Development of a phenomenological RBE model for carbon ion radiotherapy and high-precision clinical analysis

• Project/Area Number: 19K08188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: International University of Health and Welfare (2022); National Institutes for Quantum Science and Technology (2019-2021)
• Principal Investigator: Kohno Ryosuke 国際医療福祉大学, 保健医療学部, 教授 (20392227)
• Co-Investigator(Kenkyū-buntansha): 鈴木 雅雄 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線障害治療研究部, 上席研究員(定常) (70281673)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 炭素線治療 / LET / RBE / 臨床解析 / 頭頸部がん / 視神経炎 / 線量平均LET / RBE計算モデル / Carbon-ion Radiotherapy / Head and neck cancer / 生物学的効果比 / 線エネルギー付与 / 線量平均線エネルギー付与 / 生物線量

Outline of Research at the Start

本研究では、炭素線治療に対して、腫瘍や正常組織毎に生物線量を計算できる実測ベースRBE計算モデルを構築することが第一の目的である。そして、その手法を組み込んだ炭素線治療に対する高精度臨床解析システムを開発し、より正確な臨床解析を行うことが第二の目的である。本研究により、炭素線治療の有用性の評価はもちろん、高精度な臨床解析により、有害事象の知見を深め、有害事象の予測や予防に役立てることが本研究の意義であるとも考えている。

Outline of Final Research Achievements

The dose-averaged LET (LETd) calculation tool for clinical analysis of patients treated with carbon-ion radiotherapy (CIRT) was developed. The head and neck patients treated with CIRT were analyzed by this calculation tool. For prescribed RBE-weighted dose of 64 Gy (RBE) in adenoid cystic carcinoma (ACC) patients, we observed the minimum LETd was a determinant of local control (p<0.05). For the optic neuropathy, it was obvious that the optic neuropathy had a greater effect from RBE-weighted dose rather than dose-averaged LET. A phenomenological RBE calculation model based on the LETd was simply paramterised and developed by fitting in vitro experimental data in the literature with data from our experiments.

Academic Significance and Societal Importance of the Research Achievements

本研究は、炭素線治療の有用性を評価しただけでなく、高精度な臨床解析により、局所制御や有害事象に関わる新たな因子を明らかにすることができた。これは炭素線治療の理解を深める興味深い成果であり、本研究の学術的意義は高い。加えて、実測ベース型RBE計算モデルの開発は、任意の組織に対する生物線量の計算を可能にすることから、炭素線治療のより一層の治療成績の向上に繋がる可能性を示すものであり、社会的意義も高い。

Research Products

• [Journal Article] Evaluation of Patient-Specific Quality Assurance for Carbon Ion Radiotherapy Using Full Energy Scanning Method at QST Hospital (2022)
  • Author(s): Asami Inomata, Masashi Katsumata, Sung Hyun Lee, Yui Suzuki, Takeo Nakajima, Wataru Furuichi, Keishi Yamaoka, Atsushi Yamamoto, Hideyuki Mizuno, Ryosuke Kohno
  • Journal Title: International Journal of Medical Physics, Clinical Engineering and Radiation Oncology Volume: 11 Issue: 04 Pages: 200-209
  • DOI: 10.4236/ijmpcero.2022.114017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Carbon-ion beam irradiation in combination with cisplatin effectively suppresses xenografted malignant pleural mesothelioma (2022)
  • Author(s): Sei Sai, Taiju Yamada,Keiko Ito, Nobuyuki Kanematsu, Masao Suzuki, Mitsuhiro Hayashi, Masashi Koto
  • Journal Title: American Journal of Cancer Research Volume: 12 Pages: 5657-5667
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Carbon-Ion Beam Irradiation and the miR-200c Mimic Effectively Eradicate Pancreatic Cancer Stem Cells Under in vitro and in vivo Conditions (2021)
  • Author(s): Sei Sai, Eun Ho Kim, Woong Sub Koom, Guillaume Vares, Masao Suzuki, Shigeru Yamada, Mitsuhiro Hayashi
  • Journal Title: OncoTargets and Therapy Volume: 14 Pages: 4749-4760
  • DOI: 10.2147/ott.s311567
  • Peer Reviewed
• [Journal Article] Performance Evaluation for Repair of HSGc-C5 Carcinoma Cell Using Geant4-DNA (2021)
  • Author(s): Sakata Dousatsu、Suzuki Masao、Hirayama Ryoichi、Abe Yasushi、Muramatsu Masayuki、Sato Shinji、Belov Oleg、Kyriakou Ioanna、Emfietzoglou Dimitris、Guatelli Susanna、Incerti Sebastien、Inaniwa Taku
  • Journal Title: Cancers Volume: 13 Issue: 23 Pages: 6046-6046
  • DOI: 10.3390/cancers13236046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differentiation between non‐small cell lung cancer and radiation pneumonitis after carbon‐ion radiotherapy by 18F‐FDG PET/CT texture analysis (2021)
  • Author(s): Makito Suga, Ryuichi Nishii, Kenta Miwa, Yuto Kamitaka, Kana Yamazaki, Kentaro Tamura, Naoyoshi Yamamoto, Ryosuke Kohno, Masato Kobayashi, Katsuyuki Tanimoto, Hiroshi Tsuji & Tatsuya Higashi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 11509-11509
  • DOI: 10.1038/s41598-021-90674-w
  • Peer Reviewed
• [Journal Article] Effects of loading a magnetic field longitudinal to the linear particle-beam track on yields of reactive oxygen species in water (2021)
  • Author(s): Ken-ichiro Matsumoto, Ikuo Nakanishi, Yasushi Abe, Shinji Sato, Ryosuke Kohno, Dousatsu Sakata, Kota Mizushima, Sung Hyun Lee & Taku Inaniwa
  • Journal Title: Free Radical Research Volume: 55 Pages: 547-555
  • Peer Reviewed
• [Journal Article] Development of a phenomenological RBE calculation model for carbon ion radiotherapy and high-precision clinical analysis (2021)
  • Author(s): Ryosuke Kohno
  • Journal Title: Impact Volume: 2021 Issue: 6 Pages: 12-14
  • DOI: 10.21820/23987073.2021.6.12
  • Open Access
• [Journal Article] Estimating the biological effects of helium, carbon, oxygen, and neon ion beams using 3D silicon microdosimeters. (2021)
  • Author(s): Sung Hyun Lee, Kota Mizushima, Ryosuke Kohno, Yoshiyuki Iwata, Shunsuke Yonai, Toshiyuki Shirai, Vladimir A Pan, David Bolst, Linh T Tran, Anatoly B Rosenfeld, Masao Suzuki, Taku Inaniwa
  • Journal Title: Physics in Medicine and Biology Volume: 66 Issue: 4 Pages: 1-13
  • DOI: 10.1088/1361-6560/abd66f
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Application of lung substitute material as ripple filter for multi-ion therapy with helium-, carbon-, oxygen-, and neon-ion beams. (2021)
  • Author(s): Taku Inaniwa, Yasushi Abe, Masao Suzuki, Sung Hyun Lee, Kota Mizushima, Taku Nakaji, Dousatsu Sakata, Shinji Sato, Yoshiyuki Iwata, Nobuyuki Kanematsu, Toshiyuki Shirai
  • Journal Title: Physics in Medicine and Biology Volume: 66 Issue: 5 Pages: 1-10
  • DOI: 10.1088/1361-6560/abde99
  • Peer Reviewed / Open Access
• [Journal Article] Oxidation resistance 1 functions in the maintenance of cellular survival and genome stability in response to oxidative stress-independent DNA damage (2020)
  • Author(s): Ako Matsui, Kazunari Hashiguchi, Masao Suzuki, Qiu-Mei Zhang-Akiyama
  • Journal Title: Genes and Environment Volume: 42 Issue: 1 Pages: 1-6
  • DOI: 10.1186/s41021-020-00168-w
  • Peer Reviewed / Open Access
• [Journal Article] Superior Effect of the Combination of Carbon-Ion Beam Irradiation and 5-Fluorouracil on Colorectal Cancer Stem Cells in vitro and in vivo (2020)
  • Author(s): Woong Sub Koom, Sei Sai, Masao Suzuki, Akira Fujimori, Shigeru Yamada, Hirohiko Tsujii
  • Journal Title: OncoTargets and Therapy Volume: 13 Pages: 112625-12635
  • Peer Reviewed / Open Access
• [Journal Article] Unresectable Chondrosarcomas Treated With Carbon Ion Radiotherapy: Relationship Between Dose-averaged Linear Energy Transfer and Local Recurrence. (2020)
  • Author(s): Shinnosuke Matsumoto, Sung Hyun Lee, Reiko Imai, Taku Inaniwa, Naruhiro Matsufuji, Mai Fukahori, Ryosuke Kohno, Shunsuke Yonai, Noriyuki Okonogi, Shigeru Yamada, Nobuyuki Kanematsu
  • Journal Title: Anticancer Research Volume: 40 Issue: 11 Pages: 6429-6435
  • DOI: 10.21873/anticanres.14664
  • Peer Reviewed / Open Access
• [Journal Article] Biophysical Model Including a Potentially Lethal Damage Repair Parameter in Fractionated Carbon Beam (2020)
  • Author(s): Eunae Choi, Myonggeun Yoon, Masao Suzuki, Naruhiro Matsufuji, Wonguyn Jung
  • Journal Title: Journal of the Korean Physical Society Volume: 77 Issue: 2 Pages: 161-167
  • DOI: 10.3938/jkps.77.161
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Combination of carbon-ion beam and dual tyrosine kinase inhibitor, lapatinib, effectively destroys HER2 positive breast cancer stem-like cells. (2020)
  • Author(s): Sei Sai, Eun Ho Kim, Guillaume Vares, Masao Suzuki, Dong Yu, Yoshiya Horimoto, Mitsuhiro Hayashi
  • Journal Title: American Journal of Cancer Research Volume: 10 Pages: 2371-2386
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biologic Impact of Different Ultra-Low-Fluence Irradiations in Human Fibroblasts. (2020)
  • Author(s): Masao Suzuki, Yukio Uchihori, Hisashi Kitamura, Masakazu Oikawa, Teruaki Konishi
  • Journal Title: Life Volume: 10 Issue: 8 Pages: 1-12
  • DOI: 10.3390/life10080154
  • Peer Reviewed / Open Access
• [Journal Article] Biological Dose Comparison between a Fixed RBE and a variable RBE in SFO and MFO IMPT with Various Multi-Beams for Brain Cancer (2019)
  • Author(s): Ryosuke Kohno, Wenhua Cao, Pablo Yepes, Xuemin Bai, Falk Poenisch, David R Grosshans, Tetsuo Akimoto, Radhe Mohan
  • Journal Title: International Journal of Medical Physics, Clinical Engineering and Radiation Oncology Volume: 8 Issue: 01 Pages: 32-45
  • DOI: 10.4236/ijmpcero.2019.81004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biological Dose Calculation using variable RBE in Single- and Multi-field Optimization IMPT plans for 3 Brain Tumor patients (2019)
  • Author(s): Ryosuke Kohno, Wenhua Cao, Pablo Yepes, Xuemin Bai, Falk Poenisch, David R Grosshans, Tetsuo Akimoto, Radhe Mohan
  • Journal Title: Journal of Radiology and Oncology Volume: 3 Issue: 1 Pages: 001-007
  • DOI: 10.29328/journal.jro.1001027
