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Verification of the internal model deficit hypothesis of developmental coordination disorder and elucidation of early childhood prognostic factors

Research Project

Project/Area Number 19K08062
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionHirosaki University

Principal Investigator

Saito Manabu  弘前大学, 保健学研究科, 教授 (40568846)

Co-Investigator(Kenkyū-buntansha) 廣田 智也  弘前大学, 医学研究科, 客員研究員 (20832041)
三上 珠希  弘前大学, 保健学研究科, 助教 (40400501)
足立 匡基  明治学院大学, 心理学部, 准教授 (50637329)
坂本 由唯  弘前大学, 医学部附属病院, 助教 (60770386)
松原 侑里  弘前大学, 医学部附属病院, 助手 (60803179)
高橋 芳雄  東北大学, スマート・エイジング学際重点研究センター, 講師 (70760891)
大里 絢子  弘前大学, 医学研究科, 助教 (80597162)
森 裕幸  弘前大学, 医学研究科, 特任助手 (60848307)
新川 広樹  弘前大学, 医学研究科, 特任助教 (10848295)
照井 藍  弘前大学, 医学研究科, 助手 (60832904)
片貝 公紀  弘前大学, 医学部附属病院, 助手 (70866954)
小野 靖樹  弘前大学, 医学部附属病院, 助教 (00507064)
玉井 康之  弘前大学, 保健学研究科, 教授 (80349381)
小枝 周平  弘前大学, 保健学研究科, 講師 (00455734)
三上 美咲  弘前大学, 保健学研究科, 助教 (30910426)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Discontinued (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords発達性協調運動症 / 発達性協調運動障害 / 内部モデル障害 / 眼球運動 / 言語発達遅延 / コミュニケーション障害 / 内部モデル障害仮説 / 乳幼児
Outline of Research at the Start

発達性協調運動障害(DCD)は粗大運動や微細運動の発達の遅れ、新しい課題への学習の難しさを特徴に持つ神経発達障害であり、学童期の5~6%に存在し、書字及び読字困難など学業上の問題に発展するリスクが高い。病態は内部モデル障害説が有力であり、眼球運動や身体の動きの制御に伴う予測的認知や記憶、身体感覚との競合にミスマッチが生じるとされている。本研究では、内部モデルの獲得に必要な認知能力の取得時期及び幼児期における運動発達の予後について検証することを目的とする。これらは疾患モデルの解明のみならず、適切な療育方法を確立する足掛かりとなり、将来的な精神疾患や成人病の予防にも大きく貢献できる可能性が高い。

Outline of Final Research Achievements

Using records from the maternal and child health handbooks of 720 5-year-old children, we analyzed the achievement of developmental milestones over nine periods from 3-4 months to 60 months. The neurodevelopmental disorder group consistently underachieved all four milestone areas (motor, social interaction, communication, and independence) from an early stage, and signs of internal model disorders in developmental coordination disorder (DCD) were confirmed early in development. It was also suggested that boys and premature birth may be risk factors. Furthermore, when the eye movements of 69 children at risk for neurodevelopmental disorders were measured, the DCD group had significant difficulty in downward-upward eye movements, suggesting a risk for learning disabilities such as reading and writing.

Academic Significance and Societal Importance of the Research Achievements

DCDの徴候は発達の早期からマイルストーンの遅れとして把握できる可能性があること、男児や早産児がリスク因子となり得ることを明らかにしたことで、早期発見するための指標が示唆された。さらに、これまで報告されていた学習障害のリスクについて、眼球運動の視点から読字や書字のリスクを示したことで、支援法についてビジョントレーニングが有効である可能性があり、本研究の学術的および社会的意義は果たされたと言える。

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (36 results)

All 2023 2022 2021 2020 2019

All Journal Article (12 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 10 results,  Open Access: 10 results) Presentation (19 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Trajectories of emotional and behavioral problems in school-age children with coordination difficulties and their relationships to ASD/ADHD traits2023

    • Author(s)
      Mikami Misaki、Hirota Tomoya、Adachi Masaki、Takahashi Michio、Nishimura Tomoko、Saito Manabu、Nakamura Kazuhiko、Yamada Junko
    • Journal Title

