Predicting therapeutic efficacy and liver failure of molecular targeted therapy for hepatocellular carcinoma using CT with blood flow and tissue analysis.

• Project/Area Number: 19K08199
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kobe University
• Principal Investigator: Murakami Takamichi 神戸大学, 医学研究科, 教授 (20252653)
• Co-Investigator(Kenkyū-buntansha): 鶴崎 正勝 近畿大学, 大学病院, 准教授 (00379356) ; 祖父江 慶太郎 神戸大学, 医学部附属病院, 准教授 (90622027)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肝細胞癌 / 分子標的療法 / ヨードマップ / バイオマーカー / Dual-Energy CT

Outline of Research at the Start

Dual-Energy CTで撮像を行ったヨード造影剤を用いたダイナミック造影CTの各時相データから得られる血流・組織解析法を用いることで，肝細胞癌に対する分子標的薬治療前後の3次元的な腫瘍内血流ならびに背景肝実質の性状を正確に評価でき，従来のSingle-Energy CTで行われるCT値で造影効果や背景肝実質を評価する方法と比較して抗腫瘍効果の正確な判定ならびに肝予備能悪化の予測が非侵襲的かつ同時に可能となり，患者の身体的・経済的負担が軽減できるとともに不要な治療の継続や肝不全の回避につながり生命予後の改善に寄与できる，

Outline of Final Research Achievements

The purpose of this study was to simultaneously evaluate the therapeutic efficacy of molecular targeted drugs for hepatocellular carcinoma and their effect on the background liver parenchyma using tissue material decomposition imaging obtained from Dual-Energy CT.
Dynamic contrast-enhanced CT imaging could be obtained from 39 patients according to the protocol, and the patients were enrolled for this study. Response rate and progression free survival (PFS) after lenvatinib treatment were compared for each treatment response criteria (1) mRECIST, 2) Choi criteria, and 3) blood flow evaluation using iodine quantitative imaging in Dual-Energy CT. Iodine quantitative iodine imaging was the most useful for predicting of PFS after lenvatinib treatment.

Academic Significance and Societal Importance of the Research Achievements

Dual-Energy CTで撮像を行ったヨード造影剤を用いたダイナミック造影CTの各時相データから得られる血流・組織解析法を用いることで、肝細胞癌に対する分子標的薬治療前後の3次元的な腫瘍内血流ならびに背景肝実質の性状を正確に評価でき、従来のSingle-Energy CTで行われるCT値で造影効果や背景肝実質を評価する方法と比較して抗腫瘍効果の正確な判定ならびに肝予備能悪化の予測が非侵襲的かつ同時に可能となり、患者の身体的・経済的負担が軽減できるとともに不要な治療の継続や肝不全の回避につながり生命予後の改善に寄与できると考えた。

Research Products

• [Journal Article] Added value of contrast enhancement boost images in routine multiphasic contrast-enhanced CT for the diagnosis of small (<20?mm) hypervascular hepatocellular carcinoma (2023)
  • Author(s): Yabe S、Sofue K、Hori M、Maebayashi T、Nishigaki M、Tsujita Y、Yamaguchi T、Ueshima E、Ueno Y、Murakami T
  • Journal Title: European Journal of Radiology Volume: 160 Pages: 110696-110696
  • DOI: 10.1016/j.ejrad.2023.110696
• [Journal Article] Evaluation and Prediction of Treatment Response for Hepatocellular Carcinoma (2023)
  • Author(s): Yushi Tsujita, Keitaro Sofue, Eisuke Ueshima, Yoshiko Ueno, Masatoshi Hori, Masakatsu Tsurusaki, Takamichi Murakami
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 22 Issue: 2 Pages: 209-220
  • DOI: 10.2463/mrms.rev.2022-0118
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2021 version (5th JSH‐HCC Guidelines) (2023)
  • Author(s): Hasegawa K、Takemura N、Yamashita T、Watadani T、Kaibori M、Kubo S、Shimada M、Nagano H、Hatano E、Aikata H、Iijima H、Ueshima K、Ohkawa K、Genda T、Tsuchiya K、Torimura T、Ikeda M、Furuse J、Akahane M、Kobayashi S、Sakurai H、Takeda A、Murakami T、Motosugi U、Matsuyama Y、Kudo M、Tateishi R
  • Journal Title: Hepatology Research Volume: 53 Issue: 5 Pages: 383-390
  • DOI: 10.1111/hepr.13892
• [Journal Article] Improved diagnosis of histological capsule in hepatocallular carcinoma by using nonenhancing capsule appearance in addition to enhancing capsule appearance in gadoxetic acid-enhanced MRI (2023)
  • Author(s): Nishioka E、Sofue K、Maruyama K、Ueshima E、Ueno Y、Tsurusaki M、Komatsu S、Fukumoto T、Murakami T
  • Journal Title: Scientific Reports Volume: 13 Issue: 1
  • DOI: 10.1038/s41598-023-33048-8
• [Journal Article] Response Evaluation Criteria in Cancer of the liver version 6 (Response Evaluation Criteria in Cancer of the Liver 2021 revised version) (2022)
  • Author(s): Kudo M、Ikeda M、Ueshima K、Sakamoto M、Shiina S、Tateishi R、Nouso K、Hasegawa K、Furuse J、Miyayama S、Murakami T、Yamashita T、Kokudo N
  • Journal Title: Hepatology Research Volume: 52 Issue: 4 Pages: 329-336
  • DOI: 10.1111/hepr.13746
• [Journal Article] Transarterial Chemoebolization in Hepatocellular Carcinoma: A Binational Japanese-German Study (2022)
  • Author(s): Auer TA、Sofue K、Ueshima E、Rauer N、Yamaguchi T、Gebauer B、Hamm B、Murakami T、Althoff C
  • Journal Title: Journal of Hepatocellular Carcinoma Volume: Volume 9 Pages: 695-705
  • DOI: 10.2147/jhc.s359705
• [Journal Article] Deep learning image reconstruction to improve accuracy of iodine quantification and image quality in dual-energy CT of the abdomen: a phantom and clinical study (2022)
  • Author(s): Fukutomi A, Sofue K, Ueshima E, Negi N, Ueno Y, Tsujita Y, Yabe S, Yamaguchi T, Shimada R, Kusaka A, Hori M, Murakami T
  • Journal Title: European Radiology Volume: 33 Issue: 2 Pages: 1388-1399
  • DOI: 10.1007/s00330-022-09127-1
• [Journal Article] Reevaluation of Makuuchi’s criteria for resecting hepatocellular carcinoma: A Japanese nationwide survey (2022)
  • Author(s): Aramaki O、Takayama T、Matsuyama Y、Kubo S、Kokudo N、Kurosaki M、Murakami T、Shiina S、Kudo M、Sakamoto M、Nakashima O、Fukumoto T、Iijima H、Eguchi S、Soejima Y、Makuuchi M
  • Journal Title: Hepatology Research Volume: 53 Issue: 2 Pages: 127-134
  • DOI: 10.1111/hepr.13844
• [Journal Article] Report of the 22nd nationwide follow‐up Survey of Primary Liver Cancer in Japan (2012?2013) (2022)
  • Author(s): Kudo Masatoshi、Izumi Namiki、Kokudo Norihiro、Sakamoto Michiie、Shiina Shuichiro、Takayama Tadatoshi、Tateishi Ryosuke、Nakashima Osamu、Murakami Takamichi、Matsuyama Yutaka、Takahashi Arata、Miyata Hiroaki、Kubo Shoji
  • Journal Title: Hepatology Research Volume: 52 Issue: 1 Pages: 5-66
  • DOI: 10.1111/hepr.13675
• [Journal Article] Diagnosis of Hepatocellular Carcinoma Using Gd-EOB-DTPA MR Imaging (2022)
  • Author(s): Murakami T、Sofue K、Hori M.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 21 Issue: 1 Pages: 168-181
  • DOI: 10.2463/mrms.rev.2021-0031
  • NAID: 130008166199
  • ISSN: 1347-3182, 1880-2206
• [Journal Article] Effect of Diameter and Number of Hepatocellular Carcinomas on Survival After Resection, Transarterial Chemoembolization, and Ablation (2021)
  • Author(s): Kawaguchi Y、Hasegawa K、Hagiwara Y、De Bellis Mo、Famularo S、Panettieri E、Matsuyama Y、Tateishi R、Ichikawa T、Kokudo T、Izumi N、Kubo S、Sakamoto M、Shiina S、Takayama T、Nakashima O、Murakami T、Vauthey JN、Giuliante F、De Carlis L、Romano F、Ruzzenente A、Guglielmi Al、Kudo M、Kokudo N
  • Journal Title: American Journal of Gastroenterology Volume: 116 Issue: 8 Pages: 1698-1708
  • DOI: 10.14309/ajg.0000000000001256
• [Journal Article] Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update (2021)
  • Author(s): Kudo M、Kawamura Y、Hasegawa K、Tateishi R、Kariyama K、Shiina S、Toyoda H、Imai Y、Hiraoka A、Ikeda M、Izumi N、Moriguchi M、Ogasawara S、Minami Y、Ueshima K、Murakami T、Miyayama S、Nakashima O、Yano H、Sakamoto M、Hatano E、Shimada M、Kokudo N、Mochida S、Takehara T.
