Radiobiological research for clinical application of variable RBE in proton beam therapy

• Project/Area Number: 19K08190
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: National Cancer Center Japan
• Principal Investigator: Akimoto Tetsuo 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (10261851)
• Co-Investigator(Kenkyū-buntansha): 北條 秀博 国立研究開発法人国立がん研究センター, 東病院, 医員 (60638774)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 陽子線治療 / 放射線生物 / 生物効果 / 強度変調陽子線治療

Outline of Research at the Start

本研究の目的は、スキャニング照射法およびその発展型であるIMPTに対する細胞応答、化学療法などの併用による増感効果や細胞応答の修飾などを総合的に解析して、IMPTを含む陽子線治療における可変RBEの生物学的評価と治療計画への応用を図る基礎研究とすることである。最終的に陽子線の物理学的な特性に依存している治療計画法や線量分割、併用療法などを陽子線の生物学的特性を加味した治療法開発に発展させて、集学的治療における陽子線治療の有効性確立の基礎にすることである。

Outline of Final Research Achievements

In the first year, the following research were performed using in vitro cell lines. 1) cellular response to IMPT and scanning irradiation, 2) clarification of combined drugs on cellular response. In the second year, the effect of dose rate on LET and RBE in addition to cell survival analysis, and we confirmed that dose rate influenced LET and RBE. In the last year, we analyzed the correlation between in vitro data and clinical outcomes such as treatment-related toxicities and recurrence sites using clinical data of patients who were treated with IMPT to clarify the effect of dose inhomogeneity and the difference in LET.

Academic Significance and Societal Importance of the Research Achievements

スキャニング照射法やその発展型であるIMPTは、その線量集中性と腫瘍形状に沿って線量分布実現可能なフレキシビリティ性の向上から今後の陽子線治療の標準的な照射技術になっていくことが予想され、X線による強度変調放射線治療を凌駕する臨床的有用性を秘めている。しかし、その生物効果、特にRBEについては解析が必要な状況で、更にその生物学的特性を治療計画（線量計算）に反映することが可能になれば、これらの照射技術による臨床効果や有害事象の臨床的評価の基礎になることのみならず、生物学的特性に基づいた治療戦略の大きな武器となり得る。

Research Products

• [Journal Article] Radiotherapy for ductal carcinoma of the prostate: an analysis based on the Japanese radiation oncology study group survey (2022)
  • Author(s): Kawamura Hidemasa、Nakamura Katsumasa、Yoshioka Yasuo、et al.
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 53 Issue: 2 Pages: 146-152
  • DOI: 10.1093/jjco/hyac180
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of an online support program to help female cancer patients manage their health and illness: Protocol for a randomized controlled trial (2022)
  • Author(s): Mizuno M, Chiba I, Mukohara T, Kondo M, Maruo K, Ohigashi T, Naruo M, Asano Y, Onishi T, Tanabe H, Muta R, Mishima S, Okano S, Yuda M, Hosono A, Ueda Y, Bando H, Itagaki H, Ferrans CE, Akimoto T
  • Journal Title: Contemp Clin Trials Commun Volume: 30 Pages: 101035-101035
  • DOI: 10.1016/j.conctc.2022.101035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Real-world clinical outcomes in Japanese patients with locally advanced squamous cell carcinoma of the head and neck treated with radiotherapy plus cetuximab: a prospective observational study (JROSG12-2) (2022)
  • Author(s): Ota Y, Kodaira T, Fujii H, Shimokawa M, Yokota T, Nakashima T, Monden N, Homma A, Ueda S, Akimoto T
  • Journal Title: Int J Clin Oncol Volume: 27 Issue: 11 Pages: 1675-1683
  • DOI: 10.1007/s10147-022-02228-3
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of breast cosmetic changes with a computer-software; the breast cancer conservative treatment cosmetic results (BCCT. core) in hypofractionated whole breast irradiation after breast-conserving surgery-supplementary analysis of multicenter single-arm confirmatory trial: JCOG0906 (2022)
  • Author(s): Nozaki M, Kagami Y, Takahashi M, Machida R, Sekino Y, Shibata T, Ito Y, Nishimura Y, Teshima T, Ushijima H, Nagata Y, Matsumoto Y, Akimoto T, Takahashi K, Murayama S, Uno T, K, Hamamoto Y, Nakagawa K, Kodaira T, Hiraoka M; Radiation Therapy Study Group, Japan Clinical Oncology Group
  • Journal Title: Breast Cancer Volume: 29 Issue: 6 Pages: 1042-1049
  • DOI: 10.1007/s12282-022-01384-8
  • Peer Reviewed / Open Access
• [Journal Article] Multi-Institutional Study of End-to-End Dose Delivery Quality Assurance Testing for Image-Guided Brachytherapy Using a Gel Dosimeter (2022)
  • Author(s): Tachibana H, Watanabe Y, Kurokawa S, Maeyama T, Hiroki T, Ikoma H,… Akimoto T
  • Journal Title: Brachytherapy Volume: 21 Issue: 6 Pages: 956
  • DOI: 10.1016/j.brachy.2022.06.006
  • URL: https://pure.teikyo.jp/en/publications/23982351-ff9c-446a-80de-88d614950828
  • Peer Reviewed
• [Journal Article] Tumor response and survival outcomes of salvage concurrent chemoradiotherapy with three-dimensional conformal radiotherapy and 5-fluorouracil/platinum-based chemotherapy for postoperative locoregional recurrence of esophageal squamous cell carcinoma (2022)
  • Author(s): Ito R, Nakamura Y, Sunakawa H, Fujiwara H, Hojo H, Nakamura N, Fujita T, Yano T, Daiko H, Akimoto T, Yoshino T, Kojima T
  • Journal Title: Esophagus Volume: 19 Issue: 4 Pages: 645-652
  • DOI: 10.1007/s10388-022-00936-3
  • Peer Reviewed / Open Access
• [Journal Article] Salvage endoscopic resection for cT1N0M0 local recurrence after chemoradiotherapy for esophageal squamous cell carcinoma: endoscopic submucosal dissection versus endoscopic mucosal resection (2022)
  • Author(s): Nakajo K, Yoda Y, Yamashita H, Takashima K, Murano T, Kadota T, Shinmura K, Ikematsu H, Akimoto T, Yano T
  • Journal Title: Jpn J Clin Oncol Volume: 52 Pages: 982-991
  • DOI: 10.1093/jjco/hyac090
  • Peer Reviewed / Open Access
• [Journal Article] Induction chemotherapy with paclitaxel, carboplatin and cetuximab for locoregionally advanced nasopharyngeal carcinoma: A single-center, retrospective study (2022)
  • Author(s): Takeshita N, Enokida T, Okano S, Fujisawa T, Wada A, Sato M, Tanaka H, Tanaka N, Motegi A, Zenda S, Akimoto T, Tahara M
  • Journal Title: Front Oncol Volume: 12 Pages: 951387-951387
  • DOI: 10.3389/fonc.2022.951387
  • Peer Reviewed / Open Access
• [Journal Article] Summary of the Clinical Practice Guidelines for Penile Cancer 2021 by the Japanese Urological Association (2022)
  • Author(s): Yamaguchi T, Sugiyama Y, Tanaka T, Kimura T, Yumura Y, Nakano M, Sugiyama T, Miura N, Goya M, Yamamoto A, Takahashi S, Miura Y, Tsuzuki T, Masumori N, Nishiyama H, Yao M, Koie T, Miyake H, Saika T, Saito S, Akimoto T, Tamada T, Ando Y, Takahashi S, Suzuki T, Hinotsu S, Kamba T
  • Journal Title: Int J Urol Volume: 29 Issue: 8 Pages: 780-792
  • DOI: 10.1111/iju.14924
  • Peer Reviewed / Open Access
• [Journal Article] Investigation of Concrete Radioactivation in Cyclotron Type Proton Therapy Facilities using in situ ²⁴Na Measurement Method (2022)
  • Author(s): Matsumura H, Yoshida G, Toyoda A, Masumoto K, Nakamura H, Miura T, Nishikawa K, Bessho K, Akita T, Katsuta S, Akimoto T, Sugama Y, Nobuhara F, Nagashima Y
  • Journal Title: Radiation Safety Management Volume: 21 Issue: 0 Pages: 13-25
  • DOI: 10.12950/rsm.200909
  • ISSN: 1347-1511, 1884-9520
  • Peer Reviewed
• [Journal Article] Optimal Clinical Target Volume of Radiotherapy Based on Microscopic Extension around the Primary Gross Tumor in Non-Small-Cell Lung Cancer: A Systematic Review (2022)
  • Author(s): Tamaki Y, Aibe N, Komiyama T, Nagasaka S, Imagumbai T, Itazawa T, Onishi H, Akimoto T, Nagata Y, Nakayama Y
  • Journal Title: Cancers (Basel) Volume: 14 Issue: 9 Pages: 2318-2318
  • DOI: 10.3390/cancers14092318
  • Peer Reviewed / Open Access
• [Journal Article] The characteristics of missed pharyngeal and laryngeal cancers at gastrointestinal endoscopy (2022)
  • Author(s): Nakajo K, Inaba A, Aoyama N, Takashima K, Kadota T, Yoda Y, Morishita Y, Okano W, Tomioka T, Shinozaki T, Matsuura K, Hayashi R, Akimoto T, Yano T
  • Journal Title: Jpn J Clin Oncol Volume: 52 Issue: 6 Pages: 575-582
  • DOI: 10.1093/jjco/hyac036
  • Peer Reviewed / Open Access
• [Journal Article] Response to palliative radiotherapy for cancer patients with interstitial lung disease: A physician's perspective (2022)
  • Author(s): Okumura M, Hojo H, Akimoto T
  • Journal Title: Radiother Oncol Volume: 169 Pages: 157-158
  • DOI: 10.1016/j.radonc.2022.02.003
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive screening for drugs that modify radiation-induced immune responses (2022)
  • Author(s): M. Okumura, J. Du, S.I. Kageyama*, R. Yamashita, Y. Hakozaki, A. Motegi, H. Hojo, M. Nakamura, Y. Hirano, Y. Okuma, H. Okuma, K. Tsuchihara, and T. Akimoto
  • Journal Title: British journal of Cancer Volume: - Issue: 12 Pages: 1815-1823
  • DOI: 10.1038/s41416-021-01688-0
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of the STING‐IFNAR1‐STAT1‐IRF1 pathway on the cellular immune reaction induced by fractionated irradiation (2022)
  • Author(s): Du Junyan、Kageyama Shun‐Ichiro、Yamashita Riu、Hirata Hidenari、Hakozaki Yumi、Okumura Masayuki、Motegi Atsushi、Hojo Hidehiro、Nakamura Masaki、Hirano Yasuhiro、Sunakawa Hironori、Minamide Tatsunori、Kotani Daisuke、Tanaka Kosuke、Yano Tomonori、Kojima Takashi、Ohashi Akihiro、Tsuchihara Katsuya、Akimoto Tetsuo
  • Journal Title: Cancer Science Volume: 113 Issue: 4 Pages: 1352-1361
  • DOI: 10.1111/cas.15297
  • Peer Reviewed / Open Access
• [Journal Article] Neoadjuvant S-1 With Concurrent Radiotherapy Followed by Surgery for Borderline Resectable Pancreatic Cancer: A Phase II Open-label Multicenter Prospective Trial (JASPAC05) (2022)
  • Author(s): Takahashi S, Ohno I, Ikeda M, Konishi M, Kobayashi T, Akimoto T, Kojima M, Morinaga S, Toyama H, Shimizu Y, Miyamoto A, Tomikawa M, Takakura N, Takayama W, Hirano S, Otsubo T, Nagino M, Kimura W, Sugimachi K, Uesaka K
  • Journal Title: Ann Surg Volume: 276 Issue: 5 Pages: e510-e517
  • DOI: 10.1097/sla.0000000000004535
  • Peer Reviewed
• [Journal Article] Comparative analysis of the immune responses in cancer cells irradiated with X-ray, proton and carbon-ion beams (2021)
  • Author(s): Du Junyan、Kageyama Shun-Ichiro、Hirata Hidenari、Motegi Atsushi、Nakamura Masaki、Hirano Yasuhiro、Okumura Masayuki、Yamashita Riu、Tsuchihara Katsuya、Hojo Hidehiro、Hirayama Ryoichi、Akimoto Tetsuo
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 585 Pages: 55-60
  • DOI: 10.1016/j.bbrc.2021.11.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy. (2021)
  • Author(s): Hirata H,...Masuda T, Saito T, Kageyama SI, Motomura Y, Ito S, Yoshitake T, Tsurumaru D, Nishimuta Y, Yokoyama A, Hasegawa T, Chiba K, Shiraishi Y, Du J, Miura F, Morita M, Toh Y, Hirakawa M, Shioyama Y, Ito T, Akimoto T, Miyano S, Shibata T, Mori M, Suzuki Y, Ogawa S, Ishigami K, Mimori K.
  • Journal Title: Cancer Res. Volume: 81(19) Issue: 19 Pages: 4926-4938
  • DOI: 10.1158/0008-5472.can-21-0653
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Radiation pneumonitis after palliative radiotherapy in cancer patients with interstitial lung disease (2021)
  • Author(s): Okumura Masayuki、Hojo Hidehiro、Nakamura Masaki、Hiyama Takashi、Nakamura Naoki、Zenda Sadamoto、Motegi Atsushi、Hirano Yasuhiro、Kageyama Shun-Ichiro、Parshuram Raturi Vijay、Fujisawa Takeshi、Kuno Hirofumi、Akimoto Tetsuo
  • Journal Title: Radiotherapy and Oncology Volume: 161 Pages: 47-54
  • DOI: 10.1016/j.radonc.2021.05.026
  • Peer Reviewed
• [Journal Article] Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines (2021)
  • Author(s): Mizumoto M, Fuji H, Miyachi M, Soejima T, Yamamoto T, Aibe N, Demizu Y, Iwata H, Hashimoto T, Motegi A, Kawamura A, Terashima K, Fukushima T, Nakao T, Takada A, Sumi M, Oshima J, Moriwaki K, et al
  • Journal Title: Cancer Treatment Reviews Volume: 98 Pages: 102209-102209
  • DOI: 10.1016/j.ctrv.2021.102209
  • NAID: 120007178941
  • Peer Reviewed / Open Access
• [Journal Article] Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin (2021)
  • Author(s): Komine R,Kojima M,Ishi G,Kudo M,Sugimoto M,Kobayashi S,Takahashi S,Konishi M,Kobayashi T,Akimoto T,Murakami A,Sasaki M,Tanaka M,Matsuzaki A,Ohike N,Uchida K,Sugiyama T,Hirabayashi K,Tajiri T,Ishida K,Kai K,Omori Y,Notohara K,Yamaguchi H,Matsuda Y,Naito Y,Fukumura Y,Hamada Y,Mihara Y, et al.
  • Journal Title: Cancer Medicine Volume: 10 Issue: 11 Pages: 3499-3510
  • DOI: 10.1002/cam4.3809
  • Peer Reviewed
• [Journal Article] Radial incision and cutting for dilation before endoscopic submucosal dissection in patients with esophageal cancer on the distal side of severe benign esophageal strictures (2021)
  • Author(s): Nakajo Keiichiro、Yoda Yusuke、Kadota Tomohiro、Murano Tatsuro、Shinmura Kensuke、Ikematsu Hiroaki、Akimoto Tetsuo、Yano Tomonori
  • Journal Title: Diseases of the Esophagus Volume: 34 Issue: 6
  • DOI: 10.1093/dote/doaa092
  • Peer Reviewed
• [Journal Article] Final analysis of a Multicenter Single-Arm Confirmatory Trial of hypofractionated whole breast irradiation after breast-conserving surgery in Japan: JCOG0906 (2021)
  • Author(s): Nozaki Miwako、Kagami Yoshikazu、Machida Ryunosuke、Nakamura Kenichi、Ito Yoshinori、Nishimura Yasumasa、Teshima Teruki、Saito Yoshihiro、Nagata Yasushi、Matsumoto Yasuo、Akimoto Tetsuo、Hiraoka Masahiro、Japan Clinical Oncology Group, Radiation Therapy Study Group
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 6 Pages: 865-872
  • DOI: 10.1093/jjco/hyab024
  • Peer Reviewed
• [Journal Article] Comparison of a Hybrid IMRT/VMAT technique with non-coplanar VMAT and non-coplanar IMRT for unresectable olfactory neuroblastoma using the RayStation treatment planning system?EUD, NTCP and planning study (2021)
  • Author(s): Raturi Vijay P、Motegi Atsushi、Zenda Sadamoto、Nakamura Naoki、Hojo Hidehiro、Kageyama Shin-Ichiro、Okumura Masayuki、Rachi Toshiya、Ohyoshi Hajime、Tachibana Hidenobu、Motegi Kana、Ariji Takaki、Nakamura Masaki、Hirano Yasuhiro、Hirata Hidenari、Akimoto Tetsuo
  • Journal Title: Journal of Radiation Research Volume: 62 Issue: 3 Pages: 540-548
  • DOI: 10.1093/jrr/rrab010
  • Peer Reviewed
• [Journal Article] Endoscopic resection combined with the Cryoballoon focal ablation system in the porcine normal esophagus: a preclinical study (2021)
  • Author(s): Sunakawa Hironori、Yoda Yusuke、Takeshita Nobuyoshi、Hasegawa Hiro、Takashima Kenji、Kadota Tomohiro、Fujita Takeo、Akimoto Tetsuo、Fujii Satoshi、Yano Tomonori
  • Journal Title: BMC Gastroenterology Volume: 21 Issue: 1 Pages: 234-234
  • DOI: 10.1186/s12876-021-01819-0
  • Peer Reviewed
• [Journal Article] Multi-Institutional Retrospective Analysis of the Outcomes of Proton Beam Therapy for Patients With 1 to 3 Pulmonary Oligometastases From Various Primary Cancers (2021)
  • Author(s): Aibe Norihiro、Ogino Hiroyuki、Teramukai Satoshi、Yamazaki Hideya、Iwata Hiromitsu、Matsuo Yoshiro、Okimoto Tomoaki、Murakami Masao、Suzuki Motohisa、Arimura Takeshi、Ogino Takashi、Murayama Shigeyuki、Harada Hideyuki、Nakamura Masaki、Akimoto Tetsuo、Sakurai Hideyuki
  • Journal Title: Advances in Radiation Oncology Volume: 6 Issue: 4 Pages: 100690-100690
  • DOI: 10.1016/j.adro.2021.100690
  • Peer Reviewed
• [Journal Article] 食道胃接合部癌に対する放射線治療 (2021)
  • Author(s): 秋元哲夫
  • Journal Title: 消化器内科 Volume: 3 Pages: 74-78
• [Journal Article] FOLFIRINOX in advanced pancreatic cancer patients with the double-variant type of UGT1A1 *28 and *6 polymorphism: a multicenter, retrospective study (2021)
  • Author(s): Umemoto Kumiko、Takahashi Hideaki、Morizane Chigusa、Yamada Ikuhiro、Shimizu Satoshi、Shioji Kazuhiko、Yoshida Yukio、Motoya Masayo、Mizuno Nobumasa、Kojima Yasushi、Terashima Takeshi、Uesugi Kazuhiro、Ueno Makoto、Furuse Junji、Akimoto Tetsuo、Ikeda Masafumi
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 87 Issue: 3 Pages: 397-404
  • DOI: 10.1007/s00280-020-04206-w
  • Peer Reviewed / Open Access
• [Journal Article] Identification of the mutation signature of the cancer genome caused by irradiation (2021)
  • Author(s): Kageyama Shun-Ichiro、Du Junyan、Kaneko Syuzo、Hamamoto Ryuji、Yamaguchi Shigeo、Yamashita Riu、Okumura Masayuki、Motegi Atsushi、Hojo Hidehiro、Nakamura Masaki、Tsuchihara Katsuya、Akimoto Tetsuo
  • Journal Title: Radiotherapy and Oncology Volume: 155 Pages: 10-16
  • DOI: 10.1016/j.radonc.2020.10.020
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma (2020)
  • Author(s): Sunakawa Hironori、Hori Keisuke、Kadota Tomohiro、Shinmura Kensuke、Yoda Yusuke、Ikematsu Hiroaki、Tomioka Toshifumi、Akimoto Tetsuo、Hayashi Ryuichi、Fujii Satoshi、Yano Tomonori
  • Journal Title: Esophagus Volume: 18 Issue: 1 Pages: 111-117
  • DOI: 10.1007/s10388-020-00754-5
  • NAID: 40022455060
• [Journal Article] Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck (2020)
  • Author(s): Okano Susumu、Homma Akihiro、Kiyota Naomi、Tahara Makoto、Hanai Nobuhiro、Asakage Takahiro、Matsuura Kazuto、Ogawa Takenori、Saito Yuki、
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 2 Pages: 173-179
  • DOI: 10.1093/jjco/hyaa220
  • Peer Reviewed
• [Journal Article] Dose?Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis (2020)
  • Author(s): Raturi Vijay P.、Tochinai Taku、Hojo Hidehiro、Rachi Toshiya、Hotta Kenji、Nakamura Naoki、Zenda Sadamoto、Motegi Atsushi、Ariji Takaki、Hirano Yasuhiro、Baba Hiromi、Ohyoshi Hajime、Nakamura Masaki、Okumura Masayuki、Bei Yanping、Akimoto Tetsuo
