Discovery of novel BM and pathogenesis in COPD by trans-omics

• Project/Area Number: 19K08650
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Osaka University
• Principal Investigator: Takeda Yoshito 大阪大学, 大学院医学系研究科, 准教授 (40452388)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: バイオマーカー / 個別化医療 / プロテオミクス / エクソソーム / トランスオミクス / COPD / 創薬開発 / マルチオミクス / メタボローム / トランスクリプトーム / バイオインフォマティクス / 慢性炎症性呼吸器疾患 / オミクス / 呼吸器疾患

Outline of Research at the Start

本研究では、当教室にて構築した疾患モデル動物と豊富な臨床検体を活用して、各種オミクス・データを取得するとともに、最新イメージング技術を用いるマルチモーダルな病態把握（フェノタイピング）に挑戦する。これらフェノタイピングデータと各種オミクスを統合解析し、複雑多様なCOPDの個別化医療を目指したBM開発だけでなく、病態解明や創薬開発に挑戦する。

Outline of Final Research Achievements

There is an unmet need for novel biomarkers in the diagnosis of multifactorial COPD. We applied next-generation proteomics to serum extracellular vesicles (EVs) to discover novel COPD biomarkers. This is a novel strategy not only for biomarker discovery but also for clarification of pathogenesis.

Academic Significance and Societal Importance of the Research Achievements

申請者は、オミクス専門家と最新テクノロジーを駆使して、難関オミクスとされるプロテオミクスを克服した。本研究では、豊富な臨床検体と独自のモデル動物を駆使して、各階層オミクスとバイオインフォマティクスチームの専門家で構成する異分野連携チームにより、個別化医療を目指した炎症性呼吸器疾患のBM開発と病態解明を目指した。
本法の妥当性が検証されたことから、今後、種々の炎症性疾患へのアプローチが可能である。さらに、血清由来エクソソームを用いたオミクスから、新規治療薬開発を示唆する知見も得られため、創薬開発のストラテジーになりうる。

Research Products

• [Journal Article] Real-world impact of antifibrotics on prognosis in patients with progressive fibrosing interstitial lung disease (2023)
  • Author(s): Niitsu Takayuki、Fukushima Kiyoharu、Komukai Sho、Takata So、Abe Yuko、Nii Takuro、Kuge Tomoki、Iwakoshi Shinichi、Shiroyama Takayuki、Miyake Kotaro、Tujino Kazuyuki、Tanizaki Satoshi、Iwahori Kota、Hirata Haruhiko、Miki Keisuke、Yanagawa Masahiro、Takeuchi Noriyuki、Takeda Yoshito、Kida Hiroshi、Kumanogoh Atsushi
  • Journal Title: RMD Open Volume: 9 Issue: 1 Pages: e002667-e002667
  • DOI: 10.1136/rmdopen-2022-002667
  • Peer Reviewed / Open Access
• [Journal Article] WT1 Trio Peptide-Based Cancer Vaccine for Rare Cancers Expressing Shared Target WT1 (2023)
  • Author(s): Oji Y, Kagawa N, Arita H, Naka N, Hamada KI, Outani H, Shintani Y, Takeda Y, Morii E, Shimazu K, Suzuki M, Nishida S, Nakata J, Tsuboi A, Iwai M, Hayashi S, Imanishi R, Ikejima S, Kanegae M, Iwamoto M, Ikeda M, Yagi K, Shimokado H, Nakajima H, Hasegawa K, Morimoto S, Fujiki F 他
  • Journal Title: Cancers Volume: 15 Issue: 2 Pages: 393-393
  • DOI: 10.3390/cancers15020393
  • Peer Reviewed / Open Access
• [Journal Article] Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19 (2022)
  • Author(s): Kawasaki Takahiro、Takeda Yoshito、Edahiro Ryuya、Shiroyama Takayuki、Hirata Haruhiko、Adachi Jun、Okada Yukinori、Kumanogoh Atsushi
  • Journal Title: Inflammation and Regeneration Volume: 42 Issue: 1 Pages: 393-393
  • DOI: 10.1186/s41232-022-00243-5
  • Peer Reviewed / Open Access
• [Journal Article] Lee Ho, et al. (2022)
  • Author(s): Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
  • Journal Title: BMC Infectious Diseases Volume: 22 Issue: 1 Pages: 935-935
  • DOI: 10.1186/s12879-022-07927-w
  • Peer Reviewed / Open Access
• [Journal Article] Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells (2022)
  • Author(s): Yamaguchi Yuta et al.
  • Journal Title: JCI Insight Volume: 7 Issue: 22 Pages: 393-393
  • DOI: 10.1172/jci.insight.163347
  • Peer Reviewed / Open Access
• [Journal Article] Peripheral T cell cytotoxicity predicts the efficacy of anti-PD-1 therapy for advanced non-small cell lung cancer patients (2022)
  • Author(s): Iwahori Kota、Uenami Takeshi、Yano Yukihiro、Ueda Toshihiko、Tone Mari、Naito Yujiro、Suga Yasuhiko、Fukushima Kiyoharu、Shiroyama Takayuki、Miyake Kotaro、Koyama Shohei、Hirata Haruhiko、Nagatomo Izumi、Kida Hiroshi、Mori Masahide、Takeda Yoshito、Kumanogoh Atsushi、Wada Hisashi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 393-393
  • DOI: 10.1038/s41598-022-22356-0
  • Peer Reviewed
• [Journal Article] Impact of treatment line on risks and benefits of immune checkpoint inhibitor in patients with advanced non-small cell lung cancer and interstitial lung disease: a systematic review and meta-analysis of cohort studies (2022)
  • Author(s): Matsumoto Kinnosuke、Shiroyama Takayuki、Kuge Tomoki、Miyake Kotaro、Yamamoto Yuji、Yoneda Midori、Yamamoto Makoto、Naito Yujiro、Suga Yasuhiko、Fukushima Kiyoharu、Koyama Shohei、Iwahori Kota、Hirata Haruhiko、Nagatomo Izumi、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Translational Lung Cancer Research Volume: 11 Issue: 9 Pages: 1835-1846
  • DOI: 10.21037/tlcr-22-162
  • Peer Reviewed
• [Journal Article] The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force (2022)
  • Author(s): Wang Qingbo S.、et al.
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 4830-4830
  • DOI: 10.1038/s41467-022-32276-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DOCK2 is involved in the host genetics and biology of severe COVID-19 (2022)
  • Author(s): Namkoong Ho、et al.
  • Journal Title: Nature Volume: 609 Issue: 7928 Pages: 754-760
  • DOI: 10.1038/s41586-022-05163-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of the Treatment Line on the Risks and Benefits of Immune Checkpoint Inhibitors in Patients With Non-Small Cell Lung Cancer and Interstitial Lung Disease (2022)
  • Author(s): Matsumoto Kinnosuke、Shiroyama Takayuki、Yamamoto Yuji、Miyake Kotaro、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Chest Volume: 162 Issue: 1 Pages: e67-e69
  • DOI: 10.1016/j.chest.2022.02.053
  • Peer Reviewed
• [Journal Article] Multi-trait and cross-population genome-wide association studies across autoimmune and allergic diseases identify shared and distinct genetic component (2022)
  • Author(s): Shirai Y, Nakanishi Y, Suzuki A, Konaka H, Nishikawa R, Sonehara K, Namba S, Tanaka H, Masuda T, Yaga M, Satoh S, Izumi M, Mizuno Y, Jo T, Maeda Y, Nii T, Oguro-Igashira E, Morisaki T, Kam, Nakayamada S, Nishigori C, Tanaka Y, Takeda Y, Yamamoto K, Kumanogoh A, Okada Y, The Biobank Japan Project
  • Journal Title: Annals of the Rheumatic Diseases Volume: 81 Issue: 9 Pages: 1301-1312
  • DOI: 10.1136/annrheumdis-2022-222460
  • Peer Reviewed / Open Access
• [Journal Article] Leucine-rich a-2 glycoprotein as a potential biomarker of idiopathic multicentric Castleman disease with pulmonary involvement: a single-center case-control study from Japan (2022)
  • Author(s): Takata So、Takeda Yoshito、Hirata Haruhiko、Shirai Yuya、Morita Takayoshi、Futami Yu、Naito Yujiro、Masuhiro Kentaro、Shiroyama Takayuki、Miyake Kotaro、Naka Tetsuji、Kumanogoh Atsushi
  • Journal Title: Journal of Thoracic Disease Volume: 14 Issue: 5 Pages: 1332-1341
  • DOI: 10.21037/jtd-21-1973
  • Peer Reviewed
