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Trans-ethnic genetic etiology shared between schizophrenia and intellectual function

Research Project

Project/Area Number 19K08081
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionGifu University

Principal Investigator

Ohi Kazutaka  岐阜大学, 医学部附属病院, 准教授 (70629203)

Co-Investigator(Kenkyū-buntansha) 嶋田 貴充  金沢医科大学, 医学部, 助教 (70735349)
西澤 大輔  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords統合失調症 / 第1度非罹患近親者 / 病前推定IQ / 知的機能障害 / ゲノム / 遺伝的共通性 / 民族間差異 / ポリジェニックリスクスコア / 全ゲノム関連解析
Outline of Research at the Start

統合失調症は多因子遺伝を示し、臨床的・遺伝的に異種性を示す精神疾患である。その異種性を軽減するために、疾患の中核症状である知的機能障害がBiotypeとして注目されている。知能も同様に遺伝素因が関わり、欧米人においては双方に共通する遺伝基盤が示唆されている。本研究は、統合失調症患者、近親者および健常者において、知能Biotypeの全ゲノム関連解析(GWAS)を行う。欧米人統合失調症や知能の大規模GWASと本研究の日本人統合失調症および知能GWASを用いて、民族間差異を超えて共通する統合失調症と知能の遺伝的共通性を解明する。

Outline of Final Research Achievements

The polygenic risk scores (PRSs) obtained from European schizophrenia (SCZ) and bipolar disorder (BD) patients were higher in Japanese SCZ patients than in healthy controls (HCs), and these PRSs for SCZ and BD in their unaffected first-degree relatives (FRs) were intermediate between SCZ patients and HCs. In addition, high PRSs for genetic factor differentiating SCZ from BD, i.e., SCZ-specific risk, were correlated with low premorbid intelligence in SCZ patients and HCs.
These findings suggest that genetic factors for SCZ and BD in European populations are associated with pathogenesis of SCZ in Japanese population, while genetic factors differentiating SCZ from BD might affect pathogenesis of SCZ and/or pathological difference between SCZ and BD through impairment in premorbid intelligence, i.e., crystalized intelligence.

Academic Significance and Societal Importance of the Research Achievements

本研究では、統合失調症における知的機能障害の民族間差異を超えて共通する遺伝基盤を解明した。さらに、欧米人統合失調症から双極症を鑑別可能な遺伝因子(統合失調症に特異的な遺伝因子)は病前推定知能と関連していることを解明した。
このような統合失調症と知的機能障害に共通する遺伝基盤は、現在唯一の薬物治療のターゲットである陽性・陰性症状だけでなく、中核症状である知的機能障害も治療ターゲットとしての重要性が高まる。知的機能障害に対する創薬の必要性を裏付けるエビデンスにつながり、統合失調症に対する新たな治療薬の選択肢が加わるきっかけとなり得る意義のある研究である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (62 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (28 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 24 results,  Open Access: 12 results) Presentation (29 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results) Book (3 results)

  • [Int'l Joint Research] 南カリフォルニア大学(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Southern California(米国)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Investigating genetic overlaps of the genetic factor differentiating schizophrenia from bipolar disorder with cognitive function and hippocampal volume2022

    • Author(s)
      Ohi Kazutaka、Muto Yukimasa、Takai Kentaro、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      BJPsych Open

      Volume: 8 Issue: 1 Pages: 103549-103549

    • DOI

      10.1192/bjo.2021.1086

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in subcortical brain volumes among patients with schizophrenia and bipolar disorder and healthy controls2022

    • Author(s)
      Ohi Kazutaka、Ishibashi Miori、Torii Kaai、Hashimoto Mayuka、Yano Yurika、Shioiri Toshiki
    • Journal Title

      Journal of Psychiatry and Neuroscience

      Volume: 47 Issue: 2 Pages: 16-16

    • DOI

      10.1503/jpn.210144

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Common Brain Cortical Abnormality in Smoking Behavior and Bipolar Disorder: Discriminant Analysis Using Cortical Thickness and Surface Area2022

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Kuramitsu Ayumi、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 20 Pages: 4386-4396

    • DOI

      10.1093/cercor/bhab490

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools2022

    • Author(s)
      Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 21 Issue: 4 Pages: 539-552

