• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive biological network analysis of pancreatic cancer

Research Project

Project/Area Number 19K08435
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionThe University of Tokyo

Principal Investigator

TATEISHI KEISUKE  東京大学, 医学部附属病院, 講師 (20396948)

Co-Investigator(Kenkyū-buntansha) 藤原 弘明  公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) (00814500)
水野 卓  東京大学, 医学部附属病院, 助教 (30771050)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵癌 / エピゲノム / クロマチン
Outline of Research at the Start

癌を生体内の動的な細胞集団として理解するうえでは、微少細胞毎の解析を基盤とし、その多様性と腫瘍内での細胞間相互関係を明らかにすることが重要である。本研究はヒト膵癌の微少細胞レベルでの発現データを基に、膵癌幹細胞マーカー発現に焦点を当て、その分布と共発現する遺伝子群を網羅的に抽出する。さらに幹細胞マーカー陽性/陰性細胞の発現とエピゲノムプロファイルを比較検討し、膵腫瘍内の多様性と可塑性を裏付けると同時に、膵癌細胞同士のクロストークにおけるエピゲノム制御の重要性について探索・検証する。

Outline of Final Research Achievements

This research proposed a significance of epigenetic regulation in the subtype determination of pancreatic cancers. Human derived pancreatic cancer organoids were useful for the molecular and phenotypic analyses. ATAC-seq and ChIP-seq as well as RNA-seq indicated the subtype-specific profiles, which emphasized a pivotal role of epigenome status for the biological features in pancreatic cancers. This research offered a clue that epigenome is a novel target against pancreatic cancers.

Academic Significance and Societal Importance of the Research Achievements

塩基配列変化を伴わずに遺伝子転写を制御するDNAメチル化やヒストン修飾などのエピゲノム制御は、多彩な機序で癌の性質に影響を及ぼしうると考えられる。癌細胞同士や間質細胞などから構成される独自の微小環境から慢性的な刺激を受ける過程で、その外部刺激を生存・増殖に適応させ、癌細胞がaddictする特異的なエピゲノム変化を誘導している可能性がある。本研究では膵癌において、エピゲノムに基づくサブタイプが存在することを明らかにした。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2022 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (1 results)

  • [Journal Article] MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages2022

    • Author(s)
      Kato H, Tateishi K, Fujiwara H, Nakatsuka T, Yamamoto K, Kudo Y, Hayakawa Y, Nakagawa H, Tanaka Y, Ijichi H, Otsuka M, Iwadate D, Oyama H, Kanai S, Noguchi K, Suzuki T, Sato T, Hakuta R, Ishigaki K, Saito K, Saito T, Takahara N, Kishikawa T, Hamada T, Takahashi R, Miyabayashi K, et al.
    • Journal Title

      Gastroenterology

      Volume: 162 Issue: 4 Pages: 1272-1287

    • DOI

      10.1053/j.gastro.2021.12.254

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis Carcinogenesis2020

    • Author(s)
      Hiroyuki Kato, Keisuke Tateishi*, Hiroaki Fujiwara, Hideaki Ijichi, Keisuke Yamamoto, Takuma Nakatsuka, Miwako Kakiuchi, Makoto Sano, Yotaro Kudo, Yoku Hayakawa, Hayato Nakagawa, Yasuo Tanaka, Motoyuki Otsuka, Yoshihiro Hirata, Makoto Tachibana, Yoichi Shinkai, Kazuhiko Koike
    • Journal Title

      Cancer Genomics Proteomics

      Volume: 17 Issue: 6 Pages: 695705-695705

    • DOI

      10.21873/cgp.20224

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.2020

    • Author(s)
      Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K.
    • Journal Title

      Gastroenterology.

      Volume: 158 Issue: 1 Pages: 226-237

    • DOI

      10.1053/j.gastro.2019.08.032

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blocking CXCLs?CXCR2 axis in tumor?stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment2019

    • Author(s)
      Sano Makoto、Ijichi Hideaki、Takahashi Ryota、Miyabayashi Koji、Fujiwara Hiroaki、Yamada Tomoharu、Kato Hiroyuki、Nakatsuka Takuma、Tanaka Yasuo、Tateishi Keisuke、Morishita Yasuyuki、Moses Harold L.、Isayama Hiroyuki、Koike Kazuhiko
    • Journal Title

      Oncogenesis

      Volume: 8 Issue: 2 Pages: 8-8

    • DOI

      10.1038/s41389-018-0117-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] VCAM-1阻害は膵癌の進展と癌関連血栓症/血栓塞栓症を抑制し予後に寄与する2020

    • Author(s)
      佐野誠,高橋良太,伊地知秀明,石垣和祥,山田友春,宮林弘至,水野卓,中塚拓馬,田中康雄,眞杉洋平,森下保幸,田中麻理子,立石敬介,Harold L Moses,小池和彦
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report

URL: 

Published: 2019-04-18   Modified: 2023-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi