Development of novel therapeutic strategies for diabetic kidney diseases by tubular epithelium-specific protection

• Project/Area Number: 19K08679
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Kawasaki College of Allied Health Professions (2022); Okayama University (2019-2021)
• Principal Investigator: Sugiyama Hitoshi 川崎医療短期大学, 医療介護福祉学科, 教授 (60325090)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: トレフォイルファクター / 糖尿病性腎臓病 / 尿細管上皮細胞 / アルブミン尿 / 腎尿細管上皮

Outline of Research at the Start

本研究では、腎尿細管上皮においてTFF3発現増強による、DKDの腎線維化に対する新規治療法の開発を行うことを目的とする。まずDKDのヒト腎生検組織におけるTFF3発現と線維化との関連を証明する。次に遺伝子改変動物に作成したDKDモデルを用いて、TFF3過剰発現による腎尿細管障害および線維化に対する治療効果を明らかにする。更に、高糖濃度培養した腎尿細管上皮細胞を用いて、TFF3発現亢進による腎線維化抑制の細胞内シグナル伝達機構を解明する。ヒトDKDにおける病態解析を起点にして、実験動物、培養細胞を用いた機序解析を行い、腎尿細管上皮におけるTFF3過剰発現によるDKDへの新たな治療戦略を開発する。

Outline of Final Research Achievements

Trefoil factor (TFF) is a mucosal protective protein produced by epithelial cells in various organs. Among them, TFF3 is expressed in renal tubular epithelial cells. In diabetic kidney disease (DKD), urinary TFF3 significantly correlated with urinary albumin excretion, and furthermore, urinary TFF3 excretion was enhanced in the microalbuminuric group than in the normal group, and urinary TFF3 was significantly correlated with urinary α1-MG. Thus, urinary TFF3 was suggested to be an indicator of tubular damage in the early stage of DKD. The intracellular signaling mechanism of TFF3 expression in cultured renal tubular epithelial cells and the therapeutic effect of TFF3 overexpression on inhibition of renal fibrosis in DKD remain unresolved.

Academic Significance and Societal Importance of the Research Achievements

わが国において腎不全から慢性透析療法を受ける患者数は34万人を超えており1.7兆円の医療費がかかっている。糖尿病性腎臓病（DKD）はわが国における透析導入の原疾患として最も多くを占めることから、DKDの早期発見と早期治療、重症化予防による透析導入の減少は医療経済的にも喫緊の課題である。本研究ではDKD早期から尿中TFF3上昇が見られており早期診断マーカーとしての可能性が示唆された。DKDの早期発見が可能となれば早期治療へと繋がり、重症化予防と透析導入の減少が可能となる。今後、多数例を対象とした検証を行うことにより有用性を検証していく必要がある。

Research Products

• [Journal Article] Prevalence of Chronic Kidney Disease and Variation of Its Risk Factors by the Regions in Okayama Prefecture (2022)
  • Author(s): Umebayashi Ryoko、Uchida Haruhito Adam、Matsuoka-Uchiyama Natsumi、Sugiyama Hitoshi、Wada Jun
  • Journal Title: Journal of Personalized Medicine Volume: 12 Issue: 1 Pages: 97-97
  • DOI: 10.3390/jpm12010097
  • Open Access
• [Journal Article] Clinicopathologic Features of Mitochondrial Nephropathy (2022)
  • Author(s): Imasawa Toshiyuki、Hirano Daishi、Nozu Kandai、Kitamura Hiroshi、Hattori Motoshi、Sugiyama Hitoshi、Sato Hiroshi、Murayama Kei
  • Journal Title: Kidney International Reports Volume: 7 Issue: 3 Pages: 580-590
  • DOI: 10.1016/j.ekir.2021.12.028
  • Open Access
• [Journal Article] Vasohibin-1 has α-tubulin detyrosinating activity in glomerular podocytes (2022)
  • Author(s): Mifune Tomoyo、Tanabe Katsuyuki、Nakashima Yuri、Tanimura Satoshi、Sugiyama Hitoshi、Sato Yasufumi、Wada Jun
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 599 Pages: 93-99
  • DOI: 10.1016/j.bbrc.2022.02.047
• [Journal Article] A nationwide analysis of renal and patient outcomes for adults with lupus nephritis in Japan (2022)
  • Author(s): Ikeuchi Hidekazu、Sugiyama Hitoshi、Sato Hiroshi、Yokoyama Hitoshi、Maruyama Shoichi、Mukoyama Masashi、Hayashi Hiroki、Tsukamoto Tatsuo、Fukuda Michio、Yamagata Kunihiro、Ishikawa Eiji、Uchida Keiko、Kamijo Yuji、Nakagawa Naoki、Tsuruya Kazuhiko、Nojima Yoshihisa、Hiromura Keiju
  • Journal Title: Clinical and Experimental Nephrology Volume: 26 Issue: 9 Pages: 898-908
  • DOI: 10.1007/s10157-022-02232-x
• [Journal Article] Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J?RBR) (2022)
  • Author(s): Moniwa Norihito、Tanaka Marenao、Sato Hiroshi、Shimizu Akira、Sugiyama Hitoshi、Yokoyama Hitoshi、Tsuruya Kazuhiko、Hashiguchi Akinori、the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology
  • Journal Title: Clinical and Experimental Nephrology Volume: 26 Issue: 10 Pages: 963-973
  • DOI: 10.1007/s10157-022-02236-7
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study. (2022)
  • Author(s): Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Uchida S, Tsukamoto T, Tsuruya K, Akai Y, Nitta K, Fukunaga M, Hayashi H, Masutani K et al.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 9782-9782
  • DOI: 10.1038/s41598-022-13067-7
  • Peer Reviewed / Open Access
• [Journal Article] Deep learning analysis of clinical course of primary nephrotic syndrome: Japan Nephrotic Syndrome Cohort Study (JNSCS) (2022)
  • Author(s): Kimura Tomonori、Yamamoto Ryohei、Yoshino Mitsuaki、Sakate Ryuichi、Imai Enyu、Maruyama Shoichi、Yokoyama Hitoshi、Sugiyama Hitoshi、et al.
  • Journal Title: Clinical and Experimental Nephrology Volume: 26 Issue: 12 Pages: 1170-1179
  • DOI: 10.1007/s10157-022-02256-3
  • Open Access
• [Journal Article] The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study (2022)
  • Author(s): Matsuoka-Uchiyama Natsumi、Tsuji Kenji、Sang Yizhen、Takahashi Kensaku、Fukushima Kazuhiko、Takeuchi Hidemi、Inagaki Kenichi、Uchida Haruhito A.、Kitamura Shinji、Sugiyama Hitoshi、Wada Jun
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 14999-14999
  • DOI: 10.1038/s41598-022-19226-0
  • Peer Reviewed / Open Access
• [Journal Article] Acute Kidney Injury and Remission of Proteinuria in Minimal Change Disease. (2022)
  • Author(s): Yamamoto R, Imai E, Maruyama S, Yokoyama H, Sugiyama H, Takeda A, Uchida S, Tsukamoto T, Tsuruya K, Akai Y, Nitta K, Fukunaga M, Hayashi H, Shoji T, Masutani K et al.
  • Journal Title: Kidney International Reports Volume: 7 Issue: 10 Pages: 2283-2288
  • DOI: 10.1016/j.ekir.2022.07.173
  • Peer Reviewed / Open Access
• [Journal Article] The Beneficial Effect of Personalized Lifestyle Intervention in Chronic Kidney Disease Follow-Up Project for National Health Insurance Specific Health Checkup: A Five-Year Community-Based Cohort Study (2022)
  • Author(s): Takeuchi Hidemi、Uchida Haruhito A.、Katayama Katsuyoshi、Matsuoka-Uchiyama Natsumi、Okamoto Shugo、Onishi Yasuhiro、Okuyama Yuka、Umebayashi Ryoko、Miyaji Kodai、Kai Akiko、Matsumoto Izumi、Taniguchi Keiko、Yamashita Fukiko、Emi Tsutomu、Sugiyama Hitoshi、Wada Jun
  • Journal Title: Medicina Volume: 58 Issue: 11 Pages: 1529-1529
  • DOI: 10.3390/medicina58111529
  • Open Access
• [Journal Article] Acute Kidney Injury Caused by Evans Syndrome with Systemic Lupus Erythematosus and Systemic Sclerosis (2021)
  • Author(s): Matsuoka Natsumi、Watanabe Haruki、Kurooka Naoko、Kato Sumari、Higashi Chika、Tanabe Katsuyuki、Kinomura Masaru、Fujii Nobuharu、Sada Ken-ei、Sugiyama Hitoshi、Wada Jun
  • Journal Title: Internal Medicine Volume: 60 Issue: 7 Pages: 1055-1060
  • DOI: 10.2169/internalmedicine.5976-20
  • NAID: 130008014392
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-04-01
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of administration of single- and triple-course steroid pulse therapy combined with tonsillectomy for immunoglobulin A nephropathy (2021)
  • Author(s): Watanabe-Kusunoki K, Nakazawa D, Yamamoto J, Matsuoka N, Kaneshima N, Nakagaki T, Yamamoto R, Maoka T, Iwasaki S, Tsuji T, Fukasawa Y, Nishimoto N, Nishio S, Atsumi T
  • Journal Title: Medicine (Baltimore) Volume: Apr2100(50) Issue: 4 Pages: 1135-1144
  • DOI: 10.1007/s40620-022-01279-z
  • Peer Reviewed
• [Journal Article] Clinical manifestations of focal segmental glomerulosclerosis in Japan from the Japan Renal Biopsy Registry: age stratification and comparison with minimal change disease (2021)
  • Author(s): Ozeki Takaya、Maruyama Shoichi、Imasawa Toshiyuki、Kawaguchi Takehiko、Kitamura Hiroshi、Kadomura Moritoshi、Katafuchi Ritsuko、Oka Kazumasa、Yokoyama Hitoshi、Sugiyama Hitoshi、Sato Hiroshi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 2602-2602
  • DOI: 10.1038/s41598-020-80931-9
  • Peer Reviewed / Open Access
• [Journal Article] Novel urinary glycan profiling by lectin array serves as the biomarkers for predicting renal prognosis in patients with IgA nephropathy (2021)
  • Author(s): Kawakita Chieko、Mise Koki、Onishi Yasuhiro、Sugiyama Hitoshi、Yoshida Michihiro、Yamada Masao、Wada Jun
  • Journal Title: Scientific Reports Volume: 11(1) Issue: 1 Pages: 3394-3394
  • DOI: 10.1038/s41598-020-77736-1
  • NAID: 120007144312
  • Peer Reviewed / Open Access
• [Journal Article] A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease (2021)
  • Author(s): Nakatsuka A, Yamaguchi S, Eguchi J, Kakuta S, Iwakura Y, Sugiyama H, Wada J.
  • Journal Title: Commun Biol . Volume: 4 Issue: 1 Pages: 373-373
  • DOI: 10.1038/s42003-021-01902-y
  • NAID: 120007004153
  • Peer Reviewed / Open Access
• [Journal Article] Nationwide Survey of Post-Transplant Glomerular Diseases, Based on the Japan Renal Biopsy Registry (J-RBR) (2021)
  • Author(s): Usui Joichi、Yamagata Kunihiro、Nagata Michio、Shimizu Akira、Takeda Asami、Sugiyama Hitoshi、Sato Hiroshi、Yokoyama Hitoshi
  • Journal Title: Annals of Transplantation Volume: 26
  • DOI: 10.12659/aot.931873
  • Peer Reviewed / Open Access
• [Journal Article] ABO Blood Incompatibility Positively Affects Early Graft Function: Single-Center Retrospective Cohort Study (2021)
  • Author(s): Watari Shogo、Araki Motoo、Wada Koichiro、Yoshinaga Kasumi、Maruyama Yuki、Mitsui Yosuke、Sadahira Takuya、Takeuchi Hidemi、Tanabe Katsuyuki、Kitagawa Masashi、Morinaga Hiroshi、Sugiyama Hitoshi、Wada Jun、Watanabe Masami、Watanabe Toyohiko、Nasu Yasutomo
  • Journal Title: Transplantation Proceedings Volume: 53 Issue: 5 Pages: 1494-1500
  • DOI: 10.1016/j.transproceed.2021.03.043
  • Peer Reviewed
• [Journal Article] Plasma Globotriaosylsphingosine and α-Galactosidase A Activity as a Combined Screening Biomarker for Fabry Disease in a Large Japanese Cohort (2021)
  • Author(s): Maruyama Hiroki、Taguchi Atsumi、Mikame Mariko、Izawa Atsushi、Morito Naoki、Izaki Kazufumi、Seto Toshiyuki、Onishi Akifumi、Sugiyama Hitoshi、Sakai Norio、Yamabe Kenji、Yokoyama Yukio、Yamashita Satoshi、Satoh Hiroshi、Toyoda Shigeru、Hosojima Michihiro、Ito Yumi、Tazawa Ryushi、Ishii Satoshi
  • Journal Title: Current Issues in Molecular Biology Volume: 43 Issue: 1 Pages: 389-404
  • DOI: 10.3390/cimb43010032
  • Peer Reviewed / Open Access
• [Journal Article] Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study (2021)
  • Author(s): Tsuchida-Nishiwaki Mariko、Uchida Haruhito A.、Takeuchi Hidemi、Nishiwaki Noriyuki、Maeshima Yohei、Saito Chie、Sugiyama Hitoshi、Wada Jun、Narita Ichiei、Watanabe Tsuyoshi、Matsuo Seiichi、Makino Hirofumi、Hishida Akira、Yamagata Kunihiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 14990-14990
  • DOI: 10.1038/s41598-021-94467-z
  • NAID: 120007139721
  • Peer Reviewed / Open Access
• [Journal Article] Presence of decoy cells for 6?months on urine cytology efficiently predicts BK virus nephropathy in renal transplant recipients (2021)
  • Author(s): Sekito Takanori、Araki Motoo、Yoshinaga Kasumi、Maruyama Yuki、Sadahira Takuya、Nishimura Shingo、Wada Koichiro、Watanabe Masami、Watanabe Toyohiko、Tanabe Katsuyuki、Takeuchi Hidemi、Morinaga Hiroshi、Kitagawa Masashi、Kitamura Shinji、Sugiyama Hitoshi、Wada Jun、Yanai Hiroyuki、Nasu Yasutomo
  • Journal Title: International Journal of Urology Volume: 28 Issue: 12 Pages: 1240-1246
  • DOI: 10.1111/iju.14679
  • Peer Reviewed
• [Journal Article] Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR) (2021)
  • Author(s): Urushihara M, Sato H, Shimizu A, Sugiyama H, Yokoyama H, Hataya H, Matsuoka K, Okamoto T, Ogino D, Miura K, Hamada R, Hibino S, Shima Y, Yamamura T, Kitamoto K, Ishihara M, Konomoto T, Hattori M; the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology.
  • Journal Title: Clin Exp Nephrol. Volume: 25 Issue: 9 Pages: 1018-1026
  • DOI: 10.1007/s10157-021-02077-w
  • Peer Reviewed / Open Access
• [Journal Article] Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms (2021)
  • Author(s): Watari Shogo、Araki Motoo、Matsumoto Jun、Yoshinaga Kasumi、Sekito Takanori、Maruyama Yuki、Mitsui Yosuke、Sadahira Takuya、Kubota Risa、Nishimura Shingo、Wada Koichiro、Kobayashi Yasuyuki、Takeuchi Hidemi、Tanabe Katsuyuki、Kitagawa Masashi、Morinaga Hiroshi、Sugiyama Hitoshi、et al.
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 40 Pages: 100407-100407
  • DOI: 10.1016/j.dmpk.2021.100407
  • NAID: 210000178936
  • Peer Reviewed
• [Journal Article] Focal segmental glomerulosclerosis histologic variants and renal outcomes based on nephrotic syndrome, immunosuppression and proteinuria remission (2021)
  • Author(s): Kawaguchi Takehiko、Imasawa Toshiyuki、Kadomura Moritoshi、Kitamura Hiroshi、Maruyama Shoichi、Ozeki Takaya、Katafuchi Ritsuko、Oka Kazumasa、Isaka Yoshitaka、Yokoyama Hitoshi、Sugiyama Hitoshi、Sato Hiroshi
  • Journal Title: Nephrology Dialysis Transplantation Volume: 9 Issue: 9 Pages: 267-267
  • DOI: 10.1093/ndt/gfab267
  • Peer Reviewed
• [Journal Article] Demographic, clinical characteristics and treatment outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulonephritis in Japan: A retrospective analysis of data from the Japan Renal Biopsy Registry (2021)
  • Author(s): Nakagawa Naoki、Mizuno Masashi、Kato Sawako、Maruyama Shoichi、Sato Hiroshi、Nakaya Izaya、Sugiyama Hitoshi、et al.
  • Journal Title: PLOS ONE Volume: 16 Issue: 9 Pages: e0257397-e0257397
  • DOI: 10.1371/journal.pone.0257397
  • Peer Reviewed / Open Access
• [Journal Article] Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real- world Clinical Practice: The Japan Chronic Kidney Disease Database. (2021)
  • Author(s): Nagasu H, Yano Y, Kanegae H, Heerspink HJL, Tamura K, et al.
  • Journal Title: Diabetes Care. Volume: 44 Issue: 11 Pages: 2542-2551
  • DOI: 10.2337/dc21-1081
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinicopathological discordance in biopsy-proven nephrosclerosis: a nationwide cross-sectional study of the Japan Renal Biopsy Registry (J-RBR) (2021)
  • Author(s): Sumida Keiichi、Takeda Asami、Furuichi Kengo、Uesugi Noriko、Ubara Yoshifumi、Sato Hiroshi、Sugiyama Hitoshi、Shimizu Akira、Yokoyama Hitoshi
  • Journal Title: Clinical and Experimental Nephrology Volume: 26 Issue: 4 Pages: 325-332
  • DOI: 10.1007/s10157-021-02161-1
  • Peer Reviewed
• [Journal Article] JCS 2017 Guideline on Management of Vasculitis Syndrome ― Digest Version ― (2020)
  • Author(s): Isobe, M. Amano, K. Arimura, Y. Ishizu, A. Ito, S. Kaname, S. Takahashi, K. Tanemoto, K. Hasegawa, H. Harigai, M. Fujimoto, S. Miyazaki, T. et.al.
  • Journal Title: Circulation Journal Volume: 84 Issue: 2 Pages: 299-359
  • DOI: 10.1253/circj.CJ-19-0773
  • NAID: 130007789906
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-01-24
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome. (2020)
  • Author(s): Ogawa-Akiyama A, Sugiyama H, Kitagawa M, Tanaka K, Kano Y, Mise K, Otaka N, Tanabe K, Morinaga H, Kinomura M, Uchida HA, Wada J.
  • Journal Title: PLoS One. Volume: 15(1) Issue: 1 Pages: 1-15
  • DOI: 10.1371/journal.pone.0228337
  • NAID: 120006862788
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• [Journal Article] Robotic Renal Autotransplantation: A Feasibility Study in a Porcine Model (2020)
  • Author(s): Kubota R, Araki M, Wada K, Kawamura K, Maruyama Y, Mitsui Y, Sadahira T, Ariyoshi Y, Iwata T, Nishimura S, Takamoto A, Sako T, Edamura K, Kobayashi Y, Kano Y, Kitagawa M, Tanabe K, Sugiyama H, Wada J, Watanabe M, Watanabe T, Nasu Y.
  • Journal Title: Acta Medica Okayama Volume: 74 Issue: 1 Pages: 53-58
  • DOI: 10.18926/AMO/57953
  • NAID: 120006795620
  • URL: https://ousar.lib.okayama-u.ac.jp/57953
  • Peer Reviewed / Open Access
• [Journal Article] Incidence of remission and relapse of proteinuria, end-stage kidney disease, mortality, and major outcomes in primary nephrotic syndrome: the Japan Nephrotic Syndrome Cohort Study (JNSCS) (2020)
  • Author(s): Yamamoto Ryohei、Imai Enyu、Maruyama Shoichi、Yokoyama Hitoshi、Sugiyama Hitoshi、et al.
  • Journal Title: Clinical and Experimental Nephrology Volume: 24 Issue: 6 Pages: 526-540
  • DOI: 10.1007/s10157-020-01864-1
  • Peer Reviewed / Open Access
• [Journal Article] J-CKD-DB: a nationwide multicentre electronic health record-based chronic kidney disease database in Japan (2020)
  • Author(s): Nakagawa Naoki、Sofue Tadashi、Kanda Eiichiro、Nagasu Hajime、Matsushita Kunihiro、Nangaku Masaomi、Maruyama Shoichi、Wada Takashi、Terada Yoshio、Yamagata Kunihiro、Narita Ichiei、Yanagita Motoko、Sugiyama Hitoshi、et al.
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 7351-7351
  • DOI: 10.1038/s41598-020-64123-z
  • NAID: 120006958093
  • Peer Reviewed / Open Access
• [Journal Article] A Nationwide Cross-Sectional Analysis of Thrombotic Microangiopathy in the Japan Renal Biopsy Registry (J-RBR) (2020)
  • Author(s): Katsuno T, Ito Y, Kagami S, Kitamura H, Maruyama S, Shimizu A, Sugiyama H, Sato H, Yokoyama H, Kashihara N
  • Journal Title: Clin Exp Nephrol Volume: - Issue: 9 Pages: 789-797
  • DOI: 10.1007/s10157-020-01896-7
  • Peer Reviewed / Open Access
• [Journal Article] Better remission rates in elderly Japanese patients with primary membranous nephropathy in nationwide real-world practice: The Japan Nephrotic Syndrome Cohort Study (JNSCS) (2020)
  • Author(s): Yokoyama Hitoshi、Yamamoto Ryohei、Imai Enyu、Maruyama Shoichi、Sugiyama Hitoshi、et al.
  • Journal Title: Clinical and Experimental Nephrology Volume: 24 Issue: 10 Pages: 893-909
  • DOI: 10.1007/s10157-020-01913-9
  • Peer Reviewed / Open Access
• [Journal Article] Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury (2020)
  • Author(s): Miyake Hiromasa、Tanabe Katsuyuki、Tanimura Satoshi、Nakashima Yuri、Morioka Tomoyo、Masuda Kana、Sugiyama Hitoshi、Sato Yasufumi、Wada Jun
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 12 Pages: 4545-4545
  • DOI: 10.3390/ijms21124545
  • NAID: 120006872424
  • Peer Reviewed / Open Access
• [Journal Article] Age-dependent survival in rapidly progressive glomerulonephritis: A nationwide questionnaire survey from children to the elderly (2020)
  • Author(s): Takahashi-Kobayashi Mayumi、Usui Joichi、Kaneko Shuzo、Sugiyama Hitoshi、Nitta Kosaku、Wada Takashi、Muso Eri、Arimura Yoshihiro、Makino Hirofumi、Matsuo Seiichi、Yamagata Kunihiro
  • Journal Title: PLOS ONE Volume: 15 Issue: 7 Pages: e0236017-e0236017
  • DOI: 10.1371/journal.pone.0236017
  • NAID: 120007161318
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of anemia in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB) (2020)
  • Author(s): Sofue Tadashi、Nakagawa Naoki、Kanda Eiichiro、Nagasu Hajime、Matsushita Kunihiro、Nangaku Masaomi、Maruyama Shoichi、Wada Takashi、Terada Yoshio、Yamagata Kunihiro、Narita Ichiei、Yanagita Motoko、Sugiyama Hitoshi、et al.
  • Journal Title: PLOS ONE Volume: 15 Issue: 7 Pages: e0236132-e0236132
  • DOI: 10.1371/journal.pone.0236132
  • NAID: 120006888500
  • Peer Reviewed / Open Access
• [Journal Article] The revised version 2018 of the nationwide web-based registry system for kidney diseases in Japan: Japan Renal Biopsy Registry and Japan Kidney Disease Registry (2020)
  • Author(s): Ozeki Takaya、the Committee for Renal Biopsy and Disease Registry of the Japanese Society of Nephrology、Maruyama Shoichi、Nagata Michio、Shimizu Akira、Sugiyama Hitoshi、Sato Hiroshi、Yokoyama Hitoshi
  • Journal Title: Clinical and Experimental Nephrology Volume: 24 Issue: 11 Pages: 1058-1068
  • DOI: 10.1007/s10157-020-01932-6
  • Peer Reviewed / Open Access
• [Journal Article] Prevalences of hyperuricemia and electrolyte abnormalities in patients with chronic kidney disease in Japan: A nationwide, cross-sectional cohort study using data from the Japan Chronic Kidney Disease Database (J-CKD-DB) (2020)
  • Author(s): Sofue Tadashi、Nakagawa Naoki、Kanda Eiichiro、Nagasu Hajime、Matsushita Kunihiro、Nangaku Masaomi、Maruyama Shoichi、Wada Takashi、Terada Yoshio、Yamagata Kunihiro、Narita Ichiei、Yanagita Motoko、Sugiyama Hitoshi、et al.
