Development of novel antibodies against leukemia and elucidation of their blocking mechanisms

• Project/Area Number: 19K07668
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Kumamoto University
• Principal Investigator: Osato Motomi 熊本大学, 国際先端医学研究機構, 特定研究員 (90314286)
• Co-Investigator(Kenkyū-buntansha): 指田 吾郎 熊本大学, 国際先端医学研究機構, 特別招聘教授 (70349447) ; 岩崎 正幸 東京女子医科大学, 医学部, 講師 (70790913)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 白血病 / トランスレーショナルリサーチ / 分子標的治療 / ITGA9 / 抗体医薬 / がん幹細胞 / 癌 / RUNX

Outline of Research at the Start

RUNX転写因子異常に起因する白血病(RUNX白血病)においては、ITGA9過発現により、本来なら骨髄微少環境（ニッチ）に存在する時にしか細胞が受け取れないシグナル、特にself renew自己複製を制御するシグナルを、ニッチから細胞（白血病幹細胞）が離れているに状態でも可溶型遊離リガンドと結合することにより十分受け取ることが可能となり、白血病幹細胞細胞の増殖維持に貢献する、という作業仮説を本研究では検証し、その過程を遮断することが新たな治療戦略となることを立証する 。

Outline of Final Research Achievements

Leukemia stem cells (LSCs), being largely dormant at steady state, are widely believed to reside in the bone marrow niches; however, the capacity of the BM niches for LSCs is limited, and most LSCs are being maintained outside the BM, namely the extramedullarly spaces. The molecular basis for this paradox remains elusive. Here, we show that integrin a9 overexpression (ITGA9 OE) plays a pivotal role in the extramedullary maintenance of LSCs by molecularly mimicking the niche-interacting status, through the binding with its soluble-form ligand, osteopontin (Opn). The binding of ITGA9 with soluble Opn, a known negative regulator against HSC activation, induced LSC dormancy, while the disruption of ITGA9-soluble Opn interaction caused rapid cell propagation. ITGA9 OE leads to both active leukemia cell proliferation and increase of dormant LSCs in a well-balanced manner, thereby maintaining LSCs extramedullarly. The ITGA9-Opn axis would serve as a novel therapeutic target in AML.

Academic Significance and Societal Importance of the Research Achievements

白血病に対する治療成績は依然として満足できるものではなく、大量の抗癌剤使用による副作用も大きな問題である。一方で、白血病発症分子機序に基づく分子標的治療[慢性骨髄性白血病に対するイマチニブ、前骨髄球性白血病に対するレチノイン酸(ATRA)など]は、ほぼ100%に迫るかのような劇的な奏功率と、化学療法のそれと比べるとほとんど問題にならない程度の副作用で治療現場を大きく変えた。今回、本研究で同定されたインテグリンアルファ９（ITGA９)高発現は白血病幹細胞の維持に極めて大事であり、抗ITGA９抗体によるその維持機構の遮断は残存白血病細胞の駆逐排除に有用な新規分子標的治療法として期待される。

Research Products

• [Int'l Joint Research] National University of Singapore(シンガポール)
• [Int'l Joint Research] National University of Singapore/Inst. Bioengineering Nanotechnology/Institute of Molecular and Cell Biology(シンガポール)
• [Int'l Joint Research] National University of Singapore/Institute of Molecular and Cell Biology/Inst. Bioengineering Nanotechnology(シンガポール)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Journal Article] Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells (2023)
  • Author(s): Koh CP., Bahirvani AG., Wang CQ., Yokomizo T., Ng CEL., Du L., Tergaonkar V., Voon DC., Kitamura H., Hosoi H., Sonoki T., Michelle MMH., Tan LJ., Niibori-Nambu A., Zhang Y., Perkins AS., Hossain Z., Tenen DG., Ito Y., Venkatesh B., Osato M.
  • Journal Title: Gene Volume: 851 Pages: 147049-147049
  • DOI: 10.1016/j.gene.2022.147049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-throughput telomere length measurement at nucleotide resolution using the PacBio high fidelity sequencing platform. (2023)
  • Author(s): Tham CY, Poon L, Yan T, Koh JYP, Ramlee MK, Teoh VSI, Zhang S, Cai Y, Hong Z, Lee GS, Liu J, Song HW, Hwang WYK, Teh BT, Tan P, Xu L, Koh AS, Osato M, Li S.
  • Journal Title: Nat Commun Volume: 14 Issue: 1 Pages: 281-281
  • DOI: 10.1038/s41467-023-35823-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The RUNX Family, a Novel Multifaceted Guardian of the Genome. (2023)
  • Author(s): Dutta B, Osato M.
  • Journal Title: Cells Volume: 12 Issue: 2 Pages: 255-255
  • DOI: 10.3390/cells12020255
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Core binding factor fusion downregulation of ADAR2 RNA editing contributes to AML leukemogenesis. (2023)
  • Author(s): Guo M, Chan HMT, Zhou QL, An O, Li Y, Song Y, Tan ZH, Ng HEV, Peramangalam PS, Tan ZQ, Cao X, Iwanaga E, Matsuoka M, Ooi MG, Jen WY, Koh LP, Chan E, Tan LK, Goh Y, Wang W, Koh BTH, Chan MC, Fullwood MJ, Chng WJ, Osato M, Pulikkan JA, Yang H, Chen L, Tenen DG.
  • Journal Title: Blood Volume: -
  • DOI: 10.1182/blood.2022015830
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Childhood hematopoietic stem cells constitute the permissive window for RUNX1-ETO leukemogenesis. (2023)
  • Author(s): Abdallah MG, Teoh VSI, Dutta B, Yokomizo T, Osato M.
  • Journal Title: Int J Hematol Volume: - Issue: 6 Pages: 830-838
  • DOI: 10.1007/s12185-023-03605-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Runx1-enhancer Element eR1 Identified Lineage Restricted Mammary Luminal Stem Cells. (2022)
  • Author(s): Matsuo J, Mon NN, Douchi D, Yamamura A, Kulkarni M, Heng DL, Chen S, Nuttonmanit N, Li Y, Yang H, Lee MY, Tam WL, Osato M, Chuang LSH, Ito Y.
  • Journal Title: Stem Cells Volume: 40 Issue: 1 Pages: 112-122
  • DOI: 10.1093/stmcls/sxab009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Leukopenia, macrocytosis, and thrombocytopenia occur in young adults with Down syndrome. (2022)
  • Author(s): Hamaguchi Y, Kondoh T, Fukuda M, Yamasaki K, Yoshiura KI, Moriuchi H, Morii M, Muramatsu M, Minami T, Osato M.
  • Journal Title: Gene Volume: 835 Pages: 146663-146663
  • DOI: 10.1016/j.gene.2022.146663
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hepatic leukemia factor-expressing paraxial mesoderm cells contribute to the developing brain vasculature (2022)
  • Author(s): Koui Yuta、Ideue Takako、Boylan Michael、Anderson Matthew J.、Osato Motomi、Suda Toshio、Yokomizo Tomomasa、Mukouyama Yoh-suke
  • Journal Title: Biology Open Volume: 11 Issue: 9
  • DOI: 10.1242/bio.059510
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Independent origins of fetal liver haematopoietic stem and progenitor cells (2022)
  • Author(s): Yokomizo Tomomasa、Ideue Takako、Morino-Koga Saori、Tham Cheng Yong、Sato Tomohiko、Takeda Naoki、Kubota Yoshiaki、Kurokawa Mineo、Komatsu Norio、Ogawa Minetaro、Araki Kimi、Osato Motomi、Suda Toshio
  • Journal Title: Nature Volume: 609 Issue: 7928 Pages: 779-784
  • DOI: 10.1038/s41586-022-05203-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oncofetal protein IGF2BP1 regulates IQGAP3 expression to maintain stem cell potential in cancer (2022)
  • Author(s): Myint Khine、Chuang Linda Shyue Huey、Teh Yu Xuan、Mawan Nur Astiana、Shi Edward Jizhong、Mok Michelle Meng Huang、Nuttonmanit Napat、Matsuo Junichi、Li Ying、Yang Henry、Okabe Atsushi、Kaneda Atsushi、Osato Motomi、So Jimmy Bok-Yan、Yong Wei Peng、Tan Patrick、Yeoh Khay Guan、Ito Yoshiaki
  • Journal Title: iScience Volume: 25 Issue: 10 Pages: 105194-105194
  • DOI: 10.1016/j.isci.2022.105194
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia. (2022)
  • Author(s): Bae KH, Lai F, Mong J, Niibori-Nambu A, Chan KH, Her Z, Osato M, Tan MH, Chen Q, Kurisawa M.
  • Journal Title: J Nanobiotechnology Volume: 20 Issue: 1 Pages: 481-481
  • DOI: 10.1186/s12951-022-01683-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Myb enhancer-guided analysis of basophil and mast cell differentiation (2022)
  • Author(s): Matsumura Takayoshi、Totani Haruhito、Gunji Yoshitaka、Fukuda Masahiro、Yokomori Rui、Deng Jianwen、Rethnam Malini、Yang Chong、Tan Tze King、Karasawa Tadayoshi、Kario Kazuomi、Takahashi Masafumi、Osato Motomi、Sanda Takaomi、Suda Toshio
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 7064-7064
  • DOI: 10.1038/s41467-022-34906-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Self-Assembled Daunorubicin/Epigallocatechin Gallate Nanocomplex for Synergistic Reversal of Chemoresistance in Leukemia. (2022)
  • Author(s): Bae KH, Lai F, Oruc B, Osato M, Chen Q, Kurisawa M.
  • Journal Title: Int J Mol Sci Volume: 24 Issue: 1 Pages: 381-381
  • DOI: 10.3390/ijms24010381
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The acidic domain of Hmga2 and the domain's linker region are critical for driving self-renewal of hematopoietic stem cell. (2022)
  • Author(s): Sun Y, Kubota S, Iimori M, Hamashima A, Murakami H, Bai J, Morii M, Yokomizo-Nakano T, Osato M, Araki K, Sashida G.
  • Journal Title: Int J Hematol. Volume: 115 Issue: 4 Pages: 553-562
  • DOI: 10.1007/s12185-021-03274-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach (2022)
  • Author(s): 4.Douchi D, Yamamura A, Matsuo J, Lee J-W, Nuttonmanit N, Melissa Lim YH, Suda K, Shimura M, Chen S, Pang S, Kohu K, Kaneko M, Kiyonari H, Kaneda A, Yoshida H, Taniuchi I, Osato M, Yang H, Unno M, Bok-Yan So J, Yeoh KG, Huey Chuang LS, Bae S-C, Ito Y
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 13 Issue: 5 Pages: 1317-1345
  • DOI: 10.1016/j.jcmgh.2022.01.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner (2021)
  • Author(s): Abdallah Mohamed Gaber、Niibori-Nambu Akiko、Morii Mariko、Yokomizo Takako、Yokomizo Tomomasa, at al.
  • Journal Title: Leukemia Volume: 35 Issue: 10 Pages: 2983-2988
  • DOI: 10.1038/s41375-021-01268-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome (2021)
  • Author(s): Yoshino Seiko、Tanaka Miwa、Sunami Yoshitaka、Takahara Tomoko、Yamazaki Yukari、Homme Mizuki、Niibori-Nambu Akiko、Osato Motomi、Minami Takashi、Ishihara Keiichi、Nakamura Takuro
  • Journal Title: Leukemia Volume: 36 Issue: 2 Pages: 558-561
  • DOI: 10.1038/s41375-021-01384-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tocilizumab Induces IL-10-Mediated Immune Tolerance in Invasive Candidiasis. (2021)
  • Author(s): Tan Z, Mok MMH, Mar Soe W, Thamboo TP, Goh JG, Sam QH, Osato M, Ravikumar S, Chai LYA.
  • Journal Title: J Fungi (Basel) Volume: 7 Issue: 8 Pages: 656-656
  • DOI: 10.3390/jof7080656
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines (2021)
