Development and clinical establishment of polarization sensitive optical coherence tomography (PS-OCT)

• Project/Area Number: 19K08587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Wakayama Medical University
• Principal Investigator: Akasaka Takashi 和歌山県立医科大学, 医学部, 特別研究員 (70322584)
• Co-Investigator(Kenkyū-buntansha): 猪野 靖 和歌山県立医科大学, 医学部, 博士研究員 (00549793) ; 塩野 泰紹 和歌山県立医科大学, 医学部, 講師 (00584872) ; 久保 隆史 和歌山県立医科大学, 医学部, 博士研究員 (30316096)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 動脈硬化 / 光干渉断層法 / 偏光感受性 / 偏光度 / 線維性皮膜 / マクロファージ / コラーゲン / 細胞外マトリックス / 光強度画像 / 複屈折画像 / 脱分極画像 / 冠動脈 / 線維性被膜 / 膠原線維 / 冠動脈イメージング / 急性冠症候群 / 複屈折 / 冠動脈硬化

Outline of Research at the Start

心筋梗塞や狭心症の原因になる冠動脈硬化病変を従来の高解像度の光干渉断層画像だけでなく、新たに開発された高感度偏光光干渉断層像を併用して解析することにより、冠動脈硬化の進展機序やプラーク破綻による急性冠症候群の発症機序を検討し、急性心筋梗塞発症の予測と脂質低下薬をはじめとする薬物治療による冠動脈プラーク安定化の効果判定やステント留置部位の再狭窄予防の可能性を検討する。同時に高感度偏光光干渉断層法による複屈折画像・脱分極画像の日常診療における意義を確立する。

Outline of Final Research Achievements

Polarization sensitive optical coherence tomography (PS-OCT) was recorded in 15 cases (mean age;72 years), who were performed OCT-guided percutaneous coronary intervention, and intravascular ultrasound with near infrared spectroscopy (NIRS-IVUS) were obtained in 5 (mean age;63 years) of these cases. A significant correlation (r=0.92, p<0.001) was demonstrated between fibrous cap thickness (FCT) measured by OCT (mean;162μm) and that by PS-OCT in addition to a significant correlation between FCT and birefringence rate (r=0.32, p<0.05) in PS-OCT. Tendency of significant correlation (ρ＝0.12、P＝0.062) between logarithm (1-polarization degree) and normalized standard deviation (NSD) of FCT by PS-OCT might allow us to speculate the density of macrophages within fibrous cap. The ongoing study comparison between polarization degree for lipid content by PS-OCT and lip core burden indexes by NIRS-IVUS may lead us to develop the index to speculate the lipid amount by PS-OCT.

Academic Significance and Societal Importance of the Research Achievements

画像診断の進歩により冠動脈疾患の病態解明が飛躍的に進歩したが、生体内で冠動脈粥腫を覆うコラーゲンや細胞外マトリクス性状の観察技術は存在せず、それらの臨床的意義は未解明であった。偏光感受性光干渉断層法（polarization-sensitive optical coherence tomography; PS-OCT)は、OCTによる構造的観察に加え、組織の偏光特性計測によりコラーゲンや細胞外マトリクス性状を観察できる。本研究では、PS-OCTの開発とそれによる生体内冠動脈病変性状の評価により、冠動脈疾患の進展や安定化の病態解明がさらに進み、冠動脈疾患の診断治療に貢献できる可能性が示された。

Research Products

• [Journal Article] Optical coherence tomography in coronary atherosclerosis assessment and intervention (2022)
  • Author(s): Araki M, Park SJ, Dauerman HL, Uemura S, Kim JS, Di Mario C, Johnson TW, Guagliumi G, Kastrati A, Joner M, Holm NR, Alfonso F, Wijns W, Adriaenssens T, Nef H, Rioufol G, Amabile N, et al.
  • Journal Title: Nature Reviews Cardiology Volume: 19 Issue: 10 Pages: 684-703
  • DOI: 10.1038/s41569-022-00687-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography: update 2022 (2022)
  • Author(s): Fujii K, Kubo T, Otake H, Nakazawa G, Sonoda S, Hibi K, Shinke T, Kobayashi Y, Ikari Y, Akasaka T.
  • Journal Title: Cardiovascular Intervention and Therapeutics Volume: 37 Issue: 2 Pages: 248-254
  • DOI: 10.1007/s12928-022-00845-3
  • Peer Reviewed / Open Access
• [Journal Article] Automated diagnosis of optical coherence tomography imaging on plaque vulnerability and its relation to clinical outcomes in coronary artery disease (2022)
  • Author(s): Hirohiko Niioka, Teruyoshi Kume, Takashi Kubo, Tsunenari Soeda, Makoto Watanabe, Ryotaro Yamada, Yasushi Sakata, Yoshihiro Miyamoto, Bowen Wang, Hajime Nagahara, Jun Miyake, Takashi Akasaka, Yoshihiko Saito & Shiro Uemura
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 14067-14067
  • DOI: 10.1038/s41598-022-18473-5
  • Peer Reviewed / Open Access
• [Journal Article] Saline as an Alternative to Radio-Contrast for Optical Coherence Tomography-Guided Percutaneous Coronary Intervention: A Prospective Comparison. (2022)
  • Author(s): Gupta A, Chhikara S, Vijayvergiya R, Seth A, Mahesh NK, Akasaka T, Singh N.
  • Journal Title: Cardiovasc Revasc Med. Volume: 34 Pages: 86-91
  • DOI: 10.1016/j.carrev.2021.01.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nonculprit Lesion PCI in STEMI: How to Decide and When to Perform? (2022)
  • Author(s): Akasaka T, Shiono Y.
  • Journal Title: J Am Coll Cardiol Intv Volume: 15 Issue: 6 Pages: 667-669
  • DOI: 10.1016/j.jcin.2022.02.022
  • Peer Reviewed
• [Journal Article] Impact of Optical Coherence Tomography Imaging on Decision-Making During Percutaneous Coronary Intervention in Patients Presented With Acute Coronary Syndromes (2021)
  • Author(s): Khalifa Amir Kh. M.、Kubo Takashi、Shimamura Kunihiro、Ino Yasushi、Kishk Yehia Taha、Hasan-Ali Hosam、Abdel-Galeel Ahmed、Terada Kosei、Emori Hiroki、Higashioka Daisuke、Takahata Masahiro、Shiono Yasutsugu、Akasaka Takashi
  • Journal Title: Circulation Journal Volume: 85 Issue: 10 Pages: 1781-1788
  • DOI: 10.1253/circj.CJ-20-0942
  • NAID: 130008091420
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-09-24
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of coronary plaques and atherosclerosis using optical coherence tomography (2021)
  • Author(s): Shimamura Kunihiro、Kubo Takashi、Akasaka Takashi
  • Journal Title: Expert Review of Cardiovascular Therapy Volume: 19 Issue: 5 Pages: 379-386
  • DOI: 10.1080/14779072.2021.1914588
  • Peer Reviewed / Open Access
• [Journal Article] Cancer-related vulnerable lesions in patients with stable coronary artery disease (2021)
  • Author(s): Taruya Akira、Nakajima Yuki、Tanaka Atsushi、Kashiwagi Manabu、Tanimoto Takashi、Kuroi Akio、Shiono Yasutsugu、Shimamura Kunihiro、Kubo Takashi、Sougawa Hiromichi、Masuno Tomizo、Ozaki Yuichi、Satogami Keisuke、Ota Shingo、Katayama Yosuke、Ino Yasushi、Hoshiya Hironobu、Akasaka Takashi
  • Journal Title: International Journal of Cardiology Volume: 335 Pages: 1-6
  • DOI: 10.1016/j.ijcard.2021.03.050
  • Peer Reviewed / Open Access
• [Journal Article] Supporting evidence for ST-segment elevation myocardial infarction from optical coherence tomography. (2021)
  • Author(s): Satogami K, Ozaki Y, Ota S, Katayama Y, Ino Y, Akasaka T.