  • Journal Title: PLOS ONE Volume: 15 Issue: 10 Pages: e0240402-e0240402
  • DOI: 10.1371/journal.pone.0240402
  • Peer Reviewed / Open Access
• [Journal Article] Low‐dose rituximab induction therapy is effective in immunological high‐risk renal transplantation without increasing cytomegalovirus infection (2020)
  • Author(s): Yoshinaga Kasumi、Araki Motoo、Wada Koichiro、Maruyama Yuki、Mitsui Yosuke、Sadahira Takuya、Kubota Risa、Nishimura Shingo、Kobayashi Yasuyuki、Takeuchi Hidemi、Tanabe Katsuyuki、Kitagawa Masashi、Morinaga Hiroshi、Uchida Haruhito Adam、Kitamura Shinji、Sugiyama Hitoshi、Wada Jun、et al.
  • Journal Title: International Journal of Urology Volume: 27 Issue: 12 Pages: 1136-1142
  • DOI: 10.1111/iju.14382
  • Peer Reviewed / Open Access
• [Journal Article] Pembrolizumab-induced hypothyroidism caused reversible increased serum creatinine levels: a case report. (2020)
  • Author(s): Matsuoka Natsumi, Tsuji Kenji, Ichihara Eiki, Hara Takayuki, Fukushima Kazuhiko, Toma Kishio, Kitamura Shinji, Inagaki Kenichi, Sugiyama Hitoshi, Wada Jun
  • Journal Title: BMC nephrology Volume: 21 Issue: 1 Pages: 113-113
  • DOI: 10.1186/s12882-020-01775-z
  • NAID: 120006862785
  • Peer Reviewed / Open Access
• [Journal Article] Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer (2020)
  • Author(s): Tanabe Katsuyuki、Kanzaki Hiromitsu、Wada Takahira、Nakashima Yuri、Sugiyama Hitoshi、Okada Hiroyuki、Wada Jun
  • Journal Title: Medicine Volume: 99 Issue: 21 Pages: e20464-e20464
  • DOI: 10.1097/md.0000000000020464
  • Peer Reviewed / Open Access
• [Journal Article] Podocytopathy as ‘stand-alone’ involvement in systemic lupus erythematosus: a case report (2020)
  • Author(s): Tsuji Kenji、Takatsu Yoko、Katayama Yu、Fukushima Kazuhiko、Kitamura Shinji、Sugiyama Hitoshi、Wada Jun
  • Journal Title: Lupus Volume: 29 Issue: 9 Pages: 1148-1150
  • DOI: 10.1177/0961203320935988
  • Peer Reviewed / Open Access
• [Journal Article] Tubulointerstitial Nephritis Cases With IgM-Positive Plasma Cells (2020)
  • Author(s): Matsuoka-Uchiyama Natsumi、Tsuji Kenji、Fukushima Kazuhiko、Kitamura Shinji、Uchida Haruhito A.、Sugiyama Hitoshi、Takahashi Naoki、Iwano Masayuki、Wada Jun
  • Journal Title: Kidney International Reports Volume: 5 Issue: 9 Pages: 1576-1580
  • DOI: 10.1016/j.ekir.2020.06.010
  • NAID: 120006890014
  • Peer Reviewed / Open Access
• [Journal Article] HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy (2019)
  • Author(s): Kawakita Chieko、Kinomura Masaru、Otaka Nozomu、Kitagawa Masashi、Sugiyama Hitoshi、Kusano Nobuchika、Mizuno Masashi、Wada Jun
  • Journal Title: Internal Medicine Volume: 58 Issue: 20 Pages: 3001-3007
  • DOI: 10.2169/internalmedicine.2439-18
  • NAID: 130007728766
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-10-15
  • Peer Reviewed / Open Access
• [Journal Article] Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease (2019)
  • Author(s): Onishi Akifumi、Sugiyama Hitoshi、Kitagawa Masashi、Yamanari Toshio、Tanaka Keiko、Ogawa-Akiyama Ayu、Kano Yuzuki、Mise Koki、Tanabe Katsuyuki、Morinaga Hiroshi、Kinomura Masaru、Uchida Haruhito A.、Wada Jun
  • Journal Title: Disease Markers Volume: 2019 Pages: 1-10
  • DOI: 10.1155/2019/5432453
  • Peer Reviewed / Open Access
• [Journal Article] Chest High-Resolution CT Findings of Microscopic Polyangiitis: A Japanese First Nationwide Prospective Cohort Study (2019)
  • Author(s): Suzuki Aika、Sakamoto Susumu、Kurosaki Atsuko、Kurihara Yasuyuki、Satoh Keita、Usui Yusuke、Nanki Toshihiro、Arimura Yoshihiro、Makino Hirofumi、Okada Yasunori、Harigai Masayoshi、Yamagata Kunihiro、Sugiyama Hitoshi、et al.
  • Journal Title: American Journal of Roentgenology Volume: 213 Issue: 1 Pages: 104-114
  • DOI: 10.2214/ajr.18.20967
  • Peer Reviewed / Open Access
• [Journal Article] Report of health checkup system for chronic kidney disease in general population in Okayama city: effect of health guidance intervention on chronic kidney disease outcome (2019)
  • Author(s): Kakio Yuki、Uchida Haruhito、Takeuchi Hidemi、Okuyama Yuka、Umebayashi Ryoko、Watatani Hiroyuki、Maeshima Yohei、Sugiyama Hitoshi、Wada Jun
  • Journal Title: International Journal of Nephrology and Renovascular Disease Volume: Volume 12 Pages: 143-152
  • DOI: 10.2147/ijnrd.s198781
  • Peer Reviewed / Open Access
• [Journal Article] Renal tubular injury exacerbated by vasohibin-1 deficiency in a murine cisplatin-induced acute kidney injury model (2019)
  • Author(s): Tanimura Satoshi、Tanabe Katsuyuki、Miyake Hiromasa、Masuda Kana、Tsushida Keigo、Morioka Tomoyo、Sugiyama Hitoshi、Sato Yasufumi、Wada Jun
  • Journal Title: American Journal of Physiology-Renal Physiology Volume: 317 Issue: 2 Pages: F264-F274
  • DOI: 10.1152/ajprenal.00045.2019
  • Peer Reviewed / Open Access
• [Journal Article] Impaired mental health status in patients with chronic kidney disease is associated with estimated glomerular filtration rate decline (2019)
  • Author(s): Onishi Yasuhiro、Uchida Haruhito A、Takeuchi Hidemi、Kakio Yuki、Sugiyama Hitoshi、Wada Jun、Shimada Noriaki、Tokumasu Hironobu、Fukushima Masaki、Asano Kenichiro
  • Journal Title: Nephrology Volume: 24 Issue: 9 Pages: 926-932
  • DOI: 10.1111/nep.13515
  • Peer Reviewed
• [Journal Article] Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study (2019)
  • Author(s): Yamagata K, Usui J, Nagata M, Sugiyama H, et al.
  • Journal Title: Clinical and Experimental Nephrology Volume: 23 Issue: 3 Pages: 387-394
  • DOI: 10.1007/s10157-018-1656-1
  • Peer Reviewed
• [Journal Article] Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey (2019)
  • Author(s): Yamagata K, Usui J, Sugiyama H, Maruyama S, Narita I
  • Journal Title: Clinical and Experimental Nephrology Volume: 23 Issue: 4 Pages: 573-575
  • DOI: 10.1007/s10157-018-1663-2
  • Peer Reviewed
• [Journal Article] The relationship between repeated measurement of casual and 24-h urinary sodium-to-potassium ratio in patients with chronic kidney disease (2019)
  • Author(s): Okuyama Yuka、Uchida Haruhito A.、Iwahori Toshiyuki、Segawa Hiroyoshi、Kato Ayako、Takeuchi Hidemi、Kakio Yuki、Umebayashi Ryoko、Kitagawa Masashi、Sugiyama Hitoshi、Miura Katsuyuki、Ueshima Hirotsugu、Wada Jun
  • Journal Title: Journal of Human Hypertension Volume: 33 Issue: 4 Pages: 286-297
  • DOI: 10.1038/s41371-018-0127-1
  • Peer Reviewed
• [Journal Article] Clinical practice guideline for renal rehabilitation: systematic reviews and recommendations of exercise therapies in patients with kidney diseases (2019)
  • Author(s): Yamagata Kunihiro、Hoshino Junichi、Sugiyama Hitoshi、et al.
  • Journal Title: Renal Replacement Therapy Volume: 5 Issue: 1 Pages: 1-19
  • DOI: 10.1186/s41100-019-0209-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis (2019)
  • Author(s): Mifune-Morioka T, Uchida HA, Fukushima K, Watanabe M, Ouchi C, Mise K, Kawakita C, Kano Y, Onishi A, Toma K, Eguchi J, Wada N, Ikeda F, Sasaki E, Suganami Y, Kishida M, Sugiyama H, Okada H, Wada J
  • Journal Title: Acta Medica Okayama Volume: 73 Issue: 4 Pages: 367-372
  • DOI: 10.18926/AMO/56940
  • NAID: 120006713041
  • URL: https://ousar.lib.okayama-u.ac.jp/56940
  • Peer Reviewed / Open Access
• [Journal Article] Contrast-enhanced Computed Tomography-Guided Percutaneous Cryoablation of Renal Cell Carcinoma in a Renal Allograft: First Case in Asia (2019)
  • Author(s): I Tsuboi , M Araki, H Fujiwara, T Iguchi, T Hiraki, N Arichi, K Kawamura, Y Maruyama, Y Mitsui, T Sadahira, R Kubota, S Nishimura, T Sako, A Takamoto, K Wada, Y Kobayashi, T Watanabe, H Yanai, M Kitagawa, K Tanabe, H Sugiyama, J Wada, H Shiina, S Kanazawa, Y Nasu
  • Journal Title: Acta Medica Okayama Volume: 73 Issue: 3 Pages: 269-272
  • DOI: 10.18926/AMO/56871
  • NAID: 120006648007
  • URL: https://ousar.lib.okayama-u.ac.jp/56871
  • Peer Reviewed / Open Access
• [Presentation] Incidence of Glomerular Diseases During the Past Ten Years in Japan -The Japan Kidney Disease Registry/Japan Renal Biopsy Registry (J-KDR/J-RBR)- (2019)
  • Author(s): Shoichi Maruyama, Takaya Ozeki, Hitoshi Yokoyama, Hitoshi Sugiyama, Akira Shimizu, Ichiei Narita, Hiroshi Sato
  • Organizer: World Congress of Nephrology
  • Int'l Joint Research
• [Presentation] Peritoneal dialysis in patients with polycystic kidney disease is unlikely to be associated with technical failure (2019)
  • Author(s): Yasuhiro Onishi, Katsuyuki Tanabe, Nozomu Otaka, Masashi Kitagawa, Hiroshi Morinaga, Masaru Kinomura, Haruhito A Uchida, Hitoshi Sugiyama, Jun Wada
  • Organizer: The 9th Asia Pacific Chapter Meeting of the International Society for Peritoneal Dialysis (APCM-ISPD)
  • Int'l Joint Research
• [Presentation] A Consultation for Decision Making Related to Renal Replacement Therapy May Reduce a Risk for an Urgent Dialysis Initiation (2019)
  • Author(s): Yumiko Kasahara, Hiroshi Morinaga, Noriko Imoto, Mitsuko Yata, Katsuyuki Tanabe, Masaru Kinomura, Hitoshi Sugiyama and Jun Wada
  • Organizer: The 9th Asia Pacific Chapter Meeting of the International Society for Peritoneal Dialysis (APCM-ISPD)
  • Int'l Joint Research
• [Presentation] Vasohibin-1 is essential for the post-transcriptional modification of α-tubulin on microtubules in podocytes (2019)
  • Author(s): Tomoyo Morioka, Katsuyuki Tanabe, Satoshi Tanimura, Hitoshi Sugiyama, Yasufumi Sato, Jun Wada
  • Organizer: ASN Kidney Week
  • Int'l Joint Research
• [Presentation] Establishment of a Virtual Slide System Linking to the Japan Renal Biopsy Registry (2019)
  • Author(s): Ryohei Kaseda, Shoichi Maruyama, Hitoshi Sugiyama, Akira Shimizu, Hitoshi Yokoyama, Hiroshi Sato, Ichiei Narita
  • Organizer: ASN Kidney Week
  • Int'l Joint Research
• [Presentation] Risk Factors for Poor Long-Term Renal Outcome and Death in Lupus Nephritis: Analysis on a Nationwide Cohort Study in Japan (2019)
  • Author(s): Hidekazu Ikeuchi, Keiju Hiromura, Hitoshi Sugiyama, Hiroshi Sato, Hitoshi Yokoyama, Yoshihisa Nojima
  • Organizer: ASN Kidney Week
  • Int'l Joint Research
• [Presentation] The Level of Proteinuria After 6 and 12 Months of Treatment Predicts Long-Term Renal Outcomes in Lupus Nephritis: Data from a Nationwide Cohort Study in Japan (2019)
  • Author(s): Hidekazu Ikeuchi, Keiju Hiromura, Hitoshi Sugiyama, Hiroshi Sato, Hitoshi Yokoyama, Yoshihisa Nojima
  • Organizer: ASN Kidney Week
  • Int'l Joint Research
• [Presentation] Association between Histologic Variants of Focal Segmental Glomerulosclerosis and Outcomes: Results from Japan Renal Biopsy Registry (2019)
  • Author(s): Takehiko Kawaguchi, Toshiyuki Imasawa, Moritoshi Kadomura, Hiroshi Kitamura, Shoichi Maruyama, Takaya Ozeki, Ritsuko Katafuchi, Kazumasa Oka, Yoshitaka Isaka, Hitoshi Yokoyama, Hitoshi Sugiyama, Hiroshi Sato
  • Organizer: ASN Kidney Week
  • Int'l Joint Research
• [Book] エビデンスをいかに実臨床に活かすのか CKD・AKI診療 ガイドラインの内側と外側【電子版付】 (2020)
  • Author(s): 成田 一衛
  • Total Pages: 316
  • Publisher: 日本医事新報社
  • ISBN: 9784784957699
• [Book] 腎疾患・透析最新の治療2020-2022 (2020)
  • Author(s): 山縣 邦弘、南学 正臣
  • Total Pages: 384
  • Publisher: 南江堂
  • ISBN: 9784524249770
• [Book] プロフェッショナル腎臓病学 (2020)
  • Author(s): 南学 正臣
  • Total Pages: 619
  • Publisher: 中外医学社
  • ISBN: 9784498224629
• [Book] 腎代替療法選択ガイド2020 (2020)
  • Author(s): 日本腎臓学会、日本透析医学会、日本腹膜透析医学会、日本臨床腎移植学会、日本小児腎臓病学会
  • Total Pages: 124
  • Publisher: ライフサイエンス出版
  • ISBN: 9784897754123