• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Non-invasive diagnosis of non-alcoholic steatohepatitis by ultrasound attenuation imaging and two-dimensional shear wave elastography

Research Project

Project/Area Number 19K08400
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionIwate Medical University

Principal Investigator

Kuroda Hidekatsu  岩手医科大学, 医学部, 特任准教授 (70382596)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsNASH / NAFLD / 2D-SWE / UGAP / 非アルコール性脂肪肝炎 / 超音波エラストグラフィ / 超音波減衰量イメージング法 / Elastography
Outline of Research at the Start

膨大な患者数のNAFLDから、予後の悪い線維化進展例やNASHを効率よく囲い込み、診断することは重要な臨床的課題である。本研究の目的は、超音波技術を駆使した安価で高精度かつ繰り返し施行可能な非侵襲的診断法の確立である。本研究では、超音波エラストグラフィ (2D-Shear Wave Elastography: 2D-SWE)と、申請者とGEヘルスケア・ジャパン株式会社との共同研究開発した超音波減衰量イメージング法 (Ultrasound Guided Attenuation Parameter: UGAP)を用い、線維化進展例やNASHの囲い込み・診断が可能なモデル式の構築と検証を行う。

Outline of Final Research Achievements

We investigated the usefulness of combining 2D-SWE and the ultrasound-guided attenuation parameter (UGAP) for assessing the risk of progressive NASH. This prospective study included 202 patients with NAFLD who underwent 2D-SWE, UGAP, and liver biopsy (LB) on the same day. Patients were grouped according to liver stiffness (LS) and the attenuation coefficient (AC): A, low LS/low AC; B, low LS/high AC; C, high LS/low AC; and D, high LS/high AC. The percentages of progressive NASH in Groups A, B, C, and D were 0.0%, 7.7%, 35.7%, and 50.0%, respectively (P<0.001). The prediction model was established as logit (p) = 0.541 × LS (kPa) + 7.79 × AC (dB/cm/MHz) - 8.40, with AUROC, sensitivity, and specificity values of 0.83, 80.9%, and 74.6%, respectively. Combined assessment by 2D-SWE and UGAP is useful for risk stratification of progressive NASH and may be convenient for evaluating the necessity of specialist referral and LB.

Academic Significance and Societal Importance of the Research Achievements

NAFLD/NASHは世界中で患者数が急増し、そのエンドステージである肝硬変や肝細胞癌は今日臨床現場での大きな脅威となっている。膨大な患者数のNAFLDから、予後の悪い線維化進展例やNASHを効率よく囲い込むことは極めて重要な臨床的課題である。我々は、NAFLDの肝線維化診断における2D-SWEの有用性、肝脂肪化診断におけるUGAPの有用性を者の併用によりNASHならびにprogressive NASH の効率的な層別化が可能で、高精度なprogressive NASH診断予測モデルの構築に成功した。本成果は、肝生検適応や治療方針の判断への応用も期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (27 results)

All 2022 2021 2020 2019

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 5 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Diagnostic Accuracy of Two-Dimensional Shear Wave Elastography?for Liver Fibrosis: A Multicenter Prospective Study2022

    • Author(s)
      Kakegawa Tatsuya、Sugimoto Katsutoshi、Kuroda Hidekatsu、Suzuki Yasuaki、Imajo Kento、Toyoda Hidenori、Tamaki Nobuharu、Yasuda Satoshi、Yasui Yutaka、Kurosaki Masayuki、Izumi Namiki、Nakajima Atsushi、Kumada Takashi
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: 20 Issue: 6 Pages: e1478-e1482

    • DOI

      10.1016/j.cgh.2021.08.021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of Ultrasound-Guided Attenuation Parameter for Grading Steatosis With Reference to MRI-PDFF in a Large Cohort2021

    • Author(s)
      Imajo Kento、Toyoda Hidenori、Yasuda Satoshi、Suzuki Yasuaki、Sugimoto Katsutoshi、Kuroda Hidekatsu、Akita Tomoyuki、Tanaka Junko、Yasui Yutaka、Tamaki Nobuharu、Kurosaki Masayuki、Izumi Namiki、Nakajima Atsushi、Kumada Takashi
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: 21 Issue: 11 Pages: 01182-01184

