Circulating microRNAs associated with smoking-induced vascular endothelial dysfunction

• Project/Area Number: 19K07943
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Osaka Metropolitan University (2022); Osaka City University (2019-2021)
• Principal Investigator: Yasuhiko Takeoto 大阪公立大学, 大学院医学研究科, 客員教授 (20364002)
• Co-Investigator(Kenkyū-buntansha): 冨田 修平 大阪公立大学, 大学院医学研究科, 教授 (00263898) ; 首藤 太一 大阪公立大学, 大学院医学研究科, 教授 (20295687) ; 葭山 稔 大阪公立大学, 大学院医学研究科, 名誉教授 (30240956) ; 山口 雄大 大阪公立大学, 大学院医学研究科, 医員 (40726080) ; 福本 一夫 大阪公立大学, 大学院医学研究科, 講師 (20897392)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: smoking / endothelial dysfunction / circulating microRNA / 喫煙 / 早期血管障害 / 血管内皮機能 / 遺伝子検査学 / 老化

Outline of Research at the Start

我々は早期血管障害を生じていた喫煙者群と早期血管障害が生じていなかった非喫煙者群の両群で、次世代シーケンサーによるmicroarrayを用いたmicroRNA(miR)発現プロファイル解析を実施した。その結果、15のmiRで両群間に発現の差異を認めた。しかしながら、両群間で発現差異を認めたmiRが喫煙による早期血管障害に関与するのか、早期血管障害発生機序とどのように関わるか、は、明らかではない。
本研究では、喫煙者における早期血管障害に関わるmiRを明らかにし、NO産生能の低下、炎症をはじめとする血管制御因子に関わるmiRを検討し喫煙による早期血管障害におけるmiRの役割とその機序を解明することを目的とする。

Outline of Final Research Achievements

We analyzed the differential expression of total of 20 circulating microRNAs between smokers who had impaired flow-dependent dilation (FMD) responses and nonsmokers who did not. We found the significant differences in the expression of circulating miR-92a-3p and miR-126-5p. After achieving smoking cessation, the expression of circulating miR-92a-3p significantly increased and miR-126-3p and miR-126-5p tended to increase. In addition, the change in FMD after smoking cessation was suggested to be correlated with the pression of circulating miR-1, miR-126-3p, and miR-126-5p before smoking cessation treatment.

Academic Significance and Societal Importance of the Research Achievements

喫煙による早期血管障害や、禁煙達成による早期血管障害との関連が示唆される血中のmiRが明らかとなった。これら血中のmiRが、喫煙による早期血管障害のバイオマーカーとなりうる可能性があり、喫煙者における早期血管障害の機序へのmiRの関わりの解明につながる可能性が示唆された。

Research Products

• [Journal Article] Effect of Novel Stratified Lipid Risk by “LDL-Window” and Flow-Mediated Dilation on the Prognosis of Coronary Artery Disease Using the FMD-J Study A Data (2022)
  • Author(s): Abe Shichiro、Haruyama Yasuo、Kobashi Gen、Toyoda Shigeru、Inoue Teruo、Tomiyama Hirofumi、Ishizu Tomoko、Kohro Takahide、Higashi Yukihito、Takase Bonpei、Suzuki Toru、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Koba Shinji、Takemoto Yasuhiko、et al.
