Pegylated interferon therapy-related microRNA-6126 downregulates sodium taurocholate cotransporting polypeptide expression in hepatocytes
| Project/Area Number |
19K07941
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Kagawa University |
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Principal Investigator |
Fujita Koji 香川大学, 医学部附属病院, 助教 (50749421)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | B型肝炎 / 感染症 / microRNA / HBV / NTCP-1 / Hepatitis B virus |
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| Outline of Research at the Start |
B型慢性肝炎は，肝臓にB型肝炎ウイルスが感染し，増殖することにより発症します．放置すれば，肝硬変及び肝細胞癌といった合併症を引き起こすことがあります．私達は，B型肝炎ウイルスの増殖を抑える物質の一つに，microRNA-6126があることを報告しました．本研究では，microRNA-6126がB型肝炎ウイルスの増殖を抑える際のメカニズムを解明すべく，microRNA-6126により発現が抑えられる遺伝子の同定を試みたいと考えています．
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| Outline of Final Research Achievements |
We found that transfection of miR-6126 suppressed the expression of NTCP, suggesting that miR-6126 may inhibit HBV infection of hepatocytes. This suggests that miR-6126 may inhibit HBV infection of hepatocytes. Next, we searched for the target gene of miR-6126, which was not possible due to time and budget constraints. These results were submitted to Microbiology Spectrum, a journal of the American Society for Microbiology, and are now in major revision.
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| Academic Significance and Societal Importance of the Research Achievements |
microRNAはヒトの体内にもともと存在する物質です．本研究においては，microRNAのうちの一つであるmiR-6126が，HBVの感染を抑制される可能性が示唆されました．HBVの感染メカニズムとその治療方法の開発に寄与する成果です．
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Report
(4 results)
Research Products
(3 results)