  • Journal Title: Liver Cancer Volume: 10 Issue: 3 Pages: 181-223
  • DOI: 10.1159/000514174
• [Journal Article] The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma (2021)
  • Author(s): Hamada Mostafa、Ueshima Eisuke、Ishihara Takeaki、Koide Yutaka、Okada Takuya、Horinouchi Hiroki、Ishida Jun、Mayahara Hiroshi、Sasaki Koji、Gentsu Tomoyuki、Sofue Keitaro、Yamaguchi Masato、Sasaki Ryohei、Sugimoto Koji、Murakami Takamichi
  • Journal Title: Acta Radiologica Open Volume: 10 Issue: 7 Pages: 20584-20584
  • DOI: 10.1177/20584601211034965
  • NAID: 120007153054
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications (2021)
  • Author(s): Tsurusaki Masakatsu、Sofue Keitaro、Hori Masatoshi、Sasaki Kosuke、Ishii Kazunari、Murakami Takamichi、Kudo Masatoshi
  • Journal Title: Diagnostics Volume: 11 Issue: 2 Pages: 161-161
  • DOI: 10.3390/diagnostics11020161
  • Peer Reviewed / Open Access
• [Journal Article] Consensus report from the 9th International Forum for Liver Magnetic Resonance Imaging: applications of gadoxetic acid-enhanced imaging (2021)
  • Author(s): Koh Dow-Mu、Ba-Ssalamah Ahmed、Brancatelli Giuseppe、Fananapazir Ghaneh、Fiel M. Isabel、Goshima Satoshi、Ju Sheng-Hong、Kartalis Nikolaos、Kudo Masatoshi、Lee Jeong Min、Murakami Takamichi、Seidensticker Max、Sirlin Claude B.、Tan Cher Heng、Wang Jin、Yoon Jeong Hee、Zeng Mengsu、Zhou Jian、Taouli Bachir
  • Journal Title: European Radiology Volume: - Issue: 8 Pages: 5615-5628
  • DOI: 10.1007/s00330-020-07637-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Three-Dimensional Radiological Assessment of Ablative Margins in Hepatocellular Carcinoma: Pilot Study of Overlay Fused CT/MRI Imaging with Automatic Registration (2021)
  • Author(s): Minami Yasunori、Minami Tomohiro、Ueshima Kazuomi、Yagyu Yukinobu、Tsurusaki Masakatsu、Okada Takuya、Hori Masatoshi、Kudo Masatoshi、Murakami Takamichi
  • Journal Title: Cancers Volume: 13 Issue: 6 Pages: 1460-1460
  • DOI: 10.3390/cancers13061460
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of lenvatinib treatment for unresectable hepatocellular carcinoma with liver cirrhosis (2020)
  • Author(s): Komatsu Shohei、Yano Yoshihiko、Sofue Keitaro、Kido Masahiro、Tanaka Motofumi、Kuramitsu Kaori、Awazu Masahide、Gon Hidetoshi、Yamamoto Atsushi、Yanagimoto Hiroaki、Toyama Hirochika、Kodama Yuzo、Murakami Takamichi、Fukumoto Takumi
  • Journal Title: HPB Volume: 22 Issue: 10 Pages: 1450-1456
  • DOI: 10.1016/j.hpb.2020.03.002
  • Peer Reviewed
• [Journal Article] Prediction of post-hepatectomy liver failure using gadoxetic acid-enhanced magnetic resonance imaging for hepatocellular carcinoma with portal vein invasion (2020)
  • Author(s): Tsujita Yushi、Sofue Keitaro、Komatsu Shohei、Yamaguchi Takeru、Ueshima Eisuke、Ueno Yoshiko、Kanda Tomonori、Okada Takuya、Nogami Munenobu、Yamaguchi Masato、Tsurusaki Masakatsu、Hori Masatoshi、Fukumoto Takumi、Murakami Takamichi
  • Journal Title: European Journal of Radiology Volume: 130 Pages: 109189-109189
  • DOI: 10.1016/j.ejrad.2020.109189
  • Peer Reviewed
• [Journal Article] Predictive factors of truncation artifacts in the arterial phase of Gd-EOB-DTPA-enhanced MRI: a nationwide multicenter study (2020)
  • Author(s): Tsurusaki Masakatsu、Sofue Keitaro、Onishi Hiromitsu、Goshima Satoshi、Higaki Atsushi、Isoda Hiroyoshi、Haradome Hiroki、Ishii Kazunari、Murakami Takamichi
  • Journal Title: Japanese Journal of Radiology Volume: 39 Issue: 2 Pages: 165-177
  • DOI: 10.1007/s11604-020-01052-x
  • NAID: 210000163644
  • Peer Reviewed
• [Journal Article] Analysis of Patient Outcome after Non-curative Resection for Hepatocellular Carcinoma Using Nationwide Survey Data in Japan (2020)
  • Author(s): Aoki Taku、Kubota Keiichi、Kubo Shoji、Eguchi Susumu、Izumi Namiki、Kokudo Norihiro、Sakamoto Michiie、Shiina Shuichiro、Takayama Tadatoshi、Nakashima Osamu、Matsuyama Yutaka、Murakami Takamichi、Kudo Masatoshi
  • Journal Title: World Journal of Surgery Volume: 45 Issue: 2 Pages: 607-614
  • DOI: 10.1007/s00268-020-05830-6
  • Peer Reviewed
• [Journal Article] Report of the 20th Nationwide follow‐up survey of primary liver cancer in Japan (2020)
  • Author(s): Kudo M, Izumi N, Kubo S, Kokudo N, Sakamoto M, Shiina S, Tateishi R, Nakashima O, Murakami T, Matsuyama Y, Takahashi A, Miyata H, Takayama T.
  • Journal Title: Hepatology Research Volume: 50 Issue: 1 Pages: 15-46
  • DOI: 10.1111/hepr.13438
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Consensus report from the 8th International Forum for Liver Magnetic Resonance Imaging (2020)
  • Author(s): Zech CJ, Ba-Ssalamah A, Berg T, Chandarana H, Chau GY, Grazioli L, Kim MJ, Lee JM, Merkle EM, Murakami T, Ricke J, B Sirlin C, Song B, Taouli B, Yoshimitsu K, Koh DM
  • Journal Title: European Radiology Volume: 30 Pages: 370-382
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Response Evaluation Criteria in Cancer of the Liver version?5 (RECICL 2019 revised version) (2019)
  • Author(s): Kudo M, Ikeda M, Ueshima K, Sakamoto M, Shiina S, Tateishi R, Hasegawa K, Furuse J, Miyayama S, Murakami T, Yamashita T, Kokudo N.
  • Journal Title: Hepatology Research Volume: 49 Issue: 9 Pages: 981-989
  • DOI: 10.1111/hepr.13394
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2017 (4th JSH-HCC Guidelines) a 2019 update (2019)
  • Author(s): Kokudo N, Takemura N, Hasegawa K, Takayama T, Kubo S, Shimada M, Nagano H, Hatano E, Izumi N, Kaneko S, Kudo M, Iijima H, Genda T, Tateishi R, Torimura T, Igaki H, Kobayashi S, Sakurai H, Murakami T, Watadani T, Matsuyama Y
  • Journal Title: Hepatol Res Volume: 49(10) Issue: 10 Pages: 1109-1113
  • DOI: 10.1111/hepr.13411
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatic Artery Embolization Induces the Local Overexpression of Transforming Growth Factor β1 in a Rat Hepatoma Model (2019)
  • Author(s): Ueshima Eisuke、Nishiofuku Hideyuki、Takaki Haruyuki、Hirata Yutaka、Kodama Hiroshi、Tanaka Toshihiro、Kichikawa Kimihiko、Yamakado Koichiro、Okada Takuya、Sofue Keitaro、Yamaguchi Masato、Sugimoto Koji、Murakami Takamichi
  • Journal Title: Liver Cancer Volume: 9 Issue: 1 Pages: 63-72
  • DOI: 10.1159/000502774
  • NAID: 120006796524
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] New CT techniques in abdominal radiology. Application of novel imaging techniques in abdominal imaging (2022)
  • Author(s): Murakami T
  • Organizer: AOCR2022 ＆ KCR2022
  • Int'l Joint Research / Invited
• [Presentation] Advanced CT techniques in the evaluation of hepatocellular carcinoma: Roles of ultra-high-resolution CT, dual-energy CT, contrast enhancement boost technique, and radiomics (2022)
  • Author(s): Hori M, Sofue K, Yabe S, Nishigaki M, Akino N, Yamaguchi T, Tsujita Y, Ueshima E, Negi N, Kusaka A, Murakami T.