  • Journal Title: EuroIntervention Volume: 17 Issue: 6 Pages: 506-507
  • DOI: 10.4244/eij-d-20-00985
• [Journal Article] Near-infrared spectroscopy to predict microvascular obstruction after primary percutaneous coronary intervention (2021)
  • Author(s): Terada Kosei、Kubo Takashi、Madder Ryan D.、Ino Yasushi、Takahata Masahiro、Shimamura Kunihiro、Shiono Yasutsugu、Nishi Takahiro、Emori Hiroki、Higashioka Daisuke、Khalifa Amir Kh. M.、Wada Teruaki、Akasaka Takashi
  • Journal Title: EuroIntervention Volume: 17 Issue: 12 Pages: e999-e1006
  • DOI: 10.4244/eij-d-20-01421
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Target Lesion Lipid Content Detected by Near-Infrared Spectroscopy After Stenting and the Risk of Subsequent Target Lesion Failure (2021)
  • Author(s): Madder Ryan D.、Kubo Takashi、Ino Yasushi、Kameyama Takeyoshi、Terada Kosei、VanOosterhout Stacie、Mulder Abbey、McNamara Michael、Kenaan Mohamad、Samani Soroush、Kassier Adnan、Parker Jessica L.、McNamara Richard、Akasaka Takashi
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 41 Issue: 7 Pages: 2181-2189
  • DOI: 10.1161/atvbaha.120.315617
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-Risk Morphological and Physiological Coronary Disease Attributes as Outcome Markers After Medical Treatment and Revascularization. (2021)
  • Author(s): Yang S, Koo BK, Hwang D, Zhang J, Hoshino M, Lee JM, Murai T, Park J, Shin ES, Doh JH, Nam CW, Wang J, Chen S, Tanaka N, Matsuo H, Akasaka T, Chang HJ, Kakuta T, Narula J.
  • Journal Title: J Am Coll Cardiol Img Volume: 14 Issue: 10 Pages: 1977-1989
  • DOI: 10.1016/j.jcmg.2021.04.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Intimal thickening and disruption of the media occur in the arterial walls of coronary arteries not associated with coronary arterial aneurysms in patients with Kawasaki disease (2021)
  • Author(s): Tsuchihashi Tomoya、Kakimoto Nobuyuki、Takeuchi Takashi、Suenaga Tomohiro、Suzuki Takayuki、Shibuta Shoichi、Ino Yasushi、Kubo Takashi、Akasaka Takashi、Suzuki Hiroyuki
  • Journal Title: BMC Cardiovascular Disorders Volume: 21 Issue: 1 Pages: 278-278
  • DOI: 10.1186/s12872-021-02090-7
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of optical coherence tomography with angiographic coregistration in the guidance of coronary stent implantation (2021)
  • Author(s): Kubo Takashi、Ino Yasushi、Shiono Yasutsugu、Terada Kosei、Emori Hiroki、Higashioka Daisuke、Takahata Masahiro、Wada Teruaki、Shimamura Kunihiro、Khalifa Amir Kh. M.、Tu Shengxian、Akasaka Takashi
  • Journal Title: Heart and Vessels Volume: 37 Issue: 2 Pages: 200-207
  • DOI: 10.1007/s00380-021-01911-1
  • Peer Reviewed / Open Access
• [Journal Article] NIRS-IVUS for Differentiating Coronary Plaque Rupture, Erosion and Calcified Nodule in Acute Myocardial Infarction (2020)
  • Author(s): Kosei Terada, Takashi Kubo, Takeyoshi Kameyama, Yoshiki Matsuo, Yasushi Ino, Hiroki Emori, Daisuke Higashioka, Yosuke Katayama, Amir Kh.M. Khalifa, Masahiro Takahata, Kunihiro Shimamura, Yasutsugu Shiono, Atsushi Tanaka, Takeshi Hozumi, Ryan D. Madder, Takashi Akasaka
  • Journal Title: JACC: Cardiovascular Imaging Volume: - Issue: 7 Pages: 30827-5
  • DOI: 10.1016/j.jcmg.2020.08.030
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] OCT-derived coronary calcified nodule as a predictor of high-risk patients. (2020)
  • Author(s): Akasaka T, Kubo T.
  • Journal Title: EuroIntervention Volume: 16 Issue: 5 Pages: 361-363
  • DOI: 10.4244/eijv16i5a65
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility and Clinical Significance of In Vivo Cholesterol Crystal Detection Using Optical Coherence Tomography. (2020)
  • Author(s): Katayama Y, Tanaka A, Taruya A, Kashiwagi M, Nishiguchi T, Ozaki Y, Matsuo Y, Kitabata H, Kubo T, Shimada E, Kondo T, Akasaka T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 40(1) Issue: 1 Pages: 220-229
  • DOI: 10.1161/atvbaha.119.312934
  • Peer Reviewed / Open Access
• [Journal Article] Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography. (2020)
  • Author(s): Fujii K, Kubo T, Otake H, Nakazawa G, Sonoda S, Hibi K, Shinke T, Kobayashi Y, Ikari Y, Akasaka T.
  • Journal Title: Cardiovasc Interv Ther. Volume: 35 Issue: 1 Pages: 13-18
  • DOI: 10.1007/s12928-019-00626-5
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Diagnostic Performance of Intracoronary Optical Coherence Tomography-based and Angiography-based Fractional Flow Reserve for Evaluation of Coronary Stenosis. (2020)
  • Author(s): Huang J, Emori H, Ding D, Kubo T, Yu W, Huang P, Zhang S, Gutierrez-Chico JL, Akasaka T, Wijns W, Tu S.
  • Journal Title: EuroIntervention Volume: 16 Issue: 7 Pages: 568-576
  • DOI: 10.4244/eij-d-19-01034
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Stabilization of High Risk Coronary Plaque on Optical Coherence Tomography and Near-Infrared Spectroscopy by Intensive Lipid-Lowering Therapy With Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitor (2019)
  • Author(s): Ino Y, Kubo T, Shimamura K, Takahata M, Matsuo Y, Kitabata H, Shiono Y, Wada T, Terada K, Katayama Y, Emori H, Higashioka D, Tanaka A, Hozumi T, Akasaka T
  • Journal Title: Circulation Journal Volume: 83 Issue: 8 Pages: 1765
  • DOI: 10.1253/circj.CJ-18-0983
  • NAID: 130007682987
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-07-25
  • Peer Reviewed / Open Access
• [Journal Article] Plaque burden can be assessed using intravascular optical coherence tomography and a dedicated automated processing algorithm: a comparison study with intravascular ultrasound. (2019)
  • Author(s): Gerbaud E, Weisz G, Tanaka A, Luu R, Osman HASH, Baldwin G, Coste P, Cognet L, Waxman S, Zheng H, Moses JW, Mintz GS, Akasaka T, Maehara A, Tearney GJ.
  • Journal Title: Eur Heart J Cardiovasc Imaging. Volume: 0 Issue: 6 Pages: 1-13
  • DOI: 10.1093/ehjci/jez185
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical use of intracoronary imaging. Part 2: acute coronary syndromes, ambiguous coronary angiography findings, and guiding interventional decision-making: an expert consensus document of the European Association of Percutaneous Cardiovascular Interventions. (2019)
  • Author(s): Johnson TW, R&auml;ber L, di Mario C, Bourantas C, Jia H, Mattesini A, Gonzalo N, de la Torre Hernandez JM, Prati F, Koskinas K, Joner M, Radu MD, Erlinge D, Regar E, Kunadian V, Maehara A, Byrne RA, Capodanno D, Akasaka T, Wijns W, Mintz GS, Guagliumi G.
  • Journal Title: Eur Heart J Volume: 40 Issue: 31 Pages: 2566-2584
  • DOI: 10.1093/eurheartj/ehz332
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology. (2019)
  • Author(s): Shimokado A, Kubo T, Matsuo Y, Ino Y, Shiono Y, Shimamura K, Katayama Y, Taruya A, Nishiguchi T, Kashiwagi M, Kitabata H, Hozumi T, Tanaka A, Akasaka T.
