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Effects of the treatment with respiratory rehabilitation on the lung dynamic hyperinflation in COPD

Research Project

Project/Area Number 19K08599
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionShinshu University

Principal Investigator

Fujimoto Keisaku  信州大学, 医学部, 特任教授 (70242691)

Co-Investigator(Kenkyū-buntansha) 北口 良晃  信州大学, 医学部附属病院, 助教(診療) (40447751)
川内 翔平  名古屋大学, 医学系研究科(保健), 助教 (80827965)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords慢性閉塞性肺疾患 / 動的肺過膨張 / 過呼吸 / 最大吸気量 / 肺過膨張 / 運動耐容能 / QOL / SGRQ-C / 運動負荷 / 呼吸困難感 / 過去吸 / 呼吸リハビリテーション
Outline of Research at the Start

呼吸数増加に依存して肺が過膨張となる動的肺過膨張(DLH)は慢性閉塞性肺疾患に特徴的な病態で、労作時息切れ、運動耐容能低下の重要な要因である。本研究は呼吸リハビリテーション(PR)がDLHを改善させ得るのかを検証する。安定期にある中等症以上のCOPD患者を対象に、6ヶ月間PR施行し、PRをおこなわない対照群と比較して、PR前後で呼吸機能検査、DLH、運動持続時間、呼吸困難感、QOLを評価し、対照群と比較する。DLHは運動負荷時における最大吸気量(IC)の減少で評価する従来法と運動負荷を行わず段階的に呼吸数を増加させ、ICの減少量で定量的に評価する過呼吸法の両者を用いて検討をおこなう。

Outline of Final Research Achievements

It was examined whether the patients with COPD going to hospital are reduced their dynamic hyperinflation (DLH) following hyperventilation by pulmonary rehabilitation (PR) performed one time by 1-2 weeks for 6 months. In the PR group, the data of spirometry and 6-minute distance (6MD) did not significantly change. However, inspiratory capacity (IC) following hyperventilation was significantly increased at 3 months, but not 6 months. In the non-PR group, these data were not significantly change. We concluded out-patients PR may reduced hyperinflation following hyperventilation for limited short period.

Academic Significance and Societal Importance of the Research Achievements

外来通院呼吸リハビリテーション(PR)という限られた条件においても短期では有意に肺過膨張を軽減し、呼吸数増加に依存する肺過膨張を改善させた。しかしながら呼吸数増加に依存したICの減少量(ΔIC20, ΔIC30, ΔIC40)に対しては効果が得られないことが判明した。つまり、過呼吸に伴う肺への空気の取り込み、すなわちエアートラッピングに対しては無効である。この点が気管支拡張薬の効果と異なる点と考えられた。以上の結果からPRによる効果の一部に呼吸数増加に依存した肺過膨張抑制効果が関与していることが判明し、PRの効果としてDLHを評価する意義がある。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (25 results)

All 2023 2022 2021 2020 2019

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Air-permeable redox mediated transcutaneous CO2 sensor2023

    • Author(s)
      Ahuja Preety、Ujjain Sanjeev Kumar、Kukobat Radovan、Urita Koki、Moriguchi Isamu、Furuse Ayumi、Hattori Yoshiyuki、Fujimoto Keisaku、Rao Govind、Ge Xudong、Wright Thelma、Kaneko Katsumi
    • Journal Title

      Chemical Engineering Journal

      Volume: 457 Pages: 141260-141260

    • DOI

      10.1016/j.cej.2022.141260

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between sleep quality, hypertensive disorders of pregnancy, and sleep‐disordered breathing in pregnant women with and without obesity: An observational cross‐sectional study2022

    • Author(s)
      Ura Midori、Fujimoto Keisaku、Kanai Makoto
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 48 Issue: 11 Pages: 2774-2789

    • DOI

      10.1111/jog.15376

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new noninvasive method for measurement of dynamic lung compliance from fluctuations on photoplethysmography in respiration.2021

    • Author(s)
      Haruna Yamazaki, Keisaku Fujimoto
    • Journal Title

      J Appl Physiol

      Volume: 130 Issue: 1 Pages: 215-225

    • DOI

      10.1152/japplphysiol.00295.2020

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metronome-paced incremental hyperventilation may predict exercise tolerance and dyspnea as a surrogate for dynamic lung hyperinflation during exercise.2021

    • Author(s)
      Shohei Kawachi, Keisaku Fujimoto
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 15 Pages: 1061-1069

    • DOI

      10.2147/copd.s246850

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effectiveness of supplemental oxygen during exercise training in patients with chronic obstructive pulmonary disease who show severe exercise-induced desaturation: a protocol for a meta-regression analysis and systematic review2021

    • Author(s)
      Kawachi Shohei、Yamamoto Shuhei、Nishie Kenichi、Yamaga Takayoshi、Shibuya Manaka、Sakai Yasunari、Fujimoto Keisaku
    • Journal Title

      Systematic Reviews

      Volume: 10 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s13643-021-01667-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Automated Diseased Lung Volume Percentage Calculation in Quantitative CT Evaluation of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis2021

    • Author(s)
      Kitaguchi Yoshiaki、Fujimoto Keisaku、Droma Yunden、Yasuo Masanori、Wada Yosuke、Ueno Fumika、Kinjo Takumi、Kawakami Satoshi、Fukushima Kiyoyasu、Hanaoka Masayuki
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 45 Issue: 4 Pages: 649-658

    • DOI

      10.1097/rct.0000000000001182

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Respiratory and Metabolic Responses as Determinants of Exercise Endurance Time in Constant-load Exercise Test in Healthy Adult Volunteers: A Prospective Cross-sectional Study.2021

    • Author(s)
      Kawachi S, Fujimoto K.
    • Journal Title

      Shinshu Med J

      Volume: 69 Pages: 355-362

    • NAID

      130008139866

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of tiotropium and olodaterol combination therapy on dynamic lung hyperinflation evaluated by hyperventilation in COPD: an open-label, comparative before and after treatment study.2019

    • Author(s)
      Kawachi S, Fujimoto K.
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 14 Pages: 1167-1176

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] COPD治療効果の評価の仕方。2019

    • Author(s)
      藤本圭作
    • Journal Title

      日本呼吸ケア・リハビリテーション学会誌

      Volume: 28 Pages: 27-32

    • NAID

      130007668905

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] COPDに対する多角的な介入、包括的サポートにより社会復帰が進められた一例。2023

    • Author(s)
      原田雅巳、高山尚久、太田佳織、前澤沙紀、藤澤大輝、太田久彦、藤本圭作。
    • Organizer
      第8回日本呼吸ケア・リハビリテーション学会甲信越支部学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 慢性閉塞性肺疾患の動的肺過膨張に対する呼吸筋ストレッチの即時効果。2023

    • Author(s)
      川内翔平、藤本圭作、高山尚久、川路具弘、内山靖.
    • Organizer
      第8回日本呼吸ケア・リハビリテーション学会 甲信越支部学術集会.
    • Related Report
      2023 Annual Research Report
  • [Presentation] SGRQ-Cと6分間歩行試験からみたCOPD患者に対する呼吸リハビリテーションの有効性。2023

    • Author(s)
      太田佳織、高山尚久、原田雅已、前澤沙紀、藤澤大輝、栗林伴光、藤本圭作、川内翔平。
    • Organizer
      第33回日本呼吸ケア・リハビリテーション学会学術集会、
    • Related Report
      2023 Annual Research Report
  • [Presentation] 慢性閉塞性肺疾患の動的肺過膨張に対する呼吸リハビリテーションの効果。2023

    • Author(s)
      藤本圭作、高山尚久、太田佳織、原田雅已、前澤沙紀、川内翔平、栗林伴光。
    • Organizer
      第33回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] COPD患者の効果的な呼吸法開発のための動的肺過膨張評価による障害特性の検討。2023

    • Author(s)
      川内翔平、藤本圭作、川路具弘、内山靖。
    • Organizer
      第33回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Usefulness of software-based quantification for a computed tomography image analysis that simultaneously detects emphysema and pulmonary fibrosis.2020

    • Author(s)
      Kataguchi Y, Fujimoto K, Yasuo M, Wada Y, Ueno F, Kinjo T, Kawakami S, Fukushima K, Hanaoka M.
    • Organizer
      American Thoracic Society (ATS) 2020 International Conference
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] A newly developed ultra-small portable oxygen concentrator with equivalent efficacy to the conventional device.2020

    • Author(s)
      Kawachi S, Fujimoto K, Sano M.
    • Organizer
      European Respiratory Society 2020 International Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metronome-paced incremental hyperventilation can be used to predict dynamic lung hyperinflation and exercise tolerance during exercise.2020

    • Author(s)
      Kawachi S, Fujimoto K
    • Organizer
      European Respiratory Society 2020 International Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 慢性閉塞性肺疾患(COPD)における動的肺過膨張の重要性とその評価方法2020

    • Author(s)
      藤本圭作
    • Organizer
      第60回臨床呼吸機能講習会
    • Related Report
      2020 Research-status Report
  • [Presentation] 胸部CTにおいて客観的かつ同時に肺気腫および間質性肺炎を解析する有用性.2020

    • Author(s)
      北口良晃、藤本圭作、安尾将法、和田洋典、上野史香、福島喜代康、花岡正幸。
    • Organizer
      第60回日本呼吸器学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 小型・軽量化を目的とした携帯型酸素濃縮装置の開発2020

    • Author(s)
      川内翔平、藤本圭作。
    • Organizer
      日本リハビリテーション医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Effects of combined tiotropium/olodaterol on dynamic lung hyperinflation evaluated by the incremental hyperventilation method.2019

    • Author(s)
      Kawachi S, Fujimoto K.
    • Organizer
      European Respiratory Society 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非侵襲的および簡便に生体情報を得る機器の開発を目指して2019

    • Author(s)
      藤本圭作
    • Organizer
      第29回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 慢性閉塞性肺疾患(COPD)における動的肺過膨張の重要性とその評価方法2019

    • Author(s)
      藤本圭作
    • Organizer
      第29回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 慢性閉塞性肺疾患の動的肺過膨張における過呼吸法と運動負荷法の比較2019

    • Author(s)
      川内翔平, 藤本圭作, 佐野真帆子。
    • Organizer
      第29回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 定常運動負荷試験の運動持続時間に影響する要因の検討。2019

    • Author(s)
      川内翔平、藤本圭作、佐野真帆子。
    • Organizer
      第6回日本呼吸理学療法学会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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