• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of the pathophysiologic role of inflammatory monocytes in systemic lupus erythematosus

Research Project

Project/Area Number 19K08797
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionNara Medical University

Principal Investigator

Miyagawa Fumi  奈良県立医科大学, 医学部, 講師 (00346024)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords全身性エリテマトーデス / インターフェロン制御因子 / 炎症性単球 / I型Iインターフェロン経路 / NF-kB経路 / 炎症性樹状細胞 / I型インターフェロン / NF-kB / 自己抗体 / 臓器障害 / SLE / I型IFN
Outline of Research at the Start

我々はプリスタン誘発性SLEモデルマウスを作成することで、IRF7欠損マウスでは抗核抗体の産生はみられないが、糸球体腎炎は野生型マウスと同程度に誘発されること、IRF8欠損マウスでは抗核抗体の産生、糸球体腎炎がともにみられないことを明らかにした。また野生型マウスとIRF7欠損マウスでは、プリスタン投与により腹腔内に炎症性単球の浸潤がみられるが、IRF8欠損マウスではみられないことも明らかにした。本研究では、炎症性単球が炎症性サイトカインを産生することで組織障害に関与していること、炎症性単球が組織に浸潤した後樹状細胞に変化し、自己抗原(二本鎖DNA)を認識することを明らかにする。

Outline of Final Research Achievements

Using a mouse model of SLE, we recently demonstrated that type I IFN pathway leads to autoantibody production whereas NF-κB activation is sufficient for the development of glomerulonephritis. Here we studied the role of IRF8 and saw that IRF8-deficient mice failed to develop either glomerulonephritis or autoantibody production. Inflammatory monocytes migrate to the peritoneal cavity in WT and IRF7-deficient mice but not in IRF8-deficient mice, and there they produce both type I IFN and proinflammatory cytokines in WT mice, while in IRF7-deficient mice they only produce proinflammatory cytokines. Furthermore, inflammatory monocytes differentiate into dendritic cells which are capable of producing proinflammatory cytokines in response to dsDNA. Collectively, type I IFN produced from inflammatory monocytes/monocyte-derived dendritic cells might be essential for autoantibody production whereas proinflammatory cytokines produced from them might mediate tissue damages in this model.

Academic Significance and Societal Importance of the Research Achievements

本研究では、炎症性単球および、炎症性単球が変化した樹状細胞がSLEの病態形成に関与していることを初めて明らかにした。また自己抗体の産生はI型IFN経路、臓器障害はNF-kB経路という異なるシグナル経路で制御されている可能性を示した。SLEは増悪と寛解を繰り返す自己免疫疾患で、慢性に経過し標的臓器は多岐にわたる。現在SLEに対する治療は、副作用の強いステロイド内服や免疫抑制剤が主体であり、さらなる治療法の進歩が望まれている。本研究の成果により、炎症性単球やNF-kB経路を標的にした新規治療法を確立できる可能性がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (49 results)

All 2022 2021 2020 2019 2018

All Journal Article (33 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 33 results,  Open Access: 11 results) Presentation (16 results) (of which Int'l Joint Research: 14 results,  Invited: 1 results)

  • [Journal Article] Psoriatic Skin Lesions after Apalutamide Treatment2022

    • Author(s)
      Miyagawa F, Akioka N, Yoshida N, Ogawa K, Asada H
    • Journal Title

      Acta Derm Venereol

      Volume: 102 Pages: adv00659-adv00659

    • DOI

      10.2340/actadv.v102.858

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Purpura as an indicator of severity in drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: evidence from a 49-case series2022

    • Author(s)
      Takei S, Hama N, Mizukawa Y, Takahashi H, Miyagawa F, Asada H, Abe R
    • Journal Title

      J Eur Acad Dermatol Venereol

      Volume: 36 Issue: 4

    • DOI

      10.1111/jdv.17838

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recurrence of impetigo herpetiformis carrying compound heterozygous mutations in IL36RN after remission with secukinumab2022

    • Author(s)
      Kanatani Y, Shinkuma S, Matsumoto Y, Mitsui Y, Shobatake C, Ogawa K, Miyagawa F, Sugiura K, Asada H
    • Journal Title

      J Dermatol

      Volume: 49 Issue: 3

    • DOI

      10.1111/1346-8138.16247

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Soluble OX40 as a Diagnostic and Prognostic Biomarker for Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms2022

    • Author(s)
      Mitsui Y, Shinkuma S, Nakamura-Nishimura Y, Ommori R, Ogawa K, Miyagawa F, Mori Y, Tohyama M, Asada H
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 10 Issue: 2 Pages: 585-565

    • DOI

      10.1016/j.jaip.2021.10.042

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple digital ulcers on the hands and feet in anti-PL-12 antibody-positive anti-synthetase syndrome without Raynaud's phenomenon2022

    • Author(s)
      Hattori S, Miyagawa F, Mitsui Y, Nakashima R, Sasai T, Mimori T, Asada H
    • Journal Title

      J Dermatol

      Volume: 49 Issue: 1

    • DOI

      10.1111/1346-8138.16198

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythema Multiforme Major in Angioimmunoblastic T-cell Lymphoma2021

    • Author(s)
      Hattori S, Miyagawa F, Fukuda K, Ogawa K, Asada H
    • Journal Title

      Acta Derm Venereol

      Volume: 101 Issue: 12 Pages: adv00616-adv00616

    • DOI

      10.2340/actadv.v101.165

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Case of Systemic Lupus Erythematosus with Cutaneous Leukocytoclastic Vasculitis Mimicking Bullous SLE2021

    • Author(s)
      Miyagawa F, Ogawa K, Hashimoto T, Asada H
    • Journal Title

      Case Rep Dermatol

      Volume: 13 Issue: 3 Pages: 464-469

    • DOI

      10.1159/000519022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrence of secukinumab-induced eczematous eruptions after guselkumab treatment for pustular psoriasis2021

    • Author(s)
      Miyagawa F, Fukuda K, Mori A, Ogawa K, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 10

    • DOI

      10.1111/1346-8138.16047

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemokines in Severe Cutaneous Adverse Reactions (SCARs)2021

    • Author(s)
      Miyagawa F, Asada H
    • Journal Title

      Biomolecules

      Volume: 11 Issue: 6 Pages: 847-847

    • DOI

      10.3390/biom11060847

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acral persistent papular mucinosis: A case report and summary of 24 Japanese cases2021

    • Author(s)
      Mori A, Shinkuma S, Mitsui Y, Ogawa K, Miyagawa F, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 10 Pages: 1574-1578

    • DOI

      10.1111/1346-8138.16043

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS).2021

    • Author(s)
      Miyagawa F, Asada H
    • Journal Title

      Int J Mol Sci.

      Volume: 22 Issue: 4 Pages: 2147-2147

    • DOI

      10.3390/ijms22042147

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rare combination of holocrine poroma with follicular germinative differentiation.2021

    • Author(s)
      Ogawa K, Mitsui Y, Fukumoto T, Miyagawa F, Shinkuma S, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 4

    • DOI

      10.1111/1346-8138.15791

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of systemic sarcoidosis involving skin lesions that exhibited histological evidence of interstitial granulomatous dermatitis accompanied by widespread thrombophlebitis.2021

    • Author(s)
      Miyagawa F, Yamaoka K, Miyamoto S, Ogawa K, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 4

    • DOI

      10.1111/1346-8138.15768

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anaplastic lymphoma kinase-negative systemic anaplastic large cell lymphoma with secondary involvement of the breast.2021

    • Author(s)
      Miyagawa F, Ogawa K, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 2

    • DOI

      10.1111/1346-8138.15678

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of anti-laminin γ1 pemphigoid associated with ulcerative colitis and acquired perforating dermatosis.2021