  • Journal Title: Int J Cardiovasc Imaging Volume: 35 Issue: 10 Pages: 1785-1790
  • DOI: 10.1007/s10554-019-01639-0
  • Peer Reviewed / Open Access
• [Presentation] OCT/OFDIによる新たなACS治療の可能性 (2023)
  • Author(s): 赤阪隆史
  • Organizer: 第27回日本血管内OCT/OFDI研究会
  • Invited
• [Presentation] OCT based Calcium Scoring Algorithm; Sine Qua Non for Best Patient Outcome (2023)
  • Author(s): Takashi Akasaka
  • Organizer: India Live 2023
  • Int'l Joint Research / Invited
• [Presentation] Intravascular Imaging in Stent failure (2023)
  • Author(s): Takashi Akasaka
  • Organizer: India Live 2023
  • Int'l Joint Research / Invited
• [Presentation] Simple OCT Algorithm to Decode and ACS; Identify the Cause (2023)
  • Author(s): Takashi Akasaka
  • Organizer: India Live 2023
  • Int'l Joint Research / Invited
• [Presentation] Imaging-guided LM Bifurcation PCI; Is It Mandatory? (2023)
  • Author(s): Takashi Akasaka
  • Organizer: India Live 2023
  • Int'l Joint Research / Invited
• [Presentation] Plaque and Drug: Imaging Inflammation (2023)
  • Author(s): Takashi Akasaka
  • Organizer: Image guidance in PCI (IPCI) 2023
  • Int'l Joint Research / Invited
• [Presentation] Vulnerable Plaque Identification by OCT and NIRS-IVUS (2023)
  • Author(s): Takashi Akasaka
  • Organizer: Transcatheter Cardiovascular Therapeutics Asian Pasific (TCTAP) 2023
  • Int'l Joint Research / Invited
• [Presentation] 血管内イメージングにおけるAIの進歩 (2022)
  • Author(s): 赤阪隆史
  • Organizer: 第32回日本血管内画像動態学会
  • Invited
• [Presentation] 循環器画像診断におけるAI研究の進め方・企業との共同プロセス (2022)
  • Author(s): 赤阪隆史
  • Organizer: KOSMOS研究Webinar
  • Invited
• [Presentation] Accuracy of OCT Core Labs in Identifying Vulnerable Plaque (2022)
  • Author(s): Gruslova AB, Singh S, Hoyt T, Vela D, Vengrenyuk Y, Buja LM, Litovsky S, Michalek J, Maehara A, Kini A, Akasaka T, et al
  • Organizer: Transcatheter Cardiovascular Therapeutics (TCT) 2022
  • Int'l Joint Research
• [Presentation] OCT/OFDIの歴史・現状・将来 (2022)
  • Author(s): 赤阪隆史
  • Organizer: 第26回日本血管内OCT/OFDI研究会
  • Invited
• [Presentation] New Insight into Plaque Vulnerability from OCT and NIRS-IVUS (2022)
  • Author(s): Takashi Akasaka
  • Organizer: The Imperial Vulnerable Plaque and Patient Meeting (VPM) 2022
  • Int'l Joint Research / Invited
• [Presentation] Early Detection and Intervention of Vulnerable Plaque (2022)
  • Author(s): Takashi Akasaka
  • Organizer: ENCORE Seoul 2022
  • Int'l Joint Research / Invited
• [Presentation] OCT Image Interpretation; An Expert Perspective (2022)
  • Author(s): Takashi Akasaka
  • Organizer: 16th Transrcatheter Intervention Course (TRI) 2022
  • Int'l Joint Research / Invited
• [Presentation] OCT Image Interpretation in Daily Practice; An Expert Perspective (2022)
  • Author(s): Takashi Akasaka
  • Organizer: Bangladesh Radial Intervention Live (BRI) 2022
  • Int'l Joint Research / Invited
• [Presentation] Role of Imaging in Calcified Lesion Treatment (2022)
  • Author(s): Takashi Akasaka
  • Organizer: Complex PCI 2022
  • Int'l Joint Research / Invited
• [Presentation] OCT-Guided PCI for Severe Calcified Lesions and Bifurcation Lesions (2021)
  • Author(s): Akasaka T
  • Organizer: Mayo Clinic Cardiac Lab Cardiovascular Conference
  • Int'l Joint Research / Invited
• [Presentation] OCT in Acute Coronary Syndrome: Current Role and relevance (2021)
  • Author(s): Akasaka T
  • Organizer: STEMI Council CSI 2021
  • Int'l Joint Research / Invited
• [Presentation] How OCT Changed My Decision In Cath Lab (2021)
  • Author(s): Akasaka T
  • Organizer: SCAI India Seminar
  • Int'l Joint Research / Invited
• [Presentation] Crystal Clear Pictures Orange, the new gray- OCT Imaging is Obviously My choice (2021)
  • Author(s): Akasaka T
  • Organizer: SCAI USV Course
  • Int'l Joint Research / Invited
• [Presentation] How to do OCT in Ostial LM disease, Calcified disease, and Acute MI with total occlusion (2021)
  • Author(s): Akasaka T
  • Organizer: SCAI USV Course
  • Int'l Joint Research / Invited
• [Presentation] Stent Optimization: OCT or IVUS ? (2021)
  • Author(s): Akasaka T
  • Organizer: CSI-NIC 2021
  • Int'l Joint Research / Invited
• [Presentation] Contemporary approach to PCIs in Calcified Lesions (2021)
  • Author(s): Akasaka T
  • Organizer: Cardiology Next 2021
  • Int'l Joint Research / Invited
• [Presentation] Stent Optimization with Imaging Guidance: IVUS & OCT Comparison (2021)
  • Author(s): Akasaka T
  • Organizer: 4 D web conference
  • Int'l Joint Research / Invited
• [Presentation] OCT; Overview and different complex PCI (2021)
  • Author(s): Akasaka T
  • Organizer: India intervention cardiology conference
  • Int'l Joint Research / Invited
• [Presentation] Physiologyとイメージグの将来を語る (2021)
  • Author(s): Akasaka T
  • Organizer: POPAI(PCI OPTIMIZATION BY PHYSIOLOGY AND IMAGING)
  • Invited
• [Presentation] Imaging in ACS - Improving management decisions (2021)
  • Author(s): Akasaka T
  • Organizer: STEMI India
  • Int'l Joint Research / Invited
• [Presentation] Precision PCI Utilizing Imaging & Physiolgy (2021)
  • Author(s): Akasaka T
  • Organizer: 4th National Symposium on Imaging & Physiology
  • Int'l Joint Research / Invited
• [Presentation] Precise PCI Using Co-registration OCT (2021)
  • Author(s): Akasaka T
  • Organizer: The 13th Indonesian Society of Interventional Cardiology Annual Meeting - The Digital Experience
  • Int'l Joint Research / Invited
• [Presentation] Imaging Assessment of Calcium during PCI;Chosing Plaque Modification Strategies (2021)
  • Author(s): Akasaka T
  • Organizer: Imaging & Physiology Summit 2021, India
  • Int'l Joint Research / Invited
• [Presentation] OCT in ACS and bifurcation (2020)
  • Author(s): Akasaka T
  • Organizer: HKSTENT Imaging & Physiology, HongKong
  • Int'l Joint Research / Invited
• [Presentation] Optimizaing outcome of PCI through imaging (2020)
  • Author(s): Akasaka T
  • Organizer: 15th Conference on Cardiovascular Diseases, NHFH & RI, Bangladesh
  • Int'l Joint Research / Invited
• [Presentation] OCT in bifurcation (2020)
  • Author(s): Akasaka T
  • Organizer: Imaging & physiology council of India
  • Int'l Joint Research / Invited
• [Presentation] OCT changed my perception from angio. (2020)
  • Author(s): Akasaka T
  • Organizer: Education program for Canada and Latin America OCT
  • Int'l Joint Research / Invited
• [Presentation] The past, present and future OCT combined with MLD-MAX (2020)
  • Author(s): Akasaka T
  • Organizer: INDO JAPAN DigiConnect
  • Int'l Joint Research / Invited
• [Presentation] Optimizing LM PCI results with IVUS and OCT guidance (2020)
  • Author(s): Akasaka T.
  • Organizer: Singapore Live 2020
  • Int'l Joint Research / Invited
• [Presentation] Imaging assessment of calcific lesions (2020)
  • Author(s): Akasaka T.
  • Organizer: Singapore Live 2020
  • Int'l Joint Research / Invited
• [Presentation] Assessment of stabilization of plaque vulnerability by OCT (2020)
  • Author(s): Akasaka T.
  • Organizer: Cardiovascular Rsearch Technologies 2020
  • Int'l Joint Research / Invited
• [Presentation] OCT-guided PCI for bifurcation lesions (2020)
  • Author(s): Akasaka T.
  • Organizer: Cardiovascular Rsearch Technologies 2020
  • Int'l Joint Research / Invited
• [Presentation] OCT in ACS: why and how to utilize. (2019)
  • Author(s): Akasaka T.
  • Organizer: The 15th annual Complex Cardiovascular Catheter Therapeutics
  • Int'l Joint Research / Invited
• [Presentation] OCT; Image interpretation. (2019)
  • Author(s): Akasaka T.
  • Organizer: Imaging & Physiology Council of India
  • Int'l Joint Research / Invited
• [Presentation] Imaging in calcified lesions; How do I plan my procedure? (2019)
  • Author(s): Akasaka T.
