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An advanced ultrasound application used to assess microvessels in cardiovascular diseases: superb microvascular imaging

Research Project

Project/Area Number 19K08483
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionAkita University

Principal Investigator

Watanabe Hiroyuki  秋田大学, 医学系研究科, 教授 (80323145)

Co-Investigator(Kenkyū-buntansha) 飯野 健二  秋田大学, 医学系研究科, 准教授 (30400485)
佐藤 和奏  秋田大学, 医学系研究科, 助教 (50748283)
飯野 貴子  秋田大学, 医学部, 助教 (70620871)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords微小血管 / 血管エコー / 重症下肢虚血 / 高安動脈炎 / 頸動脈プラーク / 心不全 / 反応性充血 / 微小循環 / 下肢虚血 / 微小循環・血管超音波・重症下肢虚血・心不全 / 微小血流 / 微小循環、血管超音波、高安病、重症下肢虚血 / 超音波検査 / 血管炎症
Outline of Research at the Start

微小血管系は内皮機能と関連した反応性充血や血管炎/不安定プラークで増生する新生血管の場として、心血管病進展に重要な役割を果たしている。
近年、低流速血流検出に優れた新規エコー技術SMIが開発され、直接微小血流の可視・定量化が可能となった。
本研究では、SMI による末梢組織の微小血流定量化と、その心不全・末梢動脈疾患・高安動脈炎・頚動脈狭窄症への臨床応用を目指す。その結果、SMI による微小血流評価が、新規内皮機能検査法、心不全の予後指標、足部血液還流評価法、高安動脈炎活動性評価法、頚動脈プラークの不安定指標などの発見・新規開発に繋がり、広い領域にわたって循環器診療の発展に貢献できると考えている。

Outline of Final Research Achievements

A novel ultrasound modality termed superb microvascular imaging (SMI) has enabled visualization of microvessels. SMI ultrasound studies have significantly extended our knowledge of tissue microcirculation and the arterial microenvironments of atherosclerotic lesions. We here present a current knowledge on the utility of SMI assessment of vascular diseases and highlight certain peripheral microcirculation disorders for which SMI is particularly valuable. The evidence indicates that SMI reveals the foot microcirculation and yields a quantitative vascular index in line with the angiosome concept; vascularization of the carotid arterial wall detected by SMI is a potential marker of disease activity in patients with Takayasu arteritis; and, SMI can detect intraplaque neovascularization and usefully assess carotid plaque vulnerability. In general, microcirculatory evaluation by SMI is an attractive field for future research on therapeutic strategies fo peripheral vascular diseases.

Academic Significance and Societal Importance of the Research Achievements

これまで動物を用いた基礎実験や剖検でしか知りえなかった病態下での微小血流の挙動を、本研究ではリアルタイムで定量・評価できることを示した。この成果は未だ不明な心血管難病の病態メカニズム解明や新規検査法・治療法の開発など、今後の循環器領域研究の発展に大きく寄与すると考えられる。とくに高安動脈炎でのSMIによる頸動脈壁内血管増生の検出はFDG/PET検査に代わるより安価で簡便な活動性評価方法となる可能性を示唆した。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2023 2022 2021 2020 2019

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (14 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Utility of Superb Microvascular Imaging in the Assessment of Foot Perfusion in Patients with Critical Limb Ischemia2022

    • Author(s)
      Suto Yuta、Sato Wakana、Yamanaka Takayuki、Unuma Mayu、Kobayashi Yuki、Aokawa Mako、Watanabe Hiroyuki
    • Journal Title

      Diagnostics

      Volume: 12 Issue: 11 Pages: 2577-2577

    • DOI

      10.3390/diagnostics12112577

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients With Carotid Artery Stenosis2022

    • Author(s)
      Kato Tsukasa、Sato Wakana、Sato Teruki、Shimizu Hiroaki、Watanabe Hiroyuki
    • Journal Title

      Cardiology Research

      Volume: 13 Issue: 5 Pages: 289-296

    • DOI

      10.14740/cr1402

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An advanced ultrasound application used to assess peripheral vascular diseases: superb microvascular imaging2021

    • Author(s)
      Sato Wakana、Suto Yuta、Yamanaka Takayuki、Watanabe Hiroyuki
    • Journal Title

      Journal of Echocardiography

      Volume: - Issue: 3 Pages: 150-157

    • DOI

      10.1007/s12574-021-00527-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical implications of antegrade diastolic pulmonary artery flow in adults.2021

    • Author(s)
      Umeta Y, Iino T, Miura K, Kudo K, Tamura Y, Sato W, Seki K, Iino K, Watanabe H.
    • Journal Title

      Journal of Cardiology

      Volume: 78 Issue: 6 Pages: 542-549

    • DOI

      10.1016/j.jjcc.2021.07.010

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Large non-coronary sinus of Valsalva aneurysm: a case report of an unusual cause of angina pectoris2020

    • Author(s)
      Hidehiro Iwakawa, Takako Iino, Hiroshi Yamamoto, and Hiroyuki Watanabe
    • Journal Title

      Eur Heart J Case Rep.

