Elucidation of underlying mechanism of the onset and renal deterioration of kidney disease contributed by lipid chaperones

• Project/Area Number: 19K08708
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Sapporo Medical University
• Principal Investigator: Marenao Tanaka 札幌医科大学, 医学部, 研究員 (60533362)
• Co-Investigator(Kenkyū-buntansha): 古橋 眞人 札幌医科大学, 医学部, 講師 (20563852)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: FABP4 / 慢性腎臓病 / 脂質代謝異常症 / 脂質シャペロン / 糸球体内皮細胞 / 糸球体上皮細胞 / 尿バイオマーカー / lipid nephrotoxicity / 脂肪酸結合タンパク4 / 糸球体障害 / 脂肪酸結合タンパク / 腎臓 / 脂質異常症

Outline of Research at the Start

本研究では脂肪酸結合タンパク4 (FABP4)と脂肪酸結合タンパク5 (FABP5)が寄与する脂質代謝と腎臓病の関連を明らかにし、その臨床的有用性を確立する。更にFABP4が糸球体係蹄内細胞増殖や糸球体上皮細胞の形態保持などに与える影響を分子生物学的メカニズムまで掘り下げて検討し、腎機能増悪や尿タンパク出現の機序の一端を解明していく。

Outline of Final Research Achievements

In a renal biopsy cohort, urinary FABP4 excretion was associated with renal function, urinary protein levels and deterioration of renal function after 1 year. In a general population cohort, a high LDL-cholesterol level was negatively associated with change in eGFR during 10-year follow-up period and was a risk factor for the development of CKD in males. In IgA nephropathy and gddY, a IgAN-prone mouse model, expression of FABP4 was ectopically induced by glomerular injury in cells of the glomerulus including glomerular endothelial cells and macrophages, and the extent of glomerular FABP4 expression was associated with proteinuria and renal dysfunction. Expression of ER stress markers were present on the cells in glomerulus in IgAN and in gddY. In human renal glomerular endothelial cells, FABP4 was induced by treatment with VEGF and was secreted from cells. Treatment of podocytes with FABP4 significantly increased gene expression of inflammatory cytokines and ER stress markers.

Academic Significance and Societal Importance of the Research Achievements

脂質代謝異常は腎障害の原因である。本研究では障害された糸球体に脂質シャペロンの一つであるFABP4の新規発現が誘導され、尿FABP4排泄量は糸球体FABP4発現量を反映することが、その分子生物学的メカニズムの一端を含め明らかになった。また尿FABP4排泄量は糸球体障害マーカーとして腎臓病早期発見のみならず、腎疾患症例の診断予測ならびに腎障害進行予測に有用である可能性が示され、今後の腎診療に対する役割が期待される。心血管疾患発症や新型コロナウイルス感染症重症化に関わる肥満などの代謝異常と腎臓病は現代人の重要な公衆衛生上の課題であり、FABP4が介在する代謝異常と腎障害の解明には社会的意義がある。

Research Products

• [Journal Article] Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication (2022)
  • Author(s): Furuhashi Masato、Kataoka Yu、Nishikawa Ryo、Koyama Masayuki、Sakai Akiko、Higashiura Yukimura、Tanaka Marenao、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 9 Pages: 1275-1284
  • DOI: 10.5551/jat.63159
  • NAID: 130008091658
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Prediction and validation of nonalcoholic fatty liver disease by fatty liver index in a Japanese population (2022)
  • Author(s): Takahashi Satoko、Tanaka Marenao、Higashiura Yukimura、Mori Kazuma、Hanawa Nagisa、Ohnishi Hirofumi、Furuhashi Masato
  • Journal Title: Endocrine Journal Volume: 69 Issue: 4 Pages: 463-471
  • DOI: 10.1507/endocrj.EJ21-0563
  • NAID: 130008118746
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Circulating level of fatty acid‐binding protein 4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals (2022)
  • Author(s): Tanaka Marenao、Takahashi Satoko、Higashiura Yukimura、Sakai Akiko、Koyama Masayuki、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi、Furuhashi Masato
  • Journal Title: Journal of Diabetes Investigation Volume: Dec 9 Issue: 5 Pages: 878-888
  • DOI: 10.1111/jdi.13735
  • Peer Reviewed / Open Access
• [Journal Article] A case of membranous nephropathy secondary to asymptomatic Graves' disease (2022)
  • Author(s): Moniwa N, Shioya Y, Gocho Y, Takahashi S, Tanaka M, Furuhashi M, Kuroda S, Hama T, Shima Y, Ogawa Y, Miura T.
  • Journal Title: CEN Case Rep. Volume: - Issue: 3 Pages: 309-313
  • DOI: 10.1007/s13730-021-00672-0
  • Peer Reviewed / Open Access
• [Journal Article] Diabetes modulation of the myocardial infarction-acute kidney injury axis (2022)
  • Author(s): Miura Tetsuji、Kuno Atsushi、Tanaka Marenao
  • Journal Title: American Journal of Physiology-Heart and Circulatory Physiology Volume: 322 Issue: 3 Pages: H394-H405
  • DOI: 10.1152/ajpheart.00639.2021
  • Peer Reviewed / Open Access
• [Journal Article] Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication (2022)
  • Author(s): Furuhashi Masato、Higashiura Yukimura、Sakai Akiko、Koyama Masayuki、Tanaka Marenao、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi
  • Journal Title: Metabolites Volume: 12 Issue: 3 Pages: 237-237
  • DOI: 10.3390/metabo12030237
  • Peer Reviewed / Open Access
• [Journal Article] High fibrosis-4 (FIB-4) index predicts new onset of ischemic heart disease during a 10-year period in a general population (2022)
  • Author(s): Higashiura Yukimura、Tanaka Marenao、Mori Kazuma、Mikami Takuma、Hosaka Itaru、Ohnishi Hirofumi、Hanawa Nagisa、Furuhashi Masato
  • Journal Title: European Heart Journal Open Volume: - Issue: 3
  • DOI: 10.1093/ehjopen/oeac030
  • Peer Reviewed / Open Access
• [Journal Article] Reply to the comments of Naharci on “Circulating level of fatty acid‐binding protein?4 is an independent predictor of metabolic dysfunction‐associated fatty liver disease in middle‐aged and elderly individuals” (2022)
  • Author(s): Tanaka Marenao、Furuhashi Masato
  • Journal Title: Journal of Diabetes Investigation Volume: 13 Issue: 5 Pages: 928-929
  • DOI: 10.1111/jdi.13808
  • Peer Reviewed / Open Access
• [Journal Article] Increased LDL cholesterol level is associated with deterioration of renal function in males (2022)
  • Author(s): Osanami Arata、Tanaka Marenao、Furuhashi Masato、Ohnishi Hirofumi、Hanawa Nagisa、Yamashita Tomohisa、Moniwa Norihito、Miura Tetsuji
  • Journal Title: Clinical Kidney Journal Volume: - Issue: 10 Pages: 1888-1895
  • DOI: 10.1093/ckj/sfac111
  • Peer Reviewed / Open Access
• [Journal Article] Elevated circulating FABP4 concentration predicts cardiovascular death in a general population: a 12-year prospective study (2021)
  • Author(s): Saito Norie、Furuhashi Masato、Koyama Masayuki、Higashiura Yukimura、Akasaka Hiroshi、Tanaka Marenao、Moniwa Norihito、Ohnishi Hirofumi、Saitoh Shigeyuki、Ura Nobuyuki、Shimamoto Kazuaki、Miura Tetsuji
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 4008-4008
  • DOI: 10.1038/s41598-021-83494-5
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of necroptosis in contrast-induced nephropathy in a rat CKD model (2021)
  • Author(s): Shibata Satoru、Moniwa Norihito、Kuno Atsushi、Kimura Ayumu、Ohwada Wataru、Sugawara Hirohito、Gocho Yufu、Tanaka Marenao、Yano Toshiyuki、Furuhashi Masato、Tanno Masaya、Miki Takayuki、Miura Tetsuji
  • Journal Title: Clinical and Experimental Nephrology Volume: Online ahead of print Issue: 7 Pages: 708-717
  • DOI: 10.1007/s10157-021-02048-1
  • Peer Reviewed / Open Access
• [Journal Article] Antiatherosclerotic Phenotype of Perivascular Adipose Tissue Surrounding the Saphenous Vein in Coronary Artery Bypass Grafting (2021)
  • Author(s): Mikami Takuma、Furuhashi Masato、Sakai Akiko、Numaguchi Ryosuke、Harada Ryo、Naraoka Syuichi、Kamada Takeshi、Higashiura Yukimura、Tanaka Marenao、Ohori Shunsuke、Sakurada Taku、Nakamura Masanori、Iba Yutaka、Fukada Joji、Miura Tetsuji、Kawaharada Nobuyoshi
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 7
  • DOI: 10.1161/jaha.120.018905
  • NAID: 40022652837
  • Peer Reviewed / Open Access
• [Journal Article] Fatty liver index is independently associated with deterioration of renal function during a 10-year period in healthy subjects (2021)
  • Author(s): Takahashi Satoko、Tanaka Marenao、Furuhashi Masato、Moniwa Norihito、Koyama Masayuki、Higashiura Yukimura、Osanami Arata、Gocho Yufu、Ohnishi Hirofumi、Numata Keita、Hisasue Takashi、Hanawa Nagisa、Miura Tetsuji
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 8606-8606
  • DOI: 10.1038/s41598-021-88025-w
  • Peer Reviewed / Open Access
• [Journal Article] Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication (2021)
  • Author(s): Furuhashi Masato、Higashiura Yukimura、Koyama Masayuki、Tanaka Marenao、Murase Takayo、Nakamura Takashi、Akari Seigo、Sakai Akiko、Mori Kazuma、Ohnishi Hirofumi、Saitoh Shigeyuki、Shimamoto Kazuaki、Miura Tetsuji
  • Journal Title: Hypertension Research Volume: 44 Issue: 9 Pages: 1213-1220
  • DOI: 10.1038/s41440-021-00679-1
  • Peer Reviewed
• [Journal Article] High level of fatty liver index predicts new onset of diabetes mellitus during a 10-year period in healthy subjects (2021)
  • Author(s): Higashiura Yukimura、Furuhashi Masato、Tanaka Marenao、Takahashi Satoko、Koyama Masayuki、Ohnishi Hirofumi、Numata Keita、Hisasue Takashi、Hanawa Nagisa、Moniwa Norihito、Tsuchihashi Kazufumi、Miura Tetsuji
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 12830-12830
  • DOI: 10.1038/s41598-021-92292-y
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of new onset of diabetes mellitus during a 10-year period by using a combination of levels of alanine aminotransferase and γ-glutamyl transferase (2021)
  • Author(s): Miyamori Daisuke、Tanaka Marenao、Furuhashi Masato、Ohnishi Hirofumi、Koyama Masayuki、Osanami Arata、Higashiura Yukimura、Numata Keita、Hisasue Takashi、Hanawa Nagisa、Moniwa Norihito、Miura Tetsuji
  • Journal Title: Endocrine Journal Volume: 68 Issue: 12 Pages: 1391-1402
  • DOI: 10.1507/endocrj.EJ20-0823
  • NAID: 130008136495
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Seasonal variation of serum 25-hydroxyvitamin D level in hemodialysis patients in the northernmost island of Japan (2021)
  • Author(s): Gocho Yufu、Tanaka Marenao、Sugawara Hirohito、Furuhashi Masato、Moniwa Norihito、Yamashita Tomohisa、Takizawa Hideki、Mukai Hiroya、Ohno Kouhei、Maeda Takuto、Osanami Arata、Ohnishi Hirofumi、Komatsu Hiroaki、Mori Kazuma、Miura Tetsuji
  • Journal Title: Clinical and Experimental Nephrology Volume: 25 Issue: 12 Pages: 1360-1366
  • DOI: 10.1007/s10157-021-02104-w
  • Peer Reviewed
• [Journal Article] Elevated Fatty Liver Index Is Independently Associated With New Onset of Hypertension During a 10‐Year Period in Both Male and Female Subjects (2021)
  • Author(s): Higashiura Yukimura、Furuhashi Masato、Tanaka Marenao、Takahashi Satoko、Mori Kazuma、Miyamori Daisuke、Koyama Masayuki、Ohnishi Hirofumi、Moniwa Norihito、Numata Keita、Hisasue Takashi、Hanawa Nagisa、Miura Tetsuji
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 14
  • DOI: 10.1161/jaha.121.021430
  • Peer Reviewed / Open Access
• [Journal Article] Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population (2021)
  • Author(s): Furuhashi Masato、Sakai Akiko、Tanaka Marenao、Higashiura Yukimura、Mori Kazuma、Koyama Masayuki、Ohnishi Hirofumi、Saitoh Shigeyuki、Shimamoto Kazuaki
  • Journal Title: Hypertension Volume: 78 Issue: 4 Pages: 1138-1149
  • DOI: 10.1161/hypertensionaha.121.17674
  • Peer Reviewed / Open Access
• [Journal Article] Independent Association of Fatty Liver Index With Left Ventricular Diastolic Dysfunction in Subjects Without Medication (2021)
  • Author(s): Furuhashi Masato、Muranaka Atsuko、Yuda Satoshi、Tanaka Marenao、Koyama Masayuki、Kawamukai-Nishida Mina、Takahashi Satoko、Higashiura Yukimura、Miyamori Daisuke、Nishikawa Ryo、Ohnishi Hirofumi、Saitoh Shigeyuki、Shimamoto Kazuaki、Miura Tetsuji
  • Journal Title: The American Journal of Cardiology Volume: 158 Pages: 139-146
  • DOI: 10.1016/j.amjcard.2021.07.047
  • Peer Reviewed
• [Journal Article] Serum uric acid level is associated with an increase in systolic blood pressure over time in female subjects: Linear mixed-effects model analyses (2021)
  • Author(s): Mori Kazuma、Furuhashi Masato、Tanaka Marenao、Higashiura Yukimura、Koyama Masayuki、Hanawa Nagisa、Ohnishi Hirofumi
  • Journal Title: Hypertension Research Volume: 45 Issue: 2 Pages: 344-353
  • DOI: 10.1038/s41440-021-00792-1
  • Peer Reviewed
• [Journal Article] Significance of urinary fatty acid-binding protein 4 level as a possible biomarker for the identification of minimal change disease in patents with nephrotic-range proteinuria (2020)
  • Author(s): Tanaka Marenao、Furuhashi Masato、Moniwa Norihito、Maeda Takuto、Takizawa Hideki、Matsumoto Megumi、Sakai Akiko、Higashiura Yukimura、Gocho Yufu、Koyama Masayuki、Ogawa Yayoi、Miura Tetsuji
  • Journal Title: BMC Nephrology Volume: 21 Issue: 1 Pages: 459-459
  • DOI: 10.1186/s12882-020-02122-y
  • Peer Reviewed / Open Access
• [Journal Article] Differential regulation of hypoxanthine and xanthine by obesity in a general population (2020)
  • Author(s): Furuhashi Masato、Koyama Masayuki、Higashiura Yukimura、Murase Takayo、Nakamura Takashi、Matsumoto Megumi、Sakai Akiko、Ohnishi Hirofumi、Tanaka Marenao、Saitoh Shigeyuki、Moniwa Norihito、Shimamoto Kazuaki、Miura Tetsuji
  • Journal Title: Journal of Diabetes Investigation Volume: - Issue: 4 Pages: 878-887
  • DOI: 10.1111/jdi.13207
  • Peer Reviewed / Open Access
• [Journal Article] Low urine pH predicts new onset of diabetes mellitus during a 10‐year period in men: BOREAS‐DM1 study (2020)
  • Author(s): Higashiura Yukimura、Tanaka Marenao、Furuhashi Masato、Koyama Masayuki、Ohnishi Hirofumi、Numata Keita、Hisasue Takashi、Hanawa Nagisa、Moniwa Norihito、Miura Tetsuji
  • Journal Title: Journal of Diabetes Investigation Volume: 11 Issue: 6 Pages: 1490-1497
  • DOI: 10.1111/jdi.13284
  • Peer Reviewed / Open Access
• [Journal Article] U-shaped relationship between serum uric acid level and decline in renal function during a 10-year period in female subjects: BOREAS-CKD2 (2020)
  • Author(s): Mori Kazuma、Furuhashi Masato、Tanaka Marenao、Numata Keita、Hisasue Takashi、Hanawa Nagisa、Koyama Masayuki、Osanami Arata、Higashiura Yukimura、Inyaku Masafumi、Matsumoto Megumi、Moniwa Norihito、Ohnishi Hirofumi、Miura Tetsuji
  • Journal Title: Hypertension Research Volume: 44 Issue: 1 Pages: 107-116
  • DOI: 10.1038/s41440-020-0532-z
  • Peer Reviewed
• [Journal Article] Empagliflozin attenuates acute kidney injury after myocardial infarction in diabetic rats (2020)
  • Author(s): Kuno A, Kimura Y, Mizuno M, Oshima H, Sato T, Moniwa N, Tanaka M, Yano T, Tanno M, Miki T, Miura T.
  • Journal Title: Sci Rep Volume: 29 Issue: 1 Pages: 7238-7238
  • DOI: 10.1038/s41598-020-64380-y
  • Peer Reviewed / Open Access
• [Journal Article] Impact of atrial fibrillation on the risk of ischemic stroke in patients on hemodialysis: BOREAS-HD3 Study (2020)
  • Author(s): Kimura Ayumu、Tanaka Marenao、Moniwa Norihito、Osanami Arata、Abe Koki、Miyamori Daisuke、Gocho Yufu、Shibata Satoru、Terasawa Makoto、Okazaki Yusuke、Yamashita Tomohisa、Koyama Masayuki、Furuhashi Masato、Ohnishi Hirofumi、Miura Tetsuji
  • Journal Title: Clinical and Experimental Nephrology Volume: 25 Issue: 3 Pages: 297-304
  • DOI: 10.1007/s10157-020-01991-9
  • Peer Reviewed
• [Journal Article] Cardiac Light Chain Deposition Disease Mimicking Immunoglobulin Light Chain Amyloidosis: Two Branches of the Same Tree (2020)
  • Author(s): Osanami A, Yano T, Takemura G, Ikeda H, Inyaku M, Toda Y, Kamiyama N, Sugawara H, Gocho Y, Fujito T, Nagano N, Takahashi S, Muranaka A, Tanaka M, Moniwa N, Murase K, Takada K, Kuroda H, Ogawa Y, Miura T
  • Journal Title: Circ Cardiovasc Imaging Volume: 13 Issue: 9
  • DOI: 10.1161/circimaging.120.010478
  • Peer Reviewed
• [Journal Article] Annual change in plasma xanthine oxidoreductase activity is associated with changes in liver enzymes and body weight (2019)
  • Author(s): Furuhashi Masato、Koyama Masayuki、Matsumoto Megumi、Murase Takayo、Nakamura Takashi、Higashiura Yukimura、Tanaka Marenao、Moniwa Norihito、Ohnishi Hirofumi、Saitoh Shigeyuki、Shimamoto Kazuaki、Miura Tetsuji
  • Journal Title: Endocrine Journal Volume: 66 Issue: 9 Pages: 777-786
  • DOI: 10.1507/endocrj.EJ19-0053
  • NAID: 130007719399
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Differential Phenotypes in Perivascular Adipose Tissue Surrounding the Internal Thoracic Artery and Diseased Coronary Artery. (2019)
  • Author(s): Numaguchi R, Furuhashi M, Matsumoto M, Sato H, Yanase Y, Kuroda Y, Harada R, Ito T, Higashiura Y, Koyama M, Tanaka M, Moniwa N, Nakamura M, Doi H, Miura T, Kawaharada N.
  • Journal Title: J Am Heart Assoc Volume: 8 Issue: 2 Pages: 216-232
  • DOI: 10.1161/jaha.118.011147
  • Peer Reviewed / Open Access
• [Journal Article] Independent links between plasma xanthine oxidoreductase activity and levels of adipokines. (2018)
  • Author(s): Furuhashi M, Matsumoto M, Murase T, Nakamura T, Higashiura Y, Koyama M, Tanaka M, Moniwa N, Ohnishi H, Saitoh S, Shimamoto K, Miura T.
  • Journal Title: J Diabetes Investig Volume: 印刷中 Issue: 4 Pages: 1059-1067
  • DOI: 10.1111/jdi.12982
  • Peer Reviewed / Open Access
• [Presentation] CKD発症予測におけるfatty liver indexの意義 (2021)
  • Author(s): 高橋聖子, 田中希尚, 古橋眞人, 長南新太, 宮森大輔, 後町 結, 塙 なぎさ, 茂庭仁人, 大西浩文,三浦哲嗣
  • Organizer: 第64回 日本腎臓学会 学術総会
• [Presentation] CKD モデルの造影剤腎症におけるネクロプトーシスの役割 (2021)
  • Author(s): 柴田 智, 茂庭仁人, 木村 歩, 後町 結, 田中希尚, 古橋眞人, 三浦哲嗣
  • Organizer: 第64回 日本腎臓学会 学術総会
• [Presentation] 血液透析患者におけるビタミンDの季節変動に関する検討 (2021)
  • Author(s): 田中希尚, 後町 結, 菅原浩仁, 茂庭仁人, 山下智久, 古橋眞人, 滝沢英毅, 向 博也, 大野紘平, 三浦哲嗣
  • Organizer: 第66回 日本透析医学会 学術集会
• [Presentation] Fatty Liver Index (FLI) は新規高血圧発症の独立した予測因子である (2021)
  • Author(s): 東浦幸村, 古橋眞人, 田中希尚, 高橋聖子, 山下智久, 小山雅之, 大西浩文, 斎藤重幸, 塙 なぎさ,三浦哲嗣
  • Organizer: 第43回 日本高血圧学会 学術集会
• [Presentation] 一般住民におけるFatty Liver Index (FLI)と高血圧発症との関連 (2021)
  • Author(s): 東浦幸村, 古橋眞人, 田中希尚,大西浩文,三浦哲嗣
  • Organizer: 第53回 日本動脈硬化学会 学術集会
• [Presentation] 抗リン脂質抗体症候群の腎機能障害への関与が示唆されたループス腎炎の１例 (2021)
  • Author(s): 赤澤史子, 田中希尚, 山下智久, 寺沢 誠, 長南新太, 高橋聖子, 小松弘明, 安部功記, 矢野俊之, 古橋眞人, 土橋和文, 小川弥生
  • Organizer: 第51回 日本腎臓学会 東部学術大会
• [Presentation] 腎機能の自然経過し得たproliferative glomerulonephritis with monoclonal IgG depositsの一例 (2021)
  • Author(s): 田中希尚, 山下智久, 松本倫明, 遠藤圭祐, 大野絋平, 伊藤孝仁, 堀田寛之, 加藤伸郎, 三木隆幸,大岩 均, 辻 隆裕
  • Organizer: 第51回 日本腎臓学会 東部学術大会
• [Presentation] 急性腎障害が合併したBeer potomaniaによる低Na血症に持続的血液透析を施行した一例 (2021)
  • Author(s): 長南新太, 片山和規, 赤澤史子, 安部功記, 高橋聖子, 森 和真, 田中希尚, 千原伸也, 巽 博臣, 山下智久
  • Organizer: 第51回 日本腎臓学会 東部学術大会
• [Presentation] 糸球体障害の診断及び腎予後推定における尿FABP4排泄量の有用性 (2020)
  • Author(s): 田中希尚,古橋眞人,茂庭仁人,後町結,前田卓人,滝沢英毅,三浦哲嗣
  • Organizer: 第63回 日本腎臓学会学術総会
• [Presentation] Fatty liver indexはCKD発症リスクと関連する (2020)
  • Author(s): 高橋聖子,田中希尚,古橋眞人,長南新太,小山雅之,後町結,塙なぎさ,茂庭仁人,大西浩文,三浦哲嗣
  • Organizer: 第63回 日本腎臓学会学術総会
• [Presentation] 微小変化型ネフローゼ症候群における糸球体MLKL活性化の検討 (2020)
  • Author(s): 安部功記,田中希尚,矢野俊之,茂庭仁人,後町結,岡崎雄介,滝沢英毅,三浦哲嗣
  • Organizer: 第63回 日本腎臓学会学術総会
• [Presentation] ALT,γGTPの組み合わせによる新規糖尿病発症の予測能に関する検討 (2020)
  • Author(s): 宮森大輔,田中希尚,古橋眞人,茂庭仁人,沼田啓太,久末章史,塙なぎさ,小山雅之,大西浩文,三浦哲嗣
  • Organizer: 第117回 日本内科学会総会
• [Presentation] 透析症例におけるカルニチン欠乏症の予測因子に関する検討 (2020)
  • Author(s): 宮森大輔,金子尚史,吉原真由美,田中希尚,後町結,茂庭仁人,三浦哲嗣
  • Organizer: 第64回 日本透析医学会学術集会・総会
• [Presentation] 一般住民においてピポキサンチンとキサンチン濃度は肥満によって異なった制御を受ける (2020)
  • Author(s): 古橋眞人,東浦幸村,小山雅之,村瀬貴代,中村敬志,酒井晶子,田中希尚,茂庭仁人,大西浩文,斎藤重幸,三浦哲嗣
  • Organizer: 第53回 日本痛風・尿酸核酸学会総会
• [Presentation] 腎組織および心筋に軽鎖沈着を認め腎不全と心不全を合併した多発性骨髄腫の一例 (2020)
  • Author(s): 長南新太,茂庭仁人,田中希尚,高橋聖子,後町結,矢野俊之,小川弥生,三浦哲嗣
  • Organizer: 第50回 日本腎臓学会東部学術大会
• [Presentation] 尿 PH 値と新規糖尿病発症の関連についての検討 (2020)
  • Author(s): 東浦幸村, 田中希尚, 古橋眞人, 茂庭仁人, 小山雅之, 沼田啓太, 久末章史, 塙なぎさ, 大西浩文, 三浦哲嗣
  • Organizer: 第 116 回 日本内科学会総会
• [Presentation] 血漿キサンチン酸化還元酵素(XOR)活性の経年的変化とその予測因子の検討 (2020)
  • Author(s): 古橋眞人, 松本めぐみ, 東浦幸村, 小山雅之, 田中希尚, 茂庭仁人, 村瀬貴代, 中村敬志, 大西浩文, 齋藤重幸, 三浦哲嗣
  • Organizer: 第 62 回 日本内分泌学会学術総会
• [Presentation] 血清尿酸レベル低値は女性の CKD 発症と関連する (2020)
  • Author(s): 森 和真, 古橋眞人, 田中希尚, 塙なぎさ, 東浦幸村, 後町結, 小山雅之, 茂庭仁人, 大西浩文, 三浦哲嗣
  • Organizer: 第 62 回 日本腎臓学会学術総会
• [Presentation] 健常男性において LDL コレステロール値と HDL コレステロール値は eGFR の経年変化に関連する (2020)
  • Author(s): 長南新太, 田中希尚, 古橋眞人, 茂庭仁人, 小山雅之, 沼田啓太, 久末章史, 塙なぎさ, 大西浩文, 三浦哲嗣
  • Organizer: 第 62 回 日本腎臓学会学術総会
• [Presentation] 健常人において LDL コレステロール値は CKD 新規発症に関連する (2020)
  • Author(s): 長南新太, 田中希尚, 古橋眞人, 茂庭仁人, 小山雅之, 沼田啓太, 久末章史, 塙なぎさ, 大西浩文, 三浦哲嗣
  • Organizer: 第 62 回 日本腎臓学会学術総会
• [Presentation] 血液透析患者における心房細動合併と新規脳梗塞発症の関連についての検討 (2020)
  • Author(s): 木村 歩, 田中希尚, 茂庭仁人, 後町結, 山下智久, 古橋眞人, 長南新太, 小山雅之, 大西浩文, 三浦哲嗣
  • Organizer: 第 64 回 日本透析医学会学術集会・総会
• [Presentation] 一般住民におけるキサンチン酸化還元酵素 (XOR) 活性と高血圧との関連 (2020)
  • Author(s): 東浦幸村, 古橋眞人, 小山雅之, 田中希尚, 茂庭仁人, 松本めぐみ, 酒井晶子, 村瀬貴代, 中村敬志, 大西浩文, 齋藤重幸, 島本和明, 三浦哲嗣
  • Organizer: 第 42 回 日本高血圧学会総会
• [Presentation] 一般住民において血漿ピポキサンチン濃度は肥満度および喫煙と関連する (2020)
  • Author(s): 東浦幸村, 古橋眞人, 松本めぐみ, 酒井晶子, 小山雅之, 村瀬貴代, 中村敬志, 田中希尚, 茂庭仁人, 大西浩文, 齋藤重幸, 三浦哲嗣
  • Organizer: 第 40 回 日本肥満学会
• [Remarks] 札幌医科大学 循環器・腎臓・代謝内分泌内科学講座
  • URL: https://web.sapmed.ac.jp/im2/
• [Remarks] 札幌医科大学 循環器・腎臓・代謝内分泌内科学講座
  • URL: https://web.saped.ac.jp/im2/topics/sehatb00000003p9.html
• [Patent(Industrial Property Rights)] 情報処理装置、推定方法、および、推定プログラム (U-pH) (2021)
  • Inventor(s): 古橋眞人, 田中希尚, 東浦幸村, 西崎慎一郎
  • Industrial Property Rights Holder: 古橋眞人, 田中希尚, 東浦幸村, 西崎慎一郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2021-080028
  • Filing Date: 2021