寛之、小村理行、長野愛矢、稲熊真悟、高橋智
  • Organizer: 第110回日本病理学会総会
• [Presentation] CD70およびPD-L1は協調して悪性胸膜中皮腫細胞の免疫逃避を亢進させ、その予後を悪化させる (2021)
  • Author(s): 稲熊真悟、長野愛矢、小村理行、加藤寛之、内木綾、高橋智
  • Organizer: 第110回日本病理学会総会
• [Presentation] 大腸癌細胞におけるPBK発現は大腸癌患者の予後良好因子である (2021)
  • Author(s): 長野愛矢、中尾健寿、内木綾、笠井謙次、稲熊真悟、高橋智
  • Organizer: 第110回日本病理学会総会
• [Presentation] エラグ酸の膵発癌抑制効果の検討 (2021)
  • Author(s): 加藤寛之、内木綾、稲熊真悟、小村理行、長野愛矢、高橋智
  • Organizer: 第110回日本病理学会総会
• [Presentation] Novel selective lysine-specific demethylase 1 inhibitors, NCL1 and NCD38, suppress testicular tumor cell proliferation. (2021)
  • Author(s): Etani, T., Naiki, T., Shimizu, N., Noda, Y., Nagai, T., Nozaki, S., Iida, K., Ando, R., Kawai, N., Takahashi, S., Suzuki, T., Yasui, T.
  • Organizer: AUA Annual Meeting 2021
  • Int'l Joint Research
• [Presentation] Evaluation of testicular toxicity with the novel epigenome therapeutic agent NCL1. (2021)
  • Author(s): Nozaki, S., Naiki, T., Iwatsuki, S., Naiki-Ito, A., Takeda, T., Etani, T., Umemoto, Y., Takahashi, S., Yasui, T.
  • Organizer: AUA Annual Meeting 2021
  • Int'l Joint Research
• [Presentation] Luteolin suppresses squamous differentiation of bladder cancer and cancer growth via regulation of mammalian target of rapamycin pathway. (2021)
  • Author(s): Iida, K., Naiki-Ito, A., Nagai, T., Nozaki, S., Etani, T., Naiki, T., Kawai, N., Takahashi, S., Yasui, T.
  • Organizer: AUA Annual Meeting 2021
  • Int'l Joint Research
• [Presentation] エラグ酸の膵発癌抑制効果と膵癌におけるレジスチンの効果の検討 (2021)
  • Author(s): 加藤寛之、内木綾、小村理行、髙橋智
  • Organizer: 第37回日本毒性病理学会総会および学術集会
• [Presentation] LuteolinはmTORシグナルとp21発現の制御により膀胱発がんを抑制する (2021)
  • Author(s): 内木綾、加藤寛之、小村理行、髙橋智
  • Organizer: 第37回日本毒性病理学会総会および学術集会
• [Presentation] NADPH oxidase阻害剤apocyninによるニコチン誘発膀胱増殖性病変抑制効果 (2021)
  • Author(s): 鈴木周五、加藤寛之、内木綾、魏民、鰐渕英機、髙橋智
  • Organizer: 第37回日本毒性病理学会総会および学術集会
• [Presentation] CD70分子はMET-ERK経路の活性化、腫瘍細胞の免疫逃避亢進により悪性 胸膜中皮腫患者の予後を悪化させる (2020)
  • Author(s): 稲熊 真悟、Jerzy Lasota、池田 洋、笠井 謙次、 Markku Miettinen、高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] NADPH oxidase阻害剤apocyninによるニコチン誘発ラット膀胱増殖性病 変抑制効果 (2020)
  • Author(s): 鈴木 周五、加藤 寛之、内木 綾、鰐渕 英機、高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] LuteolinはSTAT3経路とDPD発現を低下させ膵発癌を抑制する (2020)
  • Author(s): 加藤 寛之、内木 綾、鈴木 周五、山下 依子、稲熊 真悟、 高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] 大腸癌細胞におけるPBK発現は大腸癌患者の予後良好因子である (2020)
  • Author(s): 中尾 健寿、稲熊 真悟、内木 綾、笠井 謙次、高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] MiR-8080はandrogen receptorスプライスバリアントの発現低下により 去勢抵抗性前立腺癌を抑制する (2020)
  • Author(s): 内木 綾、加藤 寛之、稲熊 真悟、山下 依子、高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] 前立腺癌に肺高血圧症を合併し死亡した一剖検例 (2020)
  • Author(s): 小村 理行、内木 綾、稲熊 真悟、高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] 脾臓sclerosing angiomatoid nodular transformation(SANT)の2例 (2020)
