Study of the control mechanism of myosin light chain kinase aimed at elucidating the pathogenesis of IBD

• Project/Area Number: 19K08364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Saito Eiko 東京医科歯科大学, 東京医科歯科大学病院, 助教 (00406456)
• Co-Investigator(Kenkyū-buntansha): 渡辺 守 東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127) ; 鬼澤 道夫 福島県立医科大学, 医学部, 助教 (30783352) ; 永石 宇司 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 炎症性腸疾患

Outline of Research at the Start

クローン病と潰瘍性大腸炎を代表とする炎症性腸疾患(IBD)は、再燃と寛解を繰り返す、難治性の慢性腸炎である。生物学的製剤の登場によりIBD治療は大きく前進したが、未だ内科的治療抵抗例が存在し、さらなるIBDの病態解明が急務である。IBDの腸管上皮ではミオシン軽鎖キナーゼ(MLCK)の発現異常が知られており、本研究では、腸管におけるMLCKの制御機構を明らかすることで、IBDの予防及び新規治療法の基盤創出を目指す。

Outline of Final Research Achievements

The barrier dysfunction of the intestinal epithelium, which is caused by upregulation of TNFR2 and activation of myosin light chain kinase in epithelial cells, is involved in the pathogenesis of inflammatory bowel disease. In this study, we analyzed the membrane-type TNF complex and also found a TNF mutant strain that regulates the expression of membrane-type TNF. Based on our study, it will be a new understanding of the pathophysiology of inflammatory bowel disease and the development of new treatments.

Academic Significance and Societal Importance of the Research Achievements

免疫細胞と腸管上皮細胞のクロストーク、すなわちTNFを基点としたTNFR2/ミオシン軽鎖キナーゼ/腸間上皮のバリア機能障害による炎症の持続のメカニズム解明は、炎症性腸疾患のみならず自己免疫疾患全般における新規治療法へ向けた理論、技術基盤の創出に発展するものと期待される。