  • Journal Title: Circulation Journal Volume: 86 Issue: 9 Pages: 1444-1454
  • DOI: 10.1253/circj.CJ-21-1068
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-08-25
  • Peer Reviewed / Open Access
• [Journal Article] Effect of ipragliflozin on carotid intima-media thickness in patients with type 2 diabetes: a multicenter, randomized, controlled trial (2022)
  • Author(s): Atsushi Tanaka, Masataka Sata, Yosuke Okada, Hiroki Teragawa, Kazuo Eguchi, Michio Shimabukuro, Isao Taguchi, Kazuo Matsunaga, Yumiko Kanzaki, Hisako Yoshida, Tomoko Ishizu, Shinichiro Ueda, Masafumi Kitakaze, Toyoaki Murohara, Koichi Node; PROTECT study investigators
  • Journal Title: European Heart Journal - Cardiovascular Pharmacotherapy Volume: 9 Issue: 2 Pages: 165-172
  • DOI: 10.1093/ehjcvp/pvac059
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• [Journal Article] Retroperitoneal fibrosis requiring prompt nephrostomy in a case with immunoglobulin A vasculitis (2022)
  • Author(s): Ishihama Y、Fukumoto K、Watanabe R、Nakatani S、Tsuda A、Otoshi T、Yamada K、Yamada S、Negoro N、Emoto M、Hashimoto M
  • Journal Title: Scandinavian Journal of Rheumatology Volume: 51 Issue: 5 Pages: 419-421
  • DOI: 10.1080/03009742.2022.2047312
  • Peer Reviewed
• [Journal Article] An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs (2022)
  • Author(s): Samukawa Noriaki、Yamaguchi Takehiro、Ozeki Yuriko、Matsumoto Sohkichi、Igarashi Masayuki、Kinoshita Naoko、Hatano Masaki、Tokudome Kentaro、Matsunaga Shinji、Tomita Shuhei
  • Journal Title: Microbiology Volume: 168 Issue: 12 Pages: 1-11
  • DOI: 10.1099/mic.0.001285
  • Peer Reviewed / Open Access
• [Journal Article] Augmented O-GlcNAcylation exacerbates right ventricular dysfunction and remodeling via enhancement of hypertrophy, mitophagy, and fibrosis in mice exposed to long-term intermittent hypoxia (2022)
  • Author(s): Yokoe Shunichi、Hayashi Tetsuya、Nakagawa Takatoshi、Kato Ryuji、Ijiri Yoshio、Yamaguchi Takehiro、Izumi Yasukatsu、Yoshiyama Minoru、Asahi Michio
  • Journal Title: Hypertension Research Volume: 46 Issue: 3 Pages: 667-678
  • DOI: 10.1038/s41440-022-01088-8
  • Peer Reviewed
• [Journal Article] Achilles tendon thickness is associated with coronary lesion severity in acute coronary syndrome patients without familial hypercholesterolemia (2022)
  • Author(s): Fujiwara Ryosuke、Yahiro Ryosuke、Horio Takeshi、Miyauchi Masafumi、Yoshimura Ryutaro、Matsuoka Yujiro、Yokouchi Go、Sakamoto Yuya、Matsumoto Naoki、Fukuda Kohei、Izumiya Yasuhiro、Yoshiyama Minoru、Fujimoto Kohei、Kasayuki Noriaki
  • Journal Title: Journal of Cardiology Volume: 79 Issue: 2 Pages: 311-317
  • DOI: 10.1016/j.jjcc.2021.09.021
• [Journal Article] Rivaroxaban Attenuates Right Ventricular Remodeling in Rats with Pulmonary Arterial Hypertension (2021)
  • Author(s): Imano Hideki、Kato Ryuji、Nomura Atsuo、Tamura Maki、Yamaguchi Yudai、Ijiri Yoshio、Wu Hong、Nakano Takashi、Okada Yoshikatsu、Yamaguchi Takehiro、Izumi Yasukatsu、Yoshiyama Minoru、Asahi Michio、Hayashi Tetsuya
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 44 Issue: 5 Pages: 669-677
  • DOI: 10.1248/bpb.b20-01011
  • NAID: 130008033192
  • ISSN: 0918-6158, 1347-5215
  • Year and Date: 2021-05-01
  • Peer Reviewed / Open Access
• [Journal Article] Long-term administration of tolvaptan ameliorates annual decline in estimated glomerular filtration rate in outpatients with chronic heart failure (2021)
  • Author(s): Nakao Kazuhiro、Horio Takeshi、Yoshimura Ryutaro、Fujiwara Ryosuke、Matsuoka Yujiro、Yokouchi Go、Nakamura Haruo、Sakamoto Yuya、Fujimoto Kohei、Izumiya Yasuhiro、Yoshiyama Minoru、Kasayuki Noriaki
  • Journal Title: Heart and Vessels Volume: 36 Pages: 1175-1182
  • DOI: 10.1007/s00380-021-01801-6
• [Journal Article] HIF‐1α controls palatal wound healing by regulating macrophage motility via S1P/S1P 1 signaling axis (2021)
  • Author(s): Hutami Islamy Rahma、Izawa Takashi、Khurel‐Ochir Tsendsuren、Sakamaki Takuma、Iwasa Akihiko、Tomita Shuhei、Tanaka Eiji
  • Journal Title: Oral Diseases Volume: - Issue: 4 Pages: 1157-1169
  • DOI: 10.1111/odi.13856
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predictors of the effects of smoking cessation on the endothelial function of conduit and digital vessels (2020)
  • Author(s): Fukumoto Kazuo、Takemoto Yasuhiko、Norioka Naoki、Takahashi Kanae、Namikawa Hiroki、Tochino Yoshihiro、Shintani Ayumi、Yoshiyama Minoru、Shuto Taichi
  • Journal Title: Hypertension Research Volume: 44 Issue: 1 Pages: 63-70
  • DOI: 10.1038/s41440-020-0516-z
  • Peer Reviewed
• [Journal Article] Predictors of endothelial function improvement in patients with mild hypertriglyceridemia without evidence of coronary artery disease treated with purified eicosapentaenoic acid (2020)
  • Author(s): Fukumoto Kazuo、Takemoto Yasuhiko、Yoshikawa Junichi、Norioka Naoki、Iguchi Tomokazu、Namikawa Hiroki、Tochino Yoshihiro、Yoshiyama Minoru、Shuto Taichi
  • Journal Title: Atherosclerosis Volume: 309 Pages: 27-32
  • DOI: 10.1016/j.atherosclerosis.2020.07.013
  • Peer Reviewed
• [Journal Article] Yohimbine ameliorates lipopolysaccharide-induced acute kidney injury in rats (2020)
  • Author(s): Shimokawa Takaomi、Yoneda Kozo、Yamagata Masayo、Hayashi Kohei、Tomita Shuhei
  • Journal Title: European Journal of Pharmacology Volume: 871 Pages: 172917-172917
  • DOI: 10.1016/j.ejphar.2020.172917
  • Peer Reviewed
• [Journal Article] Hypoxia inducible factor1α regulates Lipin1 differently in pre adipocytes and mature adipocytes (2020)
  • Author(s): Kihira Yoshitaka、Fujimura Yoshino、Tomita Shuhei、Tamaki Toshiaki、Sato Eiji
  • Journal Title: Molecular Medicine Reports Volume: 22 Pages: 559-565
  • DOI: 10.3892/mmr.2020.11076
  • Peer Reviewed
• [Journal Article] Factors predictive of invasive ductal carcinoma in cases preoperatively diagnosed as ductal carcinoma in situ (2020)
  • Author(s): Takada Koji、Kashiwagi Shinichiro、Asano Yuka、Goto Wataru、Morisaki Tamami、Takahashi Katsuyuki、Fujita Hisakazu、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
  • Journal Title: BMC Cancer Volume: 20 Issue: 1 Pages: 513-513
  • DOI: 10.1186/s12885-020-07001-1
  • Peer Reviewed / Open Access
• [Journal Article] Predicting therapeutic efficacy of endocrine therapy for stage IV breast cancer by tumor infiltrating lymphocytes (2020)
  • Author(s): Asano Yuka、Kashiwagi Shinichiro、Goto Wataru、Takada Koji、Takahashi Katsuyuki、Shibutani Masatsune、Amano Ryosuke、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
  • Journal Title: Molecular and Clinical Oncology Volume: 13 Issue: 2 Pages: 195-202
  • DOI: 10.3892/mco.2020.2063
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Significance of age associated quality of life in patients with stage IV breast cancer who underwent endocrine therapy in Japan (2020)
  • Author(s): Takada Koji、Kashiwagi Shinichiro、Asano Yuka、Goto Wataru、Morisaki Tamami、Takahashi Katsuyuki、Shibutani Masatsune、Amano Ryosuke、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
  • Journal Title: Oncology Letters Volume: 20 Issue: 5 Pages: 1-1
  • DOI: 10.3892/ol.2020.12041
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effects of iron depletion plus eribulin on the breast cancer microenvironment (2020)
  • Author(s): Goto Wataru、Kashiwagi Shinichiro、Asano Yuka、Takada Koji、Morisaki Tamami、Takahashi Katsuyuki、Fujita Hisakazu、Shibutani Masatsune、Amano Ryosuke、Takashima Tsutomu、Tomita Shuhei、Hirakawa Kosei、Ohira Masaichi
  • Journal Title: BMC Cancer Volume: 20 Issue: 1 Pages: 1215-1215
  • DOI: 10.1186/s12885-020-07673-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence and Risk Factors of Silent Brain Infarction in Patients with Aortic Stenosis (2020)
  • Author(s): Ito Ayaka、Iwata Shinichi、Tamura Soichiro、Kim Andrew T、Nonin Shinichi、Ishikawa Sera、Ito Asahiro、Izumiya Yasuhiro、Abe Takato、Shibata Toshihiko、Yoshiyama Minoru
  • Journal Title: Cerebrovascular Diseases Extra Volume: 10 Issue: 3 Pages: 116-123
  • DOI: 10.1159/000510438
  • Peer Reviewed / Open Access
• [Journal Article] Severe obstructive sleep apnea is associated with coronary microvascular dysfunction and obstruction in patients with ST-elevation myocardial infarction (2020)
  • Author(s): Ichikawa Yoshitaka、Izumiya Yasuhiro、Tamita Koichi、Hayashi Hiroya、Ishikawa Hirotoshi、Shibata Atsushi、Yamamuro Atsushi、Yoshiyama Minoru
  • Journal Title: European Heart Journal. Acute Cardiovascular Care Volume: in prerss Issue: 6 Pages: 645-652
  • DOI: 10.1177/2048872620919946
  • NAID: 120007034007
  • Peer Reviewed
• [Journal Article] Soluble urokinase-type plasminogen activator receptor represents exercise tolerance and predicts adverse cardiac events in patients with heart failure. (2020)
  • Author(s): Ishikawa H, Izumiya Y, Shibata A, Ichikawa Y, Yamaguchi T, Yamaguchi Y, Kitada R, Iwata S, Ehara S, Tomita S, Hanatani A, Yoshiyama M.
  • Journal Title: Heart Vessels. Volume: 35 Issue: 5 Pages: 681-688
  • DOI: 10.1007/s00380-019-01538-3
  • NAID: 120006936889
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of pre- and post-stent optical frequency domain imaging findings in the prediction of periprocedural cardiac troponin elevation in patients with coronary artery disease (2020)
  • Author(s): Otsuka Kenichiro、Shimada Kenei、Ishikawa Hirotoshi、Nakamura Haruo、Katayama Hisashi、Takeda Hisateru、Fujimoto Kohei、Kasayuki Noriaki、Yoshiyama Minoru
  • Journal Title: Heart and Vessels Volume: 35 Issue: 4 Pages: 451-462
  • DOI: 10.1007/s00380-019-01512-z
  • Peer Reviewed
• [Journal Article] Increased arterial stiffness and cardiovascular risk prediction in controlled hypertensive patients with coronary artery disease: post hoc analysis of FMD-J (Flow-mediated Dilation Japan) Study A (2020)
  • Author(s): Maruhashi Tatsuya、Tomiyama Hirofumi、Takemoto Yasuhiko、Sata Masataka、Node Koichi、Higashi Yukihito
  • Journal Title: Hypertension Research Volume: 3 Issue: 8 Pages: 1-10
  • DOI: 10.1038/s41440-020-0420-6
  • Peer Reviewed
• [Journal Article] Diagnostic Criteria of Flow‐Mediated Vasodilation for Normal Endothelial Function and Nitroglycerin‐Induced Vasodilation for Normal Vascular Smooth Muscle Function of the Brachial Artery (2020)
  • Author(s): Maruhashi Tatsuya、Tomiyama Hirofumi、Takemoto Yasuhiko、Sata Masataka、Node Koichi、Higashi Yukihito
  • Journal Title: Journal of the American Heart Association Volume: 9 Issue: 2
  • DOI: 10.1161/jaha.119.013915
  • NAID: 120006941134
  • Peer Reviewed / Open Access
• [Journal Article] Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model (2020)
  • Author(s): Kabei Kazuya、Tateishi Yu、Shiota Masayuki、Osada-Oka Mayuko、Nishide Shunji、Uchida Junji、Nakatani Tatsuya、Matsunaga Shinji、Yamaguchi Takehiro、Tomita Shuhei、Miura Katsuyuki
  • Journal Title: Journal of Pharmacological Sciences Volume: 142 Issue: 3 Pages: 93-100
  • DOI: 10.1016/j.jphs.2019.12.002
  • Peer Reviewed / Open Access
• [Journal Article] A Nationwide Survey on the Faculty Development for Simulation-Based Medical Education in Japan (2019)
  • Author(s): 志賀 隆、首藤 太一、藤崎 和彦、小松 弘幸、前野 貴美、阿部 恵子、春田 淳志、栩野 吉弘、竹本 恭彦、石川 和信
  • Journal Title: Igaku Kyoiku / Medical Education (Japan) Volume: 50 Issue: 3 Pages: 245-250
  • DOI: 10.11307/mededjapan.50.3_245
  • NAID: 130007795339
  • ISSN: 0386-9644, 2185-0453
  • Year and Date: 2019-06-25
  • Peer Reviewed
• [Journal Article] Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease ― Post Hoc Analysis of the FMD-J Study A ― (2019)
  • Author(s): Kajikawa Masato、Noma Kensuke、Nakashima Ayumu、Tomiyama Hirofumi、Takase Bonpei、Kohro Takahide、Suzuki Toru、Ishizu Tomoko、Ueda Shinichiro、Yamazaki Tsutomu、Furumoto Tomoo、Kario Kazuomi、Inoue Teruo、Koba Shinji、Watanabe Kentaro、Takemoto Yasuhiko、Hano Takuzo、Sata Masataka et al.
  • Journal Title: Circulation Journal Volume: 83 Issue: 5 Pages: 1064-1071
  • DOI: 10.1253/circj.CJ-18-1082
  • NAID: 130007636980
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-04-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease (2019)
  • Author(s): Tomiyama Hirofumi、Maruhashi Tatsuya、Takemoto Yasuhiko、Sata Masataka、Node Koichi、Higashi Yukihito
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 24
  • DOI: 10.1161/jaha.119.013004
  • NAID: 120006786177
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and virulence factors related to the 30-day mortality of Klebsiella pneumoniae bacteremia at a tertiary hospital: a case-control study (2019)
  • Author(s): Hiroki Namikawa, Makoto Niki, Mamiko Niki, Koichi Yamada, Kiyotaka Nakaie, Arata Sakiyama, Ken-Ichi Oinuma, Taishi Tsubouchi, Yoshihiro Tochino, Yasuhiko Takemoto, Yukihiro Kaneko, Taichi Shuto, Hiroshi Kakeya
  • Journal Title: European Journal of Clinical Microbiology & Infectious Diseases Volume: 38 Issue: 12 Pages: 2291-2297
  • DOI: 10.1007/s10096-019-03676-y
  • NAID: 120006900909
  • Peer Reviewed
• [Journal Article] Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate antivirulence agent against hypervirulent Klebsiella pneumoniae (2019)
  • Author(s): Namikawa Hiroki、Oinuma Ken-Ichi、Sakiyama Arata、Tsubouchi Taishi、Tahara Yuhei O.、Yamada Koichi、Niki Mamiko、Takemoto Yasuhiko、Miyata Makoto、Kaneko Yukihiro、Shuto Taichi、Kakeya Hiroshi
  • Journal Title: International Journal of Antimicrobial Agents Volume: 54 Issue: 2 Pages: 167-175
  • DOI: 10.1016/j.ijantimicag.2019.05.018
  • NAID: 120006882174
  • Peer Reviewed
• [Presentation] Effects of smoking cessation on endothelial function simultaneously evaluated by flow-mediated dilation and reactive hyperemia peripheral artery tonometry (2021)
  • Author(s): Kazuo Fukumoto, Yasuhiko Takemoto, Naoki Norioka, Kanae Takahashi, Naoki Okuyama, Hiroki Namikawa, Yoshihiro Tochino, Ayumi Shintani, Minoru Yoshiyama, Taichi Shuto
  • Organizer: European Atherosclerosis Society Congress
• [Presentation] 禁煙治療における血管内皮機能の経時的変化：導管血管と抵抗血管の同時評価 (2021)
  • Author(s): 福本一夫、竹本恭彦、則岡直樹、高橋佳苗、奥山直木、並川浩己、栩野吉弘、新谷歩、葭山稔、首藤太一
  • Organizer: 日本血管不全学会学術集会・総会
• [Presentation] Effects of smoking cessation on endothelial function assessed by flow-mediated dilation and reactive hyperemia peripheral artery tonometry (2020)
  • Author(s): Kazuo Fukumoto, Yasuhiko Takemoto, Minoru Yoshiyama, Taichi Shuto
  • Organizer: European Society of Cardiology Congress
  • Int'l Joint Research
• [Presentation] HDL-cholesterol level and EPA/AA ratio are associated with improvement of vascular endothelial function in patients with hypertriglyceridemia (2020)
  • Author(s): Kazuo Fukumoto, Yasuhiko Takemoto, Minoru Yoshiyama, Taichi Shuto
  • Organizer: European Atherosclerosis Society
  • Int'l Joint Research
• [Presentation] Increase in EPA/AA Ratio Predicts Improvement in Endothelial Function In Purified Eicosapentaenoic Acid-Treated Patients (2019)
  • Author(s): Kazuo Fukumoto, Yasuhiko Takemoto, Minoru Yoshiyama, Taichi Shutou
  • Organizer: European Society of Cardiology 2019
  • Int'l Joint Research
• [Presentation] Clinical characteristics of bacteremia caused by hypermucoviscous Klebsiella pneumoniae at a tertiary hospital (2019)
  • Author(s): Hiroki Namikawa, Yasuhiko Takemoto, Taichi Shutou
  • Organizer: WONCA Asia Pacific Regional Conference 2019
  • Int'l Joint Research
• [Presentation] 高純度EPA製剤投与によるEPA/AA 比の増加と内皮機能改善の予測に関する検討 (2019)
  • Author(s): 福本 一夫、竹本 恭彦、葭山 稔、首藤 太一
  • Organizer: 第4回日本血管不全学会学術集会
• [Presentation] Klebsiella pneumoniae菌血症の30日後死亡予測因子の解析～遺伝子学的特徴も含めて～ (2019)
  • Author(s): 並川 浩己、竹本 恭彦、首藤 太一
  • Organizer: 第10回日本プライマリ・ケア連合学会学術大会
• [Presentation] 効果的な屋根瓦式教育のための改善報告 (2019)
  • Author(s): 奥 幸子、首藤 太一
  • Organizer: 第51回日本医学教育学会大会
• [Presentation] 血管機能検査を心臓病診療に活用する (2019)
  • Author(s): 竹本 恭彦
  • Organizer: 第67回日本心臓病学会学術集会