  • Author(s): 小林 瑞穂、加藤 寛之、稲熊 真悟、内木 綾、高橋 智
  • Organizer: 第109回日本病理学会総会
• [Presentation] ルテオリンはmTORシグナルとp21発現の制御により膀胱発がんを抑制する (2020)
  • Author(s): 内木綾、加藤寛之、小村理行、高橋智
  • Organizer: がん予防学術大会2020米子
• [Presentation] ラット膀胱尿路上皮のニコチンによる増殖はNADPH oxidase阻害剤apocyninにより抑制される (2020)
  • Author(s): 鈴木周五、加藤寛之、内木綾、魏民、鰐渕英機、高橋智
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] CD70分子はMET-ERK経路の活性化、腫瘍細胞の免疫逃避亢進により悪性胸膜中皮腫患者の予後を悪化させる (2020)
  • Author(s): 稲熊真悟、Lasota Jerzy 、池田洋、笠井謙次、Miettinen Markku、高橋智
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Anti-Cancer Properties of Houttuynia cordata and Piper ribesioides on Breast Cancer Cells (2020)
  • Author(s): Subhawa Subhawat、内木綾、Chewonarin Teera、髙橋智、Banjerdpongchai Ratana
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Comparative study of anti-prostate cancer activity between hydrophilic and lipophilic extract from purple rice (2020)
  • Author(s): Yeewa Ranchana、内木綾、Kiriya Chanarat、Sakuludomkan Wannachai、Khanaree Chakkrit、髙橋智、Chewonarin Teera
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] ハムスター膵発癌モデルにおけるエラグ酸の膵癌化学予防効果の検討 (2020)
  • Author(s): 加藤寛之、内木綾、小村理行、稲熊真悟、髙橋智
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 抗酸化物質ルテオリンを用いたがん予防 (2020)
  • Author(s): 内木綾、加藤寛之、内木拓、髙橋智
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] SMARCA4欠損未分化癌の一例 (2020)
  • Author(s): 中尾健寿、小林瑞穂、稲熊真悟、内木綾、加藤寛之、髙橋智
  • Organizer: 第66回日本病理学会秋期特別総会
• [Presentation] 羊水塞栓症の一剖検例 (2020)
  • Author(s): 小林瑞穂、髙橋智、田尻佐和子
  • Organizer: 第66回日本病理学会秋期特別総会
• [Presentation] 去勢抵抗性前立腺癌におけるandrogen receptor splice variantの役割とmicroRNAによる制御機構 (2020)
  • Author(s): 内木綾、加藤寛之、鈴木周五、高橋智
  • Organizer: 第36回日本毒性病理学会総会および学術集会
• [Presentation] LuteolinはRNAサイレンシングによるAR-V7制御により去勢抵抗性前立腺癌を抑制する (2019)
  • Author(s): 内木綾、加藤寛之、鈴木周五、山下依子、高橋智
  • Organizer: 第108回日本病理学会総会
• [Presentation] Chemotherapeutic effects of purple rice (Oryza satina L. indica) extract on castration-resistant prostate cancer. (2019)
  • Author(s): Ranchana,Y., Naiki-Ito, A., Naiki, T., Kato, H., Chewonarin, T., Takahashi, S.
  • Organizer: 第26回日本がん予防学会学術大会
• [Presentation] LuteolinはRNAサイレンシングによるAR-V7制御により去勢抵抗性前立腺癌を抑制する (2019)
  • Author(s): 内木綾、加藤寛之、鈴木周五、高橋智
  • Organizer: 第26回日本がん予防学会学術大会
• [Presentation] Luteolinの去勢抵抗性前立腺癌に対する抑制効果とandrogen receptor splice variantの役割 (2019)
  • Author(s): 内木綾、内木拓、加藤寛之、山下依子、高橋智
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] nhibitory effect of purple rice (Oryza satina L. indica) extract on prostate carcinogenesis. (2019)
  • Author(s): Ranchana,Y., Naiki-Ito, A., Naiki, T., Kato, H., Chewonarin, T., Takahashi, S.
  • Organizer: 第78回日本癌学会学術総会
• [Book] 名市大ブックス5 医療の知識で自分を守る (2021)
  • Author(s): 高橋智 (分担）
  • Total Pages: 159
  • Publisher: 中日新聞社
  • ISBN: 9784806207764
• [Remarks] 名古屋市立大学大学院医学研究科実験病態病理学
  • URL: http://www.med.nagoya-cu.ac.jp/patho1.dir/index.html