Cellular immunnogenesis in MOG antibody related encephalomyelitis

• Project/Area Number: 19K07953
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52020:Neurology-related
• Research Institution: Tohoku University
• Principal Investigator: Misu Tatsuro 東北大学, 大学病院, 講師 (00396491)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脱髄性疾患 / ミエリンオリゴデンドロサイト糖タンパク / 神経免疫学 / 多発性硬化症 / 視神経脊髄炎 / 抗原 / エピトープ / T細胞エピトープ / ミエリン / 急性散在性脳脊髄炎 / 自己抗体 / 抗原応答 / ミエリンオリゴデンドロサイト糖蛋白抗体 / 自己免疫疾患 / 細胞性免疫応答

Outline of Research at the Start

今後の最も大きな課題は、MOG関連脳脊髄炎はMSと同じ疾患か区別されるべき疾患かを明確にすることである。MSにおいて上市・開発されている疾患修飾薬 の多くは、NMOにおいては無効ないし悪化させることが近年解っている。

MOG関連疾患においても同様の問題があり、これまで使われてきた免疫修飾薬を使うことができるかは喫緊の課題である。今後の免疫病態の研究において、MOG抗原に対する免疫応答を解析し従来のMSやAQP4抗体関連NMOと比較することで、MOG抗原に対する特異的な免疫応答や炎症機序を解明することは、治療方針を決定する上で極めて重要であり、患者の予後に直結する重要な研究であると考えている。

Outline of Final Research Achievements

In myelin oligodendrocyte glycoprotein (MOG) antibody associated disorders (MOGAD), it was revealed that the pathological features of MOGAD was the dominance of perivenous demyelinating lesions with infiltrations of CD4 positive T cells like acute disseminated encephalomyelitis (ADEM). It was also revealed that the mechanisms of humoral immunity in MOGAD were different from those in neuromyelitis optica spectrum disorders (NMOSD).
For cellular immunity in MOGAD, we studied the existence of antigen-specific T cells in MOGAD, which was done by peripheral blood T mononuclear cells were cultured with overlapping peptides of MOG and identified by flowcytometry. We revealed some antigen-specific T cells in MOGAD. These data suggested that both the humoral and cellular immunity were important in the pathogenesis of MOGAD.

Academic Significance and Societal Importance of the Research Achievements

特定の自己免疫性疾患において自己抗体が明らかになることがあるが、背景免疫病態としての抗体産生に関わる細胞性免疫について検討した研究は皆無である。本研究は多発性硬化症類似の脱髄性疾患であるミエリンオリゴデンドロサイト糖蛋白質（MOG)抗体を有するMOG関連疾患において、特定の抗原エピトープ部位応答性のMOG特異的T細胞の存在を証明した初めての報告であり、病態解明によって新たな治療解明が期待される。

Research Products

• [Int'l Joint Research] Oxford university(英国)
• [Int'l Joint Research] Mayo clinic(米国)
• [Journal Article] Anti-NXP2 antibody-positive dermatomyositis developed after COVID-19 manifesting as type I interferonopathy (2022)
  • Author(s): Okada Y, Izumi R, Hosaka T, Watanabe S, Shijo T, Hatchome N, Konishi R, Ichimura Y, Okiyama N, Suzuki N, Misu T, Aoki M.
  • Journal Title: Rheumatology Volume: 61 Issue: 4 Pages: e90-e92
  • DOI: 10.1093/rheumatology/keab872
  • Peer Reviewed / Open Access
• [Journal Article] MOG Antibody-Associated Disorders Following SARS- CoV-2 Vaccination: A Case Report and Literature Review. (2022)
  • Author(s): Matsumoto Y, Ohyama A, Kubota T, Ikeda K, Kaneko K, Takai Y, Warita H, Takahashi T, Misu T, Aoki M.
  • Journal Title: Front Neurol. Volume: 13 Pages: 845755-845755
  • DOI: 10.3389/fneur.2022.845755
  • Peer Reviewed / Open Access
• [Journal Article] Compassionate open- label use of rituximab following a randomised clinical trial against neuromyelitis optica (RIN-2 study): B cell monitoring-based administration. (2022)
  • Author(s): Tahara M, Oeda T, Okada K, Ochi K, Maruyama H, Fukaura H, Nomura K, Shimizu Y, Nakashima I, Misu T, Umemura A, Yamamoto K, Sawada H.
  • Journal Title: Mult Scler Relat Disord. Volume: 60 Pages: 103730-103730
  • DOI: 10.1016/j.msard.2022.103730
  • Peer Reviewed / Open Access
• [Journal Article] GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder (2021)
  • Author(s): Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T.
  • Journal Title: Neurol Neuroimmunol Neuroinflamm Volume: 9 Issue: 1
  • DOI: 10.1212/nxi.0000000000001038
  • Peer Reviewed / Open Access
• [Journal Article] Relapse activity in the chronic phase of anti-myelin-oligodendrocyte glycoprotein antibody-associated disease (2021)
  • Author(s): Akaishi T, Misu T, Fujihara K, Takahashi T, Takai Y, Nishiyama S, Kaneko K, Fujimori J, Ishii T, Aoki M, Nakashima I.
  • Journal Title: J Neurol Volume: - Issue: 6 Pages: 3136-3146
  • DOI: 10.1007/s00415-021-10914-x
  • Peer Reviewed / Open Access
• [Journal Article] White blood cell count profiles in multiple sclerosis during attacks before the initiation of acute and chronic treatments. (2021)
  • Author(s): Akaishi T, Misu T, Fujihara K, Nakaya N, Nakamura T, Kogure M, Hatanaka R, Itabashi F, Kanno I, Takahashi T, Kuroda H, Fujimori J, Takai Y, Nishiyama S, Kaneko K, Ishii T, Aoki M, Nakashima I, Hozawa A.
  • Journal Title: Sci Rep Volume: 11 Issue: 1 Pages: 22357-22357
  • DOI: 10.1038/s41598-021-01942-8
  • Peer Reviewed / Open Access
• [Journal Article] Five-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease. (2021)
  • Author(s): Akaishi T, Himori N, Takeshita T, Misu T, Takahashi T, Takai Y, Nishiyama S, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakazawa T, Nakashima I.
  • Journal Title: Mult Scler Relat Disord Volume: 56 Pages: 103222-103222
  • DOI: 10.1016/j.msard.2021.103222
  • Peer Reviewed / Open Access
• [Journal Article] Difference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder. (2021)
  • Author(s): Akaishi T, Takahashi T, Misu T, Kaneko K, Takai Y, Nishiyama S, Ogawa R, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakashima I.
  • Journal Title: Neurology. Volume: 97 Issue: 1
  • DOI: 10.1212/wnl.0000000000012175
  • Peer Reviewed / Open Access
• [Journal Article] Staging of astrocytopathy and complement activation in neuromyelitis optica spectrum disorders (2021)
  • Author(s): Takai Y, Misu T, Suzuki H, Takahashi T, Okada H, Tanaka S, Okita K, Sasou S, Watanabe M, Namatame C, Matsumoto Y, Ono H, Kaneko K, Nishiyama S, Kuroda H, Nakashima I, Lassmann H, Fujihara K, Itoyama Y, Aoki M.
  • Journal Title: Brain Volume: 144
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Early Treatment Initiation With Oral Prednisolone for Relapse Prevention Alleviates Depression and Fatigue in Aquaporin-4-Positive Neuromyelitis optica Spectrum Disorder (2021)
  • Author(s): Akaishi T, Takahashi T, Fujihara K, Misu T, Fujimori J, Takai Y, Nishiyama S, Abe M, Ishii T, Aoki M, Nakashima I.
  • Journal Title: Front Neurol Volume: 12 Pages: 608149-608149
  • DOI: 10.3389/fneur.2021.608149
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. (2021)
  • Author(s): Akaishi T, Himori N, Takeshita T, Fujihara K, Misu T, Takahashi T, Fujimori J, Ishii T, Aoki M, Nakazawa T, Nakashima I.
  • Journal Title: Brain Behav Volume: － Issue: 5
  • DOI: 10.1002/brb3.2083
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optimal management of neuromyelitis optica spectrum disorder with aquaporin-4 antibody by oral prednisolone maintenance therapy (2021)
  • Author(s): Takai Y, Kuroda H, Misu T, Akaishi T, Nakashima I, Takahashi T, Nishiyama S, Fujihara K, Aoki M.
  • Journal Title: Mult Scler Relat Disord. Volume: 49 Pages: 102750-102750
  • DOI: 10.1016/j.msard.2021.102750
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CH50 as a putative biomarker of eculizumab treatment in neuromyelitis optica spectrum disorder. (2021)
  • Author(s): Namatame C, Misu T, Takai Y, Nishiyama S, Nakashima I, Fujihara K, Aoki M.
