Usefulness of exosome-derived PDL1 in radiation therapy

• Project/Area Number: 19K08097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kobe University
• Principal Investigator: HARADA AYA 神戸大学, 医学研究科, 医学研究員 (50610284)
• Co-Investigator(Kenkyū-buntansha): 石原 武明 神戸大学, 医学部附属病院, 特命講師 (10546477) ; 佐々木 良平 神戸大学, 医学部附属病院, 教授 (30346267) ; 宮脇 大輔 神戸大学, 医学部附属病院, 特命准教授 (30546502) ; 犬伏 祥子 (カリヤ) 神戸大学, 医学研究科, 特命講師 (60585959) ; 窪田 光 神戸大学, 医学部附属病院, 医員 (60824208) ; 西村 英輝 神戸大学, 医学研究科, 客員准教授 (80444610)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: エクソソーム / PDL1 / 免疫放射線療法 / PD-L1 / 免疫チェックポイント阻害剤 / 免疫放射線治療 / リキッドバイオプシー

Outline of Research at the Start

切除不能局所進行非小細胞肺癌は根治的同時化学放射線療法後に抗PDL1抗体を逐次投与することで画期的な治療効果が得られることが最近報告された。しかし治療効果予測のバイオマーカーは明らかにはなっていない。放射線照射によりPDL1発現は変化することが知られているため、治療後のPDL1発現がバイオマーカーとなりうるが、治療後組織の再生検は困難である。そこで我々はリキッドバイオプシーの一つであるエクソソーム膜上に発現しているPDL1に着目した。治療に反応して血液中に放出されるエクソソームの膜上に発現したPDL1に関して実際の臨床症例を用いて解析し、バイオマーカーを確立する。

Outline of Final Research Achievements

The purpose of this study is to evaluate usefulness of exosome-derived PDL1 as a biomarker in patients with unresectable non-small cell lung cancer treated wit curative chemoradiotherapy. We have obtained blood samples sequentially from patients with stage III non-small cell lung cancer. We have established quantitative methods to measure the exosome-derived PDL1, and have compared pre- and post-treatment blood samples with evaluating occurrence of tumor recurrence or tumor control.Then, we clarified possibilities whether the exosome-derived PDL1 could be an useful biomarker of effectiveness of curative chemoradiotherapy. Moreover, it seems another aspect and cutting edge view point to compare the exosome-derived PDL1 and soluble PDL1 in the serum.

Academic Significance and Societal Importance of the Research Achievements

切除不能局所進行非小細胞肺癌は根治的同時化学放射線療法後に免疫チェックポイント阻害剤（抗PDL1抗体）を逐次投与することで画期的な治療効果が報告された。一方、その治療効果に関してどのようなコホートにより有効かを探求する必要性がある。治療に反応して血液中に放出されるエクソソームとその膜上に発現しうるPDL1に関して実際の臨床症例を用いて解析し、新規治療戦略を提案する。本研究の目的はリキッドバイオプシーにより化学放射線療法後のNSCLCに対する免疫チェックポイント阻害の新規バイオマーカーを開発する。特にリキッドバイオプシーの解析においてエクソソームに着目している点が先端的である。

Research Products

• [Journal Article] Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells (2022)
  • Author(s): Salah Mohammed、Akasaka Hiroaki、Shimizu Yasuyuki、Morita Kenta、Nishimura Yuya、Kubota Hikaru、Kawaguchi Hiroki、Sogawa Tomomi、Mukumoto Naritoshi、Ogino Chiaki、Sasaki Ryohei
  • Journal Title: Journal of Experimental & Clinical Cancer Research Volume: 41 Issue: 1 Pages: 146-146
  • DOI: 10.1186/s13046-022-02358-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fiducial marker position affects target volume in stereotactic lung irradiation (2022)