  • Author(s): Hosoi Hiroki、Niibori-Nambu Akiko、Nah Giselle Sek Suan、Bahirvani Avinash Govind、Mok Michelle Meng Huang、Sanda Takaomi、Kumar Alan Prem、Tenen Daniel G.、Ito Yoshiaki、Sonoki Takashi、Osato Motomi
  • Journal Title: Gene Volume: 774 Pages: 145421-145421
  • DOI: 10.1016/j.gene.2021.145421
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ZNF143 mediates CTCF-bound promoter?enhancer loops required for murine hematopoietic stem and progenitor cell function (2021)
  • Author(s): Zhou Qiling、Yu Miao、Tirado-Magallanes Roberto、Li Bin、Kong Lingshi、Guo Mingrui、Tan Zi Hui、Lee Sanghoon、Chai Li、Numata Akihiko、Benoukraf Touati、Fullwood Melissa Jane、Osato Motomi、Ren Bing、Tenen Daniel G.
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 43-43
  • DOI: 10.1038/s41467-020-20282-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Familial leukemia due to germline <i>RUNX1</i> mutations: lessons learned from two decades of research and unsolved problems (2020)
  • Author(s): 大里 元美、南部 晶子
  • Journal Title: Rinsho Ketsueki Volume: 61 Issue: 6 Pages: 687-696
  • DOI: 10.11406/rinketsu.61.687
  • NAID: 130007869120
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Hematopoietic stem cells acquire survival advantage by loss of RUNX1 methylation identified in familial leukemia (2020)
  • Author(s): Matsumura Takayoshi、Nakamura-Ishizu Ayako、Muddineni Siva Sai Naga Anurag、Tan Darren Qiancheng、Wang Chelsia Qiuxia、Tokunaga Kenji、Tirado-Magallanes Roberto、Sian Stephanie、Benoukraf Touati、Okuda Tsukasa、Asou Norio、Matsuoka Masao、Osato Motomi、Suda Toshio
  • Journal Title: Blood Volume: 136 Issue: 17 Pages: 1919-1932
  • DOI: 10.1182/blood.2019004292
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance (2020)
  • Author(s): Numata A、Kwok HS、Zhou QL、Li J、Tirado-Magallanes R、Angarica Vladimir VE、Hannah R、Park J、Wang CQ、Krishnan V、Rajagopalan D、Zhang Y、Zhou S、Welner RS.、Osato M、Jha S、Bohlander SK.、Goettgens B、Yang H、Benoukraf T、Lough JW.、Bararia D、Tenen DG.
  • Journal Title: Blood Volume: 136 Issue: 15 Pages: 1735-1747
  • DOI: 10.1182/blood.2019001279
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of RUNX3 represses RUNX1 to drive transformation of myelodysplastic syndrome. (2020)
  • Author(s): Yokomizo-Nakano T, Kubota S, Bai J, Hamashima A, Morii M, Sun Y, Katagiri S, Iimori M, Kanai A, Tanaka D, Oshima M, Harada Y, Ohyashiki K, Iwama A, Harada H, Osato M, Sashida G.
  • Journal Title: Cancer Research Volume: Epub
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells. (2020)
  • Author(s): Chuang LSH, Osato M, Ito Y.
  • Journal Title: Molecules and Cells Volume: 43 Pages: 121-125
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A two-pronged anti-leukemic agent based on a hyaluronic acid?green tea catechin conjugate for inducing targeted cell death and terminal differentiation (2020)
  • Author(s): Liang Kun、Bae Ki Hyun、Nambu Akiko、Dutta Bibek、Chung Joo Eun、Osato Motomi、Kurisawa Motoichi
  • Journal Title: Biomaterials Science Volume: 8 Issue: 1 Pages: 497-505
  • DOI: 10.1039/c9bm01146c
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Low prevalence of the BCR-ABL1 fusion gene in a normal population in southern Sarawak. (2020)
  • Author(s): Kuan JW, Su AT, Tay SP, Fong IL, Kubota S, Su'ut L, Osato M, Sashida G.
  • Journal Title: International Journal of Hematology Volume: 111 Issue: 2 Pages: 217-224
  • DOI: 10.1007/s12185-019-02768-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy (2019)
  • Author(s): Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, Tergaonkar V.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 5349-5349
  • DOI: 10.1038/s41467-019-13082-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia (2019)
  • Author(s): Zhou Jianbiao、Quah Jessie Yiying、Ng Yvonne、Chooi Jing-Yuan、Toh Sabrina Hui-Min、Lin Baohong、Tan Tuan Zea、Hosoi Hiroki、Osato Motomi、Seet Qihui、Ooi A.G. Lisa、Lindmark Bertil、McHale Mark、Chng Wee-Joo
