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Examination of Co-occurring Problems and Comorbidity in Neurodevelopmental Disorders and Exploration of Individualized Early Intervention

Research Project

Project/Area Number 19K08008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionHirosaki University

Principal Investigator

Hirota Tomoya  弘前大学, 医学研究科, 客員研究員 (20832041)

Co-Investigator(Kenkyū-buntansha) 斉藤 まなぶ  弘前大学, 保健学研究科, 教授 (40568846)
足立 匡基  明治学院大学, 心理学部, 准教授 (50637329)
坂本 由唯  弘前大学, 医学部附属病院, 講師 (60770386)
高橋 芳雄  東北大学, スマート・エイジング学際重点研究センター, 講師 (70760891)
中村 和彦  弘前大学, 医学研究科, 教授 (80263911)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords発達障害 / 疫学 / 縦断データ解析 / 発達 / 疫学研究 / 精神病理 / 神経発達障害 / 発達軌跡曲線 / ネットワーク分析
Outline of Research at the Start

5歳児発達健診の横断研究データにネットワーク分析を用いて、神経発達障害群及び内在化・外在化障害とのネットワーク構造を探索することで、個々の症状レベルでの相関と相互作用、また2つ以上の疾患の橋渡しとなる症状群を同定し、この分野で臨床上困難とされてきた合併症の精神病理の洞察を深め、今後の治療介入研究を促進することが可能となる。さらに、学校調査縦断データを用いて、児の社会性、感情、そして行動の発達の軌跡曲線パターンを探索し、予後予測因子となる5歳児の特徴的な発達ネットワーク構造を同定することで、個々の発達特性により応じたテーラーメードな早期療育と治療の開発へと大きく貢献することができる。

Outline of Final Research Achievements

In this study, we examined the relationships among neurodevelopmental traits and emotional and behavioral problems in 5-year-old children diagnosed with neurodevelopmental disorders (autism spectrum disorder, intellectual developmental disorder, attention-deficit hyperactivity disorder, and/or motor coordination disorder) on a developmental examination by our research team. At the same time, we examined changes in students' emotional, behavioral, and social characteristics in data from annual school surveys of elementary and junior high school students in Hirosaki City, and investigated how these patterns of change are related to adolescent behavior (including Internet addiction behavior).

Academic Significance and Societal Importance of the Research Achievements

本研究では発達障害と情緒・行動問題の併存のメカニズムを症状レベル調べ、異なる疾患や状態をつなぐ橋渡し症状を明らかにした。合併症の治療において橋渡し症状が介入の標的になることが近年報告されており、本研究結果は、併存状態にある発達障害における今後の介入研究の基盤となる。学校調査の研究では、発達障害の特性とインターネット依存行動の持続や発生との関連が明らかになった。この結果は、発達障害やその特性の早期発見・介入が就学後の行動への影響を持つ可能性を示した。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (17 results)

All 2023 2022 2020

All Journal Article (11 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 11 results,  Open Access: 11 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Trajectories of emotional and behavioral problems in school-age children with coordination difficulties and their relationships to ASD/ADHD traits2023

    • Author(s)
      Mikami Misaki、Hirota Tomoya、Adachi Masaki、Takahashi Michio、Nishimura Tomoko、Saito Manabu、Nakamura Kazuhiko、Yamada Junko
    • Journal Title

      Research in Developmental Disabilities

      Volume: 133 Pages: 104394-104394

    • DOI

      10.1016/j.ridd.2022.104394

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Role of the Maternal and Child Health Handbook in Developmental Surveillance: The Exploration of Milestone Attainment Trajectories2022

    • Author(s)
      Hirota Tomoya、Nishimura Tomoko、Mikami Misaki、Saito Manabu、Nakamura Kazuhiko
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 902158-902158

    • DOI

      10.3389/fpsyt.2022.902158

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] School Social Capital Mediates Associations Between ASD Traits and Depression Among Adolescents in General Population2022

    • Author(s)
      Mori Hiroyuki、Hirota Tomoya、Monden Rei、Takahashi Michio、Adachi Masaki、Nakamura Kazuhiko
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: - Issue: 10 Pages: 1-10

    • DOI

      10.1007/s10803-022-05687-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longitudinal association between addictive internet use and depression in early adolescents over a 2-year period: A study using a random intercept cross-lagged model2022

    • Author(s)
      Takahashi Michio、Adachi Masaki、Hirota Tomoya、Nishimura Tomoko、Shinkawa Hiroki、Mori Hiroyuki、Nakamura Kazuhiko
    • Journal Title

      Computers in Human Behavior

      Volume: 132 Pages: 107251-107251

    • DOI

      10.1016/j.chb.2022.107251

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The association of social capital with depression and quality of life in school-aged children2022

    • Author(s)
      Mori Hiroyuki、Takahashi Michio、Adachi Masaki、Shinkawa Hiroki、Hirota Tomoya、Nishimura Tomoko、Nakamura Kazuhiko
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 1 Pages: e0262103-e0262103

    • DOI

      10.1371/journal.pone.0262103

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Atypical Sensory Processing Profiles and Their Associations With Motor Problems In Preschoolers With Developmental Coordination Disorder2020

    • Author(s)
      Mikami Misaki、Hirota Tomoya、Takahashi Michio、Adachi Masaki、Saito Manabu、Koeda Shuhei、Yoshida Kazutaka、Sakamoto Yui、Kato Sumi、Nakamura Kazuhiko、Yamada Junko
    • Journal Title

      Child Psychiatry & Human Development

      Volume: 52 Issue: 2 Pages: 311-320

    • DOI

      10.1007/s10578-020-01013-5

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neurodevelopmental Traits and Longitudinal Transition Patterns in Internet Addiction: A 2-year Prospective Study2020

    • Author(s)
      Hirota Tomoya、Takahashi Michio、Adachi Masaki、Sakamoto Yui、Nakamura Kazuhiko
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: 51 Issue: 4 Pages: 1365-1374

    • DOI

      10.1007/s10803-020-04620-2

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pediatric health-related quality of life and school social capital through network perspectives2020

    • Author(s)
      Hirota Tomoya、Takahashi Michio、Adachi Masaki、Nakamura Kazuhiko
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 12 Pages: e0242670-e0242670

    • DOI

      10.1371/journal.pone.0242670

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Utilization of the Maternal and Child Health Handbook in Early Identification of Autism Spectrum Disorder and Other Neurodevelopmental Disorders2020

    • Author(s)
      Hirota Tomoya、Bishop Somer、Adachi Masaki、Shui Amy、Takahashi Michio、Mori Hiroyuki、Nakamura Kazuhiko
    • Journal Title

      Autism Research

      Volume: 14 Issue: 3 Pages: 551-559

    • DOI

      10.1002/aur.2442

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distributional patterns of item responses and total scores of the Patient Health Questionnaire for Adolescents in a general population sample of adolescents in Japan2020

    • Author(s)
      Adachi Masaki、Takahashi Michio、Hirota Tomoya、Shinkawa Hiroki、Mori Hiroyuki、Saito Takuya、Nakamura Kazuhiko
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 11 Pages: 628-629

    • DOI

      10.1111/pcn.13148

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children2020

    • Author(s)
      Saito Manabu、Hirota Tomoya、Sakamoto Yui、Adachi Masaki、Takahashi Michio、Osato-Kaneda Ayako、Kim Young Shin、Leventhal Bennett、Shui Amy、Kato Sumi、Nakamura Kazuhiko
    • Journal Title

      Molecular Autism

      Volume: 11 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s13229-020-00342-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 自閉スペクトラム症は増加しているのか(Is Autism spectrum disorder increasing?)2023

    • Author(s)
      廣田智也
    • Organizer
      第11回アジア児童思春期精神医学会総会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 児童思春期メンタルヘルスにおける縦断データ解析(Longitudinal data analysis in child and adolescent mental health)2023

    • Author(s)
      廣田智也
    • Organizer
      第11回アジア児童思春期精神医学会総会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sex Differences in Longitudinal Patterns of Internet Use and Predictive Factors Among a General Population Sample of Children and Adolescents2023

    • Author(s)
      廣田智也
    • Organizer
      第8回国際行動嗜癖学会(International Conference on Behavioral Addictions)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 母子手帳のさらなる科学的活用にむけて2023

    • Author(s)
      廣田智也
    • Organizer
      第64回日本児童思春期精神医学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Overview of the Assessment from Preschool to Puberty; Longitudinal Epidemiological (APPLE) study and key finding2020

    • Author(s)
      廣田智也
    • Organizer
      24th World Congress of the International Association for Child and Adolescent Psychiatry and Allied Professions
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] 子どものこころの診療のコツ 研究のコツ2023

    • Author(s)
      中村 和彦
    • Total Pages
      232
    • Publisher
      金剛出版
    • ISBN
      9784772420068
    • Related Report
      2023 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

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