Research Products

• [Int'l Joint Research] Brigham and Women's Hospital/Harvard Medical School(米国)
• [Int'l Joint Research] Imperial College London(英国)
• [Journal Article] 今月の主題 炎症性腸疾患の粘膜治癒を再考する 主題 Crohn病における小腸粘膜治癒評価の意義-バルーン内視鏡の立場から (2022)
  • Author(s): 大塚 和朗, 竹中 健人, 齊藤 詠子, 日比谷 秀爾, 河本 亜美, 森川 亮, 藤井 俊光, 清水 寛路, 長堀 正和, 岡本 隆一
  • Journal Title: 胃と腸 Volume: 57 Issue: 2 Pages: 173-181
  • DOI: 10.11477/mf.1403202659
  • ISSN: 0536-2180, 1882-1219
  • Year and Date: 2022-02-25
• [Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study (2022)
  • Author(s): Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
  • Journal Title: Lancet Gastroenterol Hepatol Volume: 7 Issue: 3 Pages: 230-237
  • DOI: 10.1016/s2468-1253(21)00372-1
  • Peer Reviewed / Open Access
• [Journal Article] Activated mucosal-associated invariant T cells have a pathogenic role in a murine model of inflammatory bowel disease. (2022)
  • Author(s): usuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Saichiko Miyake.
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology. Volume: 13 Issue: 1 Pages: 81-93
  • DOI: 10.1016/j.jcmgh.2021.08.018
  • Peer Reviewed / Open Access
• [Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. (2022)
  • Author(s): Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
  • Journal Title: Biochemical and Biophysical Research Communications. Volume: 592 Pages: 74-80
  • DOI: 10.1016/j.bbrc.2021.12.111
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 腸内細菌叢に対するIgAの重要性 (2022)
  • Author(s): 永石宇司.
  • Journal Title: 日本臨床腸内微生物学会誌. Volume: 24 Pages: 19-20
• [Journal Article] Substantial Epstein-Barr virus reactivation in a case of severe refractory ulcerative colitis: a possible role in exacerbation (2021)
  • Author(s): Shu Kato, Hiromichi Shimizu, Shohei Tomii, Hitoshi Uchida, Ami Kawamoto, Shuji Hibiya, Maiko Motobayashi, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mariko Negi, Takumi Akashi, Takatoshi Matsuyama, Yusuke Kinugasa & Mamoru Watanabe
  • Journal Title: Clinical Journal of Gastroenterology Volume: 14 Issue: 2 Pages: 584-588
  • DOI: 10.1007/s12328-020-01319-w
  • Peer Reviewed
• [Journal Article] Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease (2021)
  • Author(s): Kento Takenaka, Ami Kawamoto, Shuji Hibiya, Kohei Suzuki, Toshimitsu Fujii, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka
  • Journal Title: Aliment Pharmacol Ther Volume: 54 Issue: 8 Pages: 1052-1060
  • DOI: 10.1111/apt.16551
  • Peer Reviewed
• [Journal Article] Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus (2021)
  • Author(s): Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
  • Journal Title: BMC Gastroenterol Volume: 21 Issue: 1 Pages: 494-494
  • DOI: 10.1186/s12876-021-02043-6
  • Peer Reviewed / Open Access
• [Journal Article] 【最新の内視鏡を使いこなす】最新のスコープを使いこなす 小腸内視鏡 小腸内視鏡 オリンパス社内視鏡 (2021)
  • Author(s): 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 斎藤 詠子, 藤井 俊光, 長堀 正和, 清水 寛路, 岡本 隆一
  • Journal Title: 消化器内視鏡 Volume: 33 Pages: 1283-1287
• [Journal Article] 【エキスパートに学ぶ、安全で楽な外来内視鏡】外来内視鏡診療への展開 外来における小腸のバルーン内視鏡検査 (2021)
  • Author(s): 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 齊藤 詠子, 藤井 俊光, 長堀 正和, 岡本 隆一
  • Journal Title: 消化器内視鏡 Volume: 33 Pages: 1041-1046
• [Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice. (2021)
  • Author(s): Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
  • Journal Title: Journal of Gastroenterolog. Volume: 56 Issue: 8 Pages: 732-745
  • DOI: 10.1007/s00535-021-01792-1
  • Peer Reviewed / Open Access
• [Journal Article] A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. (2021)
  • Author(s): Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
  • Journal Title: Biochemistry and Biophysics Reports. Volume: 27 Pages: 101065-101065
  • DOI: 10.1016/j.bbrep.2021.101065
  • Peer Reviewed / Open Access
• [Journal Article] Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum (2021)
  • Author(s): Nagaishi Takashi、Watabe Taro、Kotake Kunihiko、Kumazawa Toshihiko、Aida Tomomi、et al.
  • Journal Title: Gut Volume: 71 Issue: 3 Pages: 487-496
  • DOI: 10.1136/gutjnl-2020-322873
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 免疫グロブリンAの欠損により回腸特異的な炎症が自然発症する. (2021)
  • Author(s): 安達貴弘，永石宇司
  • Journal Title: 消化器学サイエンス. Volume: 5 Pages: 230-232
• [Journal Article] 【病態別 栄養療法まるわかりガイド 病態生理・診断・治療・食事療法・栄養指導のポイント】(第1章)病態生理・診断・治療の基本 クローン病 (2021)
  • Author(s): 齊藤 詠子
  • Journal Title: Nutrition Care Volume: 春季増刊 Pages: 70-77
• [Journal Article] 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis (2021)
  • Author(s): Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe
  • Journal Title: Aliment Pharmacol Ther Volume: 53 Pages: 103-113
  • Peer Reviewed
• [Journal Article] Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis (2021)
  • Author(s): Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Journal Title: Intest Res Volume: 19 Issue: 1 Pages: 115-118
  • DOI: 10.5217/ir.2020.00030
  • Peer Reviewed / Open Access
• [Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. (2021)
  • Author(s): Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
  • Journal Title: Cell Mol Gastroenterol Hepatol. Volume: 11 Issue: 5 Pages: 1483-1503
  • DOI: 10.1016/j.jcmgh.2021.01.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. (2020)
  • Author(s): Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima.
  • Journal Title: Biochem Biophys Res Commun. Volume: 542 Pages: 17-23
  • DOI: 10.1016/j.bbrc.2021.01.023
  • Peer Reviewed / Open Access
• [Journal Article] CEACAM1 specifically suppresses B cell receptor signaling-mediated activation.. (2020)
  • Author(s): Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
  • Journal Title: Biochem Biophys Res Commun. Volume: 535 Pages: 99-105
  • DOI: 10.1016/j.bbrc.2020.11.126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. (2020)
  • Author(s): Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
  • Journal Title: FEBS letters Volume: 594 Issue: 10 Pages: 1586-1595
  • DOI: 10.1002/1873-3468.13748
  • Peer Reviewed / Open Access
• [Journal Article] Development and validation of a deep neural network for accurate evaluation of endoscopic images from patients with ulcerative colitis. (2020)
  • Author(s): Kento Takenaka , Kazuo Ohtsuka , Toshimitsu Fujii , Mariko Negi , Kohei Suzuki , Hiromichi Shimizu , Shiori Oshima , Shintaro Akiyama , Maiko Motobayashi , Masakazu Nagahori , Eiko Saito , Katsuyoshi Matsuoka , Mamoru Watanabe
  • Journal Title: Gastroenterology Volume: Epub ahead of print Issue: 8 Pages: 2150-2157
  • DOI: 10.1053/j.gastro.2020.02.012
  • Peer Reviewed
• [Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo (2020)
  • Author(s): Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 523 Issue: 2 Pages: 328-335
  • DOI: 10.1016/j.bbrc.2019.12.021
  • Peer Reviewed / Open Access
• [Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage (2020)
  • Author(s): Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 522 Issue: 4 Pages: 971-977
  • DOI: 10.1016/j.bbrc.2019.11.158
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Indolent T cell lymphoproliferative disorder with villous atrophy in small intestinediagnosed by single-balloon enteroscopy. (2019)
  • Author(s): Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe
  • Journal Title: Clin J Gastroenterol. Volume: in press Issue: 5 Pages: 434-440
  • DOI: 10.1007/s12328-019-00971-1
  • Peer Reviewed / Open Access
• [Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor (2019)
  • Author(s): Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
  • Journal Title: Clinical Gastroenterology and Hepatology Volume: inpress Issue: 7 Pages: 1545-1552
  • DOI: 10.1016/j.cgh.2019.08.024
  • Peer Reviewed / Open Access
• [Journal Article] Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis (2019)
  • Author(s): Okabayashi Shinji、Kobayashi Taku、Saito Eiko、Toyonaga Takahiko、Ozaki Ryo、Sagami Shintaro、Nakano Masaru、Tanaka Junichi、Yagisawa Keiji、Kuronuma Satoshi、Takeuchi Osamu、Hibi Toshifumi
  • Journal Title: Intestinal Research Volume: 17 Issue: 2 Pages: 218-226
  • DOI: 10.5217/ir.2018.00117
  • Peer Reviewed / Open Access
• [Presentation] 潰瘍性大腸炎に対するベドリズマブの中長期有効性と安全性について (2021)
  • Author(s): 齊藤詠子、藤井俊光、岡本隆一
  • Organizer: 第12回日本炎症性腸疾患学会
• [Presentation] 広汎な胃潰瘍を呈した不全型ベーチェット病の1例 (2021)
  • Author(s): 浜村 亮輔, 藤原 俊, 河本 亜美, 本林 麻衣子, 日比谷 秀爾, 竹中 健人, 清水 寛路, 藤井 俊光, 齊藤 詠子, 長堀 正和, 大塚 和朗, 岡本 隆一
  • Organizer: 第366回日本消化器病学会関東支部例会
• [Presentation] 潰瘍性大腸炎(UC)に対するトファシチニブ(TOF)・ベドリズマブ(VDZ)・ウステキヌマブ(UST)の実臨床データについて. (2021)
  • Author(s): 齊藤詠子、藤井俊光、岡本隆一
  • Organizer: 第107回日本消化器病学会総会
• [Presentation] The Lack of IgA spontaneously induces the inflammation only in the ileum. (2021)
  • Author(s): Daiki Yamada, Takahiro Adachi, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
  • Organizer: The 50th Annual meeting of Japanese Society of Immunology 2021
  • Int'l Joint Research
• [Presentation] A case of indolent T cell lymphoproliferative disorder of gastrointestinal tract with CCR4+ T cell infiltration. (2021)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Ryuichi Okamoto.
  • Organizer: The 80th Annual meeting of Japanese Cancer Association 2021
  • Int'l Joint Research
• [Presentation] BCR signaling-mediated activation in lymphoid tissues is regulated by the long isoform of CEACAM1. (2021)
  • Author(s): akashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto.
  • Organizer: Annual meeting of American Gastroenterology Association, Digestive Disease Week
  • Int'l Joint Research
• [Presentation] 腸内細菌叢に対するIgAの重要性. (2021)
  • Author(s): 永石宇司.
  • Organizer: 第24回日本臨床腸内微生物学会総会学術集会
  • Invited
• [Presentation] 回腸に多発潰瘍を伴い診断に苦慮した腸管子宮内膜症の一例 (2021)
  • Author(s): 五月女 浩子, 河本 亜美, 小金井 一隆, 冨井 翔平, 竹中 健人, 日比谷 秀爾, 清水 寛路, 伊藤 剛, 水谷 知裕, 油井 史郎, 根本 泰宏, 藤井 俊光, 齊藤 詠子, 永石 宇司, 長堀 正和, 大塚 和朗, 岡本 隆一
  • Organizer: 第363回日本消化器病学会関東支部例会
• [Presentation] BCR-mediated activation in lymphoid tissues is regulated by Ceacam1. (2021)
  • Author(s): Takashi Nagaishi
  • Organizer: SMI Virtual Poster Hall
  • Int'l Joint Research / Invited
• [Presentation] 小腸難治性疾患の診断と治療の新知見 クローン病のバルーン内視鏡による小腸粘膜治癒評価 (2020)
  • Author(s): 竹中 健人, 大塚 和朗, 鈴木 康平, 日比谷 秀爾, 河本 亜美, 清水 寛路, 本林 麻衣子, 福田 将義, 藤井 俊光, 齊藤 詠子, 長堀 正和, 土屋 輝一郎, 渡辺 守, 岡本 隆一
  • Organizer: 第58回日本小腸学会学術集会
• [Presentation] 下部消化管内視鏡検査にてクローン病様所見を認めたスキルス胃癌の1例 (2020)
  • Author(s): 高橋 慶子, 竹中 健人, 三好 正人, 清水 寛路, 本林 麻衣子, 齊藤 詠子, 藤井 俊光, 長堀 正和, 大塚 和朗, 岡本 隆一
  • Organizer: 第663回日本内科学会関東地方会
• [Presentation] 5ASA不耐は潰瘍性大腸炎において予後不良である (2020)
  • Author(s): 藤井 俊光, 日比谷 秀爾, 前屋舗 千明, 齊藤 詠子, 竹中 健人, 清水 寛路, 長堀 正和, 大塚 和朗, 黒崎 雅之, 矢内 常人, 泉 並木, 渡辺 守
  • Organizer: 第106回日本消化器病学会
• [Presentation] IBDの最新治療新規薬剤登場により何が変わったか 潰瘍性大腸炎に対するベドリズマブ及びトファシチニブの実臨床における治療成績について (2020)
  • Author(s): 齊藤 詠子, 清水 寛路, 渡辺 守
  • Organizer: 第106回日本消化器病学会
• [Presentation] 抗TNFα製剤治療が有効であった潰瘍性大腸炎術後に発症した壊疽性膿皮症の一例 (2020)
  • Author(s): 河崎 翔, 清水 寛路, 日比谷 秀爾, 本林 麻衣子, 竹中 健人, 油井 史郎, 根本 泰宏, 齊藤 詠子, 藤井 俊光, 岡田 英理子, 大島 茂, 岡本 隆一, 土屋 輝一郎, 永石 宇司, 長堀 正和, 大塚 和朗, 朝比奈 靖浩, 松山 貴俊, 加藤 恒平, 渡辺 守
  • Organizer: 第359回日本消化器病学会関東支部例会
• [Presentation] BCR signaling in lymphoid tissues regulated by the long isoform of Ceacam1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Yudai Kojima, Michio Onizawa, Taro Watabe, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: FOCIS 2020
  • Int'l Joint Research
• [Presentation] 慢性大腸炎モデルにおけるAPLの発現解析. (2020)
  • Author(s): 山田大貴, 永石宇司, 津川直也, 小島裕大, 渡部太郎, 渡辺 守.
  • Organizer: 第48回日本臨床免疫学会総会
• [Presentation] A case of villous atrophy with CCR4+ T cell infiltration in the small intestine. (2020)
