薬剤性及び放射線肺障害の新規バイオマーカー探索による肺がん個別化治療の確立

• Project/Area Number: 19K08606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Fukushima Medical University
• Principal Investigator: 谷野 功典 福島県立医科大学, 医学部, 准教授 (10443863)
• Co-Investigator(Kenkyū-buntansha): 海老名 雅仁 東北医科薬科大学, 医学部, 教授 (10280885) ; 二階堂 雄文 福島県立医科大学, 医学部, 助教 (20583347) ; 柴田 陽光 福島県立医科大学, 医学部, 教授 (60333978)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肺がん / 薬剤性肺障害 / 放射線肺障害 / 予測因子 / プレシージョン・メディシン / 細胞外マトリックス / miRNA / 遺伝素因 / バイオマーカー

Outline of Research at the Start

肺がん治療では分子標的治療薬、免疫チェックポイント阻害薬などの薬物治療、放射線照射技術の進歩により生命予後は飛躍的に改善しているが、薬剤性肺障害や放射線性肺障害は治療遂行の上で大きな問題である。
我々のこれまでの一連の研究において、肺の炎症病態にプロテオグリカンなどの細胞外マトリックス (ECM) が深く関与していることを見出し報告してきた。これらの研究成果を踏まえ、ECM及びそれを制御するmicroRNA、遺伝的背景を解析し、肺がん治療の課題である薬剤性及び放射線肺障害の発症と重症化を予測できるバイオマーカーを開発することによって、早期の治療介入により安全な肺がん個別化治療の実現を目指す。

Outline of Annual Research Achievements

本研究では、肺がん患者の治療における放射線肺障害、薬剤性肺障害の発症をあらかじめ予測することによるプレシージョン・メディシンの確立を目的としている。
そのために、血中細胞外マトリックス濃度、miRNAや遺伝的背景を肺障害発症患者を非発症患者と比較すること、または発症前後の経過を比較する。
現在、肺障害発症前後の肺がん患者についての血液検体の収集を行っており、検体は徐々に集まってきている状況である。また、血中細胞外マトリックス濃度の測定については一部測定を行ったが、更に検体が集まり次第、測定を開始することが、以前の検討でも同様の検討を行っており、すでに測定を行うことができる体制は確立しているが、COVID-19パンデミックの影響もあり、検体収集と測定が遅れているため、検体収取と測定解析を急ぐ必要がある。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

放射線肺障害、薬剤性肺障害発症前の肺がん患者の検体収集は進んでいるが、COVID-19の影響もあり、発症後の検体採取に遅れがあるため。

Strategy for Future Research Activity

放射線肺障害や薬剤性肺障害を発症した患者を確実に把握して、検体収集に努めるとともに測定を並行して進める。

Research Products

• [Journal Article] Development of dermatomyositis after anti-transcriptional intermediary factor 1-γ antibody seroconversion during treatment for small cell lung cancer (2022)
  • Author(s): Sato Yuki、Tanino Yoshinori、Nikaido Takefumi、Togawa Ryuichi、Kawamata Takaya、Watanabe Natsumi、Sato Riko、Yamada Ryuki、Onuma Takumi、Tomita Hikaru、Saito Mikako、Rikimaru Mami、Morimoto Julia、Suzuki Yasuhito、Minemura Hiroyuki、Saito Junpei、Kanazawa Kenya、Yamada Syoki、Hashimoto Yuko、Shibata Yoko
  • Journal Title: BMC Pulmonary Medicine Volume: 22 Issue: 1 Pages: 199-199
  • DOI: 10.1186/s12890-022-01974-4
  • Peer Reviewed / Open Access
• [Journal Article] Mortality Risk Stratification Using Cluster Analysis in Patients With Myositis-Associated Interstitial Lung Disease Receiving Initial Triple-Combination Therapy (2022)
  • Author(s): Gono Takahisa、Masui Kenichi、Sato Shinji、Kuwana Masataka、et al.
  • Journal Title: Frontiers in Medicine Volume: 9 Pages: 883699-883699
  • DOI: 10.3389/fmed.2022.883699
  • Peer Reviewed / Open Access
• [Journal Article] The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force (2022)
  • Author(s): Wang Qingbo S.、et al.