  • Organizer: Radiological Society of North America. 108th Scientific Assembly and Annual Meeting
  • Int'l Joint Research
• [Presentation] Radiomic Features of Hepatocellular Carcinoma at Ultra-High-Resolution CT with a 1024 Matrix: Dependencies on Matrix Size and Reconstruction Algorithm. (2022)
  • Author(s): Hori M, Sofue K, Akino N, Nishigaki M, Yabe S, Yamaguchi T, Tsujita Y, Ueshima E, Murakami T
  • Organizer: Radiological Society of North America. 108th Scientific Assembly and Annual Meeting
  • Int'l Joint Research
• [Presentation] Embolization Induced Tumor-Associated Macrophage Polarization in Tumor Immune Microenvironment can be Reprogrammed by Lenvatinib in a Rat Hepatoma Model (2022)
  • Author(s): Ueshima E, Sofue K, Takaki H, Hirata Y, Kodama H, Hamada M, Matsushiro K, Sasaki K, Gentsu T, Okada T, Yamaguchi M, Yamakado K, Sugimoto K, Murakami T.
  • Organizer: Society of Interventional Radiology
  • Int'l Joint Research
• [Presentation] Added Value of Contrast Enhancement Boost Images in Routine Multiphasic Contrast-Enhanced CT in Diagnosis of Small Hypervascular Hepatocellular Carcinoma (2022)
  • Author(s): Yabe S, Sofue K, Hori M, Maebayashi T, Nishigaki M, Tsujita Y, Yamaguchi T, Ueshima E, Murakami T.
  • Organizer: European Congress of Radiology 2022
  • Int'l Joint Research
• [Presentation] Added Value of Contrast Enhancement Boost Images in Routine Multiphasic Contrast-Enhanced CT in the Diagnosis of Small Hypervascular Hepatocellular Carcinoma (2022)
  • Author(s): Yabe S, Sofue K, Hori M, Maebayashi T, Nishigaki M, Tsujita Y, Yamaguchi T, Ueshima E, Murakami T.
  • Organizer: European Congress of Radiology 2022
  • Int'l Joint Research / Invited
• [Presentation] Association of psoas muscle lean volume measured on dual-energy CT with relative dose intensity in patients with hepatocellular carcinoma treated with Lenvatinib. (2020)
  • Author(s): Yamaguchi T, Sofue K, Ueshima E, Tsujita Y, Ueno Y, Okada T, Yamaguchi M, Nogami M, Hori M, Murakami T
  • Organizer: 106th Radiological Society of North America, Scientific Assembly and Annual Meeting (RSNA2020)
  • Int'l Joint Research / Invited
• [Presentation] Clinical applications of dual-energy CT for the quantitative imaging in diffuse liver diseases. (2020)
  • Author(s): Yamaguchi T, Sofue K, Ueshima E, Tsujita Y, Kanda T, Nogami M, Murakami T.
  • Organizer: The 32th Annual Meeting of European Congress of Radiology (ECR 2020)
  • Int'l Joint Research / Invited
• [Presentation] Impact of Oncologic Intervention on Tumor Microenvironment. (2020)
  • Author(s): Murakami T
  • Organizer: Japan-Korea Joint symposium. 第56回日本肝癌研究会
  • Invited
• [Presentation] 肝画像診断の新潮流：基調講演：CT・MRIによる肝脂肪化の評価 (2020)
  • Author(s): 村上卓道
  • Organizer: 第24回日本肝臓学会大会
  • Invited
• [Presentation] CE boost技術を用いたダイナミック造影CTにおける多血性肝細胞癌描出能向上の試み (2020)
  • Author(s): 矢部慎二，祖父江慶太郎，堀 雅敏，上嶋英介，辻田有志，山口 尊，上野嘉子，村上卓道
  • Organizer: 第27回肝血流動態・機能イメージング研究会
• [Presentation] 肝疾患の画像診断・評価の最近の話題：LI-RADSver.2018 CT/MRI, Dual-Energy CT (2020)
  • Author(s): 村上卓道
  • Organizer: 肝疾患の画像診断・評価アップデート
  • Invited
• [Presentation] Malignant Primary Liver Tumors. (2019)
  • Author(s): Murakami Takamichi
  • Organizer: International Society for Magnetic Resonance in Medicine.