      Volume: 4 Issue: 5 Pages: 1-6

    • DOI

      10.1093/ehjcr/ytaa241

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction2020

    • Author(s)
      Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, Gotoh T, Nakaoka Y, Penninger JM, Watanabe H, Imai Y, Takahashi S, Kuba K
    • Journal Title

      Nature Communications

      Volume: 11(1) Issue: 1 Pages: 1058-1058

    • DOI

      10.1038/s41467-020-14867-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of arterial wall vascularization using superb microvascular imaging in active-stage Takayasu arteritis.2019

    • Author(s)
      Sato W, Sato T, Iino T, Seki K, Watanabe H
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: 20 Issue: 6 Pages: 719-719

    • DOI

      10.1093/ehjci/jey285

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Manifestation of coronary subclavian steal phenomenon using reactive hyperemia in the ipsilateral forearm2019

    • Author(s)
      Iino T, Yamanaka T, Sato W, Iino K, Watanabe H
    • Journal Title

      Echocardiography

      Volume: 10 Issue: 10 Pages: 1956-1958

    • DOI

      10.1111/echo.14485

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Pathological Characteristics of Medial Calcification and the Relationship with atherosclerotic lesions including intimal calcification2023

    • Author(s)
      Tsukasa Kato,Sho Torii,Norihito Nakamura,Kazuki Aihara,Hiroyuki Watanabe,Yuji Ikari
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Underestimation of Cardio-Ankle Vascular Index (CAVI) in Patients with Severe Aortic Stenosis2023

    • Author(s)
      Nobuhiro Ogasawara,Wakana Sato,Hazuki Hatakeyama,Mayu Suzuki,Michiru Seki,Mako Aokawa,Mayu Unuma,Takayuki Yamanaka,Yusuke Takagi,Hiroyuki Watanabe
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Carotid Artery Revascularization Improves Cardiac Sympathetic Nerve Activity in Patients with Carotid Artery Stenosis2023

    • Author(s)
      Tsukasa Kato,Wakana Sato,Teruki Sato,Tomohito Suzuki,Hiroyuki Watanabe
    • Organizer
      第87回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 重症下肢虚血診療におけるSuperb Micro-vascular Imaging の有用性2023

    • Author(s)
      須藤佑太,佐藤和奏,大高麻子,小林雄紀,鵜沼 真由,山中卓之,渡邊博之
    • Organizer
      第120回日本内科学会総会・講演会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 心不全患者の運動耐容能評価における耳朶血流測定の意義2022

    • Author(s)
      Takahashi Y, Okura K, Sato T, Suzuki T, Watanabe H.
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Assessment of Foot Microcirculation by Using Superb Microvascular Imaging in Patients with Critical Ischemia2020

    • Author(s)
      Suto Y, Sato W, Yamanaka T, Sato T, Iino T, Seki K, Suzuki T, Terata K, Iino K, Watanabe H.
    • Organizer
      ACC 2020 米国心臓学会議
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Validity of Ultrasound Arterial Wall Vascularization for assessment of Vascular Inflammation2020

    • Author(s)
      Sato W, Kobayashi Y, Otaka M, Unuma M, Yamanaka T, Suto Y, Sato T, Iino T, Seki K, Suzuki T, Terata K, Iino K, Watanabe H
    • Organizer
      ESC 2020 欧州心臓病学会議
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Totally Thrombosed Valsalva Aneurysm Mimicking Cardiac Tumor.2020

    • Author(s)
      Sato W, Iino T, Seki K, Iino K, Yamamoto H, Watanabe H
    • Organizer
      ESC 2020 欧州心臓病学会議
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of Orai1/Orai3-mediated Ca2+ Entry in a Molecular Link between Inflammation and Endothelial Function.2019

    • Author(s)
      Sato T, Kuba K, Watanabe H
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Carotid Artery Revascurization Improves the Blood Pressure Variability in Patients with Carotid Artery Stenosis.2019

    • Author(s)
      Sato W, Iino T, Kobukai Y, Sato T, Seki K, Iino K, Hasegawa H, Watanabe H
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Assessment of Foot Perfusion by Using Superb Microvascular Imaging in Patients with Critical Limb Ischemia.2019

    • Author(s)
      Suto Y, Sato W, Seki K, Kobukai Y, Sato T, Iino T, Suzuki T, Iino K, Watanabe H
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Validity of the Superb Microvascular Imaging-based Vascular Index for Assessment of Endothelial Function.2019

    • Author(s)
      Yamanaka T, Sato W, Suto Y, Iino T, Iino K, Watanabe H
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 重症下肢虚血診療におけるSuperb micro-vascular imagingの有用性2019

    • Author(s)
      佐藤和奏、須藤佑太、関 勝仁、飯野貴子、飯野健二、渡邊博之
    • Organizer
      第51回日本動脈硬化学会総会・学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血流依存性血管拡張反応を利用し非侵襲的に診断し得たcoronary-subclavian steal症候群の一例2019

    • Author(s)
      貝森亮太
    • Organizer
      第23回日本心不全学会学術集会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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