• [Journal Article] Quantitative evaluation of emphysema for predicting immunotherapy response in patients with advanced non-small-cell lung cancer (2022)
  • Author(s): Noda Yoshimi、Shiroyama Takayuki、Masuhiro Kentaro、Amiya Saori、Enomoto Takatoshi、Adachi Yuichi、Hara Reina、Niitsu Takayuki、Naito Yujiro、Miyake Kotaro、Koyama Shohei、Hirata Haruhiko、Nagatomo Izumi、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 1332-1341
  • DOI: 10.1038/s41598-022-13131-2
  • Peer Reviewed
• [Journal Article] Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer (2022)
  • Author(s): Masuhiro Kentaro、Tamiya Motohiro、Fujimoto Kosuke
  • Journal Title: JCI Insight Volume: 1 Issue: 9 Pages: 1-1
  • DOI: 10.1172/jci.insight.157915
  • Peer Reviewed / Open Access
• [Journal Article] CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis by proteomics of serum extracellular vesicles. (2022)
  • Author(s): Futami Y, Takeda Y, KobaT, Narumi R, Nojima Y, Ito M, Nakayama M, Ishida M,Yoshimura H, Naito Y, Fukushima K, Takimoto T, Edahiro R, Matsuki T, Nojima S, Hirata H, Koyama S, Iwahori K, Nagatomo I, Shirai Y, Suga Y, Satoh S, Futami S, Miyake K, Shiroyama T, Inoue Y, Adachi J, Tomonaga T, Ueda K, Kumanogoh A.
  • Journal Title: International immunology Volume: - Issue: 6 Pages: 1-1
  • DOI: 10.1093/intimm/dxac009
  • Peer Reviewed / Open Access
• [Journal Article] A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity (2022)
  • Author(s): Nakagawa Yuta、Matsumoto Kinnosuke、Yamamoto Makoto、Hirata Haruhiko、Shiroyama Takayuki、Miyake Kotaro、Yamamoto Yuji、Kuge Tomoki、Yoneda Midori、Naito Yujiro、Suga Yasuhiko、Fukushima Kiyoharu、Koyama Shohei、Iwahori Kota、Nagatomo Izumi、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Respiratory Medicine Case Reports Volume: 36 Pages: 101619-101619
  • DOI: 10.1016/j.rmcr.2022.101619
  • Peer Reviewed
• [Journal Article] Mapping the human genetic architecture of COVID-19 (2022)
  • Author(s): COVID-19 Host Genetics Initiative
  • Journal Title: Nature Volume: 600(7889) Issue: 7889 Pages: 472-477
  • DOI: 10.1038/s41586-021-03767-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive and long-term surveys of COVID-19 sequelae in Japan, an ambidirectional multicentre cohort study: study protocol (2021)
  • Author(s): Nakagawara Kensuke、Namkoong Ho
  • Journal Title: BMJ Open Respiratory Research Volume: 8 Issue: 1 Pages: e001015-e001015
  • DOI: 10.1136/bmjresp-2021-001015
  • Peer Reviewed / Open Access
• [Journal Article] Impact of treatment timing and sequence of immune checkpoint inhibitors and anti-angiogenic agents for advanced non-small cell lung cancer: A systematic review and meta-analysis (2021)
  • Author(s): Matsumoto Kinnosuke、Shiroyama Takayuki、Kuge Tomoki、Miyake Kotaro、Yamamoto Yuji、Yoneda Midori、Yamamoto Makoto、Naito Yujiro、Suga Yasuhiko、Fukushima Kiyoharu、Koyama Shohei、Iwahori Kota、Hirata Haruhiko、Nagatomo Izumi、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Lung Cancer Volume: 162 Pages: 175-184
  • DOI: 10.1016/j.lungcan.2021.11.008
  • Peer Reviewed / Open Access
• [Journal Article] IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts Antitumor Immunity (2021)
  • Author(s): Suga Y, Nagatomo I, Kinehara Y, Koyama S, Okuzaki D, Osa A, Naito Y, Takamatsu H, Nishide M, Nojima S, Ito D, Tsuda T, Nakatani T, Nakanishi Y, Futami Y, Koba T, Satoh S, Hosono Y, Miyake K, Fukushima K, Shiroyama T, Iwahori K, Hirata H, Takeda Y, Kumanogoh A.
