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Analysis of the pathogenesis of pruritic skin diseases and prurirus focusing on basophils

Research Project

Project/Area Number 19K08767
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YOKOEKI HIROO  東京医科歯科大学, 大学院医歯学総合研究科, 特任教授 (90210608)

Co-Investigator(Kenkyū-buntansha) 宇賀神 つかさ  東京医科歯科大学, 医学部附属病院, 講師 (40581327)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordscontact dermatitis / prurigo / Food allergy / basophil / atopic dermatitis / stat6 / Zn / food allergy / contact dermatitis, / anti-IgE antibody / 痒疹 / 食物アレルギー / アトピー性皮膚炎 / 好塩基球 / 亜鉛
Outline of Research at the Start

難治性皮膚疾患である慢性痒疹、アトピー性皮膚炎の痒疹結節部ならびに経皮感作食物依存性アナフィラキシーの発症機序の解析と新規治療法の開発する。好塩基球の活性化に亜鉛が関与しているかマウス、ヒト好塩基球を調整してFceRIを介した刺激を加え細胞内の亜鉛濃度を測定するとともに亜鉛トランスポーター、メタルチオネイン(MT)の発現を遺伝子、蛋白レベルで確認する。難治性皮膚疾患モデルマウスを用いて特に亜鉛トランスポーター欠損マウス、MT欠損マウス、好塩基球欠損マウスに難治性皮膚疾患のモデルマウスを誘導しワイルドタイプを比較検討して皮膚疾患誘導に重要な役割を果たすか検討するとともに新規治療法を開発する。

Outline of Final Research Achievements

Anaphylaxis due to transdermal sensitization of protein antigens, such as wheat-dependent exercise-induced anaphylaxis due to percutaneous sensitization of hydrolyzed wheat, has become a social problem. This year, we analyzed the mechanism of immunotherapy by oral inoculation of food anaphylactic.

Academic Significance and Societal Importance of the Research Achievements

新規治療法を開発し、抗IgE抗体を用いた臨床研究を痒疹、食物アレルギー患者に試みていく。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (12 results)

All 2021 2020 2019

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 2 results)

  • [Journal Article] Epicutaneously sensitized food-induced anaphylaxis is ameliorated with "oral tolerance" to antigen.2021

    • Author(s)
      Mori Y, Ugajin T, Okada K, Handa Y, Umemoto N, Iijima H, Igawa K, Yokozeki H.
    • Journal Title

      Exp Dermatol.

      Volume: 30(3) Issue: 3 Pages: 367-376

    • DOI

      10.1111/exd.14216

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of prurigo caused by hair dye containing p-phenylenediamine: histopathological findings.2021

    • Author(s)
      Ugajin T, Namiki T, Yokozeki H.
    • Journal Title

      Eur J Dermatol.

      Volume: 31(1) Issue: 1 Pages: 103-104

    • DOI

      10.1684/ejd.2020.3961

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A parvalbumin allergy case was successfully treated with oral immunotherapy using hypoallergenic fish2021

    • Author(s)
      Ugajin T, Kobayashi Y, Takayama K, Yokozeki H.
    • Journal Title

      Allergology International

      Volume: 70 Issue: 4 Pages: 509-511

    • DOI

      10.1016/j.alit.2021.03.003

    • NAID

      130008103684

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic prurigo: A retrospective study of 168 cases.2020

    • Author(s)
      Inui K, Ugajin T, Namiki T, Yokozeki H.
    • Journal Title

      J Dermatol.

      Volume: 47(3) Issue: 3 Pages: 283-289

    • DOI

      10.1111/1346-8138.15212

    • Related Report
      2020 Research-status Report
  • [Journal Article] In vitro basophil activation is reduced by short-term omalizumab treatment in hydrolyzed wheat protein allergy2020

    • Author(s)
      Chinuki Y, Yagami A, Adachi A, Matsunaga K, Ugajin T, Yokozeki H, Hayashi M, Katayama I, Kohno K, Shiwaku K, Morita E
    • Journal Title

      Allergology International

      Volume: 69 Issue: 2 Pages: 284-286

    • DOI

      10.1016/j.alit.2019.09.006

    • NAID

      130007832967

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of anti‐immunoglobulin E therapy in patients with prurigo: A pilot study.2019

    • Author(s)
      Ugajin T. Yokozeki H.
    • Journal Title

      J Cutan Immunol Allergy

      Volume: 2 Pages: 75-81

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bilirubin oxidation derived from oxidative stress is associated with disease severity of atopic dermatitis in adults.2019

    • Author(s)
      Shibama S, Ugajin T, Yamaguchi T, Yokozeki H.
    • Journal Title

      Clin Exp Dermatol.

      Volume: 44 Issue: 2 Pages: 153-160

    • DOI

      10.1111/ced.13674

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] 痒疹のメカニズムに基づいたピンポイントな治療法の開発.2019

    • Author(s)
      宇賀神 つかさ, 横関 博雄
    • Organizer
      第118回日本皮膚科学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 慢性痒疹における好塩基球の役割について最新の知見.2019

    • Author(s)
      宇賀神 つかさ
    • Organizer
      第118回日本皮膚科学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 痒疹型アトピー性皮膚炎に対するDupilumabの有効性についての検討.2019

    • Author(s)
      野老 翔雲, 宇賀神 つかさ, 並木 剛, 横関 博雄
    • Organizer
      第49回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 動物モデル3: その他のアレルギー疾患 経皮感作型食物アレルギーマウスモデルにおける経口免疫寛容誘導の検討.2019

    • Author(s)
      森 有加利, 岡田 康平, 宇賀神 つかさ, 横関 博雄
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ウマアレルギーと多種の食物アレルギーを併発した1例.2019

    • Author(s)
      飯田 忠恒, 吉岡 勇輔, 内田 千恵, 宇賀神 つかさ, 横関 博雄
    • Organizer
      第884回日本皮膚科学会東京地方会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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