  • Journal Title: Heliyon Volume: － Issue: 1 Pages: e05899-e05899
  • DOI: 10.1016/j.heliyon.2021.e05899
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of comorbid Sjogren syndrome in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders (2021)
  • Author(s): Akaishi T, Takahashi T, Fujihara K, Misu T, Fujimori J, Takai Y, Nishiyama S, Abe M, Ishii T, Aoki M, Nakashima I.
  • Journal Title: J Neurol Volume: － Issue: 5 Pages: 1938-1944
  • DOI: 10.1007/s00415-020-10377-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy. (2021)
  • Author(s): Nakamura T, Kaneko K, Watanabe G, Harashima S, Kawasaki E, Tsukita K, Takahashi T, Nakashima I, Misu T, Suzuki Y.
  • Journal Title: Neurol Sci Volume: 42 Issue: 3 Pages: 1135-1138
  • DOI: 10.1007/s10072-020-04822-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rapid Administration of High-Dose Intravenous Methylprednisolone Improves Visual Outcomes After Optic Neuritis in Patients With AQP4-IgG-Positive NMOSD (2021)
  • Author(s): Akaishi T, Takeshita T, Himori N, Takahashi T, Misu T, Ogawa R, Kaneko K, Fujimori J, Abe M, Ishii T, Fujihara K, Aoki M, Nakazawa T, Nakashima I.
  • Journal Title: Front Neurol. Volume: 11 Pages: 932-932
  • DOI: 10.3389/fneur.2020.00932
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Progressive patterns of neurological disability in multiple sclerosis and neuromyelitis optica spectrum disorders. (2021)
  • Author(s): Akaishi T, Takahashi T, Misu T, Abe M, Ishii T, Fujimori J, Aoki M, Fujihara K, Nakashima I.
  • Journal Title: Sci Rep. Volume: 10(1) Issue: 1 Pages: 13890-13890
  • DOI: 10.1038/s41598-020-70919-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] T-cell Lymphoma Presenting Neutrophilic Inflammation in the Cerebrospinal Fluid (2020)
  • Author(s): Nakamura T, Takai Y, Kaneko K, Kuroda H, Misu T, Asanuma K, Saito R, Aoki M.
  • Journal Title: Internal Medicine Volume: 59 Issue: 4 Pages: 573-576
  • DOI: 10.2169/internalmedicine.3093-19
  • NAID: 130007798434
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-02-15
  • Peer Reviewed / Open Access
• [Journal Article] Distinctive lesions of brain MRI between MOG-antibody-associated and AQP4-antibody-associated diseases. (2020)
  • Author(s): Matsumoto Y, Misu T, Mugikura S, Takai Y, Nishiyama S, Kuroda H, Takahashi T, Fujimori J, Nakashima I, Fujihara K, Aoki M.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: － Issue: 6 Pages: 682-684
  • DOI: 10.1136/jnnp-2020-324818
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis. (2020)
  • Author(s): Akaishi T, Takahashi T, Fujihara K, Misu T, Nishiyama S, Takai Y, Fujimori J, Abe M, Ishii T, Aoki M,
  • Journal Title: Mult Scler Relat Disord. Volume: 45 Pages: 102382-102382
  • DOI: 10.1016/j.msard.2020.102382
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients. (2020)
  • Author(s): Whittam DH, Cobo-Calvo A, Lopez-Chiriboga AS, Pardo S, E, Ciron J, Deschamps R, Biotti D, Rostasy K, Neuteboom R, HemingwaGornall M, Cicconi S, Brandt A, Berek K, Berger T, Jelcic I, Gombolay G, Oliveira LM, Callegaro D, Kaneko K, Misu T, et al.
  • Journal Title: Mult Scler Relat Disord Volume: 44 Pages: 102251-102251
  • DOI: 10.1016/j.msard.2020.102251
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study (2020)
  • Author(s): Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Komori T, Seki M, Komatsu T, Nakamagoe K, Ikeda T, Yoshida M, Takahashi T, Ono H, Nishiyama S, Kuroda H, Nakashima I, Suzuki H, Bradl M, Lassmann H, Fujihara K, Aoki M
  • Journal Title: Brain Volume: 143 Issue: 5 Pages: 1431-1446
  • DOI: 10.1093/brain/awaa102
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Induction of aquaporin 4-reactive antibodies in Lewis rats immunized with aquaporin 4 mimotopes. (2020)
  • Author(s): Tsymala I, Nigritinou M, Zeka B, Schulz R, Niederschick F, Matkovic; M, Bauer IJ, Szalay M, Schanda K, Lerch M, Misu T, Fujihara K, Bennett JL, Dahle C, Pache F, Rommer P, Leutmezer F, Illes Z, Leite MI, Palace J, Scholze P, Reindl M, Lassmann H, Bradl M.
  • Journal Title: Acta Neuropathol Commun. Volume: 8 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s40478-020-00920-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk factors of attacks in neuromyelitis optica spectrum disorders. (2020)
  • Author(s): Akaishi T, Takahashi T, Fujihara K, Misu T, Abe M, Ishii T, Aoki M, Nakashima I.
  • Journal Title: J Neuroimmunol. Volume: 343 Pages: 577236-577236
  • DOI: 10.1016/j.jneuroim.2020.577236
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders (RIN-1 study): a multicentre, randomised, double-blind, placebo-controlled trial. (2020)
  • Author(s): Tahara M, Oeda T, Okada K, Kiriyama T, Ochi K, Maruyama H, Fukaura H, Nomura K, Shimizu Y, Mori M, Nakashima I, Misu T, Umemura A, Yamamoto K, Sawada H.
  • Journal Title: Lancet Neurol. Volume: 19 Issue: 4 Pages: 298-306
  • DOI: 10.1016/s1474-4422(20)30066-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum AQP4-IgG level is associated with the phenotype of the first attack in neuromyelitis optica spectrum disorders. (2020)
  • Author(s): Akaishi T, Takahashi T, Himori N, Fujihara K, Misu T, Abe M, Ishii T, Nakazawa T, Aoki M, Nakashima I.
  • Journal Title: J Neuroimmunol. Volume: 340 Pages: 577168-577168
  • DOI: 10.1016/j.jneuroim.2020.577168
  • Peer Reviewed
• [Journal Article] Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders: tools for clinical practice and drug trial design (2019)
  • Author(s): Palace J, Lin DY, Zeng D, Majed M, Elsone L, Hamid S, Messina S, Misu T, Sagen J, Whittam D, Takai Y, Leite MI, Weinshenker B, Cabre P, Jacob A, Nakashima I, Fujihara K, Pittock SJ
  • Journal Title: Brain Volume: 142 Issue: 5 Pages: 1310-1323
  • DOI: 10.1093/brain/awz054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two Japanese cases of anti-MOG antibody-associated encephalitis that mimicked neuro-Behçet's disease. (2019)
  • Author(s): Fujimori J, Takahashi T, Matsumoto Y, Fujihara K, Takai Y, Misu T, Nakashima I.
  • Journal Title: J Neuroimmunol Volume: 334 Pages: 577002-577002
  • DOI: 10.1016/j.jneuroim.2019.577002
  • Peer Reviewed
• [Journal Article] Circulating AQP4-specific auto-antibodies alone can induce neuromyelitis optica spectrum disorder in the rat (2018)
  • Author(s): Hillebrand Sophie、Schanda Kathrin、Nigritinou Magdalini、Tsymala Irina、Boehm Denise、Peschl Patrick、Takai Yoshiki、Fujihara Kazuo、Nakashima Ichiro、Misu Tatsuro、Reindl Markus、Lassmann Hans、Bradl Monika
  • Journal Title: Acta Neuropathologica Volume: 137 Issue: 3 Pages: 467-485
  • DOI: 10.1007/s00401-018-1950-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 抗MOG抗体関連疾患の特徴 (2021)
  • Author(s): 三須建郎．
  • Organizer: 神経免疫学会
  • Invited
• [Presentation] 神経・グリアネットワーク障害と神経疾患 視神経脊髄炎関連疾患の自己免疫現象に見る神経・グリア連関 (2021)
  • Author(s): 三須建郎