    • DOI

      10.1016/j.cgh.2021.11.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic accuracy of ultrasound-guided attenuation parameter as a noninvasive test for steatosis in non-alcoholic fatty liver disease2021

    • Author(s)
      Kuroda Hidekatsu、Abe Tamami、Fujiwara Yudai、Nagasawa Tomoaki、Takikawa Yasuhiro
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 48 Issue: 4 Pages: 471-480

    • DOI

      10.1007/s10396-021-01123-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive scoring system for advanced liver fibrosis in Japanese patients with severe obesity2021

    • Author(s)
      Nikai Haruka、Sasaki Akira、Umemura Akira、Takahashi Naoto、Nitta Hiroyuki、Akasaka Risaburo、Kakisaka Keisuke、Kuroda Hidekatsu、Ishida Kazuyuki、Takikawa Yasuhiro
    • Journal Title

      Surgery Today

      Volume: 51 Issue: 9 Pages: 1513-1520

    • DOI

      10.1007/s00595-021-02266-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis2021

    • Author(s)
      Kuroda Hidekatsu、Fujiwara Yudai、Abe Tamami、Nagasawa Tomoaki、Oguri Takuma、Noguchi Sachiyo、Kamiyama Naohisa、Takikawa Yasuhiro
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 4 Pages: e0249493-e0249493

    • DOI

      10.1371/journal.pone.0249493

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparing the Safety and Efficacy of Microwave Ablation Using Thermosphere TM Technology versus Radiofrequency Ablation for Hepatocellular Carcinoma: A Propensity Score-Matched Analysis2021

    • Author(s)
      Kuroda H, Nagasawa T, Fujiwara Y, Sato H, Abe T, Kooka Y, Endo K, Oikawa T, Sawara K, Takikawa Y.
    • Journal Title

      Cancers

      Volume: 15;13(6) Issue: 6 Pages: 1295-1295

    • DOI

      10.3390/cancers13061295

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two hepatectomy cases for initially unresectable hepatocellular carcinoma after achieving a radiological complete response to sequential therapy with lenvatinib and transcatheter arterial chemoembolization2021

    • Author(s)
      Endo Kei、Kuroda Hidekatsu、Abe Tamami、Sato Hiroki、Kooka Youhei、Oikawa Takayoshi、Sato Ayaka、Nishiya Masao、Sugai Tamotsu、Takikawa Yasuhiro
    • Journal Title

      Hepatology Research

      Volume: 51 Issue: 10 Pages: 1082-1086

    • DOI

      10.1111/hepr.13665

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contrast-enhanced ultrasonography-based hepatic perfusion for early prediction of prognosis in acute liver failure2020

    • Author(s)
      Kuroda H, Abe T, Fujiwara Y, Nagasawa T, Suzuki Y, Kakisaka K, Takikawa Y.
    • Journal Title

      Hepatology

      Volume: 5 Issue: 6 Pages: 2455-2467

    • DOI

      10.1002/hep.31615

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic problems in two-dimensional shear wave elastography of the liver.2020

    • Author(s)
      Naganuma H, Ishida H, Uno A, Nagai H, Kuroda H, Ogawa M.
    • Journal Title

      World J Radiol

      Volume: 28;12(5) Issue: 5 Pages: 76-86

    • DOI

      10.4329/wjr.v12.i5.76

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Grip Strength in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib2020

    • Author(s)
      Endo K, Kuroda H, Kanazawa J, Sato T, Fujiwara Y, Abe T, Sato H, Kooka Y, Oikawa T, Sawara K, Takikawa Y.
    • Journal Title

      Cancers

      Volume: 3;12(8) Issue: 8 Pages: 2146-2146

    • DOI

      10.3390/cancers12082146

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] HCV排除治療が非代償性肝硬変の肝硬度に及ぼす影響2021

    • Author(s)
      阿部珠美, 黒田英克, 滝川康裕
    • Organizer
      第57回日本肝臓学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Multicentral study for evaluating hepatic steatosis using ultrasound-guided attenuation parameter by comparison with MRI-determined proton density fat fraction2021