  • Author(s): Akasaka Hiroaki、Mizonobe Kazufusa、Oki Yuya、Uehara Kazuyuki、Nakayama Masao、Tamura Shuhei、Munetomo Yoshiki、Kawaguchi Haruna、Ishida Jun、Harada Aya、Ishihara Takeaki、Kubota Hikaru、Kawaguchi Hiroki、Sasaki Ryohei、Mayahara Hiroshi
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: ‐ Issue: 6 Pages: 1-10
  • DOI: 10.1002/acm2.13596
  • Peer Reviewed / Open Access
• [Journal Article] Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer (2022)
  • Author(s): Komatsu Hirokazu、Furukawa Tatsuya、Iritani Keisuke、Tatehara Shun、Takahashi Miki、Iwaki Shinobu、Kakei Yasumasa、Hasegawa Takumi、Teshima Masanori、Shinomiya Hirotaka、Otsuki Naoki、Hashikawa Kazunobu、Kiyota Naomi、Sasaki Ryohei、Akashi Masaya、Nibu Ken-ichi
  • Journal Title: Auris Nasus Larynx Volume: 49 Issue: 3 Pages: 477-483
  • DOI: 10.1016/j.anl.2021.10.013
  • Peer Reviewed / Open Access
• [Journal Article] Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base (2021)
  • Author(s): Teshima Masanori、Shinomiya Hirotaka、Kimura Hidehito、Hashikawa Kazunobu、Kiyota Naomi、Miyawaki Daisuke、Sasaki Ryohei、Kohmura Eiji、Nibu Ken‐ichi
  • Journal Title: Laryngoscope Investigative Otolaryngology Volume: 6 Issue: 6 Pages: 1347-1352
  • DOI: 10.1002/lio2.687
  • NAID: 120007179199
  • Peer Reviewed / Open Access
• [Journal Article] Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy (2021)
  • Author(s): Nakayama Masao、Akasaka Hiroaki、Miyazaki Eiichi、Goto Yoshihiro、Oki Yuya、Kawate Yosuke、Morita Kenta、Sasaki Ryohei
  • Journal Title: Physics and Imaging in Radiation Oncology Volume: 20 Pages: 94-97
  • DOI: 10.1016/j.phro.2021.11.003
  • NAID: 120007179179
  • Peer Reviewed / Open Access
• [Journal Article] PET/MRI is useful for early detection of pelvic insufficiency fractures after radiotherapy for cervical cancer (2021)
  • Author(s): Azumi Maho、Matsumoto Masuyo、Suzuki Kaho、Sasaki Ryohei、Ueno Yoshiko、Nogami Munenobu、Terai Yoshito
  • Journal Title: Oncology Letters Volume: 22 Issue: 5 Pages: 776-776
  • DOI: 10.3892/ol.2021.13037
  • NAID: 120007153052
  • Peer Reviewed / Open Access
• [Journal Article] The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma (2021)
  • Author(s): Hamada Mostafa、Ueshima Eisuke、Ishihara Takeaki、Koide Yutaka、Okada Takuya、Horinouchi Hiroki、Ishida Jun、Mayahara Hiroshi、Sasaki Koji、Gentsu Tomoyuki、Sofue Keitaro、Yamaguchi Masato、Sasaki Ryohei、Sugimoto Koji、Murakami Takamichi
  • Journal Title: Acta Radiologica Open Volume: 10 Issue: 7 Pages: 20584-20584
  • DOI: 10.1177/20584601211034965
  • NAID: 120007153054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal (2021)
  • Author(s): Shinomiya Hirotaka、Uehara Natsumi、Fujita Takeshi、Miyawaki Daisuke、Imamura Yoshinori、Teshima Masanori、Kakigi Akinobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken-ichi
  • Journal Title: European Archives of Oto-Rhino-Laryngology Volume: - Issue: 6 Pages: 2805-2810
  • DOI: 10.1007/s00405-021-06974-4
  • Peer Reviewed / Open Access
• [Journal Article] New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear (2021)
  • Author(s): Shinomiya H、Uehara N、Fujita T、Yoshida K、Imamura Y、Teshima M、Kimura H、Miyawaki D、Kakigi A、Kiyota N、Otsuki N、Sasaki R、Kohmura E、Nibu K
  • Journal Title: The Journal of Laryngology & Otology Volume: 135 Issue: 4 Pages: 297-303
  • DOI: 10.1017/s002221512100089x
  • NAID: 120007041636
  • Peer Reviewed / Open Access
• [Journal Article] Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species (2021)
  • Author(s): Nakaoka Ai、Nakahana Makiko、Inubushi Sachiko、Akasaka Hiroaki、Salah Mohammed、Fujita Yoshiko、Kubota Hikaru、Hassan Mennaallah、Nishikawa Ryo、Mukumoto Naritoshi、Ishihara Takeaki、Miyawaki Daisuke、Sasayama Takashi、Sasaki Ryohei
  • Journal Title: Oncology Reports Volume: 45 Issue: 4 Pages: 1-1
  • DOI: 10.3892/or.2021.7964
  • NAID: 120006975755
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study (2021)
  • Author(s): KAWAGUCHI HIROKI、DEMIZU YUSUKE、MUKUMOTO NARITOSHI、ISHIHARA TAKEAKI、MIYAWAKI DAISUKE、KOMATSU SHOHEI、AKASAKA HIROAKI、SHINOTO MAKOTO、SHIOYAMA YOSHIYUKI、NAKAMURA KATSUMASA、FUKUMOTO TAKUMI、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 41 Issue: 1 Pages: 503-508
  • DOI: 10.21873/anticanres.14801
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical spacer placement for proton radiotherapy in locally advanced pancreatic body and tail cancers: initial clinical results (2021)
  • Author(s): Dongha Lee et al.
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 1-11
  • DOI: 10.1186/s13014-020-01731-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma (2021)
  • Author(s): Kubota Hikaru、Miyawaki Daisuke、Mukumoto Naritoshi、Ishihara Takeaki、Matsumura Megumi、Hasegawa Takumi、Akashi Masaya、Kiyota Naomi、Shinomiya Hirotaka、Teshima Masanori、Nibu Ken-ichi、Sasaki Ryohei
  • Journal Title: Radiation Oncology Volume: 16 Issue: 1 Pages: 1-1
  • DOI: 10.1186/s13014-020-01701-5
  • NAID: 120006954052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The first pediatric case of sacral Ewing sarcoma treated with space‐making particle therapy (2021)
  • Author(s): Takagi Daisuke、Morikawa Yuri、Kamei Michi、Ogino Hiroyuki、Iwata Hiromitsu、Maeda Naoko、Akita Nobuhiro、Fukumoto Takumi、Sasaki Ryohei、Kondo Satoshi
  • Journal Title: Pediatric Blood & Cancer Volume: 68 Issue: 5
  • DOI: 10.1002/pbc.28842
  • Peer Reviewed / Open Access
• [Journal Article] Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells (2021)
  • Author(s): Morita Kenta、Nishimura Yuya、Nakamura Satoko、Arai Yuki、Numako Chiya、Sato Kazuyoshi、Nakayama Masao、Akasaka Hiroaki、Sasaki Ryohei、Ogino Chiaki、Kondo Akihiko
  • Journal Title: Colloids and Surfaces B: Biointerfaces Volume: 198 Pages: 111451-111451
  • DOI: 10.1016/j.colsurfb.2020.111451
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases) (2021)
  • Author(s): Hara H、Sakai Y、Kawamoto T、Fukase N、Kawakami Y、Takemori T、Fujiwara S、Kitayama K、Yahiro S、Miyamoto T、Kakutani K、Niikura T、Miyawaki D、Okada T、Sakashita A、Imamura Y、Sasaki R、Kizawa Y、Minami H、Matsumoto T、Matsushita T、Kuroda R、Akisue T
  • Journal Title: Journal of Bone Oncology Volume: 27 Pages: 100352-100352
  • DOI: 10.1016/j.jbo.2021.100352
  • NAID: 120007038644
  • Peer Reviewed / Open Access
• [Journal Article] Practice patterns for postoperative radiation therapy in patients with metastases to the long bones: a survey of the Japanese Radiation Oncology Study Group (2021)
  • Author(s): Kubota Hikaru、Nakamura Naoki、Shikama Naoto、Tonari Ayako、Wada Hitoshi、Harada Hideyuki、Nagakura Hisayasu、Heianna Joichi、Ito Kei、Nozaki Miwako、Tago Masao、Fushiki Masato、Uchida Nobue、Araki Norio、Sekii Shuhei、Kosugi Takashi、Takahashi Takeo、Kawamoto Terufumi、Saito Tetsuo、Yamada Kazunari
  • Journal Title: Journal of Radiation Research Volume: 62 Issue: 2 Pages: 356-363
  • DOI: 10.1093/jrr/rraa133
  • Peer Reviewed / Open Access
• [Journal Article] Palliative brachytherapy and external beam radiotherapy for dysphagia from esophageal cancer: a nationwide survey in Japan (2021)
  • Author(s): Kawamoto Terufumi、Nakamura Naoki、Saito Tetsuo、Tonari Ayako、Wada Hitoshi、Harada Hideyuki、Kubota Hikaru、Nagakura Hisayasu、Heianna Joichi、Miyazawa Kazunari、Yamada Kazunari、Tago Masao、Fushiki Masato、Nozaki Miwako、Uchida Nobue、Araki Norio、Sekii Shuhei、Kosugi Takashi、Takahashi Takeo、Shikama Naoto
  • Journal Title: Japanese Journal of Clinical Oncology Volume: hyab015 Issue: 6 Pages: 1-7
  • DOI: 10.1093/jjco/hyab015
  • Peer Reviewed / Open Access
• [Journal Article] Index and Nonindex Pain Endpoints in Radiation Therapy for Painful Tumors: A Secondary Analysis of a Prospective Observational Study (2020)
  • Author(s): Saito Tetsuo、Nakamura Naoki、Murotani Kenta、Shikama Naoto、Takahashi Takeo、Yorozu Atsunori、Heianna Joichi、Kubota Hikaru、Tomitaka Etsushi、Toya Ryo、Yamaguchi Kohsei、Oya Natsuo
  • Journal Title: Advances in Radiation Oncology Volume: 5 Issue: 6 Pages: 1118-1125
  • DOI: 10.1016/j.adro.2020.09.013
  • Peer Reviewed / Open Access
• [Journal Article] Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells (2020)
  • Author(s): Kashin Masahiko、Kakei Yasumasa、Teraoka Shun、Hasegawa Takumi、Yamaguchi Akinobu、Fukuoka Takao、Sasaki Ryohei、Akashi Masaya
  • Journal Title: BioMed Research International Volume: 2020 Pages: 1-10
  • DOI: 10.1155/2020/1281645
  • NAID: 120006940231
  • Peer Reviewed / Open Access
• [Journal Article] Oncogenic miRNAs Identified in Tear Exosomes From Metastatic Breast Cancer Patients (2020)
  • Author(s): INUBUSHI SACHIKO、KAWAGUCHI HIROKI、MIZUMOTO SACHIKO、KUNIHISA TOMONARI、BABA MOTOI、KITAYAMA YUKIYA、TAKEUCHI TOSHIFUMI、HOFFMAN ROBERT M.、SASAKI RYOHEI
  • Journal Title: Anticancer Research Volume: 40 Issue: 6 Pages: 3091-3096
  • DOI: 10.21873/anticanres.14290
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stereotactic body radiotherapy in patients with lung tumors composed of mainly ground-glass opacity (2020)
  • Author(s): Onishi H、Shioyama Y、Matsumoto Y、Shibamoto Y、Miyakawa A、Suzuki G、Nishimura Y、Sasaki R、Miyawaki D、Kuriyama K、Komiyama T、Marino K、Aoki S、Saito R、Araya M、Maehata Y、Nonaka H、Tominaga L、Saito M、Sano N、Yamada S
  • Journal Title: Journal of Radiation Research Volume: 61 Issue: 3 Pages: 426-430
  • DOI: 10.1093/jrr/rraa015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Antibody-Conjugated Signaling Nanocavities Fabricated by Dynamic Molding for Detecting Cancers Using Small Extracellular Vesicle Markers from Tears (2020)
  • Author(s): Takeuchi Toshifumi、Mori Kisho、Sunayama Hirobumi、Takano Eri、Kitayama Yukiya、Shimizu Taku、Hirose Yuzuki、Inubushi Sachiko、Sasaki Ryohei、Tanino Hirokazu
  • Journal Title: Journal of the American Chemical Society Volume: 142 Issue: 14 Pages: 6617-6624
  • DOI: 10.1021/jacs.9b13874
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Space-making particle therapy for sarcomas derived from the abdominopelvic region (2020)
  • Author(s): Komatsu Shohei、Demizu Yusuke、Sulaiman Nor Shazrina、Terashima Kazuki、Suga Masaki、Kido Masahiro、Toyama Hirochika、Tokumaru Sunao、Okimoto Tomoaki、Sasaki Ryohei、Fukumoto Takumi
  • Journal Title: Radiotherapy and Oncology Volume: 146 Pages: 194-199
  • DOI: 10.1016/j.radonc.2020.02.021
  • Peer Reviewed / Open Access
• [Journal Article] Pattern of recurrence after CyberKnife stereotactic body radiotherapy for peripheral early non-small cell lung cancer (2019)
  • Author(s): Nakamura Masaki、Nishikawa Ryo、Mayahara Hiroshi、Uezono Haruka、Harada Aya、Hashimoto Naoki、Nishimura Hideki
  • Journal Title: Journal of Thoracic Disease Volume: 11 Issue: 1 Pages: 214-221
  • DOI: 10.21037/jtd.2018.12.115
  • Peer Reviewed
• [Journal Article] First-In-Human Phase 1 Study of a Nonwoven Fabric Bioabsorbable Spacer for Particle Therapy: Space-Making Particle Therapy (SMPT) (2019)
  • Author(s): Sasaki Ryohei、Demizu Yusuke、Yamashita Tomohiro、Komatsu Shohei、Akasaka Hiroaki、Miyawaki Daisuke、Yoshida Kenji、Wang Tianyuan、Okimoto Tomoaki、Fukumoto Takumi
  • Journal Title: Advances in Radiation Oncology Volume: 4 Issue: 4 Pages: 729-737
  • DOI: 10.1016/j.adro.2019.05.002
  • NAID: 120006796509
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• [Journal Article] Comparison of salvage therapies for isolated para-aortic lymph node recurrence in patients with uterine cervical cancer after definitive treatment (2019)
  • Author(s): Kubota Hikaru、Tsujino Kayoko、Sulaiman Nor Shazrina、Sekii Shuhei、Matsumoto Yoko、Ota Yosuke、Soejima Toshinori、Yamaguchi Satoshi、Sasaki Ryohei
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  • DOI: 10.1186/s13014-019-1442-6
  • NAID: 120006796523
  • Peer Reviewed / Open Access
• [Presentation] 同一腫瘍細胞間の放射線応答を制御するエクソソーム内マイクロRNAの網羅的解析 (2021)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、西川 遼、平野 駿太、石原 武明、宮脇 大輔、佐々木 良平
  • Organizer: 第58回日本放射線腫瘍学会生物部会学術大会
• [Presentation] エクソソーム内マイクロRNAを介した放射線応答制御に関する基礎的検討 (2021)
  • Author(s): 中岡藍、仲波名真希子、椋本成俊、赤坂浩亮、清水康之、Mohammed Salah、西川遼、平野駿太、石原武明、宮脇大輔、佐々木良平
  • Organizer: 第34回 日本放射線腫瘍学会学術大会
• [Presentation] Titanium peroxide nanoparticle enhance the efficacy of immuno-radiotherapy via activated CD8+ T cell dependent antitumor effect in vivo (2021)
  • Author(s): Hikaru Kubota, Yoshiko Fujita, Mohammed Salah, Yasuyuki Shimizu, Hiroaki Akasaka, Ryohei Sasaki
  • Organizer: The 4 th International Cancer Research Symposium a Training for Oncology Professionals
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• [Presentation] Radiosensitive Effect induced by exosomes from irradiated cancer cells (2021)
  • Author(s): Ai Nakaoka, Makiko Nakahana, Naritoshi Mukumoto, Hiroaki Akasaka, Mohammed Salah, Ryo Nishikawa, Takeaki Ishihara, Daisuke Miyawaki, Takashi Sasayama and Ryohei Sasaki
  • Organizer: The 4 th International Cancer Research Symposium a Training for Oncology Professionals
  • Int'l Joint Research
• [Presentation] エクソソームを介した腫瘍細胞への放射線増感効果 (2020)
  • Author(s): 中岡 藍、仲波名 真希子、椋本 成俊、赤坂 浩亮、清水 康之、Mohammed Salah、石原 武明 、宮脇 大輔、佐々木 良平
  • Organizer: 第63回日本放射線影響学会
• [Presentation] 過酸化チタンナノ粒子による免疫放射線治療増感効果の検討 (2020)
  • Author(s): 窪田 光、藤田 佳子、清水 康之、Mohammed Salah、岩下 和真、妹尾 悟史、川口 弘毅、小林 加奈、石原 武明、宮脇 大輔、吉田 賢史、西村 勇哉、荻野 千秋、佐々木 良平
  • Organizer: 第33回日本放射線腫瘍学会
• [Presentation] Titanium peroxide nanoparticle enhance the efficacy of immuno-radiotherapy via activated CD8+ T cell dependent antitumor effect in vivo (2020)
  • Author(s): Hikaru Kubota, Yoshiko Fujita, Mohammed Salah, Yasuyuki Shimizu, Hiroaki Akasaka, Ryohei Sasaki
  • Organizer: American Society for Radiation Oncology 62nd Annual Meeting
  • Int'l Joint Research
• [Presentation] 肺腫瘍に対する根治照射後の照射野内再発に対する再照射例の検討 (2019)
  • Author(s): 岩下和真、馬屋原博、原田文、橋本直樹、藪内伴憲、北谷圭治、石原武明、川口弘毅、妹尾悟史、上原和之、溝延数房、沖裕也、王天縁、佐々木良平
  • Organizer: 第44回神戸放射線腫瘍懇話会
• [Presentation] 限局性肝細胞癌に対するサイバーナイフ動体追尾定位放射線治療の長期成績 (2019)
  • Author(s): 馬屋原 博, 橋本 直樹, 原田 文,西村 英輝, 北谷 圭司, 岩下 和真, 薮内 伴憲, 川口 弘毅, 石原 武明, 妹尾 悟史, 溝延 数房, 上原 和之, 石田 淳，藤井 正彦, 佐々木 良平
  • Organizer: 第28回日本定位放射線治療学会
• [Presentation] 局所進行膵癌に対するIMRTを用いた化学放射線治療 (2019)
  • Author(s): 橋本 直樹, 馬屋原 博, 原田 文, 藪内 伴憲, 北谷 圭治, 岩下 和真, 上原 和之, 溝延 数房, 沖 裕也, 喜多川 浩一, 岡田 秀明, 石原 武明, 川口 弘毅, 妹尾 悟史, 佐々木 良平
  • Organizer: 日本放射線腫瘍学会第32回学術大会