  • Organizer: 神経治療学会
  • Invited
• [Presentation] 自己免疫性脳炎と感染症 自己免疫性脳炎の基礎 (2021)
  • Author(s): 三須建郎
  • Organizer: 神経感染症学会
  • Invited
• [Presentation] 抗MOG抗体関連疾患における髄液中の抗MOG抗体測定の意義 (2021)
  • Author(s): 松本勇貴、金子仁彦、三須建郎、生田目知尋、高井良樹、黒田宙、高橋利幸、中島一郎、藤原一男、青木正志．
  • Organizer: 神経免疫学会
• [Presentation] 視神経脊髄炎におけるアストロサイトパチーに基づいた新たな病期分類の確立と経時変化の解析 (2021)
  • Author(s): 高井良樹、三須建郎、鈴木博義、高橋利幸、藤原一男、青木正志．
  • Organizer: 神経免疫学会
• [Presentation] 臨床的に多発性硬化症と診断される抗MOG抗体陽性患者の検討 (2020)
  • Author(s): 11.生田目 知尋(東北大学 医学系研究科神経内科学分野), 三須 建郎, 高橋 利幸, 小川 諒, 金子 仁彦, 高井 良樹, 西山 修平, 中島 一郎, 藤原 一男, 青木 正志
  • Organizer: 日本神経免疫学会
• [Presentation] 中枢病変を伴わない末梢神経障害における抗MOG抗体 連続37例での検討． (2020)
  • Author(s): 12.金子 仁彦(東北大学 脳神経内科), 佐藤 ダグラス, 高橋 利幸, 高井 良樹, 西山 修平, 三須 建郎, 中島 一郎, 藤原 一男, 青木 正志．
  • Organizer: 日本神経免疫学会
• [Presentation] MOG抗体関連疾患での血液脳関門破綻メカニズムの解明． (2020)
  • Author(s): 13.清水 文崇(山口大学 大学院医学系研究科臨床神経学), 小川 諒, 原 佳那子, 門野 ちひろ, 高橋 利幸, 竹下 幸男, 三須 建郎, 佐野 泰照, 前田 敏彦, 中島 一郎, 藤原 一男, 神田 隆．
  • Organizer: 日本神経免疫学会
• [Presentation] 抗MOG抗体及び抗AQP4抗体陽性疾患の頭部MRI画像における病変分布の比較検討． (2020)
  • Author(s): 14.松本 勇貴(東北大学 医学部脳神経内科), 三須 建郎, 麦倉 俊司, 高井 良樹, 西山 修平, 黒田 宙, 高橋 利幸, 藤盛 寿一, 中島 一郎, 藤原 一男, 青木 正志
  • Organizer: 日本神経免疫学会
• [Presentation] 臨床的に多発性硬化症と診断される抗MOG抗体陽性患者の検討 (2020)
  • Author(s): 15.生田目 知尋(東北大学 大学院医学系研究科神経内科学分野), 三須 建郎, 高橋 利幸, 小川 諒, 金子 仁彦, 高井 良樹, 西山 修平, 中島 一郎, 藤原 一男, 青木 正志．
  • Organizer: 日本神経学会総会
• [Presentation] 頭部外傷を契機に発症した抗MOG抗体関連脳脊髄炎の一例 (2019)
  • Author(s): 佐藤 一輝, 西山 亜由美, 鈴木 直輝, 張替 宗介, 齋藤 早紀, 池田 謙輔, 西山 修平, 三須 建郎, 割田 仁, 黒田 宙, 青木 正志
  • Organizer: 日本神経学会東北地方会
• [Presentation] 治療抵抗性の重症抗MOG抗体関連疾患に対するリツキシマブの使用経験 (2019)
  • Author(s): 松本 勇貴, 三須 建郎, 高井 良樹, 西山 修平, 小野 紘彦, 黒田 宙, 割田 仁, 青木 正志, 黒澤 和大, 清水 洋, 藤原 一男
  • Organizer: 日本神経治療学会
• [Presentation] 抗MOG抗体関連疾患急性期治療後の経時的障害度と予後の検討 (2019)
  • Author(s): 生田目 知尋, 三須 建郎, 西山 修平, 高井 良樹, 小野 紘彦, 松本 勇貴, 高橋 利幸, 中島 一郎, 藤原 一男, 青木 正志
  • Organizer: 日本神経免疫学会
• [Presentation] 視神経脊髄炎中枢組織障害に対するIL-6の影響に関する病理学的検討 (2019)
  • Author(s): 高井 良樹, 三須 建郎, 松本 勇貴, 生田目 知尋, 小野 紘彦, 西山 修平, 黒田 宙, 藤原 一男, 青木 正志
  • Organizer: 日本神経免疫学会
• [Presentation] 神経ベーチェット病に類似した症候を呈した抗MOG抗体陽性脳炎の2例 (2019)
  • Author(s): 藤盛 寿一, 高橋 利幸, 松本 勇貴, 藤原 一男, 高井 良樹, 三須 建郎, 中島 一郎
  • Organizer: 日本神経免疫学会
• [Presentation] NMDA型およびAMPA型抗グルタミン酸受容体抗体陽性脳炎における臨床・画像・病理の比較検討 (2019)
  • Author(s): 金子 仁彦, 三須 建郎, 黒田 宙, 加藤 量広, 板倉 裕子, 鈴木 靖士, 鈴木 博義, 藤盛 寿一, 中島 一郎, 藤原 一男
  • Organizer: 日本神経免疫学会
• [Presentation] 抗MOG抗体陽性患者におけるT細胞反応性に関する検討 (2019)
  • Author(s): 小野 紘彦, 三須 建郎, 高井 良樹, 西山 修平, 黒田 宙, 高橋 利幸, 中島 一郎, 藤原 一男, 青木 正志
  • Organizer: 日本神経免疫学会
• [Presentation] 髄膜脳炎にて発症し、生検し得た抗myelin oligodendrocyte glycoprotein(MOG)抗体関連疾患の1例 (2019)
  • Author(s): 成毛 哲思, 岩中 行己男, 橋本 智代, 岡田 和将, 金子 仁彦, 三須 建郎, 足立 弘明
  • Organizer: 日本神経学会
• [Presentation] 肺癌術後に発症し、治療に難渋した傍腫瘍性NMOSDの1例 (2019)
