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Development of a novel radio-protective technique in radiotherapy using lead-free materials

Research Project

Project/Area Number 19K08211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKindai University

Principal Investigator

Monzen Hajime  近畿大学, 大学病院, 教授 (10611593)

Co-Investigator(Kenkyū-buntansha) 吉田 謙  関西医科大学, 医学部, 准教授 (10463291)
松本 賢治  近畿大学, 大学病院, 技術職員 (30742374)
土井 啓至  近畿大学, 医学部, 講師 (50529047)
田村 命  近畿大学, 医学部, 助教 (60810968)
花岡 宏平  近畿大学, 大学病院, 技師 (80772657)
秋山 広徳  大阪歯科大学, 歯学部, 准教授 (20448111)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords放射線治療 / 放射線防護 / 放射線遮蔽材 / 鉛フリー / タングステン / ボーラス / IVR / 鉛フリーゴム
Outline of Research at the Start

開発したリアルタイム可変型の粘土状放射線遮蔽材は、加温することで柔らかくなり、常温では型が維持できる硬度を持つゴム素材である。本研究では、その素材を鉛代替放射線遮蔽材としてのポテンシャルの見極めと、放射線医学・工学への実用化を目的とする。さらに新素材の特徴を活かした新たな放射線治療の手法や放射線防護体系の確立を目指す。

Outline of Final Research Achievements

Radiation shielding abilities of tungsten functional paper (TFP) and tungsten containing rubber (TCR) were clarified as lead-free materials and we aimed those expansion to the medical field. We have developed a real-time variable shape tungsten rubber (STR) newly. The STR is easy to shape in real time when heating and its shape is maintained at room and body temperatures, and also a real-time variable shape soft rubber bolus (SRB) with water equivalent material by excluding the tungsten from the STR. This study fulfilled the following themes: 1. Reduction of radiation exposure for an operator in Interventional Radiology (IR) with TCR; 2. Reduction of radiation exposure to the eye lens of a patient in head CT examination with TFP; 3. Use as a collimator to shape an irradiation field and shielding material for normal tissue in electron radiotherapy with TCR and STR; and 4. A bolus in radiotherapy with STR and SRB.

Academic Significance and Societal Importance of the Research Achievements

医療における放射線遮蔽材は、主に鉛や低融点鉛合金が用いられているが、人体に有毒で加工が困難、廃棄による環境への悪影響などが懸念されている。今回開発した放射線遮蔽材は、人体に毒性もなく、リサイクルも可能、紙やゴムの特徴を有するTFPやTCRは裁断や折りたたみ、他の材質への貼付が容易、STRは加温することで自由自在に成形でき、常温で形状維持可能、といった特徴を有する。また、新規ボーラス(SRB)も加温することで自由自在に成形可能、皮膚に密着させて効果的に皮膚表面線量を増加できる。これらの特徴を活かし、放射線治療や放射線防護といった医療分野において幅広く応用することで、果たす役割は大きい。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (28 results)

All 2022 2021 2020 2019

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 12 results,  Invited: 2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 1 results)

  • [Journal Article] Estimating radiation exposure of the brain of a physician with a protective flap in interventional radiology: A phantom study2022

    • Author(s)
      Hattori Shota、Monzen Hajime、Tamura Mikoto、Kosaka Hiroyuki、Nakamura Yasunori、Nishimura Yasumasa
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 23 Issue: 3

    • DOI

      10.1002/acm2.13532

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dosimetric characteristics of a thin bolus made of variable shape tungsten rubber for photon radiotherapy2021

    • Author(s)
      Okuhata Katsuya、Tamura Mikoto、Monzen Hajime、Nishimura Yasumasa
    • Journal Title

      Physical and Engineering Sciences in Medicine

      Volume: 44 Issue: 4 Pages: 1249-1255

    • DOI

      10.1007/s13246-021-01059-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel real-time shapeable soft rubber bolus for clinical use in electron radiotherapy2021

    • Author(s)
      Wakabayashi Kazuki、Monzen Hajime、Tamura Mikoto、Takei Yoshiki、Okuhata Katsuya、Anami Shimpei、Doi Hiroshi、Nishimura Yasumasa
    • Journal Title

      Physics in Medicine & Biology

      Volume: 66 Issue: 18 Pages: 185013-185013

    • DOI

      10.1088/1361-6560/ac215b

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosimetric evaluation of skin collimation with tungsten rubber for electron radiotherapy: A Monte Carlo study2021

    • Author(s)
      Wakabayashi Kazuki、Monzen Hajime、Tamura Mikoto、Matsumoto Kenji、Takei Yoshiki、Nishimura Yasumasa
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 22 Issue: 4 Pages: 63-70

    • DOI

      10.1002/acm2.13210

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of Real-time Variable Shape Tungsten Rubber for Nail Radiation Protection in the Total Skin Electron Beam (TSEB) Therapy2021

    • Author(s)
      Yanagi Yuya、Tamura Mikoto、Monzen Hajime、Matsumoto Kenji、Takei Yoshiki、Noma Kazuo、Kida Tetsuo
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 77 Issue: 2 Pages: 145-152

    • DOI

      10.6009/jjrt.2021_JSRT_77.2.145

    • NAID

      130007988389

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] First clinical experience of tungsten rubber electron adaptive therapy with real-time variable-shape tungsten rubber2021

    • Author(s)
      Kawai Yoshihiro、Tamura Mikoto、Amano Morikazu、Kosugi Takashi、Monzen Hajime
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 2 Pages: 919-925

    • DOI

      10.21873/anticanres.14845

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dosimetric Characteristics of a Real Time Shapeable Tungsten Containing Rubber with Electron Beams2020

    • Author(s)
      Matsumoto Kenji、Tamura Mikoto、Otsuka Masakazu、Wakabayashi Kazuki、Kijima Kenta、Monzen Hajime
    • Journal Title

      Japanese Journal of Radiological Technology

      Volume: 76 Issue: 12 Pages: 1248-1255

    • DOI

      10.6009/jjrt.2020_JSRT_76.12.1248

    • NAID

      130007958237

    • ISSN
      0369-4305, 1881-4883
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of using tungsten functional paper as a thin bolus for electron beam radiotherapy2020

    • Author(s)
      Takei Yoshiki、Kamomae Takeshi、Monzen Hajime、Nakaya Takayoshi、Sugita Kazuma、Suzuki Kentaro、Oguchi Hiroshi、Tamura Mikoto、Nishimura Yasumasa
    • Journal Title

      Physical and Engineering Sciences in Medicine

      Volume: 43 Issue: 3 Pages: 1101-1111

    • DOI

      10.1007/s13246-020-00910-2

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduction of Occupational Exposure Using a Novel Tungsten-Containing Rubber Shield in Interventional Radiology.2020

    • Author(s)
      Kijima K, Krisanachinda A, Tamura M, Monzen H, Nishimura Y.
    • Journal Title

      Health Phys.

      Volume: - Issue: 6 Pages: 609-614

    • DOI

      10.1097/hp.0000000000001177

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Radiation dose reduction to the eye lens in head CT using tungsten functional paper and organ-based tube current modulation.2020

    • Author(s)
      Kosaka H, Monzen H, Amano M, Tamura M, Hattori S, Kono Y, Nishimura Y.
    • Journal Title

      Eur J Radiol.

      Volume: - Pages: 108814-108814

    • DOI

      10.1016/j.ejrad.2020.108814

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] リアルタイム可変型放射線遮蔽材の開発2020

    • Author(s)
      門前 一
    • Journal Title

      機能材料

      Volume: 40 Pages: 66-72

    • NAID

      40022627447

    • Related Report
      2019 Research-status Report
  • [Journal Article] Dosimetric Characterization of a novel surface collimator with tungsten functional paper for electron therapy.2019

    • Author(s)
      Kawai Y, Tamura M, Amano M, Kamomae T, Monzen H.
    • Journal Title

      Anticancer Res.

      Volume: 39 Issue: 6 Pages: 2839-2843

    • DOI

      10.21873/anticanres.13412

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of radiation shielding ability in electron therapy and brachytherapy with real time variable shape tungsten rubber2019

    • Author(s)
      Monzen Hajime、Tamura Mikoto、Kijima Kenta、Otsuka Masakazu、Matsumoto Kenji、Wakabayashi Kazuki、Choi Min-Geon、Yoon Do-Kun、Doi Hiroshi、Akiyama Hironori、Nishimura Yasumasa
    • Journal Title

      Physica Medica

      Volume: 66 Pages: 29-35

    • DOI

      10.1016/j.ejmp.2019.09.233

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Dosimetric characteristics of a thin bolus with real time variable shape tungsten rubber for photon beam.2021

    • Author(s)
      Katsuya Okuhata, Mikoto Tamura, Hajime Monzen, Yasumasa Nishimura
    • Organizer
      9th Korea-Japan Joint Meeting on Medical Physics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Protection of radiation exposure for physician’s brain using a tungsten rubber flap in interventional radiology.2021

    • Author(s)
      Shota Hattori, Hiroyuki Kosaka, Hajime Monzen, Mikoto Tamura
    • Organizer
      21st Asia-Oceania Congress of Medical Physics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Novel Real-Time Shapeable Bolus for Electron Radiotherapy2021

    • Author(s)
      Kazuki Wakabayashi, Hajime Monzen, Mikoto Tamura, Yoshiki Takei, Katsuya Okuhata, Shimpei Anami, Hiroshi Doi, Yasumasa Nishimura
    • Organizer
      21st Asia-Oceania Congress of Medical Physics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiation Protection of Nail with Real-time Shapeable Tungsten Rubber in the Total Skin Electron Beam (TSEB) Therapy2021

    • Author(s)
      Yuya Yanagi, Mikoto Tamura, Hajime Monzen
    • Organizer
      21st Asia-Oceania Congress of Medical Physics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiation shielding efficiency of tungsten rubber in interventional radiology.2019

    • Author(s)
      Kenta Kijima, Anchali Krisanachinda, Petchaleya Suwanpradit, Mikoto Tamura, Yasumasa Nishimura, Hajime Monzen.
    • Organizer
      The 7th Asia Radiation Therapy Symposium.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Feasibility study of the shielding ability of novel tungsten rubber against the electron beam in radiation therapy.2019

    • Author(s)
      Hajime Monzen, Kenta Kijima, Mikoto Tamura, Seiichi Ota, Kenji Matsumoto.The August 24th,2019
    • Organizer
      7th Annual Congress of Vietnam Association Radiation Technologist.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Feasibility of using tungsten functional paper as a thin bolus for electron beam radiotherapy.2019

    • Author(s)
      Yoshiki Takei, Takeshi Kamomae, Mikoto Tamura, Hajime Monzen.
    • Organizer
      The 19th Asia-Oceania Congress of Medical Physics.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dosimetric shield evaluation with a novel radiation shielding material, tungsten containing rubber in electron beams.2019

    • Author(s)
      Kazuki Kubo, Kenta Kijima, Kenji Matsumoto, Mikoto Tamura, Hajime Monzen.
    • Organizer
      The 19th Asia-Oceania Congress of Medical Physics.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of shielding ability of a novel radiation shielding material, free-form tungsten containing rubber2019

    • Author(s)
      Kazuki Kubo, Masakazu otsuka, Min-Geon Choi, Mikoto Tamura, Kenji Matsumoto, Hajime Monzen.
    • Organizer
      The 19th Asia-Oceania Congress of Medical Physics.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] To compare the radiation shielding ability of tungsten functional paper and Organ-based tube current modulation for the eye lens in head computed tomography: A phantom study.2019

    • Author(s)
      Hiroyuki Kosaka, Shota Hattori, Koji Yamada, Mikoto Tamura, Hajime Monzen.
    • Organizer
      The 19th Asia-Oceania Congress of Medical Physics.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Shielding Efficiency of Novel Tungsten Rubber Against Radionuclides at Nuclear Medicine Division.2019

    • Author(s)
      Kenta Kijima, Anchali Krisanachinda, Panya Pasawang, Kohei Hanaoka, Hajime Monzen, Yasumasa Nishimura.
    • Organizer
      The 19th Asia-Oceania Congress of Medical Physics.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Feasibility of a tungsten rubber grid collimator for electron grid therapy.2019

    • Author(s)
      Kenta Kijima, Anchali Krisanachinda, Mikoto Tamura, Yasumasa Nishimura, Hajime Monzen.
    • Organizer
      European Society Radiotherapy & Oncology meets Asia 2019.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] ボーラス形成材およびそれを用いたボーラス2022

    • Inventor(s)
      門前 一
    • Industrial Property Rights Holder
      門前 一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ボーラス形成材およびそれを用いたボーラス2021

    • Inventor(s)
      門前 一
    • Industrial Property Rights Holder
      門前 一
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 温度変性放射線遮蔽材2019

    • Inventor(s)
      門前 一
    • Industrial Property Rights Holder
      早川ゴム株式会社/学校法人近畿大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-147919
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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