  • Int'l Joint Research / Invited
• [Presentation] Malignant Primary Liver Tumors. (2019)
  • Author(s): Murakami Takamichi
  • Organizer: Asian Congress of Abominal Radiology.
  • Int'l Joint Research / Invited
• [Presentation] Imaging diagnosis of HCC. Session: Diagnosis and staging of HCC. (2019)
  • Author(s): Murakami Takamichi
  • Organizer: APPLE Academy2019,APPLE2019
  • Int'l Joint Research / Invited
• [Presentation] Development and Assessment of Respiratory Motion-Resolved Hepatobiliary Phase Cine-MRI using Compressed SENSE for Stereotactic Body Radiotherapy in Liver Tumor (2019)
  • Author(s): Shimada R, Sofue K, Kyotani K, Wang T, Ueno Y, Ishihara T, Horii S, Nogami M, Kusaka A, Murakami T
  • Organizer: 105th Radiological Society of North America, Scientific Assembly and Annual Meeting.
  • Int'l Joint Research
• [Book] II章 A.検査 7画像診断 肝臓専門医テキスト改訂第3版 (2020)
  • Author(s): 祖父江慶太郎、村上卓道
  • Total Pages: 31
  • Publisher: 南江堂
• [Book] 肝癌の診断；肝癌診断のアルゴリズム：乏血性肝細胞性結節（異型結節、早期肝癌）の自然経過と治療対応 肝癌診療マニュアル第4版 (2020)
  • Author(s): 今井康陽，工藤正俊，泉並木，村上卓道，熊田 卓
  • Total Pages: 4
  • Publisher: 日本肝臓学会 医学書院
• [Book] 臨床に役立つ肝細胞癌の画像診断 Imaging diagnosis of hepatocellular carcinoma for clinical practice (2020)
  • Author(s): 祖父江慶太郎，矢部慎二，辻田有志，山口尊，上嶋英介，上野嘉子，堀雅敏，村上卓道
  • Total Pages: 8
  • Publisher: 臨床画像
• [Book] 外科医が知っておきたい画像診断：5. 肝 消化器外科 (2020)
  • Author(s): 鶴﨑正勝, 村上卓道
  • Total Pages: 7
  • Publisher: へるす出版
• [Book] 【特集】Precision Medicine時代のAbdominal Imaging 2020【後編】：Ⅳ CT：腹部領域における技術の到達点と臨床の最前線：1．CTの技術進歩で変わる臨床の今と未来：4）CTによる肝脂肪定量・肝線維化推定の実際と今後の展望 (2020)
  • Author(s): 山口尊，祖父江慶太郎，村上卓道
  • Total Pages: 3
  • Publisher: Innervision
• [Book] 【特集】Precision Medicine時代のAbdominal Imaging 2020【後編】：Ⅳ CT：腹部領域における技術の到達点と臨床の最前線：1．CTの技術進歩で変わる臨床の今と未来：4）CTによる肝脂肪定量・肝線維化推定の実際と今後の展望 (2020)
  • Author(s): 山口 尊，祖父江慶太郎，村上卓道
  • Total Pages: 3
  • Publisher: Innervision
  • ISBN: 9784902131864
• [Book] 肝癌診療マニュアル 第4版 (2020)
  • Author(s): 一般社団法人 日本肝臓学会
  • Total Pages: 4
  • Publisher: 医学書院
  • ISBN: 9784260040815
• [Book] Part IV Abdomen: Cirrhotic Liver. In: Nikolau K, Bamberg F, Laghi A, and Rubin GD, ed. Multislice CT, Fourth Edition (2019)
  • Author(s): Sofue K, Tsurusaki M, Murakami T
  • Total Pages: 43
  • Publisher: Springer
  • ISBN: 9783319425856