      Research in Developmental Disabilities

      Volume: 133 Pages: 104394-104394

    • DOI

      10.1016/j.ridd.2022.104394

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epidemiology of ASD in Preschool-age Children in Japan2022

    • Author(s)
      Saito M, Sakamoto Y and Terui A.
    • Journal Title

      IntechOpen

      Volume: - Pages: 1-14

    • DOI

      10.5772/intechopen.108674

    • ISBN
      9781837683420, 9781837683437
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of the Maternal and Child Health Handbook in Developmental Surveillance: The Exploration of Milestone Attainment Trajectories2022

    • Author(s)
      Hirota Tomoya、Nishimura Tomoko、Mikami Misaki、Saito Manabu、Nakamura Kazuhiko
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 902158-902158

    • DOI

      10.3389/fpsyt.2022.902158

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 発達障害のある患者2022

    • Author(s)
      斉藤まなぶ
    • Journal Title

      調剤と情報

      Volume: 28(6) Pages: 868-873

    • Related Report
      2022 Annual Research Report
  • [Journal Article] ICT利用の低年齢化と睡眠2022

    • Author(s)
      斉藤まなぶ
    • Journal Title

      チャイルドヘルス

      Volume: 25(7) Pages: 495-498

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Toward mapping pragmatic impairment of autism spectrum disorder individuals through the development of a corpus of spoken Japanese2022

    • Author(s)
      Kato, S., Hanawa, K., Linh, V. P., Saito, M., Iimura, R., Inui, K., & Nakamura, K.
    • Journal Title

      PLoS One

      Volume: 17(2) Issue: 2 Pages: e0264204-e0264204

    • DOI

      10.1371/journal.pone.0264204

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cohort Profile: The Assessment from Preschool to Puberty? Longitudinal Epidemiological (APPLE) study in Hirosaki, Japan2021

    • Author(s)
      Hirota, T., Adachi, M., Takahashi, M., Mori, H., Shinkawa, H., Sakamoto, Y., Saito, M., & Nakamura, K.
    • Journal Title

      International Journal of Epidemiology

      Volume: 50 Issue: 6 Pages: 1782-1783

    • DOI

      10.1093/ije/dyab112

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnosing Autism Spectrum Disorder Without Expertise: A Pilot Study of 5- to 17-Year-Old Individuals Using Gazefinder2021

    • Author(s)
      Tsuchiya Kenji J.、Hakoshima Shuji、Hara Takeshi、Ninomiya Masaru、Saito Manabu、Fujioka Toru、Kosaka Hirotaka、Hirano Yoshiyuki、Matsuo Muneaki、Kikuchi Mitsuru、Maegaki Yoshihiro、Harada Taeko、Nishimura Tomoko、Katayama Taiichi
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 603085-603085

    • DOI

      10.3389/fneur.2020.603085

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interformat Reliability of Web-Based Parent-Rated Questionnaires for Assessing Neurodevelopmental Disorders Among Preschoolers: Cross-sectional Community Study2021

    • Author(s)
      Tanaka Masanori、Saito Manabu、Takahashi Michio、Adachi Masaki、Nakamura Kazuhiko
    • Journal Title

      JMIR Pediatrics and Parenting

      Volume: 4 Issue: 1 Pages: e20172-e20172

    • DOI

      10.2196/20172

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children2020

    • Author(s)
      Saito Manabu、Hirota Tomoya、Sakamoto Yui、Adachi Masaki、Takahashi Michio、Osato-Kaneda Ayako、Kim Young Shin、Leventhal Bennett、Shui Amy、Kato Sumi、Nakamura Kazuhiko
    • Journal Title

      Molecular Autism

      Volume: 11 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s13229-020-00342-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Atypical Sensory Processing Profiles and Their Associations With Motor Problems In Preschoolers With Developmental Coordination Disorder2020