  • Organizer: Imaging & Physiology Council of India
  • Int'l Joint Research / Invited
• [Presentation] OCT follow up of CTO PCI: What I have learnt? (2019)
  • Author(s): Akasaka T.
  • Organizer: Imaging & Physiology Council of India
  • Int'l Joint Research / Invited
• [Presentation] Stent failure; Insights from OCT imaging. (2019)
  • Author(s): Akasaka T.
  • Organizer: Imaging & Physiology Council of India
  • Int'l Joint Research / Invited
• [Presentation] Cholesterol crystals in superficial plaque layer detected by optical coherence tomography as a new morphological feature for plaque rupture. (2019)
  • Author(s): .Katayama Y, Tanaka A, Kitabata H, Kashiwagi M, Terada K, Emori H, Shiono Y, Kuroi A, Matsuo Y, Ino Y, Hozumi T, Kubo T, Akasaka T.
  • Organizer: European Society of Cardiology (ESC) Congress 2019
  • Int'l Joint Research
• [Presentation] Imaging-guided is essential. (2019)
  • Author(s): Akasaka T.
  • Organizer: 24th Asean Federation Cardiology Congress with 28th Annual Scientific Meeting of the Indonesian Heart Association
  • Int'l Joint Research / Invited
• [Presentation] Detection ability of optical coherence tomography for cholesterol crystal: Histopathological validation study. (2019)
  • Author(s): Katayama Y, Tanaka A, Terada K, Matsuo Y, Ino Y, Kitabata H, Emori H, Shimamura K, Shiono Y, Kubo T, Hozumi T, Akasaka T.
  • Organizer: The 31st Transcatheter Cardiovascular Therapeutics
  • Int'l Joint Research
• [Presentation] OCT guided PCI for diffuse and/or severe calcified lesion. (2019)
  • Author(s): Akasaka T
  • Organizer: The 13th Endovascular and Coronary Revascularization
  • Int'l Joint Research / Invited
• [Presentation] Coronary imaging and physiology: What's new in 2019? (2019)
  • Author(s): Akasaka T.
  • Organizer: The 13th Endovascular and Coronary Revascularization
  • Int'l Joint Research / Invited
• [Presentation] Role of OCT in PCI of Calcified Lesion. (2019)
  • Author(s): Akasaka T.
  • Organizer: Annual Meeting of the Society of Coronary Imaging and Physiology 2019
  • Int'l Joint Research / Invited
• [Presentation] OCT guided PCI for complex coronary lesions. (2019)
  • Author(s): Akasaka T.
  • Organizer: Update in Cardiology 2019
  • Int'l Joint Research / Invited
• [Presentation] Healed coronary plaque-histologic validation. (2019)
  • Author(s): Akasaka T.
  • Organizer: Update in Cardiology 2019
  • Int'l Joint Research / Invited
• [Presentation] Role of imaging in the management of coronary artery disease in current era. (2019)
  • Author(s): Akasaka T.
  • Organizer: 17th International Conference of Cardiac Society of Nepal
  • Int'l Joint Research / Invited
• [Presentation] Coronary artery imaging by OCT in ACS. (2019)
  • Author(s): Akasaka T.
  • Organizer: 10th Annual Scientific Conference of the Cardiovascular Intervention Association of Thailand
  • Int'l Joint Research / Invited
• [Presentation] Optimize Your Stent: A to Z of Imaging Guidance for PCI. (2019)
  • Author(s): Akasaka T.
  • Organizer: COMPLEX PCI 2019
  • Int'l Joint Research / Invited
• [Presentation] ACR-OCT-will it change our practice in Left main diseases. (2019)
  • Author(s): Akasaka T.
  • Organizer: 14th National Heart Foundation Conference on Cardiovascular Diseases in Bangladesh
  • Int'l Joint Research / Invited
• [Book] 特発性冠動脈解離による急性冠症候群 門田一繁編：上級医を目指す循環器治療手技・PCI (2021)
  • Author(s): 江守裕紀・久保隆史・赤阪隆史
  • Total Pages: 299
  • Publisher: 日本医事新報社
  • ISBN: 9784784963188
• [Book] Optical coherence tomography in Textbook of Interventional Cardiology (2019)
  • Author(s): Guagliumi G, Raber L, Shimamura K, Akasaka T.
  • Publisher: Elsevier Health Sciences
  • ISBN: 9780323568142