    • DOI

      10.2463/mrms.rev.2021-0050

    • NAID

      130008076114

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Switching from blonanserin oral tablets/powders to transdermal patches alleviates extrapyramidal symptoms in patients with schizophrenia: A 52-week open-label study2022

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Kuramitsu Ayumi、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 113 Pages: 110470-110470

    • DOI

      10.1016/j.pnpbp.2021.110470

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患と中間表現型間における遺伝的共通性と特異性2022

    • Author(s)
      大井 一高
    • Journal Title

      日本生物学的精神医学会誌

      Volume: -

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation2021

    • Author(s)
      Sugiyama Shunsuke、Taniguchi Tomoya、Kinukawa Tomoaki、Takeuchi Nobuyuki、Ohi Kazutaka、Shioiri Toshiki、Nishihara Makoto、Inui Koji
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 13 Pages: 2785-2796

    • DOI

      10.1093/cercor/bhab381

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gray matter volume differences between transgender men and cisgender women: A voxel-based morphometry study2021

    • Author(s)
      Fukao Taku、Ohi Kazutaka、Shioiri Toshiki
    • Journal Title

      Australian & New Zealand Journal of Psychiatry

      Volume: 56 Issue: 5 Pages: 535-541

    • DOI

      10.1177/0004867421998801

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intelligence decline across major depressive disorder, bipolar disorder, and schizophrenia2021

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Sugiyama Shunsuke、Kitagawa Hiromi、Kataoka Yuzuru、Soda Midori、Kitaichi Kiyoyuki、Kawasaki Yasuhiro、Ito Munechika、Shioiri Toshiki
    • Journal Title

      CNS Spectrums

      Volume: - Pages: 1-7

    • DOI

      10.1017/s1092852921000298

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis2021

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Kuramitsu Ayumi、Sugiyama Shunsuke、Soda Midori、Kitaichi Kiyoyuki、Shioiri Toshiki
    • Journal Title

      European Psychiatry

      Volume: 64 Issue: 1 Pages: 4103-4112

    • DOI

      10.1192/j.eurpsy.2021.2237

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Genome-Wide Neuroticism-Associated Variants on Five-Factor Model Personality Traits in Schizophrenia2021

    • Author(s)
      Ohi Kazutaka、Sugiyama Shunsuke、Soda Midori、Kitaichi Kiyoyuki、Kawasaki Yasuhiro、Shioiri Toshiki
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 87-91

    • DOI

      10.1016/j.neures.2021.04.004

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects2021

    • Author(s)
      Ohi Kazutaka、Nishizawa Daisuke、Sugiyama Shunsuke、Takai Kentaro、Kuramitsu Ayumi、Hasegawa Junko、Soda Midori、Kitaichi Kiyoyuki、Hashimoto Ryota、Ikeda Kazutaka、Shioiri Toshiki
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 24 Issue: 7 Pages: 562-569

    • DOI

      10.1093/ijnp/pyab014

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shared Trans-ancestry Genetic Etiology between Panic Disorder and Anxiety Disorders.2021

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sugiyama S, Muto Y, Tanahashi S, Kaiya H, Nishimura F, Sasaki T, Tanii H, Shioiri T
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 75 Issue: 6 Pages: 1-2

    • DOI

      10.1111/pcn.13214

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects2021

    • Author(s)
      Ohi Kazutaka、Nemoto Kiyotaka、Kataoka Yuzuru、Sugiyama Shunsuke、Muto Yukimasa、Shioiri Toshiki、Kawasaki Yasuhiro
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 110 Pages: 110291-110291

    • DOI

      10.1016/j.pnpbp.2021.110291

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study2021

    • Author(s)
      Ohi Kazutaka、Ochi Ryo、Noda Yoshihiro、Wada Masataka、Sugiyama Shunsuke、Nishi Akira、Shioiri Toshiki、Mimura Masaru、Nakajima Shinichiro
    • Journal Title

      Translational Psychiatry

      Volume: 11 Issue: 1 Pages: 187-187

    • DOI

      10.1038/s41398-021-01308-8

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders2021

    • Author(s)
      Sugiyama S, Ohi K, Kuramitsu A, Takai K, Muto Y, Taniguch T, Kinukawa T, Takeuchi N, Motomura E, Nishihara M, Shioiri T, Inui K.
    • Journal Title

      Front Psychiatry

      Volume: 12 Pages: 644541-644541

    • DOI

      10.3389/fpsyt.2021.644541

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Shared transethnic genetic basis of panic disorder and psychiatric and related intermediate phenotypes.2021

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sugiyama S, Muto Y, Tanahashi S, Kaiya H, Nishimura F, Sasaki T, Tanii H, Shioiri T
    • Journal Title

      Eur Neuropsychopharmacol

      Volume: 42 Pages: 87-96

    • DOI

      10.1016/j.euroneuro.2020.11.003

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] パニック症と精神疾患や中間表現型間における民族差を超えた共通の遺伝的基盤2021

    • Author(s)
      大井 一高, 音羽 健司, 嶋多 美穂子, 杉山 俊介, 棚橋 俊介, 貝谷 久宣, 西村 文親, 佐々木 司, 谷井 久志, 塩入 俊樹
    • Journal Title

      不安症研究

      Volume: -

    • NAID

      130008141613

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 不安症のゲノム研究最前線2021

    • Author(s)
      大井 一高
    • Journal Title

      精神科ResidentVol3No1特集 不安症

      Volume: -

    • Related Report
      2021 Annual Research Report
  • [Journal Article] ヒトゲノム×脳画像統合研究2021

    • Author(s)
      小池進介、大井一高
    • Journal Title

      Precision Medicine

      Volume: -

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Polygenic risk scores for late smoking initiation associated with the risk of schizophrenia2020

    • Author(s)
      Ohi Kazutaka、Nishizawa Daisuke、Muto Yukimasa、Sugiyama Shunsuke、Hasegawa Junko、Soda Midori、Kitaichi Kiyoyuki、Hashimoto Ryota、Shioiri Toshiki、Ikeda Kazutaka
    • Journal Title

      npj Schizophrenia

      Volume: 6 Issue: 1 Pages: 36-36

    • DOI

      10.1038/s41537-020-00126-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and Efficacy in Randomized Controlled Trials of Second-Generation Antipsychotics Versus Placebo for Cognitive Impairments in Schizophrenia2020

    • Author(s)
      Ohi Kazutaka、Muto Yukimasa、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Journal of Clinical Psychopharmacology

      Volume: Publish Ahead of Print Issue: 2 Pages: 227-229

    • DOI

      10.1097/jcp.0000000000001232

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in Executive Function Among Patients With Schizophrenia, Their Unaffected First-Degree Relatives, and Healthy Participants2020

    • Author(s)
      Kataoka Yuzuru、Shimada Takamitsu、Koide Yoko、Okubo Hiroaki、Uehara Takashi、Shioiri Toshiki、Kawasaki Yasuhiro、Ohi Kazutaka
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 23 Issue: 11 Pages: 731-737

    • DOI

      10.1093/ijnp/pyaa052

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic correlations between subcortical brain volumes and psychiatric disorders2020

    • Author(s)
      Ohi Kazutaka、Shimada Takamitsu、Kataoka Yuzuru、Yasuyama Toshiki、Kawasaki Yasuhiro、Shioiri Toshiki、Thompson Paul M.
    • Journal Title

      The British Journal of Psychiatry

      Volume: 216 Issue: 5 Pages: 280-283

    • DOI

      10.1192/bjp.2019.277

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polygenetic risk scores for major psychiatric disorders among schizophrenia patients, their first-degree relatives, and healthy participants.2020

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K
    • Journal Title

      Int J Neuropsychopharmacol

      Volume: 23 Issue: 3 Pages: 157-164

    • DOI

      10.1093/ijnp/pyz073

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intelligence decline between present and premorbid IQ in schizophrenia: Schizophrenia Non-Affected Relative Project (SNARP)2019

    • Author(s)
      Ohi Kazutaka、Shimada Takamitsu、Kataoka Yuzuru、Koide Yoko、Yasuyama Toshiki、Uehara Takashi、Okubo Hiroaki、Kawasaki Yasuhiro
    • Journal Title

      European Neuropsychopharmacology

      Volume: 29 Issue: 5 Pages: 653-661

    • DOI

      10.1016/j.euroneuro.2019.03.003

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes.2019

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sasaki T, Tanii H.
    • Journal Title

      Psychological Medicine

      Volume: - Issue: 4 Pages: 692-704

    • DOI

      10.1017/s003329171900059x

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A 1.5-year longitudinal study of social activity in patients with schizophrenia.2019

    • Author(s)
      Ohi K, Sumiyoshi C, Fujino H, Yasuda Y, Yamamori H, Fujimoto M, Sumiyoshi T, Hashimoto R.
    • Journal Title

      Front Psychiatry, section Schizophrenia

      Volume: 10 Pages: 567-567

    • DOI

      10.3389/fpsyt.2019.00567

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects2022

    • Author(s)
      大井一高
    • Organizer
      第16回日本統合失調症学会(Web)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Cognitive Performances across Individuals at High Genetic Risk for Schizophrenia, High Genetic Risk for Bipolar Disorder, and Low Genetic Risks: A Combined Polygenic Risk Score Approach2022

    • Author(s)
      Ohi K, Nishizawa D, Sugiyama S, Takai K, Fujikane D, Kuramitsu A, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Ikeda K, Shioiri T
    • Organizer
      2021年度新学術領域研究 学術研究支援基盤形成先端モデル動物支援プラットフォーム 成果発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ―症例ディスカッションを通じてガイドラインの使い方を学ぶ―EGUIDEプロジェクト2021

    • Author(s)
      大井一高
    • Organizer
      第117回日本精神神経学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 精神疾患と中間表現型間における遺伝的共通性と特異性2021

    • Author(s)
      大井一高
    • Organizer
      第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 日本人パニック症と欧米人精神疾患や中間表現型間における民族間差異を超えた遺伝的要因の共通性2021

    • Author(s)
      大井一高
    • Organizer
      第13回日本不安症学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 不安症のゲノム研究最前線2021

    • Author(s)
      大井一高
    • Organizer
      第13回日本不安症学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Intelligence Decline across Major Depressive Disorder, Bipolar Disorder and Schizophrenia2021

    • Author(s)
      Ohi K, Takai K, Sugiyama S, Kitagawa H, Kataoka Y, Soda M, Kitaichi K, Kawasaki Y, Ito M, Shioiri T
    • Organizer
      2021 Congress of the Schizophrenia International Research Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polygenic Risk Scores for Late Smoking Initiation Associated with the Risk of Schizophrenia2021

    • Author(s)
      Ohi K, Nishizawa D, Muto Y, Sugiyama S, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Shioiri T, Ikeda K
    • Organizer
      2021 Congress of the Schizophrenia International Research Society
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects2021

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K
    • Organizer
      32nd World Congress of Neuropsychopharmacology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] ガイドラインに沿った再発再燃時の薬物療法、統合失調症薬物治療ガイド/ガイドラインを利用したSDM(共同意思決定)の実践2021

    • Author(s)
      大井一高
    • Organizer
      第15回日本統合失調症学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 統合失調症の認知機能障害2021

    • Author(s)
      大井一高
    • Organizer
      岐阜県精神科医会
    • Related Report
      2020 Research-status Report
  • [Presentation] 不安症とうつ病が併存する病態2021

    • Author(s)
      大井一高
    • Organizer
      MDDシンポジウム Web講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects2020

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K
    • Organizer
      7th Biennial Schizophrenia International Research Society Conference
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects2020

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K
    • Organizer
      10th Takeda Science Foundation Symposium on PharmaSciences
    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 不安症とうつ病が併存する病態2020

    • Author(s)
      大井一高
    • Organizer
      1st Mist(Mental illness Specialist) Seminar in GIFU
    • Related Report
      2020 Research-status Report
  • [Presentation] 不安症とうつ病が併存する病態2020

    • Author(s)
      大井一高
    • Organizer
      3rdメディアシンポジウム(m3)
    • Related Report
      2020 Research-status Report
  • [Presentation] 統合失調症患者、非罹患近親者、健常者間における各精神疾患のポリジェニックリスクスコア2020

    • Author(s)
      大井一高、西澤大輔、嶋田貴充、片岡譲、長谷川準子、塩入俊樹、川﨑康弘、橋本亮太、池田和隆
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 統合失調症の認知機能障害2020

    • Author(s)
      大井一高
    • Organizer
      岐阜薬科大学附属薬局リカレント講座Ⅰ
    • Related Report
      2020 Research-status Report
  • [Presentation] 3回の臨床研究立ち上げを振り返って2020

    • Author(s)
      大井一高
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会・令和2年度若手研究者育成プログラム交流会 in 仙台
    • Related Report
      2020 Research-status Report
  • [Presentation] 精神疾患と中間表現型間における遺伝的共通性をターゲットとしたPrecision Medicineの可能性2020

    • Author(s)
      大井一高
    • Organizer
      第50回日本神経精神薬理学会年会・第42回日本生物学的精神医学会年会・第4回日本精神薬学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 統合失調症とニコチン依存に共通する遺伝素因2020

    • Author(s)
      大井一高
    • Organizer
      2019年度新学術領域研究 学術研究支援基盤形成先端モデル動物支援プラットフォーム 成果発表会
    • Related Report
      2020 Research-status Report 2019 Research-status Report
  • [Presentation] 非罹患近親者および健常者における病前推定IQと現在のIQ間の知的機能障害2019

    • Author(s)
      大井一高、嶋田貴充、片岡譲、小出蓉子、上原隆、大久保裕章、川﨑康弘
    • Organizer
      第14回日本統合失調症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症患者、非罹患近親者および健常者における病前推定IQと現在のIQ間の知的機能障害2019

    • Author(s)
      大井一高、嶋田貴充、片岡譲、小出蓉子、上原隆、大久保裕章、川﨑康弘
    • Organizer
      第115回日本精神神経学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症の現在IQ・病前IQより推定する知的機能低下: Schizophrenia Non-Affected Relative Project (SNARP)2019

    • Author(s)
      大井一高、嶋田貴充、片岡譲、小出蓉子、上原隆、大久保裕章、川﨑康弘
    • Organizer
      第41回日本生物学的精神医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症の認知機能障害:創薬戦略2019

    • Author(s)
      大井一高
    • Organizer
      医療心理懇話会 第4回集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 統合失調症の現在IQ・病前IQより推定する知的機能低下: Schizophrenia Non-Affected Relative Project (SNARP)2019

    • Author(s)
      大井一高、嶋田貴充、片岡譲、小出蓉子、上原隆、大久保裕章、川﨑康弘
    • Organizer
      第49回日本神経精神薬理学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 精神疾患の中間表現型を用いたゲノム研究2019

    • Author(s)
      大井一高
    • Organizer
      第49回日本神経精神薬理学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Shared Genetic Etiology between Anxiety Disorders and Psychiatric and Related Intermediate Phenotypes2019

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sasaki T, Tanii H
    • Organizer
      6th Congress of Asian College of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
  • [Presentation] Cognitive impairments in schizophrenia: Drug discovery strategy and potential targets2019

    • Author(s)
      Ohi K
    • Organizer
      6th Congress of Asian College of Neuropsychopharmacology
    • Related Report
      2019 Research-status Report
  • [Book] 統合失調症のリカバリーに向けた認知社会機能障害の評価. 統合失調症治療の新たなストラテジー2021

    • Author(s)
      大井一高, 住吉チカ, 住吉太幹, 松本純弥, 三浦健一郎, 長谷川尚美, 杉山俊介, 塩入俊樹, 橋本亮太
    • Publisher
      先端医学社
    • Related Report
      2020 Research-status Report
  • [Book] 統合失調症において精神症状,認知機能および身体機能がQOL に及ぼす影響. 統合失調症治療の新たなストラテジー2021

    • Author(s)
      大井一高, 武藤恭昌, 高井健太朗, 杉山俊介, 塩入俊樹
    • Publisher
      先端医学社
    • Related Report
      2020 Research-status Report
  • [Book] 皮質下体積と精神疾患間における遺伝的共通性2020

    • Author(s)
      大井一高
    • Publisher
      PSYCHOABSTRACT
    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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