  • Author(s): Takashi Nagaishi, Daiki Yamada, Naoya Tsugawa, Taro Watabe, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe.
  • Organizer: UEGW 2020
  • Int'l Joint Research
• [Presentation] BCR signaling in lymphoid tissues is regulated by the long isoform of Ceacam1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Yudai Kojima, Richard S. Blumberg, Mamoru Watanabe.
  • Organizer: MICS 2020
  • Int'l Joint Research
• [Presentation] B cell receptor signaling in lymphoid tissues may be regulated by CEACAM1. (2020)
  • Author(s): Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Mamoru Watanabe.
  • Organizer: European Crohn’s and Colitis Organization 2020
  • Int'l Joint Research
• [Presentation] IBDモデルにおける腸管二次リンパ組織の機能解析. (2020)
  • Author(s): 永石宇司、渡部太郎、渡辺 守.
  • Organizer: 日本応用酵素協会「全身性炎症疾患の病因・病態に関する研究助成」 第9回研究発表会
• [Presentation] IgA-deficiency causes spontaneous enteritis. (2019)
  • Author(s): Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa.
  • Organizer: 第48回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1. (2019)
  • Author(s): Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Yudai Kojima, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: 第48回日本免疫学会学術集会
  • Int'l Joint Research
• [Presentation] 培養腸上皮幹細胞を用いた炎症性腸疾患に対する再生医療の開発. (2019)
  • Author(s): 岡本隆一、清水寛路、鈴木康平、高橋純一、川井麻央、平栗優衣、竹岡さや香、杉原ハディ優樹、永田紗矢香、竹中健人、齋藤詠子、福田将義、藤井俊光、長堀正和、油井史郎、土屋輝一郎、大塚和朗、渡辺 守
  • Organizer: 厚生労働科学研究費 難治性疾患政策研究事業 「難治性炎症性腸管障害に関する調査研究」令和元年度 第1回総会
• [Presentation] Analysis of ileocecal immune response in an animal model of colitis. (2019)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima,Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe.
  • Organizer: International Congress of Mucosal Immunology 2019
  • Int'l Joint Research
• [Presentation] Analysis of APL expression in an animal model of chronic colitis. (2019)
  • Author(s): Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Daiki Yamada, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
  • Organizer: Federation of Clinical Immunology Societies 2019
  • Int'l Joint Research
• [Presentation] APL downregulation in an animal model of chronic colitis. (2019)
  • Author(s): Daiki Yamada, Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
  • Organizer: Asian Organization of Crohn’s and Colitis 2019
  • Int'l Joint Research
• [Presentation] Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies. (2019)
  • Author(s): Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe
  • Organizer: Asian Organization of Crohn’s and Colitis 2019
  • Int'l Joint Research
• [Presentation] The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD). (2019)
  • Author(s): Eiko Saito, Kohei Suzuki, Shuuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
  • Organizer: Asian Organization of Crohn’s and Colitis 2019
  • Int'l Joint Research
• [Presentation] 慢性大腸炎モデルのT細胞におけるAPLの発現抑制. (2019)
  • Author(s): 山田大貴、永石宇司、津川直也、小島裕大、渡部太郎、鈴木雅博、鬼沢道夫、細谷明徳、Jose, Nisha、渡辺 守.
  • Organizer: 第105回日本消化器病学会総会
• [Presentation] APL expression is downregulated in an animal model of chronic colitis. (2019)
  • Author(s): Takashi Nagaishi, Yudai Kojima, Daiki Yamada, Taro Watabe, Naoya Tsugawa, Nisha Jose, Michio Onizawa, Mamoru Watanabe.
  • Organizer: European Crohn’s and Colitis Organization 2019
  • Int'l Joint Research
• [Presentation] 慢性大腸炎モデルにおけるAPL発現の解析. (2019)
  • Author(s): 山田大貴、永石宇司、小島裕大、渡部太郎、津川直也、細谷明徳、Jose, Nisha、鈴木雅博、鬼沢道夫、渡辺 守.
  • Organizer: 第15回日本消化管学会総会学術集会
• [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物 (2020)
  • Inventor(s): 永石 宇司
  • Industrial Property Rights Holder: 永石 宇司
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2018-554239
  • Filing Date: 2020
  • Acquisition Date: 2020
• [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物 (2019)
  • Inventor(s): 永石宇司、渡辺守
  • Industrial Property Rights Holder: 永石宇司
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019