    • Author(s)
      Hidekatsu Kuroda
    • Organizer
      第57回日本肝臓学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] UGAPとテクスチャ解析による軽度脂肪肝の定量評価精度向上手法の検討2021

    • Author(s)
      大栗 拓真, 神山 直久, 野口 幸代, 黒田 英克, 阿部 珠美, 三上 有里子, 細野 みゆき, 滝川 康裕
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 最新技術で極める肝臓の超音波診断2021

    • Author(s)
      黒田 英克
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 2D-SWEとUGAPを用いたprogressive NASHリスク層別化の試み2021

    • Author(s)
      黒田 英克, 阿部 珠美, 藤原 裕大, 長澤 倫明, 大栗 拓真, 野口 幸代, 神山 直久, 滝川 康裕
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 慢性肝疾患におけるUGAPを用いた肝脂肪測定~MRI PDFFとの比較検討~(多施設共同研究)2021

    • Author(s)
      鈴木 康秋, 安田 諭, 豊田 秀徳, 今城 健人, 中島 淳, 杉本 勝俊, 黒田 英克, 安井 豊, 黒崎 雅之, 熊田 卓
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 2D-SWEとUGAPを用いたprogressive NASHリスク層別化の試み2021

    • Author(s)
      黒田 英克、阿部 珠美、藤原 裕大、長澤 倫明、大栗 拓真、野口 幸代、神山 直久、滝川 康裕
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非侵襲的肝脂肪化診断におけるUltrasound-Guided Attenuation Parameterの有用性 -多施設共同研究2021

    • Author(s)
      黒田 英克
    • Organizer
      第57回日本肝臓学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] UGAPとテクスチャ解析による軽度脂肪肝の定量評価精度向上手法の検討2021

    • Author(s)
      大栗拓真、神山直久、野口幸代、黒田英克、阿部珠美、三上有里子、滝川康裕
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 超音波減衰量イメージングとエラストグラフィによるNASHの非侵襲的診断法の確立2020

    • Author(s)
      黒田 英克、阿部 珠美、滝川 康裕
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] UGAPと2D-SWEを用いたNASHの非侵襲的診断法の確立2020

    • Author(s)
      黒田 英克、阿部 珠美、藤原 裕大、長澤 倫明、大栗 拓真、野口 幸代、神山 直久、滝川 康裕
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] UGAPを用いたNAFLDの脂肪化推定とballooning hepatocyte出現予測の試み2019

    • Author(s)
      黒田 英克1, 岡本 卓也1, 藤原 裕大1, 阿部 珠美1, 大栗 拓真2, 金山 侑子2, 野口 幸代2, 神山 直久2, 滝川 康裕1
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高精度NAFLD高度線維化予測スコアリングモデルの構築2019

    • Author(s)
      阿部 珠美, 黒田 英克, 岡本 卓也, 藤原 裕大, 滝川 康裕
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 2D-Shear Wave Elastography multi-modeの検査者内再現性と測定所要時間に関する検討2019

    • Author(s)
      三上 有里子1, 黒田 英克2, 阿部 珠美2, 滝川 康裕2, 大栗 拓真3, 金山 侑子3, 野口 幸代3, 神山 直久3, 諏訪部 章4
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] エコー信号のSN比を利用したびまん性肝疾患の定量法と表現法に関する一検討2019

    • Author(s)
      大栗 拓真1, 神山 直久1, 野口 幸代1, 金山 侑子1, 黒田 英克2, 阿部 珠美2, 藤原 裕大2, 三上 有里子2, 滝川 康裕2
    • Organizer
      日本超音波医学会第92回学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Accuracy of ultrasound-guided attenuation parameter (UGAP)2019

    • Author(s)
      黒田 英克
    • Organizer
      第55回肝臓総会
    • Related Report
      2019 Research-status Report
  • [Book] INNERVISION2020

    • Author(s)
      黒田英克
    • Total Pages
      3
    • Publisher
      インナービジョン
    • ISBN
      9784902131840
    • Related Report
      2020 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi