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Elucidaion of muscular pathology of SBMA using disease specific iPSCs

Research Project

Project/Area Number 19K07969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionAichi Medical University

Principal Investigator

Doyu Manabu  愛知医科大学, 医学部, 教授 (90293703)

Co-Investigator(Kenkyū-buntansha) 岡田 洋平  愛知医科大学, 加齢医科学研究所, 教授 (30383714)
伊藤 卓治  愛知医科大学, 加齢医科学研究所, 助教 (30794151)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords疾患iPS細胞 / 球脊髄性筋萎縮症 / 骨格筋 / トランスクリプトーム / iPS細胞
Outline of Research at the Start

球脊髄性筋萎縮症(SBMA)は、30-50歳代の男性に発症する緩徐進行性の下位運動ニューロン変性疾患である。従来は運動ニューロンに着目した解析がほとんどであったが、近年、骨格筋そのもの、あるいは骨格筋による運動ニューロンへの非細胞自律的な病態が示唆されている。しかし、その存在を直接的に示した報告はなく、またその詳細な分子機序は未解明である。本研究では、SBMA疾患iPS細胞由来骨格筋における病態変化と、その背景にある分子メカニズムを解明する。また、この骨格筋病態が運動ニューロンに及ぼす影響をiPS細胞による神経・筋共培養システムを用いて明らかにする。

Outline of Final Research Achievements

Spinal bulbar muscular atrophy (SBMA) is a slowly progressive lower motor neuron degenerative disease that occurs in males in their 30s to 50s. Although motor neuron degeneration has been considered the main pathogenesis of SBMA, skeletal muscle itself or skeletal muscle-induced neurodegeneration has been suggested, and elucidation of skeletal muscle pathology has been expected. In this study, we developed a culture method to rapidly and efficiently induce the differentiation of human iPSCs into skeletal muscle, and differentiated SBMA disease-specific iPSCs into skeletal muscle for pathological analysis. As a result, it was found that skeletal muscle derived from SBMA patients exhibited pathological conditions such as increased expression of genes involved in muscle differentiation and decreased expression of fast-twitch muscle markers, suggesting the involvement of the muscle pathology in SBMA.

Academic Significance and Societal Importance of the Research Achievements

SBMAでは、これまで運動ニューロンに着目した病態解析が数多く進められてきたが、近年では骨格筋病態の重要性が示唆されている。また、モデルマウスとヒト患者では骨格筋病理がやや異なることなどから、よりヒト患者の病態を忠実に反映する疾患モデルが求められてきた。本研究では、ヒトiPS細胞から迅速・高効率に骨格筋を分化誘導する培養法を確立し、患者由来骨格筋における病態を明らかにすることができた。今後の病態解明、創薬研究に有用な知見が得られたと考えられる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (71 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 10 results) Presentation (48 results) (of which Int'l Joint Research: 12 results,  Invited: 10 results) Remarks (4 results)

  • [Journal Article] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023

    • Author(s)
      Nakamura R, Tohnai G, Nakatochi M,… Onodera K, Ito T, Okada Y, Okano H, Sobue G
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 94 Issue: 10 Pages: 816-824

    • DOI

      10.1136/jnnp-2022-330851

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling2023

    • Author(s)
      Rashid Muhammad Irfanur、Ito Takuji、Miya Fuyuki、Shimojo Daisuke、Arimoto Kanae、Onodera Kazunari、Okada Rina、Nagashima Takunori、Yamamoto Kazuki、Khatun Zohora、Shimul Rayhanul Islam、Niwa Jun-ichi、Katsuno Masahisa、Sobue Gen、Okano Hideyuki、Sakurai Hidetoshi、Shimizu Kazunori、Doyu Manabu、Okada Yohei
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 8146-8146

    • DOI

      10.1038/s41598-023-34445-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis2023