    • Author(s)
      Mikami Misaki、Hirota Tomoya、Takahashi Michio、Adachi Masaki、Saito Manabu、Koeda Shuhei、Yoshida Kazutaka、Sakamoto Yui、Kato Sumi、Nakamura Kazuhiko、Yamada Junko
    • Journal Title

      Child Psychiatry & Human Development

      Volume: 52 Issue: 2 Pages: 311-320

    • DOI

      10.1007/s10578-020-01013-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Concerns for labor analgesia and autism spectrum disorders2020

    • Author(s)
      Saito Manabu、Nakamura Kazuhiko、Hirota Kazuyoshi
    • Journal Title

      Journal of Anesthesia

      Volume: 35 Issue: 2 Pages: 319-320

    • DOI

      10.1007/s00540-020-02880-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Estimating the Prevalence of Autism Spectrum Disorders in 3-Year-Old Children in Community-Based Survey in 5-Year-Old Children, Including the Use of Web Systems.2022

    • Author(s)
      M. Saito, T. Mikami, A. Terui, Y. Sakamoto, A. Osato, M. Takahashi, M Adachi, T. Hirota, K. Nakamura.
    • Organizer
      INSAR 2022 Virtual Annual Meeting
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳幼児期におけるDCD児の診察について~健診現場での問診や観察のポイント~2022

    • Author(s)
      斉藤まなぶ
    • Organizer
      第6回日本DCD学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 発達障害児の早期発見・早期介入~地域での取組~2022

    • Author(s)
      斉藤まなぶ
    • Organizer
      第16回日本小児心身医学会東北地方会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 視線計測装置(Gazefinder)を用いた発達性協調運動障害児の視線の向け方に関する予備的研究2022

    • Author(s)
      小枝周平、斉藤まなぶ、沢中智香、三上美咲、照井藍、吉田和貴、山田順子
    • Organizer
      第6回日本DCD学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 視線計測装置(Gazefinder)を用いた発達性協調運動障害児の 視線の向け方に関する予備的研究2022

    • Author(s)
      小枝周平, 斉藤まなぶ, 沢中智香, 三上美咲, 照井藍, 吉田和貴, 山田順子
    • Organizer
      第5回日本DCD学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 発達性協調運動障害を持つ幼児の感覚処理の問題と協調運動機能との関連2021

    • Author(s)
      三上美咲 廣田智也 高橋芳雄 足立匡基 斉藤まなぶ 小枝周平 中村和彦 山田順子
    • Organizer
      第4回日本DCD学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 日本人の自閉症児における栄養と食物摂取2020

    • Author(s)
      小枝周平、三上美咲、斉藤まなぶ、中村和彦、山田順子
    • Organizer
      第54回日本作業療法学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 幼児期における発達障害児の筆記具操作と描線運動2020

    • Author(s)
      三上美咲、小枝周平、斉藤まなぶ、中村和彦、山田順子
    • Organizer
      第54回日本作業療法学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 顕在化しにくい発達障害の早期発見と支援2020

    • Author(s)
      斉藤まなぶ、大里絢子、吉田和貴、中村和彦
    • Organizer
      第62回日本小児神経学会学術集会シンポジウム8
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 5歳児発達健診Webスクリーニングシステム(ここあぽ)の完成2020

    • Author(s)
      斉藤まなぶ、田中勝則、山村靖彦、和久田学、大里絢子、足立匡基、三上珠希、坂本由唯、照井藍、森裕幸、新川広樹、高橋芳雄、栗林理人、中村和彦
    • Organizer
      第116回日本精神神経学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 地域における5歳の自閉スペクトラム症の疫学調査~調整有病率と累積発生率~2020

    • Author(s)
      斉藤まなぶ、坂本 由唯、足立 匡基、高橋 芳雄、大里 絢子、三上 珠希 、照井 藍、栗林 理人 、中村 和彦
    • Organizer
      第61回日本児童青年精神医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 視線追跡装置(Gazefinder)を用いた5歳児のASDスクリーニングアルゴリズムの開発2020

    • Author(s)
      斉藤 まなぶ、坂本 由唯、吉田 和貴、三上 珠希、大里 絢子、照井 藍、中村 和彦
    • Organizer
      第61回日本児童青年精神医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 幼児期に発達障害傾向を 検査するスクリーニングツール2020

    • Author(s)
      斉藤 まなぶ
    • Organizer
      イノベーションジャパン2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Prevalence of sleep problems in Japanese preschoolers and children with developmental disabilities2020

    • Author(s)
      Manabu Saito, M Takahashi, A Terui, Y Sakamoto, M Adachi, H Shinkawa, H Mori, K Nakamura
    • Organizer
      24th IACAPAP Virtual Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sensory and cognitive correlates with motor coordination in 5-years old children with developmental disorders including DCD, ASD and ADHD2019

    • Author(s)
      Kaneda-Osato, A., Saito, M., Mikami, M., Koeda, S., Masuda, T., Tsuji, M., Kimura, M., Uchida, Y., Wakuta, M., Yamada, J., and Nakamura, K
    • Organizer
      The 13th International conference on Developmental Coordination Disorder
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Innovation of Eye tracking device for early detection of children with developmental coordination disorder2019

    • Author(s)
      Saito, M., Aoki, T., Koeda, S., Mikami, M., Yoshida, K., Kaneda-Osato, A., Masuda, T., Sakamoto, Y., Mikami, T., Yamada, J., Tsuchiya, K., Katayama, T., and Nakamura, K
    • Organizer
      The 13th International conference on Developmental Coordination Disorder
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence and Cumulative Incidence of Autism Spectrum Disorders and the Patterns of Co-occurring Neurodevelopmental Disorders in a Total Population Sample of 5-years-old children.2019

    • Author(s)
      Manabu Saito, Tomoya Hirota, Yui Sakamoto, Masaki Adachi, Michio Takahashi, Ayako Osato-Kaneda, Young Shin Kim, Bennett Leventhal, Amy Shui, Sumi Kato, Kazuhiko Nakamura
    • Organizer
      The 10th Congress of The Asian Society for Child and Adolescent Psychiatry and Allied Professions (ASCAPAP)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 就学前のDCD早期発見のためのチェックリストの完成2019

    • Author(s)
      斉藤まなぶ・北洋輔・稲垣真澄
    • Organizer
      第3回日本DCD学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 就学前の発達性協調運動障害(DCD)早期発見のための チェックリストと活用マニュアルの完成2019

    • Author(s)
      斉藤まなぶ・北洋輔・大里絢子・三上美咲・小枝周平・三上珠希・稲垣真澄・中村和彦
    • Organizer
      第60回日本児童青年精神医学会
    • Related Report
      2019 Research-status Report
  • [Book] 発達障がい2022

    • Author(s)
      大阪大学大学院連合小児発達学研究科
    • Total Pages
      168
    • Publisher
      朝倉書店
    • ISBN
      9784254301250
    • Related Report
      2022 Annual Research Report
  • [Book] 吃音?チック?読み書き障害?不器用?の子どもたちへ 保育所・幼稚園・巡回相談に役立つ”気づきと手立て”のヒント集2020

    • Author(s)
      稲垣 真澄
    • Total Pages
      100
    • Publisher
      診断と治療社
    • ISBN
      9784787824707
    • Related Report
      2020 Research-status Report
  • [Book] そだちの科学 発達障害の30年2019

    • Author(s)
      斉藤 まなぶ (共著)
    • Total Pages
      186
    • Publisher
      日本評論社
    • ISBN
      9784535907324
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 発達障害可能性評価装置及び発達障害可能性評価表2022

    • Inventor(s)
      斉藤まなぶ、大里絢子、坂本由唯、三上珠希
    • Industrial Property Rights Holder
      国立大学法人弘前大学
    • Industrial Property Rights Type
      実用新案
    • Filing Date
      2022
    • Acquisition Date
      2023
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 発達障害可能性評価装置、および発達障害可能性評価方法2019

    • Inventor(s)
      斉藤まなぶ、中村和彦、大里絢子、足立匡基、田中勝則、高柳伸哉
    • Industrial Property Rights Holder
      国立大学法人弘前大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2023
    • Related Report
      2022 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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