|Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|Outline of Research at the Start
Abnormal energy metabolisms are reported in brains of schizophrenia (SZ). Mitochondria have a central role in energy metabolisms and significant reduction of mitochondria mass in oligodendrocytes have been observed in SZ brains. PGC-1 alpha is a key regulator of mitochondrial biogenesis. In a set of preliminary experiments, we hypothesize that PGC-1 alpha plays a crucial role in oligodendrocyte differentiation via regulating mitochondrial biogenesis and involved in pathophysiology of SZ. Here, we propose our project to verify this hypothesis.