    • Author(s)
      Oiwa Kotaro、Watanabe Seiji、Onodera Kazunari、Iguchi Yohei、Kinoshita Yukako、Komine Okiru、Sobue Akira、Okada Yohei、Katsuno Masahisa、Yamanaka Koji
    • Journal Title

      Science Advances

      Volume: 9 Issue: 31

    • DOI

      10.1126/sciadv.adf6895

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study.2023

    • Author(s)
      Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N, Kanazawa Y, Matsumoto Y, Arisawa A, Kawai H, Sato Y, Sakaguchi S, Yagi K, Hamatani T, Kagimura T, Yanagawa H, Mochizuki H, Doyu M, Sobue G, Harada M, Izumi Y.
    • Journal Title

      JMIR Res Protoc.

      Volume: 12 Pages: e42032-e42032

    • DOI

      10.2196/42032

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] iPS 細胞を用いた神経疾患の病態解明と治療戦略2023

    • Author(s)
      岡田洋平
    • Journal Title

      機能的脳神経外科

      Volume: 62 Pages: 42-48

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] iPS細胞を用いた神経疾患研究2023

    • Author(s)
      岡田洋平、伊藤卓治、小野寺一成
    • Journal Title

      日本臨床検査医学会誌

      Volume: 71 Pages: 704-710

    • Related Report
      2023 Annual Research Report
  • [Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022

    • Author(s)
      Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
    • Journal Title

      Journal of Neuroscience

      Volume: 42 Issue: 47 Pages: 8881-8896

    • DOI

      10.1523/jneurosci.0455-22.2022

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SBMAの病態解明・治療開発研究2022

    • Author(s)
      岡田梨奈、岡田洋平
    • Journal Title

      生体の科学

      Volume: 73 Pages: 480-481

    • Related Report
      2022 Research-status Report
  • [Journal Article] Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis2021

    • Author(s)
      Koike H, Mouria N, Fukamia Y, Iijima M, Matsuo K, Yagi N, Saito A, Nakamura H, Takahashi K, Nakae Y, Okada Y, Tanaka F, Sobue G, Katsuno M
    • Journal Title

      Commun Biol.

      Volume: 421 Pages: 117305-117305

    • DOI

      10.1016/j.jns.2020.117305

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.2021

    • Author(s)
      Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M.
    • Journal Title

      Mol Ther Nucleic Acids.

      Volume: 24 Pages: 1-10

    • DOI

      10.1016/j.omtn.2021.02.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Human Neuromuscular Tissue-on-a-Chip Model on a 24-Well-Plate-Format Compartmentalized Microfluidic Device2021

    • Author(s)
      Yamamoto K, Yamaoka N, Imaizumi Y, Nagashima T, Furutani T, Ito T, Okada Y, Honda H, Shimizu K
    • Journal Title

      Lab on a Chip

      Volume: 21 Issue: 10 Pages: 1897-1907

    • DOI

      10.1039/d1lc00048a

    • NAID

      120007169522

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.2021

    • Author(s)
      Taguchi S, Koide H, Oiwa H, Hayashi M, Ogawa K, Ito C, Nakashima K, Yuasa T, Yasumoto A, Ando H, Fujikake A, Fukuoka T, Tokui K, Izumi M, Tsunoda Y, Kawagashira Y, Okada Y, Niwa JI, Doyu M.
    • Journal Title

      PLoS One.

      Volume: 16 Issue: 7 Pages: e0255274-e0255274

    • DOI

      10.1371/journal.pone.0255274

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs2020

    • Author(s)
      Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y
    • Journal Title

      Mol. Brain

      Volume: 13 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s13041-020-0561-1

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of oxygen tension, acidosis, and cell density is crucial for neural differentiation of human induced pluripotent stem cells.2020

    • Author(s)
      Okada R, Onodera K, Ito T, Doyu M, Okano HJ, Okada Y
    • Journal Title

      Neurosci. Res.