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Commissioning of a fluoroscopic-based real-time markerless tumor tracking system in a superconducting rotating gantry for carbon-ion pencil beam scanning treatment (2019)
  • Author(s): Shinichiro Mori, Yukinobu Sakata, Ryuske Hirai, Wataru Furuichi, Kazuki Shimabukuro, Ryosuke Kohno, Wong Sub Koom, Shigeru Kasai, Keiko Okaya and Yasushi Iseki
  • Journal Title: Medical Physics Volume: 46 Issue: 4 Pages: 1561-1574
  • DOI: 10.1002/mp.13403
  • Peer Reviewed
• [Journal Article] The radiobiological effects of He, C and Ne ions as a function of LET on various glioblastoma cell lines. (2019)
  • Author(s): C.M.Tsuey, D.A.Bradley, M.Suzuki, N.Matsufuji, T.Murakami, B.Jones, A.Nisbet
  • Journal Title: Journal of Radiation Research Volume: 60(2) Issue: 2 Pages: 178-188
  • DOI: 10.1093/jrr/rry099
  • Peer Reviewed
• [Journal Article] 13. Quality Assurance for Heavy Charged Particle Therapy (2019)
  • Author(s): 森慎一郎, 河野良介
  • Journal Title: Japanese Journal of Radiological Technology Volume: 75 Issue: 10 Pages: 1200-1204
  • DOI: 10.6009/jjrt.2019_JSRT_75.10.1200
  • NAID: 130007731552
  • ISSN: 0369-4305, 1881-4883
  • Peer Reviewed
• [Journal Article] Lethal and mutagenic bystander effects in human fibroblast cell cultures subjected to low-energy-carbon ions. (2019)
  • Author(s): M.Suzuki, N.Yasuda, H.Kitamura
  • Journal Title: International Journal of Radiation Biology Volume: 96(2) Issue: 2 Pages: 179-186
  • DOI: 10.1080/09553002.2020.1683637
  • Peer Reviewed
• [Journal Article] Ion beams for space radiation radiobiological effect studies. (2019)
  • Author(s): C.M.Tsuey, A.Nisbet, B.Jones, M.Suzuki, N.Matsufuji, T.Murakami, D.A.Bradley
  • Journal Title: Radiation Physics and Chemistry Volume: 165 Pages: 108373-108377
  • DOI: 10.1016/j.radphyschem.2019.108373
  • Peer Reviewed
• [Presentation] Radio-adaptive response induced by the targeted cytoplasmic irradiation in normal human fibroblasts with X-ray micorbeams via gap-junction mediated cell to cell communication relationship between magnetic-field mediated cell killing and radio-adaptive response by targeted cytoplasmic irradiations with X-ray microbeams via bystander effects. (2022)
  • Author(s): 鈴木雅雄、宇佐美徳子、崔星、小藤昌志
  • Organizer: 日本放射線影響学会第65回大会
• [Presentation] 頭頸部がんの重粒子線治療における線量平均LET最適化シミュレーション研究 (2022)
  • Author(s): 小藤昌志、河野良介、伊川裕明、篠藤誠、瀧山博年、磯崎哲朗、今井礼子、山田滋
  • Organizer: 第18回日本粒子線治療臨床研究会
• [Presentation] Bystander effect via gap junction between carbon-ion irradiated tumor and un irradiated normal cells. (2022)
  • Author(s): 鈴木雅雄、崔星、小藤昌志
  • Organizer: 日本放射線腫瘍学会第35回学術大会
• [Presentation] ヒトがん細胞のP53遺伝子依存的バイスタンダー致死効果に対するエネルギーの異なる炭素イオンマイクロビーム間比較 (2022)
  • Author(s): 鈴木雅雄、舟山知夫、鈴木芳代
  • Organizer: QST高崎サイエンスフェスタ2022
• [Presentation] 頭頸部がんに対する重粒子線治療における線量平均LET最適化シミュレーション研究 (2021)
  • Author(s): 小藤 昌志、河野良介、伊川裕明、青木秀梨、篠藤誠、瀧山博年、今井礼子、山田滋、辻比呂志
  • Organizer: 第34回日本放射線腫瘍学会
• [Presentation] Relationship between magnetic-field mediated cell killing and radio-adaptive response by targeted cytoplasmic irradiations with X-ray microbeams via bystander effects (2021)
  • Author(s): 鈴木雅雄、宇佐美徳子、崔星、藤森亮、小藤昌志
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 放射光X線マイクロビームを用いた細胞致死効果に対する細胞質限定的照射による放射線適応応答誘導の細胞内・細胞間応答の関与 (2021)
  • Author(s): 鈴木雅雄、宇佐美徳子、崔星、藤森亮、小藤昌志
  • Organizer: 日本放射線影響学会第64回大会
• [Presentation] Dose-Averaged LET Evaluation in Head and Neck Adenoid Cystic Carcinoma Patients for Carbon-Ion Radiotherapy (2021)
  • Author(s): R. Kohno, S. Lee, A. Yamamoto, K. Yamaoka, M. Suga, M. Koto
  • Organizer: AAPM2021
  • Int'l Joint Research
• [Presentation] Clinical evaluation of RBE-weighted dose and dose-averaged LET in patients receiving carbon-ion radiotherapy for head and neck adenoid cystic carcinoma (2021)
  • Author(s): 3.Ryosuke Kohno, Sung Hyun Lee, Atsushi Yamamoto, Keishi Yamaoka, Eika Hotta, Miyabi Yamamoto, Makito Suga, Asami Inomata, Yui Suzuki, Masashi Koto
  • Organizer: JSMP121
• [Presentation] Effect of longitudinal magnetic field to the linear particle-beam track on yields of hydroxyl radical and hydrogen peroxide in wate (2021)
  • Author(s): Ken-ichiro Matsumoto, Ikuo Nakanishi, Yasushi Abe, Shinji Sato, Masayuki Muramatsu, Ryosuke kohno, Dousatsu Sakata, Kota Mizushima, Hideyuki Mizuno, Taku Inaniwa
  • Organizer: 20th Biennial Meeting of SFRR International
  • Int'l Joint Research
• [Presentation] 炭素イオンマイクロビーム照射で誘導したヒト正常細胞のバイスタンダー効果に対するメタボローム解析 (2020)
  • Author(s): 鈴木 雅雄, 舟山 知夫, 鈴木 芳代, 横田 裕一郎, 小林 泰彦
  • Organizer: QST高崎サイエンスフェスタ2020
• [Presentation] The enhancement of cell death irradiated with carbon-ion beams by applying longitudinal magnetic field relate to gap-junction mediated cell-cell communication (2020)
  • Author(s): 鈴木雅雄
  • Organizer: 日本放射線影響学会第63回大会
  • Invited
• [Presentation] Development of a vector DNA system for visualization of intracellular repair dynamics of DNA damage by ionizing radiation (2020)
  • Author(s): 小畑 結衣, 平嵜 敬志朗, 秋光 信佳, 鈴木 雅雄, 横谷 明徳
  • Organizer: 日本放射線影響学会第63回大会
• [Presentation] The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication (2020)
  • Author(s): 鈴木雅雄
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] Preliminary Clinical Analysis with Dose-Averaged LET Calculation for Head and Neck Cancer Patients Treated by Using Carbon-Ion Radiotherapy (2020)
  • Author(s): Sung-Hyun Lee, Atsushi Yamamoto, Keisi Yamaoka, Eika Hotta, Miyabi Yamamoto, Yui Suzuki, Asami Inomata, Makito Suga, Masashi Koto, Ryosuke Kohno
  • Organizer: AAPM2020
  • Int'l Joint Research
• [Presentation] RBE calculation using the Survival simulation tool for HSG, V79 and CHO cells irradiated by 12C, 20Ne and 3He ions (2020)
  • Author(s): Makito Suga, 本間 大晴, Sung-Hyun Lee, Masao Suzuki, Hiroyuki Kato, 橋本 光康, Katsuyuki Tanimoto, Ryosuke Kohno
  • Organizer: AAPM2020
  • Int'l Joint Research
• [Presentation] RBE calculation using radiobiological computation software ‘Survival’ for human salivary gland cell (2020)
  • Author(s): 菅 満喜人, 本間 大晴, Lee Sung Hyun, 鈴木 雅雄, 山尾 天翔, 井出 紳介, 加藤 弘之, 橋本 光康, 谷本 克之, 河野 良介
  • Organizer: 第119回日本医学物理学会学術大会
• [Presentation] Evaluation of Patient-specific Quality Assurance for Spot-Scanning Carbon Ion Radiotherapy (2020)
  • Author(s): 猪俣 麻美, 鈴木 優維, 勝間田 匡, 中島 猛雄, 古市 渉, 山岡 恵士, 菅 満喜人, 山本 淳史, 水野 秀之, 河野 良介
  • Organizer: 第119回日本医学物理学会学術大会
• [Presentation] Clinical Analysis of Dose-averaged LET Calculation in Carbon-Ion Radiotherapy for Head and Neck Cancer (2020)
  • Author(s): 山本 淳史, Lee Sung Hyun, 山岡 恵士, 鈴木 優維, 伊川 裕明, 金子 崇, 小藤 昌志, 谷本 克之, 辻 比呂志, 河野 良介
  • Organizer: 第119回日本医学物理学会学術大会
• [Presentation] 磁場併用による重粒子線に対する細胞致死効果の増感作用 (2020)
  • Author(s): 鈴木雅雄
  • Organizer: 第22回菅原・大西記念癌治療増感シンポジウム
  • Invited
• [Presentation] MICRODOSIMETRIC STUDY FOR HELLIUM-ION BEAM USING FULLY 3D SILICON MICRODOSIMETERS (2020)
  • Author(s): Sung Hyun Lee, Kota Mizushima, Dosatsu Sakata, Ryosuke Kohno, Makoto Sakama, Yoshiyuki Iwata, Toshiyuki Shirai, Vladimir Pan, Linh T Tran, Anatoly B Rosenfeld, Masao Suzuki, Taku Inaniwa
  • Organizer: MMND-ITRO 2020
  • Int'l Joint Research
• [Presentation] 18F-FDG PET/CT 画像の Texture 解析による肺がんと炎症の鑑別 (2019)
  • Author(s): 菅満喜人、西井龍一、山崎香奈、上髙祐人、河野良介、三輪建太、谷本克之、東達也、辻比呂志
  • Organizer: 第595回千葉県下国立病院医師会定例連合研究会
• [Presentation] Enhancement of cell killing in human tumor cells irradiated with carbon ions by applysing a longitudinal magnetic field. (2019)
  • Author(s): 鈴木雅雄、稲庭拓、佐藤眞二、野田章、松村正幸、岩田佳之、兼松伸幸、白井敏之、野田耕司
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Dose the enhancement of cell-killing effect in human cells irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response in the cells pre-irradiated cytoplasm with low-LET radiations? (2019)
  • Author(s): 鈴木雅雄、稲庭拓、宇佐美徳子、佐藤眞二、野田章、松村正幸、岩田佳之、兼松伸幸、白井敏之、野田耕司
  • Organizer: 日本放射線影響学会第62回大会
• [Presentation] 画像誘導炭素線治療におけるPatient Handling Systemに対する位置決めQA (2019)
  • Author(s): 山岡恵士、伊達美聡、勝間田匡、山本淳史、菅満喜人、中島猛雄、谷本克之、河野良介、辻 比呂志
  • Organizer: 第32回日本放射線腫瘍学会
• [Presentation] 頭頸部腫瘍に対する炭素線治療における線量平均LET計算 (2019)
  • Author(s): 山本淳史、李聖賢、鈴木優維、古市渉、伊川裕明、金子崇、小藤昌志、菅満喜人、山岡恵士、谷本克之、河野良介、辻比呂志
  • Organizer: 第32回日本放射線腫瘍学会
• [Presentation] PET画像のTexture解析を用いた非小細胞肺癌と放射線肺臓炎との診断能評価 (2019)
  • Author(s): 菅 満喜人, 西井 龍一, 山崎 香奈, 三輪 建太, 上髙 祐人, 河野 良介, 山岡 恵士, 山本 淳史, 谷本 克之, 東 達也, 辻 比呂志
  • Organizer: 第32回日本放射線腫瘍学会
• [Presentation] Microdosimetric study at the NIRS scanning beam for the multi-ion therapy (2019)
  • Author(s): Sung Hyun Lee, Kota Mizushima, Dosatsu Sakata, Makoto Sakama, Ryosuke Kohno, Yoshiyuki Iwata, Toshiyuki Shirai, Linh T Tran, Anatoly B Rosenfeld, Masao Suzuki, Taku Inaniwa
  • Organizer: PTCOG-AO 2019
  • Int'l Joint Research
• [Book] 測定ベースの IMRT QA における許容限界及び方法論 (2023)
  • Author(s): 赤坂浩亮, 富田哲也, 街道亮斗, 米田洋介, 齋藤正英, 高橋侑大, 谷本祐樹, 中林匡, 本間大晴, 松永卓磨, 南佳孝, 河野千恵, 櫻木亜美, 白崎展行, 武居秀行
  • Total Pages: 46
  • Publisher: 日本医学物理士会
• [Book] 放射線治療中の画像誘導におけるイメージング線量: 定量化, 管理及び低減 (2022)
  • Author(s): 河野千恵, 柴田洋希, 伊藤旭, 井上耕介, 沖裕也, 白崎展行, 中林匡, 廣瀧康太, 大野剛, 櫻木亜美, 武居秀行, 河野良介
  • Total Pages: 34
  • Publisher: 日本医学物理士会
• [Book] 人体のメカニズムから学ぶ 放射線治療学 (2022)
  • Author(s): 大友邦, 小塚拓洋, 橋本光康
  • Total Pages: 528
  • Publisher: メジカルビュー
  • ISBN: 9784758320832
• [Book] 放射線治療における陽子線に対する放射線生物学的効果 (2021)
  • Author(s): 河野良介、加瀬優紀、脇田明尚、菅満喜人、本間大晴、橋本雨音、橋本光康
  • Total Pages: 56
  • Publisher: 日本医学物理士会
• [Book] 実践 放射線治療技術学 放射線治療装置を立ち上げよう (2020)
  • Author(s): 森 慎一郎, 河野 良介
  • Total Pages: 160
  • Publisher: メディカルトリビューン