    • Author(s)
      Kakehi Y, Miyagawa F, Ogawa K, Hashimoto T, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 1

    • DOI

      10.1111/1346-8138.15624

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Generalized morphea with extensive telangiectasia on the palms.2020

    • Author(s)
      Miyagawa F, Ogawa K, Asada H
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 1

    • DOI

      10.1111/1346-8138.15609

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognosis of patients with adult T-cell leukemia/lymphoma in Japan: A nationwide hospital-based study.2020

    • Author(s)
      Imaizumi Y, Iwanaga M, Nosaka K, Ishitsuka K, Ishizawa K, Ito S, Amano M, Ishida T, Uike N, Utsunomiya A, Ohshima K, Tanaka J, Tokura Y, Tobinai K, Watanabe T, Uchimaru K, Tsukasaki K; for collaborative Investigators.
    • Journal Title

      Cancer Sci

      Volume: 111 Issue: 12 Pages: 4567-4580

    • DOI

      10.1111/cas.14658

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parallel changes in serum thymus and activation-regulated chemokine levels in response to flare-ups in drug-induced hypersensitivity syndrome.2020

    • Author(s)
      Kanatani Y, Miyagawa F, Ogawa K, Arima A, Asada H
    • Journal Title

      J Dermatol

      Volume: 47 Issue: 11

    • DOI

      10.1111/1346-8138.15548

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Apocrine mixed tumor of the skin with panfollicular differentiation: A rare case report with immunohistochemical evaluation.2020

    • Author(s)
      Kurimoto T, Ogawa K, Koga K, Ishida E, Mitsui Y, Nomi K, Miyagawa F, Shinkuma S, Asada H
    • Journal Title

      J Dermatol

      Volume: 47 Issue: 11

    • DOI

      10.1111/1346-8138.15539

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine model of systemic lupus erythematosus.2020

    • Author(s)
      Miyagawa F, Tagaya Y, Ozato K, Horie K, Asada H
    • Journal Title

      J Transl Autoimmun

      Volume: 15 Pages: 100060-100060

    • DOI

      10.1016/j.jtauto.2020.100060

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Composite EBV-negative marginal zone lymphoma and angioimmunoblastic T-cell lymphoma presenting as multiple subcutaneous nodules.2020

    • Author(s)
      Miyagawa F, Nakajima A, Ogawa K, Takeda M, Nakamine H, Amano I, Asada H
    • Journal Title

      Eur J Dermatol

      Volume: 30 Issue: 4 Pages: 427-429

    • DOI

      10.1684/ejd.2020.3810

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced induction of human β-defensins is involved in the pathological mechanism of cutaneous adverse effects caused by epidermal growth factor receptor monoclonal antibodies.2020

    • Author(s)
      Ommori R, Nakamura Y, Miyagawa F, Shobatake C, Ogawa K, Koyama F, Sho M, Ota I, Kitahara T, Hontsu S, Muro S, Asada H
    • Journal Title

      Clin Exp Dermatol

      Volume: 45 Issue: 8 Pages: 1055-1058

    • DOI

      10.1111/ced.14311

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acquired agminated melanocytic nevus in the acral area is a potential mimicker of acral lentiginous melanoma: A three-case series report and published work review.2020

    • Author(s)
      Ogawa K, Fujimoto M, Takai T, Mitsui Y, Iwasa K, Ohsita A, Komori S, Asai J, Azukizawa H, Miyagawa F, Yurugi S, Kuwahara M, Sasaki C, Ando J, Asada H
    • Journal Title

      J Dermatol

      Volume: 47 Issue: 7 Pages: 770-773

    • DOI

      10.1111/1346-8138.15353

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Primary cutaneous follicle center lymphomas with high Ki-67 indices arising on the arm and leg.2020

    • Author(s)
      Miyagawa F, Ogawa K, Kurimoto T, Nakajima A, Himuro Y, Asada H
    • Journal Title

      J Dermatol

      Volume: 47 Issue: 7

    • DOI

      10.1111/1346-8138.15359

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of nodal nevus with melanocytic cell aggregates in the lymphatic hilum: A potential diagnostic pitfall that requires differentiation from metastatic melanoma of the lymph node.2020

    • Author(s)
      Ogawa K, Kobayashi N, Miyagawa F, Nakai T, Fukumoto T, Mitsui Y, Arai E, Asada H
    • Journal Title

      J Dermatol

      Volume: 47 Issue: 6

    • DOI

      10.1111/1346-8138.15325

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation Between Expression of CD134, a Human Herpesvirus 6 Cellular Receptor, on CD4+ T cells and Th2-type Immune Responses in Drug-induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms2020

    • Author(s)
      Miyagawa F、Nakamura-Nishimura Y、Kanatani Y、Asada H
    • Journal Title

      Acta Dermato Venereologica

      Volume: - Issue: 6 Pages: adv00102-2

    • DOI

      10.2340/00015555-3465

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adult-onset Asymmetrical Lipomatosis.2020

    • Author(s)
      Aoki Y, Miyagawa F, Ogawa K, Yurugi S, Kuwahara M, Asada H
    • Journal Title

      Acta Derm Venereol

      Volume: 100 Issue: 6 Pages: adv00080-2

    • DOI

      10.2340/00015555-3439

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] First case report of the coexistence of hydrophilic polymer embolism and cholesterol crystal embolism associated with an endovascular procedure.2020

    • Author(s)
      Mashiba K, Mitsui Y, Ogawa K, Miyagawa F, Miyata R, Kuwahara M, Asada H
    • Journal Title

      J Dermatol

      Volume: 47 Issue: 3

    • DOI

      10.1111/1346-8138.15223

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postpartum pruritic urticarial papules and plaques of pregnancy with blister formation resembling herpes gestationis2019

    • Author(s)
      Miyagawa Fumi、Arima Ai、Iwasa Kentaro、Ishii Norito、Hashimoto Takashi、Asada Hideo
    • Journal Title

      European Journal of Dermatology

      Volume: 29 Issue: 6 Pages: 669-671

    • DOI

      10.1684/ejd.2019.3669

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nivolumab-associated bullous pemphigoid reactions involving multiple epitopes2019

    • Author(s)
      Aoki Yuki、Miyagawa Fumi、Miyashita Kazuya、Nishimura Yuki、Hashimoto Takashi、Asada Hideo
    • Journal Title

      European Journal of Dermatology

      Volume: 29 Issue: 5 Pages: 552-554

    • DOI

      10.1684/ejd.2019.3619

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Iatrogenic immunodeficiency-associated lymphoproliferative disorder resembling B-cell pseudo-lymphoma on the lip and conjunctivae.2019

    • Author(s)
      Miyagawa F, Aoki Y, Hayashino A, Sotozono C, Asada H
    • Journal Title

      Acta Derm Venereol

      Volume: 99 Issue: 7 Pages: 683-684

    • DOI

      10.2340/00015555-3172

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-PL-12 antibody-positive antisynthetase syndrome with recurrent digital ulcers.2019

    • Author(s)
      Miyagawa F, Azukizawa H, Mimori T, Asada H
    • Journal Title

      J Dermatol

      Volume: 46 Issue: 4

    • DOI

      10.1111/1346-8138.14661

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mucosal lichen planus mimicking mucosal lesions in Stevens-Johnson syndrome after nivolumab therapy.2018

    • Author(s)
      5.Miyagawa F, Nakajima A, Ohyama S, Aoki Y, Nishikawa M, Nishimura Y, Hashimoto T, Asada H
    • Journal Title

      Acta Derm Venerol

      Volume: 印刷中 Issue: 7 Pages: 687-688

    • DOI

      10.2340/00015555-3185

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 全身性エリテマトーデス2021

    • Author(s)
      宮川 史
    • Organizer
      第72回日本皮膚科学会中部支部学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 薬剤性過敏症症候群における合併症、続発症を規定する因子の解明2021

    • Author(s)
      宮川 史、御守里絵、浅田秀夫
    • Organizer
      第51回日本免疫皮膚アレルギー学会総会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Type I IFN derived from inflammatory monocytes controls type 2 inflammation by suppressing basophil proliferation in atopic dermatitis2021

    • Author(s)
      Miyagawa F, Asada H
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Persistent HHV-6 infection has an increased risk of autoimmune disorders in patients with DIHS2021

    • Author(s)
      Nishimura Y, Shobatake C, Miyagawa F, Shinkuma S, Watanabe H, Kira M, Nakajima S, Higashi Y, Asada H
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cutaneous adverse events caused by EGFR inhibitors may result from reduced expression of human beta-defensins induced by staphylococci2021

    • Author(s)
      Ommori R, Nishimura Y, Miyagawa F, Shobatake C, Ogawa K, Shinkuma S, Asada H
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine lupus.2020

    • Author(s)
      Fumi Miyagawa, Hideo Asada
    • Organizer
      The 45th annual meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Persistent HHV-6 infection has an increased risk of more severe complications in patients with DIHS2020

    • Author(s)
      Yuki Nishimura, Fumi Miyagawa, Hideaki Watanabe, Masahiro Kira, Saeko Nakajima, Yuko Higashi, Hideo Asada
    • Organizer
      The 45th annual meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduced induction of human b-defensins is involved in the pathological mechanism of cutaneous adverse effects caused by EGFR inhibitors2020

    • Author(s)
      Rie Ommori, Yuki Nakamura, Fumi Miyagawa, Chinatsu Shobatake, Kohei Ogawa, Fumikazu Koyama, Masayuki Sho, Ichiro Ota, Tadashi Kitahara, Shigeto Hontsu, Sigeo Muro, Hideo Asada
    • Organizer
      The 45th annual meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine model of systemic lupus erythematosus.2020

    • Author(s)
      Fumi Miyagawa, Hideo Asada
    • Organizer
      The 78th annual meeting of Society for Investigative Dermatology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Monocyte-derived dendritic cells mediate autoimmunity in murine model of systemic lupus erythematosus.2019

    • Author(s)
      Miyagawa F, Asada H
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] The characteristics of patients with persistent HHV-6 infection after DIHS/DRESS.2019

    • Author(s)
      Nakamura Y, Miyagawa F, Miyashita K, Ommori R, Shobatake C, Azukizawa H, Asada H
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Human b-defensins are involved with pathological mechanism of cutaneous adverse effects caused by EGFR inhibitors.2019

    • Author(s)
      Ommori R, Miyagawa F, Azukizawa H, Asada H
    • Organizer
      The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Monocyte-derived dendritic cells mediate autoimmunity in murine model of systemic lupus erythematosus.2019

    • Author(s)
      Miyagawa F, Asada H
    • Organizer
      The 49th Annual European Society for Dermatological Research Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Human b-defensins are involved with pathological mechanism of cutaneous adverse effects caused by EGFR inhibitors.2019

    • Author(s)
      Ommori R, Miyagawa F, Azukizawa H, Asada H
    • Organizer
      The 49th Annual European Society for Dermatological Research Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunological and clinical features of patients with persistent human herpesvirus 6 infection after drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms.2019

    • Author(s)
      Asada H, Nakamura-Nishimura Y, Miyagawa F, Miyashita K, Shobatake C, Ommori R, Azukizawa H
    • Organizer
      The 49th Annual European Society for Dermatological Research Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] The characteristics of patients with persistent HHV-6 infection after drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS).2019

    • Author(s)
      Asada H, Nakamura-Nishimura Y, Miyagawa F, Miyashita K, Ommori R, Azukizawa H
    • Organizer
      The 77th Annual Meeting of the Society for Investigative Dermatology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi