A Multidimensional, Longitudinal Study of the Neural Basis of Mood Swings in Bipolar Disorder

• Project/Area Number: 19K08049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Kyushu University
• Principal Investigator: Oribe Naoya 九州大学, 医学研究院, 特別教員 (70730498)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2021: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 双極性障害 / 脳波 / 聴性定常反応 / 縦断研究 / 縦断的研究 / 機能的MRI

Outline of Research at the Start

本研究の目的は、双極性障害患者を対象に、i）多チャンネル脳波計を用いて聴性定常反応（ASSR）の測定を行うこと、ii）安静時機能MRIを測定して脳内の機能結合の評価を行うこと、iii)上記検査を異なる病相（躁病相、うつ病相、寛解期）で行い、脳内でのどのような神経回路の異常により病相の変化が起こっているのかを明らかにすることである。

Outline of Final Research Achievements

EEGs were obtained from 33 bipolar patients and 45 normal subjects when presented with 20 Hz, 30 Hz, 40 Hz, and 80 Hz click stimuli. Of these, 4 patients were able to perform multiple tests (2 patients were able to perform 3 tests and 2 patients were able to perform 2 tests).
Cross-sectionally, evoked power (t=0.25, p=0.03) and phase synchrony (t=2.0, p=0.05; t=2.9, p=0.006) to 80-Hz and 40-Hz stimuli were significantly reduced in bipolar patients compared to normal subjects. In patients for whom longitudinal data were available, a positive correlation was found between phase synchrony to 40 Hz stimulation and a manic symptom rating scale (n=10, rho=0.83, p=0.03).

Academic Significance and Societal Importance of the Research Achievements

今回の結果は40Hz及び80Hz刺激に対する位相同期性の障害が認められており、これは先行研究と合致した 知見であった。双極性障害は、極端な気分症状を繰り返す病態であり、その経過の中で聴性定常反応がどのように変化がみられるか、そしてそれが症状とどのような関連があるかについては知られていなかった。今回の研究では同一の患者で複数回の計測を行い、その結果、躁症状と40Hz刺 激に対する位相同期性が正の相関を持っていることが示唆された。このことは今後の双極性障害の研究を進めていく中で、病態解明に向けた大きな意義をもつと 考えられる。

Research Products

• [Journal Article] Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study (2021)
  • Author(s): Jinya Sato, Yoji Hirano*, Noriaki Hirakawa, Junichi Takahashi, Naoya Oribe, Hironori Kuga, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao, Toshiaki Onitsuka
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 2 Pages: 121-121
  • DOI: 10.3390/jpm11020121
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of Group Cognitive Behavior Therapy Targeting Time Management for Adults with Attention Deficit / Hyperactivity Disorder in Japan: A Randomized Control Pilot Trial. (2021)
  • Author(s): Misuzu Nakashima, Naoko Inada, Yoshie Tanigawa, Masako Yamashita, Emi Maeda, Megumi Kouguchi, Yoko Sarada, Hiroyuki Yano, Keisuke Ikari, Hironori Kuga, Naoya Oribe, Hitoshi Kaname, Tsuyoshi Harada, Takefumi Ueno, Toshihide Kuroki
  • Journal Title: Journal of Attention Disorders Volume: 26 Issue: 3 Pages: 377-390
  • DOI: 10.1177/1087054720986939
  • Peer Reviewed
• [Journal Article] Correlation between Post-Acute Electroconvulsive Therapy Alpha-Band Spectrum Power Increase and Improvement of Psychiatric Symptoms (2021)
  • Author(s): Iwanaga Hideyuki、Ueno Takefumi、Oribe Naoya、Hashimoto Manabu、Nishimura Jun、Nakayama Naho、Haraguchi Nami、Tateishi Hiroshi、Kunitake Yutaka、Mizoguchi Yoshito、Monji Akira
  • Journal Title: Journal of Personalized Medicine Volume: 11 Issue: 12 Pages: 1315-1315
  • DOI: 10.3390/jpm11121315
  • Peer Reviewed
• [Journal Article] 精神病ハイリスク群における視覚P300の縦断的評価 : 事象関連電位研究 (2021)
  • Author(s): 織部 直弥, 平野 羊嗣, 上野 雄文, 鬼塚 俊明
  • Journal Title: 精神神経学雑誌 Volume: 123 Pages: 629-639
  • NAID: 40022746667
  • Peer Reviewed
• [Journal Article] Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task (2020)
  • Author(s): Fukushima Shou、Kuga Hironori、Oribe Naoya、Mutou Takeo、Yuzuriha Takefumi、Ozawa Hiroki、Ueno Takefumi
  • Journal Title: PLOS ONE Volume: 15 Issue: 7 Pages: e0229187-e0229187
  • DOI: 10.1371/journal.pone.0229187
  • Peer Reviewed / Open Access
• [Journal Article] The Efficacy of Extended Metacognitive Training for Psychosis: A Randomized Controlled Trial (2020)
  • Author(s): Ishikawa R, Ishigaki T, Shimada T et al.
  • Journal Title: Schizophrenia Research Volume: 215 Pages: 399-407
  • DOI: 10.1016/j.schres.2019.08.006
  • Peer Reviewed / Open Access
• [Journal Article] Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia (2020)
  • Author(s): Hirano Yoji, Oribe Naoya, Onitsuka Toshiaki, Kanba Shigenobu, Nestor Paul G., Hosokawa Taiga, Levin Margaret, Shenton Martha E., McCarley Robert W., Spencer Kevin M
  • Journal Title: Clinical EEG and Neuroscience Volume: 51 Issue: 4 Pages: 244-251
  • DOI: 10.1177/1550059420914201
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal evaluation of visual P300 amplitude in clinical high‐risk subjects: An event‐related potential study (2020)
  • Author(s): Oribe Naoya, Hirano Yoji, Re Elisabetta, Mesholam‐Gately Raquelle I., Woodberry Kristen A., Ueno Takefumi, Kanba Shigenobu, Onitsuka Toshiaki, Shenton Martha E., Spencer Kevin M., Niznikiewicz Margaret A.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 74 Issue: 10 Pages: 527-534
  • DOI: 10.1111/pcn.13083
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study (2020)
  • Author(s): Ohara Naotoshi, Hirano Yoji*, Oribe Naoya, Tamura Shunsuke, Nakamura Itta, Hirano Shogo, Tsuchimoto Rikako, Ueno Takefumi, Togao Osamu, Hiwatashi Akio, Nakao Tomohiro, Onitsuka Toshiaki
  • Journal Title: Frontiers in Psychiatry Volume: 11 Pages: 554844-554844
  • DOI: 10.3389/fpsyt.2020.554844
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals (2019)
  • Author(s): Oribe Naoya、Hirano Yoji、del Re Elisabetta、Seidman Larry J.、Mesholam-Gately Raquelle I.、Woodberry Kristen A.、Wojcik Joanne D.、Ueno Takefumi、Kanba Shigenobu、Onitsuka Toshiaki、Shenton Martha E.、Goldstein Jill M.、Niznikiewicz Margaret A.、McCarley Robert W.、Spencer Kevin M.
  • Journal Title: Schizophrenia Research Volume: In Press Pages: 145-152
  • DOI: 10.1016/j.schres.2019.03.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Gamma band auditory steady-state responses in bipolar disorder patients (2019)
  • Author(s): N. ORIBE, Y. HIRANO, S. HIRANO, T. ONITSUKA, T. UENO
  • Organizer: neuroscience meeting 2019
  • Int'l Joint Research