      Volume: - Pages: 30043-2

    • DOI

      10.1016/j.neures.2020.01.015

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions2019

    • Author(s)
      Nao Yamaoka、Shimizu Kazunori、Yu Imaizumi、Takuji Ito、Yohei Okada、Hiroyuki Honda
    • Journal Title

      BioChip Journal

      Volume: in press Issue: 2 Pages: 127-132

    • DOI

      10.1007/s13206-018-3202-3

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.2019

    • Author(s)
      Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, et al.
    • Journal Title

      EBioMedicine

      Volume: 45 Pages: 362-378

    • DOI

      10.1016/j.ebiom.2019.06.013

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy2019

    • Author(s)
      Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M
    • Journal Title

      Nat. Commun.

      Volume: 10 Pages: 4262-4262

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532019

    • Author(s)
      Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H.
    • Journal Title

      Cell Rep.

      Volume: 30 Issue: 4 Pages: 1195-1207

    • DOI

      10.1016/j.celrep.2019.12.064

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motor Improvement-Related Regional Cerebral Blood Flow Changes in Parkinson's Disease in Response to Antiparkinsonian Drugs.2019

    • Author(s)
      Taguchi S, Tanabe N, Niwa JI, Doyu M.
    • Journal Title

      Parkinsons Dis.

      Volume: 0 Pages: 7503230-7503230

    • Related Report
      2019 Research-status Report
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023

    • Author(s)
      小野寺 一成, 下門 大祐, 石原 康晴, 太田 明伸, 宮 冬樹, Rashid Muhammad Irfanur, 伊藤 卓治, 岡田 梨奈, 細川 好孝, 道勇 学, 祖父江 元, 勝野 雅央, 岡野 栄之, 岡田 洋平
    • Organizer
      第64回日本神経学会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Pathophysiological analysis of motor neuron diseases focusing on neuromuscular interactions2023

    • Author(s)
      Okada Y
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた神経変性疾患の病態解明・治療開発研究2023

    • Author(s)
      岡田洋平
    • Organizer
      愛知医科大学加齢医科学研究所40周年記念学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Understanding the pathology caused by neuromuscular interactions in motor neuron disease2023

    • Author(s)
      Okada Y
    • Organizer
      Fujita International Symposium on Brain Science 2023
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Exploration of pathogenic molecules in motor neuron disease using the human ipsc-derived neuromuscular model2023

    • Author(s)
      Ito T, Rashid MI, Onodera K, Okada R, Shimojo D, Tanaka S, Katsuno M, Sobue G, Doyu M, Okano H, Okada Y
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] The effects of small molecule compounds on the differentiation and maturation of iPSCderived skeletal muscle2023

    • Author(s)
      Jamee FU, Ito T, Rashid MI, Sakurai H, Okada Y
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2023

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] The effects of small molecule compounds on the maturation of iPSC-derived skeletal muscle2023

    • Author(s)
      Jamee FU, Ito T, Rashid MI, Sakurai H, Okada Y
    • Organizer
      第23回日本再生医療学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ALSの早期診断・遺伝子診断2023

    • Author(s)
      中村亮一、熱田直樹,藤内玄規,丹羽淳一,道勇 学,祖父江 元
    • Organizer
      第64回日本神経学会学術大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 筋萎縮性側索硬化症(ALS)新規治療基軸エダラボンの臨床効果に関する検証2023

    • Author(s)
      湯淺知子,川頭祐一,丹羽淳一,道勇 学
    • Organizer
      第64回日本神経学会学術大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Phase 3b extension study to evaluate the efficacy and safety of 2 dosing regimens of oral edaravone in patients with amyotrophic lateral sclerosis2023

    • Author(s)
      Rothstein J, De Silva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Sakata T, Wamil A, Salah A, Apple S
    • Organizer
      148th Annual Meeting American-Neurological-Association (ANA)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis2023

    • Author(s)
      Rothstein J, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Wamil A, Salah A, Apple S
    • Organizer
      22nd Annual Meeting of the Northeast Amyotrophic Lateral Sclerosis Consortium (NEALS)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023

    • Author(s)
      Nakamura R, Tohnai G, Nakatochi M, Niwa JI, Doyu M, Fujimori K, Morimoto S, Okada Y, Okano H, Sobue G et al.,
    • Organizer
      34th international symposium on ALS/MND
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis2023

    • Author(s)
      Rothstein J, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Wamil A, Salah A, Apple S
    • Organizer
      26th World Congress of Neurology (WCN)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase 3B study evaluating superiority of daily dosing vs approved on/off oral edaravone dosing over 48 weeks in patients with amyotrophic lateral sclerosis (MT-1186-A02)2023

    • Author(s)
      Salah A, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M Wamil A, Apple S
    • Organizer
      26th World Congress of Neurology (WCN)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞を用いたSBMAの病態解明、治療開発研究2022

    • Author(s)
      岡田洋平
    • Organizer
      SBMAの会 2022年度医療セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] iPS細胞を用いた神経疾患の病態解明と治療戦略2022

    • Author(s)
      岡田洋平
    • Organizer
      第62回日本定位・機能神経外科学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2022

    • Author(s)
      小野寺一成, 下門大祐, Bruno De Araujo Herculano1, 石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央,岡野栄之,岡田洋平
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022

    • Author(s)
      大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋, 岡田洋平, 勝野雅央, 山中 宏二
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Bulk differentiation of iPSCs into contractible muscles for muscular disease modeling2022

    • Author(s)
      Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の早期病態解明と治療開発2022

    • Author(s)
      小野寺一成、下門大祐、石原康晴、太田明伸、Muhammad Irfanur Rashid、伊藤卓治、岡田梨奈、細川好孝、道勇学、祖父江元、勝野雅央、岡野栄之、岡田洋平
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 疾患特異的iPS細胞を用いた運動ニューロン疾患の病態解明と治療開発2021

    • Author(s)
      岡田洋平
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 病態に基づいた神経疾患の再生戦略2021

    • Author(s)
      岡田洋平
    • Organizer
      浜松医科大学尖端医学シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経・筋病態の解明2021

    • Author(s)
      岡田洋平
    • Organizer
      第60回日本臨床検査医学会東海・北陸支部総会、第344回日本臨床化学会東海・北陸支部例会 連合大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2021

    • Author(s)
      小野寺一成, 下門大祐, de Ara?jo Herculano B,石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid MI, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田 洋平
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] SynGAP variant from ALS cohort causes spine abnormality by excessive recruitment of FUS and hnRNPK2021

    • Author(s)
      横井聡, 伊藤卓治, 佐橋健太郎, 中村亮一, 石垣診祐, 熱田直樹, 勝野雅央, 岡田 洋平, 祖父江元
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 脳卒中患者における自律神経機能と病状との関連2021

    • Author(s)
      中島 康自, 小出 弘文, 林 未久, 伊藤 千弘, 湯淺 知子, 安本 明弘, 安藤 宏明, 田口 宗太郎, 藤掛 彰史, 福岡 敬晃, 徳井 啓介, 川頭 祐一, 岡田 洋平, 丹羽 淳一, 道勇 学
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Allele selective suppression of mutant polyQ protein by LNP-delivered siRNA targeting CAG expansions2021

    • Author(s)
      蛭薙智紀, 佐橋健太郎, 立川潔, Leu A, Nguyen M, Mukthavaram R, Karmali P, Chivukula P, 藤内玄規, 飯田円, 小野寺一成, 大山学, 岡田 洋平, 岡野栄之, 勝野雅央
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] The effects of g-secretase inhibitor on differentiation of iPSC-derived neurons2021

    • Author(s)
      福井ナナミ、伊藤卓治、杉山香織、岡田梨奈、小野寺一成、Zohora Khatun、道勇学、岡田洋平
    • Organizer
      第44回日本神経科学大会 CJK第1回国際会議
    • Related Report
      2021 Research-status Report
  • [Presentation] Establishment of hiPSC-derived functional neuromuscular models for the analysis of neuromuscular diseases2021

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、田中智史、下門大祐、岡野栄之、道勇学、岡田洋平
    • Organizer
      ヒトiPS細胞由来運動ニューロンと骨格筋を用いた機能的神経筋共培養モデルの構築、第44回日本神経科学大会 CJK第1回国際会議
    • Related Report
      2021 Research-status Report
  • [Presentation] Efficient, reproducible, and functional differentiation of human induced pluripotent stem cells (iPSCs) into skeletal muscles for muscular disease modeling.2021

    • Author(s)
      Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
    • Organizer
      PACTALS 2021 NAGOYA
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidating early pathophysiology of Spinal-bulbar muscular atrophy using diseasespecific iPSCs.2021

    • Author(s)
      Onodera K, Shimojo D, de Ara?jo Herculano B, Ishihara Y, Yoda M, Ota A, Rashid MI, Ito T, Okada R, Hosokawa Y, Doyu M, Sobue G, Katsuno M, Okano H, Okada Y
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of iPSC-derived neuromuscular co-culture model for the analysis of non-cell autonomous neurodegeneration in motor neuron diseases2021

    • Author(s)
      Ito T, Rashid MI, Tanaka S, Shimojo D, Okano H, Doyu M, Okada Y.
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient, reproducible and functional differentiation of human iPSCs into skeletal muscles for muscular disease modeling.2021

    • Author(s)
      Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 疾患iPS細胞による神経・筋共培養を活用した神経変性疾患の病態解析2020

    • Author(s)
      伊藤卓治, 小野寺一成, 小野寺一成, 下門大祐, 下門大祐, 田中智史, 田中智史, 岡田梨奈, RASHID Muhammad Irfanur, 道勇学, 岡野栄之, 岡田洋平
    • Organizer
      日本再生医療学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs.2019

    • Author(s)
      Onodera K, Shimojo D, Yoda M, Ishihara Y, Ito T, Okada R, Doyu M, Katsuno M, Okano H, Sobue G, Okada Y
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] FUS depletion induces spine abnormality and SynGAP depletion in hiPSC-derived motor neuron.2019

    • Author(s)
      Yokoi S, Ito T, Sahashi K, Ishigaki S, Katsuno M, Okada Y, Sobue G.
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] The effects of hypoxia on differentiation and maturation of human induced pluripotent stem cell-derived neural progenitors.2019

    • Author(s)
      Okada Y, Okada R, Li J, Onodera K, Ito T, Okano HJ, Doyu M
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of motor function in peripheral nerves by transplanatation of human iPSC-derived motor neuron progenitors.2019

    • Author(s)
      Niwa S, Saeki M, Shinkai H, Kurimoto S, Hirata H, Doyu M, Okada Y
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidation of non-cell autonomous neurodegeneration in spinal and bulbar muscular atrophy using iPSC-derived neuromuscular models.2019

    • Author(s)
      Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] iPS細胞を用いた神経疾患研究2019

    • Author(s)
      岡田洋平
    • Organizer
      SBMAの会 第8回医療セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] iPS細胞を用いたNMJ形成②2019

    • Author(s)
      岡田洋平
    • Organizer
      AMED再生医療実現拠点ネットワークプログラム「疾患特異的iPS細胞の利活用促進・難病研究加速プログラム」研究拠点I疾患別ミーティング
    • Related Report
      2019 Research-status Report
    • Invited
  • [Remarks] 愛知医科大学 医学部 神経内科

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2023 Annual Research Report
  • [Remarks] 愛知医科大学 加齢医科学研究所 神経iPS細胞研究部門

    • URL

      https://okadalab-hp.com/

    • Related Report
      2023 Annual Research Report
  • [Remarks] 愛知医科大学医学部内科学講座(神経内科)

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2021 Research-status Report
  • [Remarks] 愛知医科大学 神経内科

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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