  • Journal Title: Frontiers in Oncology Volume: 10 Pages: 517061-517061
  • DOI: 10.3389/fonc.2020.517061
  • Peer Reviewed
• [Journal Article] Distinction of surgically resected gastrointestinal stromal tumor by near-infrared hyperspectral imaging (2020)
  • Author(s): Sato Daiki、Takamatsu Toshihiro、Umezawa Masakazu、Kitagawa Yuichi、Maeda Kosuke、Hosokawa Naoki、Okubo Kyohei、Kamimura Masao、Kadota Tomohiro、Akimoto Tetsuo、Kinoshita Takahiro、Yano Tomonori、Kuwata Takeshi、Ikematsu Hiroaki、Takemura Hiroshi、Yokota Hideo、Soga Kohei
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 21852-21852
  • DOI: 10.1038/s41598-020-79021-7
  • Peer Reviewed / Open Access
• [Journal Article] Neoadjuvant S-1 With Concurrent Radiotherapy Followed by Surgery for Borderline Resectable Pancreatic Cancer: A Phase II Open-Label Multicenter Prospective Trial (JASPAC05) (2020)
  • Author(s): Takahashi S, Ohno I, Ikeda M, Konishi M, Kobayashi T, Akimoto T, Kojima M, Morinaga S, Toyama H, Shimizu Y, Miyamoto A, Tomikawa M, Takakura N, Takayama W, Hirano S, Otsubo T, Nagino M, Kimura W, Sugimachi K, Uesaka K
  • Journal Title: Ann Surg Volume: -
  • Peer Reviewed
• [Journal Article] Real-world clinical outcomes and prognostic factors in Japanese patients with recurrent or metastatic squamous cell carcinoma of head and neck treated with chemotherapy plus cetuximab: a prospective observation study (JROSG12-2) (2020)
  • Author(s): Yokota Tomoya、Ota Yosuke、Fujii Hirofumi、Kodaira Takeshi、Shimokawa Mototsugu、Nakashima Torahiko、Monden Nobuya、Homma Akihiro、Ueda Shinya、Akimoto Tetsuo
  • Journal Title: International Journal of Clinical Oncology Volume: 26 Issue: 2 Pages: 316-325
  • DOI: 10.1007/s10147-020-01817-4
  • Peer Reviewed
• [Journal Article] Morphological, immune and genetic features in biopsy sample associated with the efficacy of pembrolizumab in patients with non-squamous non-small cell lung cancer (2020)
  • Author(s): Sakai Tetsuya、Udagawa Hibiki、Matsumoto Shingo、Yoh Kiyotaka、Nosaki Kaname、Ikeda Takaya、Zenke Yoshitaka、Kirita Keisuke、Niho Seiji、Akimoto Tetsuo、Goto Koichi、Ishii Genichiro
  • Journal Title: Journal of Cancer Research and Clinical Oncology Volume: 147 Issue: 4 Pages: 1227-1237
  • DOI: 10.1007/s00432-020-03413-5
  • Peer Reviewed
• [Journal Article] Diagnostic Value of Model-Based Iterative Reconstruction Combined with a Metal Artifact Reduction Algorithm during CT of the Oral Cavity (2020)
  • Author(s): Kubo Y.、Ito K.、Sone M.、Nagasawa H.、Onishi Y.、Umakoshi N.、Hasegawa T.、Akimoto T.、Kusumoto M.
  • Journal Title: American Journal of Neuroradiology Volume: 41 Issue: 11 Pages: 2132-2138
  • DOI: 10.3174/ajnr.a6767
  • Peer Reviewed
• [Journal Article] Radial incision and cutting for dilation before endoscopic submucosal dissection in patients with esophageal cancer on the distal side of severe benign esophageal strictures (2020)
  • Author(s): Nakajo K, Yoda Y, Kadota T, Murano T, Shinmura K, Ikematsu H, Akimoto T, Yano T
  • Journal Title: Dis Esophagus Volume: -
  • Peer Reviewed
• [Journal Article] Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation. (2020)
  • Author(s): Masayuki Okumura, Atsushi Motegi, Sadamoto Zenda, Naoki Nakamura, Hidehiro Hojo, Masaki Nakamura, Yasuhiro Hirano, Shun-Ichiro Kageyama, Satoko Arahira, Raturi Vijay Parshuram, Hirofumi Kuno, Ryuichi Hayashi, Makoto Tahara, Yoshiyuki Itoh , Shinji Naganawa, Tetsuo Akimoto
  • Journal Title: Head Neck. Volume: - Issue: 8 Pages: 1775-1782
  • DOI: 10.1002/hed.26092
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of radiofrequency ablation and stereotactic body radiation therapy for colorectal liver metastasis as local therapies for elderly, vulnerable patients (2020)
  • Author(s): Gotohda Naoto、Nomura Shogo、Doi Manami、Karasawa Katsuyuki、Ohki Takamasa、Shimizu Yasuhiro、Inaba Yoshitaka、Takeda Atsuya、Takaki Haruyuki、Anai Hiroshi、Ikeda Masafumi、Sugimoto Motokazu、Akimoto Tetsuo
  • Journal Title: JGH Open Volume: 4 Issue: 4 Pages: 722-728
  • DOI: 10.1002/jgh3.12325
  • Peer Reviewed
• [Journal Article] Improved efficacy of taxanes and ramucirumab combination chemotherapy after exposure to anti-PD-1 therapy in advanced gastric cancer (2020)
  • Author(s): Sasaki Akinori、Kawazoe Akihito、Eto Testuya、Okunaka Mashiro、Mishima Saori、Sawada Kentaro、Nakamura Yoshiaki、Kotani Daisuke、Kuboki Yasutoshi、Taniguchi Hiroya、Kojima Takashi、Doi Toshihiko、Yoshino Takayuki、Akimoto Tetsuo、Shitara Kohei
  • Journal Title: ESMO Open Volume: 5 Issue: 4 Pages: e000775-e000775
  • DOI: 10.1136/esmoopen-2020-000775
  • Peer Reviewed
• [Journal Article] Optimal Androgen Deprivation Therapy Combined with Proton Beam Therapy for Prostate Cancer: Results from a Multi-Institutional Study of the Japanese Radiation Oncology Study Group (2020)
  • Author(s): Murakami Motohiro、Ishikawa Hitoshi、Shimizu Shosei、Iwata Hiromitsu、Okimoto Tomoaki、Takagi Masaru、Murayama Shigeyuki、Akimoto Tetsuo、Wada Hitoshi、Arimura Takeshi、Sato Yoshitaka、Gosho Masahiko、Nakamura Katsumasa、Sakurai Hideyuki
  • Journal Title: Cancers Volume: 12 Issue: 6 Pages: 1690-1690
  • DOI: 10.3390/cancers12061690
  • NAID: 120007159547
  • Peer Reviewed / Open Access
• [Journal Article] Radiobiological model-based approach to determine the potential of dose-escalated robust intensity-modulated proton radiotherapy in reducing gastrointestinal toxicity in the treatment of locally advanced unresectable pancreatic cancer of the head (2020)
  • Author(s): Raturi Vijay P.、Hojo Hidehiro、Hotta Kenji、Baba Hiromi、Takahashi Ryo、Rachi Toshiya、Nakamura Naoki、Zenda Sadamoto、Motegi Atsushi、Tachibana Hidenobu、Ariji Takaki、Motegi Kana、Nakamura Masaki、Okumura Masayuki、Hirano Yasuhiro、Akimoto Tetsuo
  • Journal Title: Radiation Oncology Volume: 15 Issue: 1 Pages: 157-157
  • DOI: 10.1186/s13014-020-01592-6
  • Peer Reviewed
• [Journal Article] Review of early endoscopic findings in patients with local recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma (2020)
  • Author(s): Yamamoto Yoichi、Kadota Tomohiro、Yoda Yusuke、Hori Keisuke、Hatogai Ken、Kojima Takashi、Fujii Satoshi、Akimoto Tetsuo、Yano Tomonori
  • Journal Title: Esophagus Volume: 17 Issue: 4 Pages: 433-439
  • DOI: 10.1007/s10388-020-00734-9
  • NAID: 40022353359
  • Peer Reviewed
• [Journal Article] A phase II study of adaptive two-step intensity-modulated radiation therapy (IMRT) with chemotherapy for loco-regionally advanced nasopharyngeal cancer (JCOG1015) (2020)
  • Author(s): Nishimura Y, Ishikura S, Shibata T, Kodaira T, Ito Y, Tsuchiya K, Murakami Y, Saitoh JI, Akimoto T, Nakata K, Yoshimura M, Teshima T, Toshiyasu T, Ota Y, Ishikawa K, Shimizu H, Minemura T, Nakamura K, Hiraoka M
  • Journal Title: International Journal of Clinical Oncology Volume: 25 Issue: 7 Pages: 1250-1259
  • DOI: 10.1007/s10147-020-01665-2
  • Peer Reviewed
• [Journal Article] End-to-end delivery quality assurance of computed tomography-based high-dose-rate brachytherapy using a gel dosimeter (2020)
  • Author(s): Tachibana Hidenobu、Watanabe Yusuke、Mizukami Shinya、Maeyama Takuya、Terazaki Tsuyoshi、Uehara Ryuzo、Akimoto Tetsuo
  • Journal Title: Brachytherapy Volume: － Issue: 3 Pages: 362-371
  • DOI: 10.1016/j.brachy.2020.02.002
  • Peer Reviewed
• [Journal Article] Enhanced Tumor Response to Radiotherapy After PD-1 Blockade in Metastatic Gastric Cancer (2020)
  • Author(s): Sasaki A, Nakamura Y, Togashi Y, Kuno H, Hojo H, Kageyama S, Nakamura N, Takashima K, Kadota T, Yoda Y, Mishima S, Sawada K, Kotani D, Kawazoe A, Kuboki Y, Taniguchi H, Kojima T, Doi T, Yoshino T, Yano T, Kobayashi T, Akimoto T, Nishikawa H, Shitara K.
  • Journal Title: Gastric Cancer Volume: - Issue: 5 Pages: 893-903
  • DOI: 10.1007/s10120-020-01058-4
  • NAID: 40022329655
  • Peer Reviewed
• [Journal Article] The “histological replacement growth pattern” represents aggressive invasive behavior in liver metastasis from pancreatic cancer (2020)
  • Author(s): Watanabe Kazuo、Mitsunaga Shuichi、Kojima Motohiro、Suzuki Hidetaka、Irisawa Ai、Takahashi Hideaki、Sasaki Mitsuhito、Hashimoto Yusuke、Imaoka Hiroshi、Ohno Izumi、Ikeda Masafumi、Akimoto Tetsuo、Ochiai Atsushi
  • Journal Title: Cancer Medicine Volume: 9 Issue: 9 Pages: 3130-3141
  • DOI: 10.1002/cam4.2954
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic results of proton beam therapy with concurrent chemotherapy for cT1 esophageal cancer and salvage endoscopic therapy for local recurrence (2020)
  • Author(s): Sato Daiki、Motegi Atsushi、Kadota Tomohiro、Kojima Takashi、Bando Hideaki、Shinmura Kensuke、Hori Keisuke、Yoda Yusuke、Oono Yasuhiro、Zenda Sadamoto、Ikematsu Hiroaki、Akimoto Tetsuo、Yano Tomonori
  • Journal Title: Esophagus Volume: 17 Issue: 3 Pages: 305-311
  • DOI: 10.1007/s10388-020-00715-y
  • NAID: 40022275933
  • Peer Reviewed
• [Journal Article] 強度変調放射線治療 (2020)
  • Author(s): 秋元哲夫
  • Journal Title: 泌尿器外科 Volume: 33 Pages: 1397-1400
  • Peer Reviewed
• [Journal Article] 陽子線棟 (2020)
  • Author(s): 秋元哲夫
  • Journal Title: 泌尿器外科 Volume: 33 Pages: 1406-1411
  • Peer Reviewed
• [Journal Article] III期非小細胞肺癌に対するIMRTおよびVMATの有効性 (2020)
  • Author(s): 秋元哲夫
  • Journal Title: インナービジョン 35 Volume: 11 Pages: 72-73
  • Peer Reviewed
• [Journal Article] 肉腫に対する陽子線治療 (2020)
  • Author(s): 秋元哲夫
  • Journal Title: 日本臨床 Volume: 78 Pages: 511-518
  • Peer Reviewed
• [Journal Article] 高リスク前立腺癌に対する粒子線治療の現状と可能性 (2020)
  • Author(s): 秋元哲夫
  • Journal Title: 泌尿器外科 Volume: 33 Pages: 707-709
  • Peer Reviewed
• [Journal Article] 陽子線治療がSturge-Weber症候群に伴うびまん性滲出性網膜剥離に有効であった1例 (2020)
  • Author(s): 大原裕美、湯浅勇生、平田潤子、山根 健、秋元哲夫、永田 靖、木内良明
  • Journal Title: 日本眼科学会雑誌 Volume: 124 Pages: 432-440
  • Peer Reviewed
• [Journal Article] 陽子線治療の技術的な進歩と可能性-強度変調陽子線治療を中心に- (2020)
  • Author(s): 秋元哲夫
  • Journal Title: ライフライン21 がんの先進医療 Volume: 36 Pages: 14-17
  • Peer Reviewed
• [Journal Article] Impact of intraoperative indocyanine green fluorescence angiography on anastomotic leakage after laparoscopic sphincter-sparing surgery for malignant rectal tumors. (2020)
  • Author(s): Hasegawa H, Tsukada Y, Wakabayashi M, Nomura S, Sasaki T, Nishizawa Y, Ikeda K, Akimoto T, Ito M.
  • Journal Title: Int J Colorectal Dis. Volume: 35 Issue: 3 Pages: 3-3
  • DOI: 10.1007/s00384-019-03490-0
• [Journal Article] Proton Beam Therapy for Histologically or Clinically Diagnosed Stage I Non-Small Cell Lung Cancer (NSCLC): The First Nationwide Retrospective Study in Japan (2020)
  • Author(s): Ohnishi Kayoko、Nakamura Naoki、Harada Hideyuki、Tokumaru Sunao、Wada Hitoshi、Arimura Takeshi、Iwata Hiromitsu、Sato Yoshitaka、Sekino Yuta、Tamamura Hiroyasu、Mizoe Jun-etsu、Ogino Takashi、Ishikawa Hitoshi、Kikuchi Yasuhito、Okimoto Tomoaki、Murayama Shigeyuki、Akimoto Tetsuo、Sakurai Hideyuki
  • Journal Title: International Journal of Radiation Oncology*Biology*Physics Volume: 106 Issue: 1 Pages: 82-89
  • DOI: 10.1016/j.ijrobp.2019.09.013
  • NAID: 120007132698
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Proton Beam Irradiation of an Anatomic Subsegment of the Liver for Hepatocellular Carcinoma (2019)
  • Author(s): Hojo Hidehiro、Raturi Vijay、Nakamura Naoki、Arahira Satoko、Akita Tsunemichi、Mitsunaga Shuichi、Nakamura Masaki、Motegi Atsushi、Kageyama Shun-ichiro、Zenda Sadamoto、Okumura Masayuki、Ikeda Masafumi、Akimoto Tetsuo
  • Journal Title: Practical Radiation Oncology Volume: S1879-8500 Issue: 4 Pages: 30276-0
  • DOI: 10.1016/j.prro.2019.09.012
• [Journal Article] Nutritional support dependence after curative chemoradiotherapy in head and neck cancer: supplementary analysis of a phase II trial (JCOG0706S1) (2019)
  • Author(s): Imamura Yoshinori、Kiyota Naomi、Ogawa Gakuto、Akimoto Tetsuo、Fujii Masato、Hanai Nobuhiro、Iwae Shigemichi、Monden Nobuya、Matsuura Kazuto、Onozawa Yusuke、Hayashi Ryuichi、Tahara Makoto、Minami Shujiro、Eba Junko、Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 11 Pages: 1009-1015
  • DOI: 10.1093/jjco/hyz121
• [Journal Article] Phase II feasibility study of preoperative concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil and elective lymph node irradiation for clinical stage II/III esophageal squamous cell carcinoma. (2019)
  • Author(s): Hashimoto J, Kato K, Ito Y, Kojima T, Akimoto T, Daiko H, Hamamoto Y, Matsushita H, Katano S, Hara H, Tanaka Y, Saito Y, Nagashima K, Igaki H.
  • Journal Title: Int J Clin Oncol. Volume: 24 Issue: 1 Pages: 60-67
  • DOI: 10.1007/s10147-018-1336-x
• [Journal Article] Expression of Monocarboxylate Transporter 1 Is Associated With Better Prognosis and Reduced Nodal Metastasis in Pancreatic Ductal Adenocarcinoma (2019)
  • Author(s): Sukeda Aoi、Nakamura Yuka、Nishida Yasunori、Kojima Motohiro、Gotohda Naoto、Akimoto Tetsuo、Ochiai Atsushi
  • Journal Title: Pancreas Volume: 48 Issue: 8 Pages: 1102-1110
  • DOI: 10.1097/mpa.0000000000001369
• [Journal Article] HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer (2019)
  • Author(s): Kaito Akio、Kuwata Takeshi、Tokunaga Masanori、Shitara Kohei、Sato Reo、Akimoto Tetsuo、Kinoshita Takahiro
  • Journal Title: World Journal of Clinical Cases Volume: 7 Issue: 15 Pages: 1964-1977
  • DOI: 10.12998/wjcc.v7.i15.1964
• [Journal Article] Extra-perigastric Extranodal Metastasis is a Significant Prognostic Factor in Node-Positive Gastric Cancer. (2019)
  • Author(s): Tonouchi A, Sugano M, Tokunaga M, Sugita S, Watanabe M, Sato R, Kaito A, Akimoto T, Ochiai A, Kinoshita T, Kuwata T.
  • Journal Title: World J Surg. Volume: 43 Issue: 10 Pages: 2499-2505
  • DOI: 10.1007/s00268-019-05076-x
• [Journal Article] Frequency and predictors of detecting early locoregional recurrence/disease progression of oral squamous cell carcinoma with high-risk factors on imaging tests before postoperative adjuvant radiotherapy. (2019)
  • Author(s): Kibe Y, Nakamura N, Kuno H, Hiyama T, Hayashi R, Zenda S, Motegi A, Hojo H, Nakamura M, Ariji T, Oyoshi H, Akimoto T.
  • Journal Title: Int J Clin Oncol. Volume: 24 Issue: 10 Pages: 1182-1189
  • DOI: 10.1007/s10147-019-01479-x
  • Peer Reviewed
• [Journal Article] A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition) (2019)
  • Author(s): Head and Neck Cancer Study Group、Monden N、Asakage T、Kiyota N、Homma A、Matsuura K、Hanai N、Kodaira Ti、Zenda S、Fujii H、Tahara M、Yokota T、Akimoto T、Iwae S、Onitsuka T、Ogawa T、Okano S、Takahashi S、Shimizu Y、Yonezawa K、Hayashi R
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 7 Pages: 589-595
  • DOI: 10.1093/jjco/hyz052
  • Peer Reviewed
• [Journal Article] Liver phantom design and dosimetric verification in participating institutions for a proton beam therapy in patients with resectable hepatocellular carcinoma: Japan Clinical Oncology Group trial (JCOG1315C) (2019)
  • Author(s): Nishio T, Tachibana H, Kase Y, Hotta K, Nakamura M, Tamura M, Terunuma T, Toshito T, Yamashita H, Ishikura S, Fuji H, Akimoto T, Nishimura Y.
  • Journal Title: Radiother Oncol. Volume: 29 Pages: 98-104
  • DOI: 10.1016/j.radonc.2019.06.005
  • Peer Reviewed
• [Journal Article] Hypofractionated proton beam therapy for centrally located lung cancer. (2019)
  • Author(s): Nakamura N, Hotta K, Zenda S, Baba H, Kito S, Akita T, Motegi A, Hojo H, Nakamura M, Parshuram RV, Okumura M, Akimoto T.
  • Journal Title: J Med Imaging Radiat Oncol. Volume: 63 Issue: 4 Pages: 552-556
  • DOI: 10.1111/1754-9485.12901
• [Journal Article] National survey on total-body irradiation prior to reduced-intensity stem cell transplantation in Japan: The Japanese Radiation Oncology Study Group. (2019)
  • Author(s): Kawaguchi H, Soejima T, Ishibashi N, Akiba T, Hasegawa M, Isobe K, Ito H, Imai M, Ejima Y, Hata M, Sasai K, Shimoda E, Oguchi M, Akimoto T; Japanese Radiation Oncology Study Group.
  • Journal Title: J Radiat Res. Volume: 60 Issue: 5 Pages: 509-516
  • DOI: 10.1093/jrr/rrz028
• [Journal Article] Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey. (2019)
  • Author(s): Akamatsu H, Nakamura K, Ebara T, Inaba K, Itasaka S, Jingu K, Kosaka Y, Murai T, Nagata K, Soejima T, Takahashi S, Toyoda T, Toyoshima S, Nemoto K, Akimoto T.
  • Journal Title: J Radiat Res. Volume: 60 Issue: 4 Pages: 509-516
  • DOI: 10.1093/jrr/rrz018
  • Peer Reviewed / Open Access
• [Journal Article] Impact of EGFR Mutation and ALK Translocation on Recurrence Pattern After Definitive Chemoradiotherapy for Inoperable Stage III Non-squamous Non-small-cell Lung Cancer. (2019)
  • Author(s): Nakamura M, Kageyama SI, Niho S, Okumura M, Hojo H, Motegi A, Nakamura N, Zenda S, Yoh K, Goto K, Akimoto T.
  • Journal Title: Clin Lung Cancer. Volume: printing Issue: 3 Pages: e256-e264
  • DOI: 10.1016/j.cllc.2019.02.021
  • Peer Reviewed
• [Journal Article] Carboplatin, S-1 and concurrent thoracic radiotherapy for elderly patients with locally advanced non-small cell lung cancer: a multicenter Phase I/II study (2019)
  • Author(s): Niho Seiji、Hosomi Yukio、Okamoto Hiroaki、Nihei Keiji、Tanaka Hiroshi、Hida Toyoaki、Umemura Shigeki、Goto Koichi、Akimoto Tetsuo、Ohe Yuichiro
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 7 Pages: 614-619
  • DOI: 10.1093/jjco/hyz039
• [Journal Article] Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps. (2019)
  • Author(s): Takashima K, Oono Y, Kojima M, Ikematsu H, Akimoto T, Yano T.
  • Journal Title: Endosc Int Open Volume: 7 Issue: 03 Pages: E330-E336
  • DOI: 10.1055/a-0820-2179
  • Peer Reviewed / Open Access
• [Journal Article] Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer. (2019)
  • Author(s): Okano S, Enokida T, Onoe T, Ota Y, Motegi A, Zenda S, Akimoto T, Tahara M.
  • Journal Title: Int J Clin Oncol. Volume: 24 Issue: 7 Pages: 789-797
  • DOI: 10.1007/s10147-019-01418-w
• [Journal Article] Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak. (2019)
  • Author(s): Hojo H, Dohmae T, Hotta K, Kageyama SI, Baba H, Kohno R, Motegi A, Tsuchihara K, Akimoto T.
  • Journal Title: Acta Oncol Volume: 58(4) Issue: 4 Pages: 475-482
  • DOI: 10.1080/0284186x.2018.1555373
  • Peer Reviewed
• [Journal Article] Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer. (2019)
  • Author(s): Sasaki A, Nakamura Y, Mishima S, Kawazoe A, Kuboki Y, Bando H, Kojima T, Doi T, Ohtsu A, Yoshino T, Kuwata T, Akimoto T, Shitara K.
  • Journal Title: Gastric Cancer. Volume: 22 Issue: 4 Pages: 793-802
  • DOI: 10.1007/s10120-018-00922-8
  • NAID: 40021925994
  • Peer Reviewed
• [Journal Article] A primary analysis of a multicenter, prospective, single-arm, confirmatory trial of hypofractionated whole breast irradiation after breast-conserving surgery in Japan: JCOG0906. (2019)
  • Author(s): Nozaki M, Kagami Y, Shibata T, Nakamura K, Ito Y, Nishimura Y, Kawaguchi Y, Saito Y, Nagata Y, Matsumoto Y, Akimoto T, Hiraoka M; Radiation Therapy Study Group, Japan Clinical Oncology Group.
  • Journal Title: Jpn J Clin Oncol Volume: 49 Issue: 1 Pages: 57-62
  • DOI: 10.1093/jjco/hyy160
  • Peer Reviewed
• [Journal Article] Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2) (2019)
  • Author(s): Matsuzuka Takashi、Kiyota Naomi、Mizusawa Junki、Akimoto Tetsuo、Fujii Masato、Hasegawa Yasuhisa、Iwae Shigemichi、Monden Nobuya、Matsuura Kazuto、Onozawa Yusuke、Hayashi Ryuichi、Tahara Makoto、Japan Clinical Oncology Group(JCOG) Head and Neck Cancer Study Group
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 1 Pages: 37-41
  • DOI: 10.1093/jjco/hyy145
  • Peer Reviewed / Open Access
• [Journal Article] 陽子線治療 肝細胞がん. (2019)
  • Author(s): 秋元哲夫
  • Journal Title: 先進医療NAVIGATOR がん先進医療の最前線 Volume: B42 Pages: 55-58
• [Journal Article] 頭頸部癌領域の粒子線治療の適応 (2019)
  • Author(s): 秋元哲夫
  • Journal Title: 日本耳鼻咽喉科学会誌 Volume: 122 Pages: 246-248
  • NAID: 130007629711
• [Journal Article] Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy (2018)
  • Author(s): Motegi Kana、Tachibana Hidenobu、Motegi Atsushi、Hotta Kenji、Baba Hiromi、Akimoto Tetsuo
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 20 Issue: 1 Pages: 229-236
  • DOI: 10.1002/acm2.12515
  • Peer Reviewed / Open Access
• [Presentation] 肺腺癌の髄膜播種に対する全脳照射後の臨床結果に影響する予後因子の検討 (2022)
  • Author(s): 大吉秀和, 平田秀成, 平野靖弘, 全田貞幹, 藤澤建志, 中村匡希, 北條秀博, 茂木厚, 影山俊一郎, 富澤建斗, 周宇政, 秋元哲夫
  • Organizer: 日本放射線腫瘍学会第35回学術大会
• [Presentation] Prognosis After Whole-brain Radiotherapy for Leptomeningeal Metastasis in Patients With Lung Adenocarcinoma With or Without EGFR/ALK Alterations (2022)
  • Author(s): Hidekazu Oyoshi, Hidenari Hirata, Yasuhiro Hirano, Sadamoto Zenda, Takeshi Fujisawa, Masaki Nakamura, Hidehiro Hojo, Atsushi Motegi, Shun-ichiro Kageyama, Tetsuo Akimoto
  • Organizer: ASTRO's 64th Annual Meeting
  • Int'l Joint Research
• [Presentation] 患者と共有して決める食道がん治療法の今 (2022)
  • Author(s): 秋元哲夫
  • Organizer: 第60回日本癌治療学会スポンサードシンポジウム
• [Presentation] 放射線治療を含むがん治療抵抗性をもたらす遺伝子異常の同定と抵抗性克服を目指すトランスレーショナルリサーチ (2022)
  • Author(s): 平田秀成, 三森功士、秋元哲夫
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] Genetic intratumor heterogeneity and clonal evolution in cancers treated with radiotherapy (2022)
  • Author(s): Hidenari Hirata, Tetsuo Akimoto, Koshi Mimori
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] 化学放射線療法へ抵抗性を示す食道扁平上皮がんゲノムのクローン進化 (2022)
  • Author(s): 平田秀成, 三森功士、秋元哲夫
  • Organizer: 第76回日本食道学会学術集会
• [Presentation] がん免疫応答におけるX線、陽子線、重粒子線の比較解析 (2022)
  • Author(s): 北條 秀博, 杜 君顔, 影山 俊一郎, 平山亮一, 茂木 厚, 中村 匡希, 平田 秀成, 土原 一哉, 秋元 哲夫
  • Organizer: 第59回日本放射線腫瘍学会生物部会学術大会
• [Presentation] 放射線誘導がん免疫応答を修飾する薬剤のHigh Throughput Screening (2022)
  • Author(s): 奥村 真之, 杜 君顔, 影山 俊一郎, 山下 理宇, 茂木 厚, 北條 秀博, 中村 匡希, 大熊 裕介, 大熊 ひとみ, 土原 一哉, 秋元 哲夫
  • Organizer: 第59回日本放射線腫瘍学会生物部会学術大会
• [Presentation] Transposal Elements-RNA virus sensorを介した放射線誘導がん免疫応答の制御 (2022)
  • Author(s): 杜 君顔, 影山 俊一郎, 山下 理宇, 奥村 真之, 茂木 厚, 北條 秀博, 中村 匡希, 平田 秀成, 鈴木 絢子, 鈴木 穣, 土原 一哉, 秋元 哲夫
  • Organizer: 第59回日本放射線腫瘍学会生物部会学術大会
• [Presentation] 1細胞解析(scRNA sequencing)、空間的transcriptome(VISIUM)を用いた放射線治療後のがん微小環境変化解析への試み (2022)
  • Author(s): 影山 俊一郎, 杜 君顔, 山下 理宇, 奥村 真之, 茂木 厚, 北條 秀博, 中村 匡希, 平田 秀成, 鈴木 絢子, 鈴木 穣, 土原 一哉, 秋元 哲夫
  • Organizer: 第59回日本放射線腫瘍学会生物部会学術大会, 2022/6/24
• [Presentation] Parotid Cancer on Molecular Biology Advances in radiation therapy for parotid cancer (2022)
  • Author(s): 秋元哲夫
  • Organizer: the 14th International Facial Nerve Symposium (IFNS 2022)
• [Presentation] 頭頸部強度変調放射線治療における臓器特異的耐容線量の解明(JCOG1015A1) (2021)
  • Author(s): 稲田正浩、西村恭昌、石川一樹、村上直也、石倉聡、古平毅、伊藤芳紀、土屋和彦、村上祐司、齋藤 淳一、秋元 哲夫、峯村 俊行
  • Organizer: 日本医学放射線学会第34回学術大会(WEB開催)
• [Presentation] Comprehensive screening for drugs that modify radiation-induced immune responses (2021)
  • Author(s): Masayuki Okumura, Junyan Du, Shun-Ichiro Kageyama, Riu Yamashita, Atsushi Motegi, Hidehiro Hojo, Masaki Nakamura, Yasuhiro Hirano, Yusuke Okuma, Hitomi S Okuma, Katsuya Tsuchihara, Akimoto Tetsuo
  • Organizer: ESTRO(ONLINE)
  • Int'l Joint Research
• [Presentation] 局所進行頭頸部癌に対する強度変調陽子線治療の可能性 (2021)
  • Author(s): 秋元 哲夫
  • Organizer: 第45回日本頭頚部癌学会(WEB開催),
• [Presentation] 体幹部定位放射線治療の現状と可能性 (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第29回日本定位放射線治療学会ウェブセミナー(WEB開催)
• [Presentation] PACIFICレジメンにおける根治の可能性～照射工夫編～ (2020)
  • Author(s): 秋元哲夫
  • Organizer: Virtual Radiation Oncology Conference (WEB開催)
• [Presentation] HalcyonTM Update (2020)
  • Author(s): 秋元哲夫
  • Organizer: 日本放射線腫瘍学会第33回学術大会(WEB開催)
• [Presentation] Radiation Oncology in esophageal cancer (2020)
  • Author(s): 秋元哲夫
  • Organizer: Taiwan Esophageal Cancer Forum 2020 (WEB開催)
  • Int'l Joint Research
• [Presentation] 放射線治療に関する臨床研究推進におけるJROSGの役割と意義 (2020)
  • Author(s): 秋元哲夫
  • Organizer: 日本放射線腫瘍学会第33回学術大会(WEB開催)
• [Presentation] 前立腺癌放射線治療 (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第58回日本癌治療学会学術集会(WEB開催)
• [Presentation] AGREEⅡによる評価の概略 (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第58回日本癌治療学会学術集会(WEB開催)
• [Presentation] 頭頸部がんに対する粒子線治療 ～適応と今後の可能性～ (2020)
  • Author(s): 秋元哲夫
  • Organizer: Japan Cancer Forum 2020 (WEB開催)
• [Presentation] 放射線科における医師主導治験についてのノウハウ (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第56回日本医学放射線学会秋季臨床大会(WEB開催)
• [Presentation] Novel drugs in combination with RT for head and neck cancer (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第18回日本臨床腫瘍学会学術集会(WEB開催)
• [Presentation] New Normal時代の放射線腫瘍学 (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第19回九州放射線治療システム研究会(WEB開催)
• [Presentation] Updated Information from Medical Physics Group of Kyoto University (2020)
  • Author(s): 秋元哲夫
  • Organizer: 第34回高精度放射線外部照射部会学術大会バリアン共催セミナー(WEB開催)
• [Presentation] 頭頸部癌に対する粒子線治療の進歩と可能性 (2019)
  • Author(s): 石川一樹，古平 毅，秋元哲夫，清田尚臣，石倉 聡
  • Organizer: 第43回日本頭頸部癌学会
• [Presentation] Clinical Efficacy of Proton beam therapy (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第1回日中先進医療技術フォーラム
  • Invited
• [Presentation] Technical Advancement of Proton beam therapy and Radiotherapeutic technique (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第1回日中先進医療技術フォーラム
  • Invited
• [Presentation] Current status and future direction of proton beam therapy in Japan (2019)
  • Author(s): 秋元哲夫
  • Organizer: THE 19th ANNUAL NATIONAL CANCER CONTROL CONFERENCE
• [Presentation] 救済外科療法困難な症例に対する放射線治療 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第17回日本臨床腫瘍学会学術集会
• [Presentation] 頭頸部癌における粒子線治療の役割 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 日本頭頸部外科学会 第8回教育セミナー
• [Presentation] Phase I dose-escalation trial of proton beam therapy with concurrent full-dose chemotherapy for patients with cStage IB/Ⅱ/Ⅲ(non-T4) esophageal squamous cell carcinoma (2019)
  • Author(s): Akimoto T, Kojima T, Hojo H, Onozawa M, Okumura M, Nakamura M, Motegi A, Hotta K, Baba H, Zenda S, Fujita T, Nakamura N, Daiko H
  • Organizer: 61st ASTRO Annual meeting
  • Int'l Joint Research
• [Presentation] Single nucleotide polymorphism (SNP) as a predictive factor for radiation-induced toxicities (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 放射線治療効果の増強を目指した基礎・橋渡し・臨床研究 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 日本放射線影響学会第62回大会
• [Presentation] 高リスク前立腺癌に対する粒子線治療 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第84回日本泌尿器学会東部総会
  • Invited