  • Journal Title: The Journal of Immunology Volume: 207 Issue: 5 Pages: 1456-1467
  • DOI: 10.4049/jimmunol.2100076
  • Peer Reviewed / Open Access
• [Journal Article] Cytomegalovirus infection in critically ill patients with COVID-19 (2021)
  • Author(s): Niitsu Takayuki、Shiroyama Takayuki、Hirata Haruhiko、Noda Yoshimi、Adachi Yuichi、Enomoto Takatoshi、Hara Reina、Amiya Saori、Uchiyama Akinori、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Journal of Infection Volume: 83 Issue: 4 Pages: 496-522
  • DOI: 10.1016/j.jinf.2021.07.004
  • Peer Reviewed / Open Access
• [Journal Article] Proteomics of serum extracellular vesicles identifies a novel COPD biomarker, fibulin-3 from elastic fibres. (2021)
  • Author(s): Koba, Takeda, Narumi, Shiromizu, Nojima, Ito, Kuroyama, Futami, Takimoto, Matsuki, Edahiro, Nojima, Hayama, Fukushima, Hirata, Koyama, Iwahori, Nagatomo, Suzuki, Shirai, Murakami, Nakanishi, Nakatani, Suga, Miyake, Shiroyama, Kida, Sasaki, Ueda, Mizuguchi, Adachi, Tomonaga, Kumanogoh
  • Journal Title: ERJ open research. Volume: 7(1) Issue: 1 Pages: 00658-2020
  • DOI: 10.1183/23120541.00658-2020
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predicting recurrence of respiratory failure in critically ill patients with COVID-19: A preliminary study (2021)
  • Author(s): Adachi Yuichi、Shiroyama Takayuki、Yamaguchi Yuta、Murakami Teruaki、Hirata Haruhiko、Amiya Saori、Niitsu Takayuki、Noda Yoshimi、Hara Reina、Enomoto Takatoshi、Morita Takayoshi、Kato Yasuhiro、Uchiyama Akinori、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Journal of Infection Volume: 82 Issue: 5 Pages: e33-e35
  • DOI: 10.1016/j.jinf.2021.01.016
  • Peer Reviewed / Open Access
• [Journal Article] Greater reductions in blood flow after anti-angiogenic treatment in non-small cell lung cancer patients are associated with shorter progression-free survival (2021)
  • Author(s): Katayama Daisuke、Yanagawa Masahiro、Matsunaga Keiko、Watabe Hiroshi、Watabe Tadashi、Kato Hiroki、Kijima Takashi、Takeda Yoshito、Kumanogoh Atsushi、Shimosegawa Eku、Hatazawa Jun、Tomiyama Noriyuki
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 1-2
  • DOI: 10.1038/s41598-021-86405-w
  • Peer Reviewed / Open Access
• [Journal Article] Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema (2020)
  • Author(s): Tripathi Lokesh P.、Itoh Mari N.、Takeda Yoshito、Tsujino Kazuyuki、Kondo Yasushi、Kumanogoh Atsushi、Mizuguchi Kenji
  • Journal Title: Frontiers in Genetics Volume: 11 Pages: 1-2
  • DOI: 10.3389/fgene.2020.585998
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary metastases of lung adenocarcinoma mimicking COVID-19 pneumonia (2020)
  • Author(s): Shiroyama Takayuki、Hirata Haruhiko、Nagatomo Izumi、Takeda Yoshito、Kumanogoh Atsushi
  • Journal Title: Journal of Thoracic Disease Volume: 12 Issue: 10 Pages: 6125-6126