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 4830-4830
  • DOI: 10.1038/s41467-022-32276-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bioinformatic identification and analysis of immune-related chromatin regulatory genes as potential biomarkers in idiopathic pulmonary fibrosis (2022)
  • Author(s): Li Kaixin、Liu Pulin、Zhang Wei、Liu Xue、Tanino Yoshinori、Koga Yasuhiko、Yan Xiaoyan
  • Journal Title: Annals of Translational Medicine Volume: 10 Issue: 16 Pages: 896-896
  • DOI: 10.21037/atm-22-3700
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DOCK2 is involved in the host genetics and biology of severe COVID-19 (2022)
  • Author(s): Namkoong Ho、et al.
  • Journal Title: Nature Volume: 609 Issue: 7928 Pages: 754-760
  • DOI: 10.1038/s41586-022-05163-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical effect of early administration of tocilizumab following the initiation of corticosteroid therapy for patients with COVID-19 (2022)
  • Author(s): Kawamata Takaya、Tanino Yoshinori、Nikaido Takefumi、Minemura Hiroyuki、Sato Yuki、Togawa Ryuichi、Watanabe Natsumi、Yamada Ryuki、Sato Riko、Onuma Takumi、Tomita Hikaru、Saito Mikako、Rikimaru Mami、Suzuki Yasuhito、Tsukada Yasuhiko、Nakamura Kiwamu、Kanemitsu Keiji、Iseki Ken、Shibata Yoko
  • Journal Title: Journal of Infection and Chemotherapy Volume: 28 Issue: 12 Pages: 1639-1644
  • DOI: 10.1016/j.jiac.2022.08.021
  • Peer Reviewed
• [Journal Article] Real-world clinical outcomes of treatment with casirivimab-imdevimab among patients with mild-to-moderate coronavirus disease 2019 during the Delta variant pandemic (2022)
  • Author(s): Suzuki Yasuhito、Shibata Yoko、Minemura Hiroyuki、Nikaido Takefumi、Tanino Yoshinori、et al.
  • Journal Title: International Journal of Medical Sciences Volume: 19 Issue: 5 Pages: 834-841
  • DOI: 10.7150/ijms.71132
  • Peer Reviewed / Open Access
• [Journal Article] Lee Ho, et al. (2022)
  • Author(s): Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
  • Journal Title: BMC Infectious Diseases Volume: 22 Issue: 1 Pages: 935-935
  • DOI: 10.1186/s12879-022-07927-w
  • Peer Reviewed / Open Access
• [Journal Article] Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias (2021)
  • Author(s): Enomoto Noriyuki、Homma Sakae、Inase Naohiko、Kondoh Yasuhiro、Saraya Takeshi et al.
  • Journal Title: Thorax Volume: 77 Issue: 2 Pages: 143-153
  • DOI: 10.1136/thoraxjnl-2020-216263
  • Peer Reviewed
• [Journal Article] Usefulness of diurnal variation of fractional exhaled nitric oxide for predicting early therapeutic response to asthma treatment (2021)
  • Author(s): Uematsu M, Saito J, Sato S, Fukuhara A, Suzuki Y, Rikimaru M, Onuma T, Tomita H, Watanabe N, Saito M, Morimoto J, Kawamata T, Umeda T, Togawa R, Sato Y, Koizumi T, Hirai K, Minemura H, Nikaido T, Kanazawa K, Tanino Y, Munakata M, Shibata Y.
  • Journal Title: Journal of Asthma Volume: - Issue: 10 Pages: 1-12
  • DOI: 10.1080/02770903.2021.1984524
  • Peer Reviewed
• [Journal Article] Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP® (2021)
  • Author(s): Shirai T, Tanino Y, Nikaido T, Takaku Y, Hashimoto S, Taguchi Y, Baba T, Ogura T, Kataoka K, Nakayama M, Yamada Y, Matsushima S, Nakayama S, Miyazaki Y
  • Journal Title: Allergology International Volume: 70 Issue: 2 Pages: 208-214
  • DOI: 10.1016/j.alit.2020.09.003
  • NAID: 130008024347
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk stratification modeling based on a combination of initial serum biomarkers in myositis-associated interstitial lung disease: JAMI risk score (2021)
  • Author(s): Takahisa Gono, Kenichi Masui, Naoshi Nishina, Yasushi Kawaguchi, Atsushi Kawakami, Kei Ikeda, Yohei Kirino, Yumiko Sugiyama, Yoshinori Tanino, et al.
  • Journal Title: Arthritis Rheumatol Volume: 7 Issue: 4 Pages: 677-686
  • DOI: 10.1002/art.41566
  • Peer Reviewed
• [Journal Article] Safety and tolerability of combination therapy with pirfenidone and nintedanib for idiopathic pulmonary fibrosis: a multicenter retrospective observational study in Japan (2021)
  • Author(s): Shu Hisata, Masashi Bando, Sakae Homma, Kensuke Kataoka, Takashi Ogura, Shinyu Izumi, Susumu Sakamoto, Kizuku Watanabe, Yoshinobu Saito, Yasuo Shimizu, Motoyasu Kato, Yasuhiro Nishioka, Hiromichi Hara, Yuko Waseda, Yoshinori Tanino, et al.
  • Journal Title: Respir Investig Volume: 59 Issue: 6 Pages: 819-826
  • DOI: 10.1016/j.resinv.2021.04.005
  • Peer Reviewed
• [Journal Article] Pirfenidone plus inhaled N-acetylcysteine for idiopathic pulmonary fibrosis: a randomised trial (2020)
  • Author(s): Sakamoto Susumu、Kataoka Kensuke、Kondoh Yasuhiro、Kato Motoyasu、Okamoto Masaki、Mukae Hiroshi、et al.
  • Journal Title: European Respiratory Journal Volume: 57 Issue: 1 Pages: 2000348-2000348
  • DOI: 10.1183/13993003.00348-2020
  • Peer Reviewed
• [Journal Article] Clinical Significance of Thyroid Hormone and Antibodies in Patients with Idiopathic Interstitial Pneumonia (2020)
  • Author(s): Sato Y, Tanino Y, Nikaido T, Togawa R, Misa K, Wang X, Fukuhara N, Saito M, Watanabe N, Kawamata T, Rikimaru M, Umeda T, Morimoto J, Koizumi T, Suzuki Y, Hirai K, Uematsu M, Minemura H, Fukuhara A, Sato S, Saito J, Kanazawa K, Shibata Y.
  • Journal Title: J Thorac Dis Volume: 12 Issue: 3 Pages: 522-37
  • DOI: 10.21037/jtd.2020.01.02
  • Peer Reviewed / Open Access
• [Journal Article] Acute exacerbation of idiopathic interstitial pneumonias related to chemotherapy for lung cancer: A nationwide surveillance in Japan (2020)
  • Author(s): Minegishi Y, Gemma A, Homma S, Kishi K, Azuma A, Ogura T, Hamada N, Taniguchi H, Hattori N, Nishioka Y, Tanizawa K, Johkoh T, Yokoyama T, Mori K, Taguchi Y, Ebina M, Inase N, Hagiwara K, Ohnishi H, Mukae H, Inoue Y, Kuwano K, Chiba H, Ohta K, Tanino Y, Sakai F, Sugiyama Y, for the Diffuse Lung Diseases Research Group
  • Journal Title: ERJ OPEN RES Volume: 6 Issue: 2 Pages: 00142-202
  • DOI: 10.1183/23120541.00184-2019
  • Peer Reviewed / Open Access
• [Journal Article] Seasonal and residential clustering at disease onset of anti-MDA5-associated interstitial lung disease (2020)
  • Author(s): Nishina N, Sato S, Masui K, Gono T, Kuwana M, JAMI Investigators
  • Journal Title: RMD Open Volume: 6 Issue: 2 Pages: e001202-e001202
  • DOI: 10.1136/rmdopen-2020-001202
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of usefulness in surfactant protein D as a predictor of mortality in myositis-associated interstitial lung disease (2020)
  • Author(s): Kaieda S, Gono T, Masui K, Sato S, Kuwana M, JAMI Investigators
  • Journal Title: PLoS One Volume: 15 Issue: 6 Pages: e0234523-e0234523
  • DOI: 10.1371/journal.pone.0234523
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of cough frequency patterns in patients with and without asthma (2020)
  • Author(s): Fukuhara A, Saito J, Birring SS, Sato S, Uematsu M, Suzuki Y, Watanabe N, Saito M, Rikimaru M, Kawamata T, Umeda T, Togawa R, Sato Y, Koizumi T, Hirai K, Minemura H, Nikaido T, Kanazawa K, Tanino Y, Munakata M, Shibata Y
  • Journal Title: J Allergy Clin Immunol Pract Volume: 8 Issue: 2 Pages: 654-661
  • DOI: 10.1016/j.jaip.2019.08.053
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Monomorphic epitheliotropic intestinal T-cell lymphoma involving the lung and brain: a rare case study (2020)
  • Author(s): Suzuki Y, Minemura H, Tomita H, Saito M, Watanabe N, Umeda T, Kawamata T, Rikimaru M, Morimoto J, Koizumi T, Togawa R, Sato Y, Hirai K, Uematsu M, Nikaido T, Fukuhara N, Fukuhara A, Sato S, Saito J, Kanazawa K, Tanino Y, Shibata Y
  • Journal Title: Intern Med Volume: 59 Issue: 20 Pages: 2559-2563
  • DOI: 10.2169/internalmedicine.4710-20
  • NAID: 130007926294
  • Peer Reviewed / Open Access
• [Journal Article] Multidisciplinary team approach on a case of bilateral interstitial pneumonia (2020)
  • Author(s): Yijun He, Yu Xia, Yongbin Hu, Hui Zhou, Hongjun Zhao, Qun Luo, Wanli Ma, Martin Kolb, Amornpun Wongkarnjana, Reoto Takei, Yoshinori Tanino, Jie Meng
  • Journal Title: J Xiangya Med Volume: 5 Pages: 1-1
  • DOI: 10.21037/jxym.2019.12.01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two cases with autoantibodies to small ubiquitin-like modifier activating enzyme: a potential unique subset of dermatomyositis-associated interstitial lung disease (2019)
  • Author(s): Takahisa Gono, Yoshinori Tanino, Ayumi Nishikawa, Takaya Kawamata, Kenichiro Hirai, Yuka Okazaki, Yoko Shibata, Masataka Kuwana
  • Journal Title: Int J Rheum Dis Volume: 22 Issue: 8 Pages: 1582-86
  • DOI: 10.1111/1756-185x.13593
  • Peer Reviewed
• [Journal Article] A case of primary lung squamous cell carcinoma mimicking malignant mesothelioma producing granulocyte colony stimulating factor with chemotherapy (cisplatin and gemcitabine)-associated thrombotic thrombocytopenic purpura (TTP); an autopsy case report (2019)
  • Author(s): 14.Suzuki Y, Minemura H, Tomita H, Saito M, Watanabe N, Umeda T, Kawamata T, Rikimaru M, Morimoto J, Koizumi T, Togawa R, Sato Y, Hirai K, Uematsu M, Nikaido T, Fukuhara N, Fukuhara A, Sato S, Saito J, Kanazawa K, Tanino Y, Shibata Y
  • Journal Title: Lung cancer Volume: 136 Pages: 105-108
  • DOI: 10.1016/j.lungcan.2019.08.018
  • Peer Reviewed
• [Journal Article] Syndecan-4 inhibits the development of pulmonary fibrosis by attenuating TGF-β signaling (2019)
  • Author(s): Yoshinori Tanino, Xintao Wang, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Masami Kikuchi, Charles Frevert, Mishie Tanino, Tetsuhito Kojima, Yoko Shibata
  • Journal Title: Int J Mol Sci Volume: 20 Issue: 20 Pages: 4989-4989
  • DOI: 10.3390/ijms20204989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Large expert-curated database for benchmarking document similarity in biomedical literature search (2019)
  • Author(s): Peter Brown, RELISH Consortium and Yaoqi Zhou
  • Journal Title: Database (Oxford) Volume: 2019 Pages: 1-66
  • DOI: 10.1093/database/baz085
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 間質性肺炎における抗Trichosporon asahii抗体の臨床的意義の検討 (2022)
  • Author(s): 河俣貴也，谷野功典, 二階堂雄文, 佐藤佑樹, 東川隆一, 渡邉菜摘, 山田龍輝, 佐藤理子, 冨田ひかる, 斉藤美加子, 力丸真美, 梅田隆志, 森本樹里亜, 鈴木康仁, 峯村浩之, 斎藤純平, 金沢賢也，柴田 陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 特発性肺線維症に対するnintedanib低用量の効果の検討 (2022)
  • Author(s): 渡邉菜摘, 谷野功典, 二階堂雄文, 佐藤佑樹, 東川隆一, 河俣貴也, 福原奈緒子, 山田龍輝, 佐藤理子, 大沼巧, 梅田隆志, 力丸真美, 森本樹里亜, 鈴木康仁, 峯村浩之, 斎藤純平, 金沢賢也，柴田 陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 睡眠時無呼吸症候群を合併した特発性肺線維症患者の臨床的特徴 (2022)
  • Author(s): 東川隆一、谷野功典、二階堂雄文、佐藤佑樹、河俣貴也、渡邉菜摘、山田龍輝、佐藤理子、大沼巧、梅田隆志、力丸真美、森本樹里亜、鈴木康仁、峯村浩之、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 特発性間質性肺炎における末梢血単球数の予後予測バイオマーカーとしての検討 (2022)
  • Author(s): 佐藤佑樹、谷野功典、二階堂雄文、東川隆一、河俣貴也、渡邉菜摘、福原奈緒子、佐藤理子、山田龍輝、大沼巧、梅田隆志、力丸真美、森本樹里亜、鈴木康仁、峯村浩之、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] HMGB1 fragmentsはPoly(I:C)誘導性急性肺炎を抑制する (2022)
  • Author(s): 二階堂雄文、谷野功典、王新涛、佐藤佑樹、東川隆一、河俣貴也、峯村浩之、玉井克人、柴田陽光
  • Organizer: 第62回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] Efficacy of Low-Dose Nintedanib in Idiopathic Pulmonary Fibrosis, a retrospective single institute analysis (2022)
  • Author(s): Natsumi Watanabe, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Takaya Kawamaya, Naoko Fukuhara, Tomoyoshi Lee Tomoyoshi, Riko Sato, Takumi Onuma, Mikako Saito, Hikaru Tomita, Mami Rikimaru, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Synthesized HMGB1 peptide attenuates Poly(I:C)-induced lung inflammation in mice (2022)
  • Author(s): Takefumi Nikaido, Tanino Yoshinori, Xintao Wang, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Natsumi Watanabe, Katsuto Tamai, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Clinical Significance of Sleep Apnea Syndrome in Patients with Idiopathic Pulmonary Fibrosis (2022)
  • Author(s): Ryuichi Togawa, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Takaya Kawamata, Natsumi Watanabe, Naoko Fukuhara, Tomoyoshi Lee, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Mami Rikimaru, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Peripheral blood monocyte count as a prognostic biomarker in idiopathic interstitial pneumonia other than idiopathic pulmonary fibrosis (2022)
  • Author(s): Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Natsumi Watanabe, Naoko Fukuhara, Lee Tomoyoshi, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Mami Rikimaru, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] Importance of clinical history of antigen exposure and anti-Trichosporon asahii antibody evaluation for diagnosis of summer-type hypersensitivity pneumonitis in patients with chronic interstitial lung diseases (2022)
  • Author(s): Takaya Kawamata, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Natsumi Watanabe, Naoko Fukuhara, Tomoyoshi Lee, Riko Sato, Takumi Onuma, Hikaru Tomita, Mikako Saito, Mami Rikimaru, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 26h Congress of the APSR
  • Int'l Joint Research
• [Presentation] 特発性間質性肺炎急性増悪における血中心臓由来脂肪酸結合蛋白の臨床的有用性の検討 (2021)
  • Author(s): 二階堂雄文、谷野功典、佐藤佑樹、東川隆一、河俣貴也、福原奈緒子、冨田ひかる、齋藤美加子、力丸真美、梅田隆志、森本樹里亜、鈴木康仁、植松学、峯村浩之、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第61回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] IPF以外の特発性間質性肺炎における進行性フェノタイプ (PF-ILD) の臨床的特徴 (2021)
  • Author(s): 東川隆一、谷野功典、二階堂雄文、河俣貴也、佐藤佑樹、河俣貴也、福原奈緒子、大沼巧、冨田ひかる、齋藤美加子、梅田隆志、力丸真美、森本樹里亜、鈴木康仁、峯村浩之、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第61回日本呼吸器学会学術講演会
  • Int'l Joint Research
• [Presentation] 過敏性肺炎診断における血中鳥特異的IgGの臨床的な役割について (2021)
  • Author(s): 谷野功典
  • Organizer: 第70回日本アレルギー学会学術大会
  • Int'l Joint Research / Invited
• [Presentation] Clinical significance of serum heart-type fatty acid-binding protein (H-FABP) in acute exacerbation of idiopathic interstitial pneumonias (2021)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Naoko Fukuhara, Ryuki Yamada, Riko Fujii, Takumi Onuma, Hikaru Tomita, Mikako Saito, Natsumi Watanabe, Mami Rikimaru, Takashi Umeda, Julia Morimoto, Yasuhito Suzuki, Hiroyuki Minemura, Junpei Saito, Kenya Kanazawa, Yoko Shibata
  • Organizer: The 25th Congress of the APSR
  • Int'l Joint Research
• [Presentation] 特発性間質性肺炎において血中ヒト心臓由来脂肪酸結合蛋白濃度は疾患活動性や重症度と関連する (2020)
  • Author(s): 二階堂雄文、谷野功典、佐藤佑樹、東川隆一、河俣貴也、冨田ひかる、渡邉菜摘、力丸真美、梅田隆志、小泉達彦、鈴木康仁、植松学、峯村浩之、福原敦朗、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第60回日本呼吸器学会
• [Presentation] 抗ARS抗体陽性特発性間質性肺炎の臨床的特徴の検討 (2020)
  • Author(s): 河俣貴也、谷野功典、二階堂雄文、佐藤佑樹、東川隆一、冨田ひかる、渡邉菜摘、力丸真美、梅田隆志、小泉達彦、鈴木康仁、平井健一郎、植松 学、峯村浩之、福原敦朗、斎藤純平、金沢賢也、柴田陽光
  • Organizer: 第60回日本呼吸器学会
• [Presentation] 特発性間質性肺炎におけるSP-Aの臨床的意義の検討 (2020)
  • Author(s): 佐藤佑樹，谷野功典，二階堂雄文，東川隆一，河俣貴也，冨田ひかる，渡邉菜摘，力丸真美，梅田隆志，小泉達彦，鈴木康仁，平井健一郎，植松学，峯村浩之，福原敦朗，斎藤純平，金沢賢也，柴田陽光
  • Organizer: 第60回日本呼吸器学会
• [Presentation] 特発性肺線維症における上皮細胞障害マーカーの役割の検討 (2020)
  • Author(s): 東川 隆一、谷野 功典、二階堂 雄文、佐藤 佑樹、河俣 貴也、冨田 ひかる、渡邉 菜摘、梅田 隆志、力丸 真美、鈴木 康仁、植松 学、峯村 浩之、福原 敦朗、斎藤 純平、金沢 賢也、柴田 陽光
  • Organizer: 第60回日本呼吸器学会
• [Presentation] 肺癌化学療法における増悪リスク因子としての軽度間質性陰影に関する研究 (2020)
  • Author(s): 梅田隆志、峯村浩之、谷野功典、平井健一郎、金沢賢也、柴田陽光
  • Organizer: 第61回日本肺癌学会学術集会
• [Presentation] Baseline Serum Lactate Dehydrogenase and %VC may Predict the Short Time Decline of FVC in Patients with Idiopathic Pulmonary Fibrosis (2019)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Mikako Saito, Natsumi Watanabe, Takashi Umeda, Mami Rikimaru, Yasuhito Suzuki, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Suguru Sato, Junpei Saito, Kenya Kanazawa, and Yoko Shibata
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Are The Autoantibodies Associated with The Distinctive Clinical Characteristics in Interstitial Pneumonia Patients with Systemic Sclerosis? (2019)
  • Author(s): R Togawa, Y Tanino, T Nikaido, Y Sato, T kawamata, M Saito, N Watanabe, T Umeda, M Rikimaru, Y Suzuki, M Uematsu, H Minemura, A Fukuhara, S Sato, J Saito, K Kanazawa, Y Shibata
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Clinical Significance of Desaturation during a 6-minute Walk Test in Patients with Idiopathic Interstitial Pneumonia without Hypoxemia at Rest (2019)
  • Author(s): Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Mikako Saito, Natsumi Watanabe, Takashi Umeda, Mami Rikimaru, Yasuhito Suzuki, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Suguru Sato, Junpei Saito, Kenya Kanazawa, and Yoko Shibata
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Prognostic analysis of idiopathic interstitial pneumonias with rheumatologic features: A prospective multicenter cohort study (PAIR cohort study) (2019)
  • Author(s): Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takafumi Suda
  • Organizer: American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] PAR-2 antagonist inhibits BLM-induced lung fibrosis (2019)
  • Author(s): T. Suzuki, X. Wang, T. Nikaido, Y. Tanino, M. Saitou, M. Munakata, Y. Shibata, K. Niitsuma
  • Organizer: European Respiratory Society International Meeting
  • Int'l Joint Research
• [Presentation] Clinical Characteristics of Idiopathic Interstitial Pneumonia with Anti-ARS Antibody (2019)
  • Author(s): Takaya Kawamata, Yoshinori Tanino, Takefumi Nikaido, Yuki Sato, Ryuichi Togawa, Hikaru Tomita, Natsumi Watanabe, Takashi Umeda, Mami Rikimaru, Yasuhito Suzuki, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Jumpei Saito, Kenya Kanazawa,Yoko Shibata
  • Organizer: WASOG/JSSOG 2019
  • Int'l Joint Research
• [Presentation] Syndecan-4 inhibits the development of pulmonary fibrosis by attenuating TGF-β signaling (2019)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Xintao Wang, Yuki Sato, Ryuichi Togawa, Takaya Kawamata, Masami Kikuchi, Charles W. Frevert, Mishie Tanino, Tetsuhito Kojima , Yoko Shibata
  • Organizer: 11th International Conference on Proteoglycan
  • Int'l Joint Research
• [Presentation] Predictive factors for mortality in anti-melanoma-associated gene 5 antibody-associated interstitial lung disease (2019)
  • Author(s): Takahisa Gono, Kenichi Masui, Naoshi Nishina, Shinji Sato, Masataka Kuwana and JAMI investigators
  • Organizer: ACR/ARP annual meeting
  • Int'l Joint Research
• [Book] Interstitial Lung Disease: From Diagnosis to Treatment (2022)
  • Author(s): Yuki Sato, Yoshinori Tanino, Takefumi Nikaido, Ryuichi Togawa, Takaya Kawamata, Natsumi Watanabe, Xintao Wang, Yoko Shibata
  • Total Pages: 12
  • Publisher: Nova Science Publishers, Inc
• [Book] 別冊日本臨床 領域別症候群シリーズ No.19 呼吸器症候群（第3版）III -その他の呼吸器疾患を含めて- (2021)
  • Author(s): 谷野功典
  • Total Pages: 15
  • Publisher: 日本臨牀社
• [Book] Advances in Medicine and Biology (2019)
  • Author(s): Takefumi Nikaido, Yoshinori Tanino, Yuki Sato, Ryuichi Togawa, Xintao Wang, Yoko Shibata
  • Publisher: Nova Science Publishers, Inc, NY
  • ISBN: 9781536150650
• [Book] 呼吸器疾患最新の治療2019-2020 (2019)
  • Author(s): 谷野功典
  • Publisher: 南江堂
  • ISBN: 9784524245574
• [Book] 今日の処方 改訂第6版 (2019)
  • Author(s): 谷野功典
  • Publisher: 南江堂
  • ISBN: 9784524251193