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Immune regulation via intestinal autophagy for the treatment of Crohn's disease

Research Project

Project/Area Number 19K08438
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Nagahori Masakazu  東京医科歯科大学, 東京医科歯科大学病院, 准教授 (60420254)

Co-Investigator(Kenkyū-buntansha) 永石 宇司  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464)
渡辺 守  東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腸管免疫 / 腸管上皮 / 炎症性腸疾患 / オートファジー
Outline of Research at the Start

我々はこれまでの研究結果から、本研究では腸管粘膜の免疫恒常性は腸管上皮細胞のオートファジー機能と粘膜内リンパ球とのクロストークによって制御され、その破綻がIBDの本態となるという概念を提唱しつつ、大腸上皮特異的Atg5欠損マウス、大腸上皮細胞の初代(三次元)培養・移植技術、生体イメージング技術等々、我々が既に独自に樹立している技術を融合し、さらに上皮細胞のオートファジーによる腸管粘膜の新規免疫調節機構という新しい概念に着眼する。

Outline of Final Research Achievements

Inflammatory bowel disease (IBD) including Crohn’s disease is characterized by unrestrained lymphocyte activation that results in the production of a variety of pro-inflammatory cytokines as well as other mediators. Understanding the mechanisms of lymphocyte regulation is therefore of significant importance in the study of dysregulated mucosal inflammation such as IBD. Associated with this, several studies have revealed the importance of autophagy in several cell types of IBD pathology, such as intestinal epithelial cells. In this regard, we were able to observe ex vivo activities where functions of these lymphocytes can be modulated by autophagy in the epithelial cells derived from mouse intestines. Defining the physiological mechanisms of autophagy in intestinal epithelial cells will lead to a greater understanding of how manipulation of effecter lymphocyte function may provide insights into novel treatment of IBD.

Academic Significance and Societal Importance of the Research Achievements

炎症性腸疾患(IBD)の新規治療法開発を困難にしている理由は、腸管の免疫調節機構が未だ不明確なことにある。本研究の意義は腸管の粘膜免疫応答に関する研究を独自に展開してきた申請者らが、マウス腸管組織由来の上皮細胞初代培養技術を応用しつつ腸管特有の免疫調節機構を繙くことで、これまで実現し得なかった「腸管上皮細胞オートファジーによる免疫応答調節機構」の解明に向けた技術基盤を樹立するという免疫学的貢献ばかりでなく、IBDにおける腸管粘膜傷害に対するその特異的な免疫調節異常を標的とした新規治療法の開発基盤の創出に発展するものと期待できる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (65 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (33 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 27 results,  Open Access: 18 results) Presentation (28 results) (of which Int'l Joint Research: 15 results,  Invited: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Int'l Joint Research] Brigham and Women's Hospital/Harvard Medical School(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Imperial College London(英国)

    • Related Report
      2020 Research-status Report
  • [Journal Article] 外来クローン病患者における生体インピーダンス法を用いた体組成の評価2022

    • Author(s)
      斎藤 恵子, 太田 一樹, 長堀 正和, 藤井 俊光, 竹中 健人, 大塚和朗, 井津井 康浩, 篠原 夏美, 松下 由佳子, 岡本 隆一
    • Journal Title

      学会誌JASPEN

      Volume: 4 Pages: 35-43

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【炎症性腸疾患の粘膜治癒を再考する】Crohn病における小腸粘膜治癒評価の意義 バルーン内視鏡の立場から2022

    • Author(s)
      大塚 和朗, 竹中 健人, 齊藤 詠子, 日比谷 秀爾, 河本 亜美, 森川 亮, 藤井 俊光, 清水 寛路, 長堀 正和, 岡本 隆一
    • Journal Title

      胃と腸

      Volume: 57 Pages: 173-181

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022

    • Author(s)
      Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Lancet Gastroenterol Hepatol

      Volume: 7 Issue: 3 Pages: 230-237

    • DOI

      10.1016/s2468-1253(21)00372-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.2022

    • Author(s)
      Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
    • Journal Title

      Biochemical and Biophysical Research Communications.

      Volume: 592 Pages: 74-80

    • DOI

      10.1016/j.bbrc.2021.12.111

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activated mucosal-associated invariant T cells have a pathogenic role in a murine model of inflammatory bowel disease.2022

    • Author(s)
      usuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Saichiko Miyake.
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology.

      Volume: 13 Issue: 1 Pages: 81-93

    • DOI

      10.1016/j.jcmgh.2021.08.018

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腸内細菌叢に対するIgAの重要性.2022

    • Author(s)
      永石宇司.
    • Journal Title

      日本臨床腸内微生物学会誌.

      Volume: 24 Pages: 19-20

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 【診断の決め手となった画像・所見II-消化器】消化管 クローン病の診断2021

    • Author(s)
      北詰 良雄, 竹中 健人, 藤井 俊光, 長堀 正和, 大塚 和朗
    • Journal Title

      臨床放射線

      Volume: 66 Pages: 1491-1498

    • Related Report
      2021 Annual Research Report
  • [Journal Article] IBD診療現場のPros & Cons[No.3](その1) クローン病に対する生物学的製剤治療にチオプリン製剤を併用するか?併用するの立場から2021

    • Author(s)
      長堀 正和
    • Journal Title

      IBD Research

      Volume: 15 Pages: 177-180

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 【最新の内視鏡を使いこなす】最新のスコープを使いこなす 小腸内視鏡 小腸内視鏡 オリンパス社内視鏡2021

    • Author(s)
      大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 斎藤 詠子, 藤井 俊光, 長堀 正和, 清水 寛路, 岡本 隆一
    • Journal Title

      消化器内視鏡

      Volume: 33 Pages: 1283-1287

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus2021

    • Author(s)
      Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
    • Journal Title

      BMC Gastroenterol

      Volume: 21 Issue: 1 Pages: 494-494

    • DOI

      10.1186/s12876-021-02043-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease2021

    • Author(s)
      Kento Takenaka, Ami Kawamoto, Shuji Hibiya, Kohei Suzuki, Toshimitsu Fujii, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka
    • Journal Title

      Aliment Pharmacol Ther

      Volume: 54 Issue: 8 Pages: 1052-1060

    • DOI

      10.1111/apt.16551

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Substantial Epstein-Barr virus reactivation in a case of severe refractory ulcerative colitis: a possible role in exacerbation2021

    • Author(s)
      Shu Kato, Hiromichi Shimizu, Shohei Tomii, Hitoshi Uchida, Ami Kawamoto, Shuji Hibiya, Maiko Motobayashi, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mariko Negi, Takumi Akashi, Takatoshi Matsuyama, Yusuke Kinugasa & Mamoru Watanabe
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 14 Issue: 2 Pages: 584-588

    • DOI

      10.1007/s12328-020-01319-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A nationwide survey concerning the mortality and risk of progressing severity due to arterial and venous thromboembolism in inflammatory boweldisease in Japan2021

    • Author(s)
      Katsuyoshi Ando,Kenji Watanabe, Sakiko Hiraoka, Taku Kobayashi,Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Motohiro Esaki, Makoto Naganuma, Satoshi Motoya,Masayuki Saruta, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu,Masahiro Iizuka, Mamoru Watanabe, YasuoSuzuki, and Tadakazu Hisamatsu
    • Journal Title

      J Gastroenterol .

      Volume: 56 Issue: 12 Pages: 1062-1079

    • DOI

      10.1007/s00535-021-01829-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum2021

    • Author(s)
      Nagaishi Takashi、Watabe Taro、Kotake Kunihiko、Kumazawa Toshihiko、Aida Tomomi、et al.
    • Journal Title

      Gut

      Volume: 71 Issue: 3 Pages: 487-496

    • DOI

      10.1136/gutjnl-2020-322873

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production.2021

    • Author(s)
      Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
    • Journal Title

      Biochemistry and Biophysics Reports.

      Volume: 27 Pages: 101065-101065

    • DOI

      10.1016/j.bbrep.2021.101065

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice.2021

    • Author(s)
      Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
    • Journal Title

      Journal of Gastroenterolog.

      Volume: 56 Issue: 8 Pages: 732-745

    • DOI

      10.1007/s00535-021-01792-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 免疫グロブリンAの欠損により回腸特異的な炎症が自然発症する.2021

    • Author(s)
      安達貴弘,永石宇司.
    • Journal Title

      消化器学サイエンス.

      Volume: 5 Pages: 230-232

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis2021

    • Author(s)
      Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe
    • Journal Title

      Aliment Pharmacol Ther

      Volume: 53 Pages: 103-113

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis2021

    • Author(s)
      Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Intest Res

      Volume: 19 Issue: 1 Pages: 115-118

    • DOI

      10.5217/ir.2020.00030

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Week 2 Symptomatic Response with Vedolizumab as a Predictive Factor in Japanese Anti-TNFα-Naive Patients with Ulcerative Colitis: A post hoc Analysis of a Randomized, Placebo-Controlled Phase 3 Trial2021

    • Author(s)
      Masakazu Nagahori, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Takanori Kanai, Toshiyuki Matsui, Yasuo Suzuki, Philippe Pinton, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Toshifumi Hibi, Mamoru Watanabe
    • Journal Title

      Digestion

      Volume: 15 Issue: 5 Pages: 1-11

    • DOI

      10.1159/000512235

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021

    • Author(s)
      Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
    • Journal Title

      Cell Mol Gastroenterol Hepatol.

      Volume: 11 Issue: 5 Pages: 1483-1503

    • DOI

      10.1016/j.jcmgh.2021.01.014

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis2020

    • Author(s)
      Taku Kobayashi, Hiroaki Ito, Toshifumi Ashida, Tadashi Yokoyama, Masakazu Nagahori, Tomoki Inaba, Mitsuhiro Shikamura, Takayoshi Yamaguchi, Tetsuharu Hori, Philippe Pinton, Mamoru Watanabe, Toshifumi Hibi
    • Journal Title

      Intest Res

      Volume: 18 Issue: 4 Pages: 448-460

    • DOI

      10.5217/ir.2020.00026

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-conception status, obstetric outcome and use of medications during pregnancy of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) in Japan: Multi-center retrospective descriptive study2020

    • Author(s)
      Sayaka Tsuda, Azusa Sameshima, Michikazu Sekine, Haruna Kawaguchi, Daisuke Fujita, Shintaro Makino, Akio Morinobu, Yohko Murakawa, Kiyoshi Matsui, Takao Sugiyama, Mamoru Watanabe, Yasuo Suzuki, Masakazu Nagahori, Atsuko Murashima, Tatsuya Atsumi, Kenji Oku, Nobuaki Mitsuda, Syuji Takei, Takako Miyamae, et al.
    • Journal Title

      Mod Rheumatol

      Volume: 30 Issue: 5 Pages: 852-861

    • DOI

      10.1080/14397595.2019.1661592

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62.2020

    • Author(s)
      Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 542 Pages: 17-23

    • DOI

      10.1016/j.bbrc.2021.01.023

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CEACAM1 specifically suppresses B cell receptor signaling-mediated activation..2020

    • Author(s)
      Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 535 Pages: 99-105

    • DOI

      10.1016/j.bbrc.2020.11.126

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells.2020

    • Author(s)
      Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
    • Journal Title

      FEBS letters

      Volume: 594 Issue: 10 Pages: 1586-1595

    • DOI

      10.1002/1873-3468.13748

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evidence-based diagnosis and clinical practice guidelines for intestinal Behçet's disease 2020 edited by intractable diseases, the Health and Labour Sciences Research Grants.2020

    • Author(s)
      Kenji Watanabe , Satoshi Tanida , Nagamu Inoue , Reiko Kunisaki , Kiyonori Kobayashi , Masakazu Nagahori , Katsuhiro Arai , Motoi Uchino , Kazutaka Koganei , Taku Kobayashi , Mitsuhiro Takeno , Fumiaki Ueno , Takayuki Matsumoto , Nobuhisa Mizuki , Yasuo Suzuki , Tadakazu Hisamatsu
    • Journal Title

      J Gastroenterol.

      Volume: Epub ahead of print Issue: 7 Pages: 679-700

    • DOI

      10.1007/s00535-020-01690-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development and validation of a deep neural network for accurate evaluation of endoscopic images from patients with ulcerative colitis.2020

    • Author(s)
      Kento Takenaka , Kazuo Ohtsuka , Toshimitsu Fujii , Mariko Negi , Kohei Suzuki , Hiromichi Shimizu , Shiori Oshima , Shintaro Akiyama , Maiko Motobayashi , Masakazu Nagahori , Eiko Saito , Katsuyoshi Matsuoka , Mamoru Watanabe
    • Journal Title

      Gastroenterology

      Volume: Epub ahead of print Issue: 8 Pages: 2150-2157

    • DOI

      10.1053/j.gastro.2020.02.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo2020

    • Author(s)
      Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 523 Issue: 2 Pages: 328-335

    • DOI

      10.1016/j.bbrc.2019.12.021

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage2020

    • Author(s)
      Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 522 Issue: 4 Pages: 971-977

    • DOI

      10.1016/j.bbrc.2019.11.158

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Indolent T cell lymphoproliferative disorder with villous atrophy in small intestinediagnosed by single-balloon enteroscopy.2019

    • Author(s)
      Takashi Nagaishi, Daiki Yamada, Kohei Suzuki, Ryosuke Fukuyo, Eiko Saito, Masayoshi Fukuda, Taro Watabe, Naoya Tsugawa, Kengo Takeuchi, Kouhei Yamamoto, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Clin J Gastroenterol.

      Volume: in press Issue: 5 Pages: 434-440

    • DOI

      10.1007/s12328-019-00971-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019

    • Author(s)
      Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: inpress Issue: 7 Pages: 1545-1552

    • DOI

      10.1016/j.cgh.2019.08.024

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictors of mucosal healing during induction therapy in patients with acute moderate‐to‐severe ulcerative colitis2018

    • Author(s)
      Motobayashi Maiko、Matsuoka Katsuyoshi、Takenaka Kento、Fujii Toshimitsu、Nagahori Masakazu、Ohtsuka Kazuo、Iwamoto Fumihiko、Tsuchiya Kiichiro、Negi Mariko、Eishi Yoshinobu、Watanabe Mamoru
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: in press Issue: 6 Pages: 1004-1010

    • DOI

      10.1111/jgh.14565

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] The Lack of IgA spontaneously induces the inflammation only in the ileum.2021

    • Author(s)
      Daiki Yamada, Takahiro Adachi, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
    • Organizer
      The 50th Annual meeting of Japanese Society of Immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A case of indolent T cell lymphoproliferative disorder of gastrointestinal tract with CCR4+ T cell infiltration.2021

    • Author(s)
      Daiki Yamada, Takashi Nagaishi, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Ryuichi Okamoto.
    • Organizer
      The 80th Annual meeting of Japanese Cancer Association
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] BCR signaling-mediated activation in lymphoid tissues is regulated by the long isoform of CEACAM1.2021

    • Author(s)
      akashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto.
    • Organizer
      Annual meeting of American Gastroenterology Association, Digestive Disease Week
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腸内細菌叢に対するIgAの重要性.2021

    • Author(s)
      永石宇司.
    • Organizer
      第24回日本臨床腸内微生物学会総会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 回腸に多発潰瘍を伴い診断に苦慮した腸管子宮内膜症の一例2021

    • Author(s)
      五月女 浩子, 河本 亜美, 小金井 一隆, 冨井 翔平, 竹中 健人, 日比谷 秀爾, 清水 寛路, 伊藤 剛, 水谷 知裕, 油井 史郎, 根本 泰宏, 藤井 俊光, 齊藤 詠子, 永石 宇司, 長堀 正和, 大塚 和朗, 岡本 隆一
    • Organizer
      第363回日本消化器病学会関東支部例会
    • Related Report
      2020 Research-status Report
  • [Presentation] BCR-mediated activation in lymphoid tissues is regulated by Ceacam1.2021

    • Author(s)
      Takashi Nagaishi
    • Organizer
      SMI Virtual Poster Hall
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 小腸難治性疾患の診断と治療の新知見 クローン病のバルーン内視鏡による小腸粘膜治癒評価2020

    • Author(s)
      竹中 健人, 大塚 和朗, 鈴木 康平, 日比谷 秀爾, 河本 亜美, 清水 寛路, 本林 麻衣子, 福田 将義, 藤井 俊光, 齊藤 詠子, 長堀 正和, 土屋 輝一郎, 渡辺 守, 岡本 隆一
    • Organizer
      第58回日本小腸学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 下部消化管内視鏡検査にてクローン病様所見を認めたスキルス胃癌の1例2020

    • Author(s)
      高橋 慶子, 竹中 健人, 三好 正人, 清水 寛路, 本林 麻衣子, 齊藤 詠子, 藤井 俊光, 長堀 正和, 大塚 和朗, 岡本 隆一
    • Organizer
      第663回日本内科学会関東地方会
    • Related Report
      2020 Research-status Report
  • [Presentation] 5ASA不耐は潰瘍性大腸炎において予後不良である2020

    • Author(s)
      藤井 俊光, 日比谷 秀爾, 前屋舗 千明, 齊藤 詠子, 竹中 健人, 清水 寛路, 長堀 正和, 大塚 和朗, 黒崎 雅之, 矢内 常人, 泉 並木, 渡辺 守
    • Organizer
      第106回日本消化器病学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 抗TNFα製剤治療が有効であった潰瘍性大腸炎術後に発症した壊疽性膿皮症の一例2020

    • Author(s)
      河崎 翔, 清水 寛路, 日比谷 秀爾, 本林 麻衣子, 竹中 健人, 油井 史郎, 根本 泰宏, 齊藤 詠子, 藤井 俊光, 岡田 英理子, 大島 茂, 岡本 隆一, 土屋 輝一郎, 永石 宇司, 長堀 正和, 大塚 和朗, 朝比奈 靖浩, 松山 貴俊, 加藤 恒平, 渡辺 守
    • Organizer
      第359回日本消化器病学会関東支部例会
    • Related Report
      2020 Research-status Report
  • [Presentation] BCR signaling in lymphoid tissues regulated by the long isoform of Ceacam1.2020

    • Author(s)
      Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Yudai Kojima, Michio Onizawa, Taro Watabe, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      FOCIS 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性大腸炎モデルにおけるAPLの発現解析.2020

    • Author(s)
      山田大貴, 永石宇司, 津川直也, 小島裕大, 渡部太郎, 渡辺 守.
    • Organizer
      第48回日本臨床免疫学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] A case of villous atrophy with CCR4+ T cell infiltration in the small intestine.2020

    • Author(s)
      Takashi Nagaishi, Daiki Yamada, Naoya Tsugawa, Taro Watabe, Eiko Saito, Masayoshi Fukuda, Ayako Arai, Kazuo Ohtsuka, Mamoru Watanabe.
    • Organizer
      UEGW 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] BCR signaling in lymphoid tissues is regulated by the long isoform of Ceacam1.2020

    • Author(s)
      Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Yudai Kojima, Richard S. Blumberg, Mamoru Watanabe.
    • Organizer
      MICS 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] B cell receptor signaling in lymphoid tissues may be regulated by CEACAM1.2020

    • Author(s)
      Takashi Nagaishi, Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Mamoru Watanabe.
    • Organizer
      European Crohn’s and Colitis Organization 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] IBDモデルにおける腸管二次リンパ組織の機能解析.2020

    • Author(s)
      永石宇司、渡部太郎、渡辺 守
    • Organizer
      日本応用酵素協会「全身性炎症疾患の病因・病態に関する研究助成」 第9回研究発表会
    • Related Report
      2019 Research-status Report
  • [Presentation] IgA-deficiency causes spontaneous enteritis.2019

    • Author(s)
      Takahiro Adachi, Taro Watabe, Takashi Nagaishi, Mamoru Watanabe, Hajime Karasuyama, Soichiro Yoshikawa.
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] BCR signaling in the activated B cells may be regulated by the long isoform of Ceacam1.2019

    • Author(s)
      Naoya Tsugawa, Takashi Nagaishi, Daiki Yamada, Yudai Kojima, Taro Watabe, Shuang Wang, Michio Onizawa, Takahiro Adachi, Mamoru Watanabe.
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 培養腸上皮幹細胞を用いた炎症性腸疾患に対する再生医療の開発2019

    • Author(s)
      高橋純一、川井麻央、平栗優衣、竹岡さや香、杉原ハディ優樹、永田紗矢香、竹中健人、齋藤詠子、福田将義、藤井俊光、長堀正和、油井史郎、土屋輝一郎、大塚和朗、渡辺 守
    • Organizer
      厚生労働科学研究費 難治性疾患政策研究事業 「難治性炎症性腸管障害に関する調査研究」令和元年度 第1回総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Analysis of ileocecal immune response in an animal model of colitis.2019

    • Author(s)
      Daiki Yamada, Takashi Nagaishi, Taro Watabe, Naoya Tsugawa, Yudai Kojima,Nisha Jose, Akinori Hosoya, Takahiro Adachi, Mamoru Watanabe.
    • Organizer
      International Congress of Mucosal Immunology.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of APL expression in an animal model of chronic colitis2019

    • Author(s)
      Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Daiki Yamada, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
    • Organizer
      Federation of Clinical Immunology Societies.
    • Related Report
      2019 Research-status Report
  • [Presentation] APL downregulation in an animal model of chronic colitis.2019

    • Author(s)
      Daiki Yamada, Takashi Nagaishi, Yudai Kojima, Taro Watabe, Naoya Tsugawa, Nisha Jose, Akinori Hosoya, Masahiro Suzuki, Michio Onizawa, Mamoru Watanabe.
    • Organizer
      Asian Organization of Crohn’s and Colitis
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies.2019

    • Author(s)
      Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe
    • Organizer
      Asian Organization of Crohn’s and Colitis
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD).2019

    • Author(s)
      Eiko Saito, Kohei Suzuki, Shuuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      Asian Organization of Crohn’s and Colitis
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 潰瘍性大腸炎罹患粘膜に発生した腫瘍性病変に対するESDの検討.2019

    • Author(s)
      福田将義、永石宇司、根木真理子、大塚和朗、渡辺 守.
    • Organizer
      第108回日本消化器内視鏡学会関東支部例会
    • Related Report
      2019 Research-status Report
  • [Presentation] 慢性大腸炎モデルのT細胞におけるAPLの発現抑制.2019

    • Author(s)
      山田大貴、永石宇司、津川直也、小島裕大、渡部太郎、鈴木雅博、鬼沢道夫、細谷明徳、Jose, Nisha、渡辺 守.
    • Organizer
      第105回日本消化器病学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] APL expression is downregulated in an animal model of chronic colitis.2019

    • Author(s)
      Takashi Nagaishi, Yudai Kojima, Daiki Yamada, Taro Watabe, Naoya Tsugawa, Nisha Jose, Michio Onizawa, Mamoru Watanabe.
    • Organizer
      European Crohn’s and Colitis Organization
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性大腸炎モデルにおけるAPL発現の解析.2019

    • Author(s)
      山田大貴、永石宇司、小島裕大、渡部太郎、津川直也、細谷明徳、Jose, Nisha、鈴木雅博、鬼沢道夫、渡辺 守.
    • Organizer
      第15回日本消化管学会総会学術集会
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物2020

    • Inventor(s)
      永石 宇司
    • Industrial Property Rights Holder
      永石 宇司
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-554239
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 炎症性腸疾患の治療方法およびそれに用いるための医薬組成物2019

    • Inventor(s)
      永石宇司
    • Industrial Property Rights Holder
      永石宇司
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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