Development of novel immune combination therapy for interstitial pneumonia associated with connective tissue disease
Project/Area Number |
19K08623
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53030:Respiratory medicine-related
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
Nakamura Yutaro 浜松医科大学, 医学部附属病院, 講師 (60436962)
|
Co-Investigator(Kenkyū-buntansha) |
須田 隆文 浜松医科大学, 医学部, 教授 (30291397)
|
Project Period (FY) |
2019-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 間質性肺炎 / 膠原病 / 樹状細胞 / 樹状細胞療法 / 間質性肺疾患 / 免疫療法 / 間質影肺炎 / 関節リウマチ |
Outline of Research at the Start |
申請者らは,効率的で優れた樹状細胞(DC)の免疫調節能を利用し,動物モデルで各種腫瘍および感染症に,極めて有望なワクチンを開発してきた.本研究はこれらの技術を応用し,治療選択の極めて限定された膠原病に伴う間質性肺炎に対して,免疫反応を抑える制御性DCおよび免疫チェックポイントの賦活により,治療ワクチンおよび複合免疫療法としての研究基盤を確立することが目的である.肺における過剰な免疫反応を抑制する本研究の実験系は,今後の病態解析にも有用なモデルとなる可能性もあり,極めて発展性の高い研究と考える.
|
Outline of Final Research Achievements |
We aimed to develop a novel therapeutic vaccine for the patients with interstitial pneumonia associated with connective tissue disease, suppressing local inflammation of the lung. We also analyzed the histological findings with human lung specimens from the patients with rheumatoid lung disease (RLD). Eventually we found that fibrotic components might be more important for the prognosis of RLD patients than inflammatory components.
|
Academic Significance and Societal Importance of the Research Achievements |
我々は人の肺の外科的生検検体を用いた検討において,炎症性病態も重要であるが,より線維化病態が予後に与える影響が大きい可能性を示した.これらの結果より現状では,ほぼ炎症性病態のみを標的とした樹状細胞を用いた治療ワクチンの効果は限定的であり,さらに医学的効果のみならず臨床応用後の対費用効果の面からもその有用性は乏しいことが考慮された.以上から引き続き,人,マウスの検体を用いた検討をさらに進め,より効果的な膠原病に伴う間質性肺疾患の治療ターゲットを探索する研究を継続している.
|
Report
(4 results)
Research Products
(15 results)
-
-
[Journal Article] Simple method for detecting idiopathic interstitial pneumonias by measuring vertical lung length on chest X-ray.2021
Author(s)
Karayama M, Aoshima Y, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T.
-
Journal Title
Sci Rep.
Volume: 11(1)
Issue: 1
Pages: 7669-7669
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
[Journal Article] Assessment of Immune-Related Interstitial Lung Disease in Patients With NSCLC Treated with Immune Checkpoint Inhibitors: A Multicenter Prospective Study2020
Author(s)
Suzuki Y, Karayama M, Uto T, Fujii M, Matsui T, Asada K, Kusagaya H, Kato M, Matsuda H, Matsuura S, Toyoshima M, Mori K, Ito Y, Koyauchi T, Yasui H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
-
Journal Title
Journal of Thoracic Oncology
Volume: S1556
Issue: 8
Pages: 1317-1327
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] Frequency and clinical relevance of anti-cyclic citrullinated peptide antibody in idiopathic interstitial pneumonias2019
Author(s)
Katsumata M, Hozumi H, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
-
Journal Title
Respir Med
Volume: 154
Pages: 102-108
DOI
Related Report
Peer Reviewed
-
[Journal Article] Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone.2019
Author(s)
Kono M, Nakamura Y, Enomoto N, Saito G, Koyanagi Y, Miyashita K, Tsutsumi A, Kobayashi T, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Miki Y, Hashimoto D, Fujisawa T, Inui N, Suda T, Nakamura H.
-
Journal Title
Respir Investig.
Volume: 57
Issue: 6
Pages: 552-560
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Presentation] Clinical significance of the lower-lobe interstitial lung disease in patients with idiopathic pleuroparenchymal fibroelastosis.2019
Author(s)
Kono M, Nakamura Y, Enomoto N, Fujita Y, Takeda K, Miyashita K, Tsutsumi A, Kobayashi T, Miki Y, Hashimoto D, Suda T, Nakamura H
Organizer
American Thoracic Society International Conference
Related Report
Int'l Joint Research
-
[Presentation] Prognostic and clinical value of cluster analysis of idiopathic pleuroparenchymal fibroelastosis phenotypes.2019
Author(s)
Nakamura Y, Enomoto Y, Kono M, Satake Y, Sumikawa H, Johkoh T, Colby TV, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Inui N, Iwashita T, Kuroishi S, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Yamada T, Shirai T, Hayakawa H, Suda T
Organizer
European Respiratory Society International Congress
Related Report
Int'l Joint Research