  • DOI: 10.21037/jtd-20-2393
  • Peer Reviewed / Open Access
• [Journal Article] Metabolomic analysis of fibrotic mice combined with public RNA‐Seq human lung data reveal potential diagnostic biomarker candidates for lung fibrosis (2020)
  • Author(s): Nojima Yosui、Takeda Yoshito、Maeda Yohei、Bamba Takeshi、Fukusaki Eiichiro、Itoh Mari N.、Mizuguchi Kenji、Kumanogoh Atsushi
  • Journal Title: FEBS Open Bio Volume: 10 Issue: 11 Pages: 2427-2436
  • DOI: 10.1002/2211-5463.12982
  • Peer Reviewed / Open Access
• [Journal Article] Association of the RPA3-UMAD1 locus with interstitial lung diseases complicated with rheumatoid arthritis in Japanese (2020)
  • Author(s): Shirai Yuya、Honda Suguru、Ikari Katsunori、Kanai Masahiro、Takeda Yoshito、Kamatani Yoichiro、Morisaki Takayuki、Tanaka Eiichi、Kumanogoh Atsushi、Harigai Masayoshi、Okada Yukinori
  • Journal Title: Annals of the Rheumatic Diseases Volume: 79 Issue: 10 Pages: 1305-1309
  • DOI: 10.1136/annrheumdis-2020-217256
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring Antibody Binding to T Cells in a Pembrolizumab-Treated Patient With Lung Adenocarcinoma on Hemodialysis (2019)
  • Author(s): Akio Osa, Takeshi Uenami, Yujiro Naito, Haruhiko Hirata, Shohei Koyama, Takayuki Takimoto, Takayuki Shiroyama, Shinji Futami, Saeko Nakatsubo, Nobuhiko Sawa, Yukihiro Yano, Izumi Nagatomo, Yoshito Takeda, Masahide Mori, Hiroshi Kida, Atsushi Kumanogoh
  • Journal Title: Thorac Cancer Volume: 11 Issue: 11 Pages: 2183-2187
  • DOI: 10.1111/1759-7714.13197
  • Peer Reviewed / Open Access
• [Journal Article] A lung abscess caused by secondary syphilis - the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report. (2019)
  • Author(s): Futami S, Takimoto T, Nakagami F, Satoh S, Hamaguchi M, Kuroyama M, Miyake K, Koyama S, Iwahori K, Hirata H, Nagatomo I, Takeda Y, Kida H, Kumanogoh A.
  • Journal Title: BMC Infect Dis. Volume: 19(1):598. Issue: 1 Pages: 598-598
  • DOI: 10.1186/s12879-019-4236-4
  • Peer Reviewed / Open Access
• [Presentation] Leucine-Rich a2-Glycoprotein as a Potential Biomarker for multicentric Castleman disease with pulmonary involvement (2021)
  • Author(s): So Takata1、Yoshito Takeda1、Haruhiko Hirata1、Takayoshi Morita1、Yu Futami1、Yujiro Naito1、Kentaro Masuhiro1、Mana Nakayama1、Tetsuji Naka2、Atsushi Kumanogoh1.
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] エクソソームの次世代プロテオミクスによるサルコイドーシスの新規バイオマーカー探索 (2021)
  • Author(s): 網屋沙織，武田吉人，足立雄一，榎本貴俊，新津敬之，野田成美，原 伶奈，白井雄也，白山敬之，三宅浩太郎，平田陽彦，足立 淳，伊藤眞里，夏目やよい，熊ノ郷淳
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] 気管支肺胞洗浄液を用いた肺癌微小環境の免疫解析によるニボルマブ効果予測因子の探索 (2021)
  • Author(s): 内藤 祐二朗、田宮 基裕、益弘 健太朗、小山 正平、白山 敬之、井上 貴子、西野 和美、鈴木 秀和、岡本 紀雄、平島 智徳、熊谷 融、武田 吉人、熊ノ郷 淳
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] 次世代プロテオミクスによる進行性線維化を伴う間質性肺疾患の新規バイオマーカー探索 (2021)
  • Author(s): 榎本貴俊, 武田吉人, 足立雄一, 網屋沙織, 野田成美, 白井雄也, 福島清春, 白山敬之, 三宅浩太郎, 平田陽彦, 足立淳, 夏目やよい, 伊藤眞里, 熊ノ郷淳
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] エクソソームの次世代プロテオミクスによる悪性胸膜中皮腫の新規バイオマーカー開発 (2021)
  • Author(s): 安部 祐子, 武田 吉人, 木庭 太郎, 福島 清春, 白山 敬之,平田 陽彦, 足立淳, 伊藤眞里, 横井 崇, 南 俊行, 栗林 康造, 木島 貴志, 熊ノ郷 淳
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] 次世代プロテオミクスとバイオインフォマティクスが紐解くIPFとNSIPの病態解明 (2021)
  • Author(s): 足立雄一 武田吉人 榎本貴俊 網屋沙織 野田成美 原伶奈 新津敬之 白井雄也 福島清春 白山敬之 三宅浩太郎 平田晴彦 夏目やよい 足立淳 伊藤眞里 熊ノ郷淳
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] 「PRISM」データから見えてきた新たな線維化バイオマーカー (2021)
  • Author(s): 白井雄也、武田吉人、足立雄一、榎本貴俊、網屋沙織、野田成美、福島清春、白山敬之、三宅浩太郎、平田陽彦、足立淳、夏目やよい、伊藤眞里、 熊ノ郷淳
  • Organizer: 第61回呼吸器学会学術講演会
• [Presentation] Identification of novel biomarkers for malignant pleural mesothelioma by proteomics of serum exosomes (2021)
  • Author(s): Yuko Abe, Yoshito Takeda, Hanako Yoshimura, Taro Koba, Yasuhiko Suga, Kiyoharu Fukushima, Takayuki Shiroyama, Syohei Koyama, Haruhiko Hirata, Kota Iwahori, Izumi Nagatomo, Atsushi Kumanogoh
  • Organizer: 第80回 日本癌学会総会
• [Presentation] 次世代プロテオミクスによる進行性線維化を伴う間質性肺疾患の新規バイオマーカー探索 (2021)
  • Author(s): 榎本貴俊, 武田吉人, 白井雄也, 足立淳, 伊藤眞里, 夏目やよい, 熊ノ郷淳
  • Organizer: 第8回日本細胞外小胞学会学術集会
• [Presentation] Discovery of novel biomarkers of small cell lung cancer by proteomics of exosomes (2021)
  • Author(s): Hanako Yoshimura, Yoshito Takeda, Taro Koba, Yasuhiko Suga, Kiyoharu Fukushima, Takayuki Shiroyama, Haruhiko Hirata, Shohei Koyama, Izumi Nagatomo, Kota Iwahori, Mari Itoh, Atsushi Kumanogoh
  • Organizer: ATS 2021
  • Int'l Joint Research
• [Presentation] 血清エクソソームの最新プロテオミクスによる新規COPDバイオマーカーの同定 (2019)
  • Author(s): 木庭太郎、武田吉人、玄山宗到、木田博、熊ノ郷淳
  • Organizer: 日本呼吸器学会学術講演会
• [Presentation] 血清エクソソームの最新プロテオミクスによる新規喘息・COPDバイオマーカーの探索 (2019)
  • Author(s): 木庭太郎、武田吉人、玄山宗到、木田博、熊ノ郷淳
  • Organizer: 日本呼吸器学会学術講演会
• [Presentation] 分子オーガナイザー：テトラスパニン ～肺の恒常性維持から老化まで～ (2019)
  • Author(s): 武田吉人
  • Organizer: 日本細胞生物学会総会
  • Invited
• [Presentation] Proteomic Profiling of Serum Exosomes to Identify Novel Biomarkers for COPD (2019)
  • Author(s): T. Koba, Y. Takeda, R. Narumi
  • Organizer: アメリカ胸部学会
  • Int'l Joint Research
• [Presentation] Proteomic profiling of serum exosomes to find novel biomarkers in sarcoidosis (2019)
  • Author(s): Yu Nishijima-Futami 1Yoshito Takeda, 2Ryohei Narumi
  • Organizer: アメリカ胸部学会
  • Int'l Joint Research
• [Presentation] Proteomic profiling of serum exosomes to identify novel biomarkers for lymphangioleiomyomatosis (2019)
  • Author(s): Takayuki Takimoto1, Yoshito Takeda1, Takashi Shiromizu2
  • Organizer: アメリカ胸部学会
  • Int'l Joint Research
• [Remarks] 最新プロテオミクスによる呼吸器疾患における新規バイオマーカーの開発
  • URL: http://www.imed3.med.osaka-u.ac.jp/research/r-resp08.html
• [Remarks] 大阪大学 呼吸器・免疫内科教室
  • URL: http://www.imed3.med.osaka-u.ac.jp/research/r-resp.html