  • Author(s): 松原 史歩, 西山 修平, 中屋 亮彦, 小野 理佐子, 西山 亜由美, 三須 建郎, 割田 仁, 黒田 宙, 青木 正志
  • Organizer: 日本神経学会東北地方会
• [Presentation] IFN beta is not effective in MOG-IgG plus disease: a study in 26 MOG-IgG+ Japanese patients (2019)
  • Author(s): Kaneko K, Sato DK, Takahashi T, Ogawa R, Takai Y, Nishiyama S, Misu T, Kuroda H, Nakashima I, Fujihara K.
  • Organizer: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS CY
  • Int'l Joint Research
• [Presentation] A large international aquaporin-4 antibody data set: combines individual factors to predict prognosis, identifies the risk of post-onset attack disability and calculates the power for future clinical trials. (2019)
  • Author(s): Nakashima I, Palace J, Lin DY, Zeng D, Majed M, Elsone L, Hamid S, Messina S, Misu T, Sagen J, Whittam D, Takai Y, Leite MI, Weinshenker B, Cabre P, Jacob A, Fujihara K, Pittock SJ.
  • Organizer: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS
  • Int'l Joint Research
• [Presentation] Perivenous inflammatory demyelination with MOG-dominant myelin loss is a characteristic feature of MOG antibody-associated disease (2019)
  • Author(s): Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida S, et al.
  • Organizer: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS
  • Int'l Joint Research
• [Presentation] Kuroda H, Takai Y, Nishiyama S, Takahashi T, Misu T, Nakashima I, Fujihara K, Aoki, M. (2019)
  • Author(s): Endothelial damage in patients with neuromyelitis optica spectrum disorder with aquaporin-4 IgG
  • Organizer: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS
  • Int'l Joint Research
• [Presentation] Kaneko K, Sato DK, Takahashi T, Ogawa R, Takai Y, Nishiyama S, Misu T, Kuroda H, Sato R, Kobayashi O, Tanaka S, Nomura K, Nakashima I, Fujihara K. (2019)
  • Author(s): Myelin oligodendrocyte glycoprotein-IgG-positive disease associated with herpes simplex virus infection to central nervous system: distinct clinical and radiological features in 2 cases
  • Organizer: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS
  • Int'l Joint Research
• [Presentation] .Blood-brain barrier-activation in anti-myelin oligodendrocyte glycoprotein antibody associated disorders (2019)
  • Author(s): Shimizu F, Ogawa R, Hara K, Takahashi T, Takeshita Y, Misu T, Maeda T, Sano Y, Fujikawa S, Nakashima I, Fujihara K, Kanda T.
  • Organizer: 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS
  • Int'l Joint Research
• [Presentation] Insights into the concept and pathology of NMOSD and MS in association with AQP4 and MOG antibodies. (2019)
  • Author(s): Misu T.
  • Organizer: 日本神経学会
  • Invited
• [Presentation] The pathologiacl spectrum of MOG-antibody associated disease (2019)
  • Author(s): Misu T.
  • Organizer: European Charcot Foundation
  • Int'l Joint Research / Invited