  • Journal Title: Haematologica Volume: Epub Issue: 9 Pages: 2286-2297
  • DOI: 10.3324/haematol.2019.230482
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] EVI1 triggers metabolic reprogramming associated with leukemogenesis and increases sensitivity to L-asparaginase (2019)
  • Author(s): Saito Yusuke、Sawa Daisuke、Kinoshita Mariko、Yamada Ai、Kamimura Sachiyo、Suekane Akira、Ogoh Honami、Matsuo Hidemasa、Adachi Souichi、Taga Takashi、Tomizawa Daisuke、Osato Motomi、Soga Tomoyoshi、Morishita Kazuhiro、Moritake Hiroshi
  • Journal Title: Haematologica Volume: Epub Issue: 8 Pages: 2118-2129
  • DOI: 10.3324/haematol.2019.225953
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Systematic Review of Normal Subjects Harbouring <b><i>BCR-ABL1</i></b> Fusion Gene (2019)
  • Author(s): Kuan JW, Su AT, Leong CF, Osato M, Sashida G.
  • Journal Title: Acta Haematologica Volume: 143 Issue: 2 Pages: 96-111
  • DOI: 10.1159/000501146
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors., (2019)
  • Author(s): Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku, Akihiko Shimono, Hitoshi Takizawa, Naomi Nakagata, Seiichi Mori, Mineo Kurokawa, Daniel Tenen, Motomi Osato, Toshio Suda, and Norio Komatsu.
  • Journal Title: J Exp Med Volume: 216 Issue: 7 Pages: 1599-1614
  • DOI: 10.1084/jem.20181399
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm (2019)
  • Author(s): Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Oshima M, Tan KT, Yang H, Kanai A. Iwanaga E, Asou N, Maeda T, Nakagata N. Ito T, Iwama A. Ohyashiki K, Osato M, Sashida G.
  • Journal Title: Nat Commun Volume: 10 Issue: 1 Pages: 1653-1653
  • DOI: 10.1038/s41467-019-09710-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] TUBB1 dysfunction identified in inherited thrombocytopenia causes impaired proplatelet formation and genome instability (2019)
  • Author(s): Matsumura T, Nakamura-Ishizu A, Maki H, Takaoka K, Naga SSA, Muddineni A, COW CQW, Suzushima H, Kawakita M, Asou N, Matsuoka M, Kurokawa M, Osato M,, Suda T
  • Journal Title: Brit J Haematol. Volume: 0 Issue: 5 Pages: 0-0
  • DOI: 10.1111/bjh.15835
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Familial leukemia due to germline RUNX1 mutations: Lessons from two decades of research, and unsolved questions. (2021)
  • Author(s): Osato M
  • Organizer: Cancer Genomics Haematol Disord Conf, Newcastle Univ Med Malaysia
  • Int'l Joint Research / Invited
• [Presentation] RUNX1-ETO induces myeloid leukemia in mice in an age-dependent manner. (2021)
  • Author(s): Osato M
  • Organizer: the 39th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] t(8:21)白血病研究の新展開：マウスモデルの確立と新規治療戦略の構築 (2021)
  • Author(s): 大里元美
  • Organizer: 第25回造血器腫瘍研究会
• [Presentation] Hematological abnormalities in Down syndrome: segmental aging in blood (2019)
  • Author(s): Motomi Osato
  • Organizer: 第42 回日本分子生物学会年会、福岡
• [Presentation] Lessons from two decades of research on germ line RUNX1 mutations (2019)
  • Author(s): Motomi Osato
  • Organizer: 第81回日本血液学会学術集会、東京
  • Int'l Joint Research / Invited
• [Presentation] Activation of Notch signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia (2019)
  • Author(s): Motomi Osato
  • Organizer: 第78回日本癌学会学術総会、京都
• [Presentation] Integrin a9 overexpression synergizes with RUNX alteration in leukemogenesis (2019)
  • Author(s): Motomi Osato
  • Organizer: 22nd International RUNX Conference 2019, Seoul, Korea
  • Int'l Joint Research
• [Presentation] ダウン症関連急性巨核芽球性白血病に対する新規治療・予防法 (2019)
  • Author(s): Motomi Osato
  • Organizer: 第１回 ダウン症基礎研究会、大阪
• [Remarks] The RUNX1 Enhancer Element eR1
  • URL: https://www.csi.nus.edu.sg/web/the-runx1-enhancer-element-er1-a-versatile-marker-for-adult-stem-cells-mol-cells-jan-2020/