• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Standardization of image-guided brachytherapy for cervical cancer

Research Project

Project/Area Number 19K08103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Wakatsuki Masaru  国立研究開発法人量子科学技術研究開発機構, QST病院 治療診断部, 部長 (40399449)

Co-Investigator(Kenkyū-buntansha) 加藤 眞吾 (加藤 真吾)  埼玉医科大学, 医学部, 教授 (00370875)
小此木 範之  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 重粒子線治療研究部, 医長(定常) (00750572)
大野 達也  群馬大学, 大学院医学系研究科, 教授 (10344061)
大谷 侑輝  大阪大学, 大学院医学系研究科, 招へい研究員 (70462215)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords画像誘導小線源治療 / 子宮頸癌 / 放射線治療 / 小線源治療 / 画像誘導腔内照射 / HR-CTV / IR-CTV / 子宮頸がん
Outline of Research at the Start

子宮頸癌放射線治療の標準治療は外部放射線治療と腔内照射の併用となっている。近年この腔内照射が従来の正側X線画像を用いた二次元腔内照射からCTやMRIを用いた三次元画像誘導腔内照射に移行しつつある。しかしながら日本におけるCTを用いた画像誘導腔内照射の標準的な線量処方はいまだ未確立である。
本研究では、すでに施行中である「局所進行子宮頸癌に対する画像誘導小線源治療に関する多施設共同前向き観察研究」(UMIN000016140)の付随研究として、腫瘍に対する必要となる線量や直腸や膀胱などの正常臓器に対する耐容線量を明らかにし、画像誘導腔内照射における標準的な目標線量を確立することを目的とする。

Outline of Final Research Achievements

The purpose of this study is to standardize the use of 3D-Image-Guided Brachytherapy (IGBT) using CT.
First, we surveyed JASTRO-accredited facilities in Japan to determine the actual dose prescription to the uterine and vaginal regions during 3D-IGBT in clinical practice. Next, a comparison of contouring based on CT and MRI images was performed by 29 radiation oncologists in cooperation with the Gynecology Group of the Japan Research Organization of Radiation Oncology (JROSG) to identify problems with the currently used HR-CTV contouring guidelines.
Based on the results of this study, it is expected that the guidelines for HR-CTV contouring will be improved to standardize 3D-IGBT.

Academic Significance and Societal Importance of the Research Achievements

現在子宮頸癌放射線治療において、CTを用いた三次元画像誘導小線源治療が急速に普及している。そのため三次元画像誘導小線源治療の均てん化が喫緊の課題である。
本研究の成果により、CT-baseのCTVHR contouringガイドラインが改善されることにより、三次元画像誘導小線源治療を新たに開始した施設であっても高い治療成果が期待できることから、施設間格差を是正することが期待され、日本における子宮頸癌放射線治療の標準化・均てん化が期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020 2019

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Clinical advantage and outcomes of computed tomography‐based transvaginal hybrid brachytherapy performed only by sedation without general or saddle block anesthesia2022

    • Author(s)
      Okonogi Noriyuki、Murata Kazutoshi、Matsui Toshiaki、Iwai Yuma、Mori Yasumasa、Kaneko Takashi、Wakatsuki Masaru、Tsuji Hiroshi
    • Journal Title

      Cancer Reports

      Volume: 5 Issue: 11

    • DOI

      10.1002/cnr2.1607

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dosimetric feasibility of computed tomography-based image-guided brachytherapy in locally advanced cervical cancer: a Japanese prospective multi-institutional study2021

    • Author(s)
      Otani Yuki、Ohno Tatsuya、Ando Ken、Murata Kazutoshi、Kato Shingo、Noda Shin-ei、Murofushi Keiko、Ushijima Hiroki、Yoshida Daisaku、Okonogi Noriyuki、Isohashi Fumiaki、Wakatsuki Masaru、Nakano Takashi
    • Journal Title

      Journal of Radiation Research

      Volume: rraa138 Issue: 3 Pages: 1-9

    • DOI

      10.1093/jrr/rraa138

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multi-institutional Observational Study of Prophylactic Extended-Field Concurrent Chemoradiation Therapy Using Weekly Cisplatin for Patients With Pelvic Node-Positive Cervical Cancer in East and Southeast Asia2019

    • Author(s)
      Wakatsuki M, Kato S, Ohno T, Banu PA, Hoang NC, Yadamsuren E, Supriana N, Cao J, Devi CRB, Calaguas MJ, Chansilpa Y, Cho CK, Adylkhanov T, Okonogi N, Nakano T, Tsujii H.
    • Journal Title

      Int J Radiat Oncol Biol Phys .

      Volume: 105 Issue: 1 Pages: 183-189

    • DOI

      10.1016/j.ijrobp.2019.04.039

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 子宮頸癌画像誘導小線源治療における高リスク臨床標的体積の画像モダリティ間での比較研究2021

    • Author(s)
      安藤 謙、若月 優、大野達也、他
    • Organizer
      日本放射線腫瘍学会第34回学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 子宮頸癌IGBTにおける子宮体部・腟側に対する線量評価に関するアンケート結果2020

    • Author(s)
      若月 優、安藤 謙 、大野達也
    • Organizer
      日本放射線腫瘍学会第33回学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Multi - institutional observational study of prophylactic extended - field concurrent chemoradiotherapy using weekly cisplatin for patients with pelvic node - positi ve cervical cancer in East and Southeast Asia2019

    • Author(s)
      Masaru Wakatsuki , Shingo Kato , Tatsuya Ohno, Parvin Akhter Banu, Nguyen Cong Hoang, Erdenetuya Yadamsuren, Nana Supriana, Jianping Cao, C. R. Beena Devi, Miriam Joy Calaguas, Yaowalak Chansilpa, Chul - Koo Cho, Tasbolat Adylkhanov, Noriyuki Okonogi, Takashi Nakano, Hirohiko Tsujii
    • Organizer
      T he 4th annual Meeting of Federation of Asian Organizations for Radiation Oncology (FARO
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multi - institutional observational study of prophylactic extended - field concurrent chemoradiotherapy using weekly cisplatin for patients with pelvic node - positi ve cervical cancer in East and Southeast Asia2019

    • Author(s)
      Masaru Wakatsuki , Shingo Kato , Tatsuya Ohno, Parvin Akhter Banu, Nguyen Cong Hoang, Erdenetuya Yadamsuren, Nana Supriana, Jianping Cao, C. R. Beena Devi, Miriam Joy Calaguas, Yaowalak Chansilpa, Chul - Koo Cho, Tasbolat Adylkhanov, Noriyuki Okonogi, Takashi Nakano, Hirohiko Tsujii
    • Organizer
      American Society for Radiation Oncology (ASTRO) 61st Annual Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] EBRT for cervical cancer with intact uterus2019

    • Author(s)
      Masaru Wakatsuki
    • Organizer
      IAEA INT 6062 Workshop on Transitioning from 2 - D to 3 - D Radiation Therapy for Cervical Cance
    • Related Report
      2019 Research-status Report
    • Invited

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi