Optimizing immunomodulation of hematopoietic stem cell transplantation focusing on allelic polymorphisms of KIRs

• Project/Area Number: 19K08812
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kyoto University
• Principal Investigator: Shindo Takero 京都大学, 医学研究科, 助教 (10646706)
• Co-Investigator(Kenkyū-buntansha): 高折 晃史 京都大学, 医学研究科, 教授 (20324626) ; 伊村 明浩 京都大学, 医学研究科, 特定病院助教 (60362513)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 同種造血幹細胞移植 / NK細胞受容体 / KIR / GVHD / 抗腫瘍免疫 / KIRアレル / 全ゲノムシークエンシング / NK細胞活性 / 成人T細胞白血病 / 慢性骨髄性白血病 / 次世代シークエンサー / KIRシグナル / 免疫チェックポイント阻害剤 / 移植片対宿主病 / 移植片対腫瘍効果 / NK細胞多型

Outline of Research at the Start

今回、日本赤十字社に保管された本邦全土の非血縁者間骨髄移植のドナーDNAを用いてKIRのアレルタイピングを行う。同多型とレシピエントHLAの組み合わせと移植成績の相関性を解析し、予後因子を抽出する。またKIRアレルのより簡便な診断法の開発を行う。さらにin vitro/in vivoでKIRアレルの機能解析を行い、NK細胞免疫と強く相関するKIRアレルを決定する。以上の臨床・非臨床研究により、KIRアレル多型という新しい視点で最適な移植ドナー選定アルゴリズムを提示し、KIRシグナルを標的とした新規免疫チェックポイント療法の可能性を検討する。

Outline of Final Research Achievements

Killer cell immunoglobulin-like receptors (KIRs) belong to NK cell receptors and modulate NK cell immunity through binding histocompatibility leukocyte antigens (HLAs). Although the combinations of donor KIRs and recipient HLAs are assumed to be associated with the prognosis of allogeneic hematopoietic stem cell transplantation, clinical significance of KIRs is unclear due to their abundant and undetermined polymorphisms.
We established a novel method to determine alleles, copy numbers and haplotypes of 17 KIRs. We then investigated associations between KIR alleles and the prognosis in allogeneic hematopoietic stem cell transplantation. Finally, we confirmed that targeting specific KIR alleles enhances anti-tumor immunity against hematologic malignancies.
Based on these results, we aim to propose a novel algorithm to select the best donors to suppress severe GVHD and relapsing malignancies following allogeneic hematopoietic stem cell transplantation.

Academic Significance and Societal Importance of the Research Achievements

KIR多型は同種造血幹細胞移植の予後と相関すると考えられるが、その複雑さゆえ正確なタイピング手法は未確立で、臨床的意義も不明であった。今回KIRアレルの自動化タイピング法を新規に開発し、移植症例でその臨床的意義を検証した。さらにKIR3DL1アレルの機能阻害でNK細胞免疫を賦活できることを見出し、KIR多型に基づく免疫療法という概念を確立した。
現在移植ドナー選定はHLAにのみ基づいて行われるが、それでは限界があり、重度のGVHDや生着不全、免疫再構築の遅延による感染症死を抑制しきれない。本研究でこれら合併症が克服され予後の改善を見込め、移植合併症による社会資源使用の軽減が期待される。

Research Products

• [Journal Article] Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis (2022)
  • Author(s): Muranushi Hiroyuki、Shindo Takero、Chen-Yoshikawa Toyofumi F、Yoshizawa Akihiko、Ngo Huong Thi、Gochi Fumiaki、Date Hiroshi、Takaori-Kondo Akifumi
  • Journal Title: Blood Advances Volume: - Issue: 1 Pages: 106-121
  • DOI: 10.1182/bloodadvances.2021006678
  • Peer Reviewed / Open Access
• [Journal Article] Favorable HLA Polymorphisms are Associated with Lower Molecular Relapse after Tyrosine Kinase Discontinuation in Patients with Chronic Myeloid Leukemia (2022)
  • Author(s): Ureshino Hiroshi、Kamachi Kazuharu、Shindo Takero、Kimura Shinya
  • Journal Title: Indian Journal of Hematology and Blood Transfusion Volume: - Issue: 4 Pages: 760-761
  • DOI: 10.1007/s12288-022-01538-w
  • Peer Reviewed
• [Journal Article] Impact of HLA Epitope Matching on Outcomes After Unrelated Bone Marrow Transplantation (2022)
  • Author(s): Iwasaki Makoto、Kanda Junya、Tanaka Hidenori、Shindo Takero、Sato Takahiko、Doki Noriko、Fukuda Takahiro、Ozawa Yukiyasu、Eto Tetsuya、Uchida Naoyuki、Katayama Yuta、Kataoka Keisuke、Ara Takahide、Ota Shuichi、Onizuka Makoto、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Morishima Satoko
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 811733-811733
  • DOI: 10.3389/fimmu.2022.811733
  • Peer Reviewed / Open Access
• [Journal Article] Development of a novel Indium-111 radiolabeled mogamulizumab targeting CCR4 for imaging adult T-cell leukemia/lymphoma in vivo (2022)
  • Author(s): Shimizu Yoichi、Koyasu Sho、Suzukida Mari、Izumi Kiyotaka、Kidera Eitaro、Shindo Takero、Saga Tsuneo、Ono Masahiro、Takaori-Kondo Akifumi、Nakamoto Yuji
  • Journal Title: Annals of Nuclear Medicine Volume: 36 Issue: 3 Pages: 319-326
  • DOI: 10.1007/s12149-021-01706-4
  • Peer Reviewed
• [Journal Article] KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia (2021)
  • Author(s): Izumi Kiyotaka、Shindo Takero、Ngo Huong Thi、Nakayama-Hosoya Kaori、Akahane Koshi、Tamai Minori、Nguyen Thao T. T.、Kawana-Tachikawa Ai、Inukai Takeshi、Takaori-Kondo Akifumi
  • Journal Title: ImmunoHorizons Volume: 5 Issue: 8 Pages: 687-702
  • DOI: 10.4049/immunohorizons.2100054
  • Peer Reviewed / Open Access
• [Journal Article] Small B-cell neoplasm responding to ibrutinib after 17 years of cold agglutinin disease symptom (2021)
  • Author(s): 森本 俊、山下 浩平、羽賀 博典、髙折 晃史、進藤 岳郎、伊賀 雄平、森田 真梨、万木 紀美子、増田 健太、堀 利行、菱澤 方勝、近藤 忠一
  • Journal Title: Rinsho Ketsueki Volume: 62 Issue: 12 Pages: 1678-1683
  • DOI: 10.11406/rinketsu.62.1678
  • NAID: 130008141274
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Pharmacological MEK inhibition promotes polyclonal T-cell reconstitution and suppresses xenogeneic GVHD (2021)
  • Author(s): Itamura Hidekazu、Shindo Takero、Muranushi Hiroyuki、Kitaura Kazutaka、Okada Seiji、Shin-I Tadasu、Suzuki Ryuji、Takaori-Kondo Akifumi、Kimura Shinya
  • Journal Title: Cellular Immunology Volume: 367 Pages: 104410-104410
  • DOI: 10.1016/j.cellimm.2021.104410
  • Peer Reviewed
• [Journal Article] Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy (2021)
  • Author(s): Okamura Hiroshi、Nakamae Hirohisa、Shindo Takero、Ohtani Katsuki、Hidaka Yoshihiko、Ohtsuka Yasufumi、Makuuchi Yosuke、Kuno Masatomo、Takakuwa Teruhito、Harada Naonori、Nishimoto Mitsutaka、Nakashima Yasuhiro、Koh Hideo、Hirose Asao、Nakamae Mika、Wakamiya Nobutaka、Hino Masayuki、Inoue Norimitsu
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 695037-695037
  • DOI: 10.3389/fimmu.2021.695037
  • NAID: 120007124372
  • Peer Reviewed / Open Access
• [Journal Article] Next‐generation sequencing in two cases of de novo acute basophilic leukaemia (2021)
  • Author(s): Shimizu Takuya、Kondo Tadakazu、Nannya Yasuhito、Watanabe Mizuki、Kitawaki Toshio、Shindo Takero、Hishizawa Masakatsu、Yamashita Kouhei、Ogawa Seishi、Takaori‐Kondo Akifumi
  • Journal Title: Journal of Cellular and Molecular Medicine Volume: 25 Issue: 14 Pages: 7095-7099
  • DOI: 10.1111/jcmm.16591
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] T-cell chimerism prior to graft-versus-host disease (2021)
  • Author(s): Noguchi Misa、Shindo Takero、Yamada Yosuke、Date Hiroshi
  • Journal Title: European Journal of Cardio-Thoracic Surgery Volume: - Issue: 1 Pages: 194-196
  • DOI: 10.1093/ejcts/ezaa484
  • Peer Reviewed
• [Journal Article] HLA Polymorphisms Are Associated with Treatment-Free Remission Following Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia (2021)
  • Author(s): Ureshino H, Shindo T, Tanaka H, Saji H, Kimura S
  • Journal Title: Molecular Cancer Therapeutics Volume: 20 Issue: 1 Pages: 142-149
  • DOI: 10.1158/1535-7163.mct-20-0336
  • Peer Reviewed / Open Access
• [Journal Article] Hepatitis-associated Aplastic Anemia with Rapid Progression of Liver Fibrosis Due to Repeated Hepatitis (2020)
  • Author(s): Sawada K, Takai A, Yamada T, Araki O, Yamauchi Y, Eso Y, Takahashi K, Shindo T, Sakurai T, Ueda Y, Seno H
  • Journal Title: Internal Medicine Volume: 59 Issue: 8 Pages: 1035-1040
  • DOI: 10.2169/internalmedicine.4072-19
  • NAID: 130007831808
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-04-15
  • Peer Reviewed
• [Journal Article] Donor‐dominant one‐way matching of human leukocyte antigen‐A/B/DR alleles predicts graft‐versus‐host disease following living donor liver transplantation (2020)
  • Author(s): Hirata Masaaki、Yagi Shintaro、Shindo Takero、Yoshizawa Atsushi、Kiguchi Gozo、Kaneshiro Masakatsu、Yurugi Kimiko、Miyachi Yosuke、Iwamura Sena、Yao Siyuan、Uemoto Shinji
  • Journal Title: Hepatology Research Volume: 51 Issue: 1 Pages: 135-148
  • DOI: 10.1111/hepr.13579
  • Peer Reviewed
• [Journal Article] Correction: GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma (2020)
  • Author(s): Muranushi Hiroyuki、Shindo Takero、Hishizawa Masakatsu、Tokunaga Masahito、Wake Atsushi、Nakano Nobuaki、Eto Tetsuya、Hidaka Michihiro、Choi Ilseung、Miyamoto Toshihiro、Uchida Naoyuki、Moriuchi Yukiyoshi、Miyazaki Yasuhiko、Fukuda Takahiro、Ichinohe Tatsuo、Atsuta Yoshiko、Kato Koji
  • Journal Title: Bone Marrow Transplantation Volume: 56 Issue: 1 Pages: 298-298
  • DOI: 10.1038/s41409-020-01037-4
  • Peer Reviewed
• [Journal Article] Primary hepatic lymphoma as other iatrogenic immunodeficiency-related lymphoproliferative disorders: a case report and review of the literature (2020)
  • Author(s): Tsuji Hideaki、Yoshifuji Hajime、Shindo Takero、Hishizawa Masakatsu、Ishida Ayami、Fujimoto Masakazu、Kitagori Koji、Akizuki Shuji、Murakami Kosaku、Nakashima Ran、Hashimoto Motomu、Tanaka Masao、Ohmura Koichiro
  • Journal Title: Modern Rheumatology Case Reports Volume: 5 Issue: 1 Pages: 172-177
  • DOI: 10.1080/24725625.2020.1826627
  • Peer Reviewed
• [Journal Article] Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation (2020)
  • Author(s): Wada Fumiya、Nishikori Momoko、Hishizawa Masakatsu、Watanabe Mitsumasa、Aiba Akiko、Kitano Toshiyuki、Shimazu Yayoi、Shindo Takero、Kondo Tadakazu、Takaori-Kondo Akifumi
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 5 Pages: 609-613
  • DOI: 10.1007/s12185-020-03007-4
  • Peer Reviewed / Open Access
• [Journal Article] Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review (2020)
  • Author(s): Matsuoka Yui、Iemura Yoshiki、Fujimoto Masakazu、Shibuya Shinsuke、Yamada Atsushi、Fujii Shigehiko、Kusaka Toshihiro、Shindo Takero、Minamiguchi Sachiko、Haga Hironori
  • Journal Title: International Journal of Surgical Pathology Volume: - Issue: 5 Pages: 550-556
  • DOI: 10.1177/1066896920964566
  • Peer Reviewed
• [Journal Article] Allelic polymorphisms of KIRs and antitumor immunity against chronic myeloid leukemia (2020)
  • Author(s): Shindo Takero、Ureshino Hiroshi、Kojima Hiroto、Tanaka Hidenori、Kimura Shinya
  • Journal Title: Immunological Medicine Volume: in press Issue: 2 Pages: 1-8
  • DOI: 10.1080/25785826.2020.1796062
  • Peer Reviewed / Open Access
• [Journal Article] Drug monitoring for mycophenolic acid in graft‐ vs ‐host disease prophylaxis in cord blood transplantation (2020)
  • Author(s): Muranushi Hiroyuki、Kanda Junya、Arai Yasuyuki、Shindo Takero、Hishizawa Masakatsu、Yamamoto Takashi、Kondo Tadakazu、Yamashita Kohei、Matsubara Kazuo、Takaori‐Kondo Akifumi
  • Journal Title: British Journal of Clinical Pharmacology Volume: 86 Issue: 12 Pages: 2464-2472
  • DOI: 10.1111/bcp.14354
  • NAID: 120006938957
  • Peer Reviewed
• [Journal Article] The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation (2020)
  • Author(s): Seiichiro Tada, Takayuki Anazawa et al.
  • Journal Title: Transplantation Direct Volume: 6 Issue: 9 Pages: e591-e591
  • DOI: 10.1097/txd.0000000000001045
  • Peer Reviewed / Open Access
• [Journal Article] The prognostic impact of FLT3-ITD, NPM1 and CEBPa in cytogenetically intermediate-risk AML after first relapse (2020)
  • Author(s): Kurosawa Saiko、Yamaguchi Hiroki、Yamaguchi Takuhiro、Fukunaga Keiko、Yui Shunsuke、Kanamori Heiwa、Usuki Kensuke、Uoshima Nobuhiko、Yanada Masamitsu、Takeuchi Jin、Mizuno Ishikazu、Kanda Junya、Okamura Hiroshi、Yano Shingo、Tashiro Haruko、Shindo Takero、Chiba Shigeru、Tomiyama Junji、Inokuchi Koiti、Fukuda Takahiro
  • Journal Title: International Journal of Hematology Volume: 112 Issue: 2 Pages: 200-209
  • DOI: 10.1007/s12185-020-02894-x
  • Peer Reviewed
• [Journal Article] Reconstitution of NK Cells Expressing KIR3DL1 Is Associated With Reduced NK Cell Activity and Relapse of CML After Allogeneic Hematopoietic Stem Cell Transplantation (2020)
  • Author(s): Ureshino H, Shindo T, Sano H, Kubota Y, Ando T, Kidoguchi K, Kusaba K, Itamura H, Kojima H, Kusunoki Y, Miyazaki Y, Kojima K, Tanaka H, Saji H, Oshima K, Kimura S
  • Journal Title: International Journal of Hematology Volume: 111 Issue: 5 Pages: 733-738
  • DOI: 10.1007/s12185-019-02809-5
  • Peer Reviewed
• [Journal Article] Phosphorylated ERK1/2 in CD4 T cells is associated with acute GVHD in allogeneic hematopoietic stem cell transplantation (2020)
  • Author(s): Itamura H, Shindo T, Yoshida S, Ishikawa T, Kimura S
  • Journal Title: Blood Avvances Volume: 4 Issue: 4 Pages: 667-671
  • DOI: 10.1182/bloodadvances.2019000343
  • NAID: 120006878504
  • Peer Reviewed / Open Access
• [Journal Article] Drug monitoring for mycophenolic acid in graft-versus-host disease prophylaxis in cord blood transplantation. (2020)
  • Author(s): Muranushi H, Kanda J, Arai Y, Shindo T, Hishizawa M, Yamamoto T, Kondo T, Yamashita K, Matsubara K, Takaori-Kondo A
  • Journal Title: Br J Clin Pharmacol Volume: -
  • Peer Reviewed
• [Journal Article] Clinical impact of the CONUT score in patients with multiple myeloma (2020)
  • Author(s): Okamoto S, Ureshino H*, Kidoguchi K, Kusaba K, Kizuka-Sano H, Sano H, Nishioka A, Yamaguchi K, Kamachi K, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Kawaguchi A, Sueoka E, Kimura S.
  • Journal Title: Ann Hematol Volume: 99 Issue: 1 Pages: 113-119
  • DOI: 10.1007/s00277-019-03844-2
  • Peer Reviewed
• [Journal Article] Role of cancer immunology in chronic myelogenous leukemia. (2020)
  • Author(s): Ureshino H, Shindo T, Kimura S
  • Journal Title: Leuk Res Volume: 88 Pages: 196273-196273
  • DOI: 10.1016/j.leukres.2019.106273
  • Peer Reviewed
• [Journal Article] Trametinib attenuates delayed rejection and preserves thymic function following rat lung transplantation (2019)
  • Author(s): 150.Takahagi A, Shindo T, Chen-Yoshikawa TF, Yoshizawa A, Gochi F, Miyamoto E, Saito M, Tanaka S, MotoyamaH, Date H
  • Journal Title: Am J Respir Cell Mol Biol. Volume: 印刷中 Issue: 3 Pages: 3550366-3550366
  • DOI: 10.1165/rcmb.2018-0188oc
  • Peer Reviewed / Open Access
• [Journal Article] Epstein-Barr virus-related diffuse large B cell lymphoma in mogamulizumab-treated adult T cell leukemia with incomplete T cell reconstitution. (2019)
  • Author(s): Kamachi K, Shindo T*, Miyahara M, Kitaura K, Akashi M, Shin-I T, Suzuki R, Ohshima K, Kimura S
  • Journal Title: Int J Hematol Volume: 109 Issue: 2 Pages: 221-227
  • DOI: 10.1007/s12185-018-2552-x
  • Peer Reviewed
• [Journal Article] Clinical impact of the CONUT score and mogamulizumab in adult T cell leukemia/lymphoma. (2019)
  • Author(s): Ureshino H, Kusaba K, Kidoguchi K, Sano H, Nishioka A, Itamura H, Yoshimura M, Yokoo M, Shindo T, Kubota Y, Ando T, Kojima K, Sueoka E, Kimura S.
  • Journal Title: Annals of Hematology Volume: 98 Issue: 2 Pages: 465-471
  • DOI: 10.1007/s00277-018-3502-7
  • Peer Reviewed / Open Access
• [Presentation] HLAエピトープ多型からみる移植免疫 (2022)
  • Author(s): 進藤岳郎、平田真章
  • Organizer: 第70回日本輸血・細胞治療学会総会
  • Invited
• [Presentation] チロシンキナーゼ阻害剤はCD155-DNAM1シグナルの増強によりCMLに対するNK細胞免疫を賦活する (2022)
  • Author(s): 加藤安梨沙、Huong Thi Ngo、進藤岳郎、蒲池和晴、Nguyen Thi Thu Thao、犬飼岳史、木村晋也、髙折晃史
  • Organizer: 第26回がん免疫学会総会
• [Presentation] MEK阻害薬コビメチニブは単球およびB細胞の抑制を介して肺GVHDを抑制する (2021)
  • Author(s): 村主啓行、進藤岳郎、Ngo HT、合地史明、吉澤明彦、芳川豊史、髙折晃史
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] KIR3DL1 allotype-dependent modulation of NK cell immunity against chronic myeloid leukemia. (2021)
  • Author(s): Izumi K, Shindo T, Ngo HT, Nakayama-Hosoya K, Akahane K, Tamai M, Nguyen TT, Kawana-Tachikawa A, Inukai T, Takaori-Kondo A.
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] The MEK inhibitor cobimetinib suppresses lung GVHD through inhibition of B cells and monocytes. (2021)
  • Author(s): Muranushi H, Shindo T, Ngo HT, Gochi F, Yoshizawa A, Yoshikawa T, Takaori-Kondo A.
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] Genetic manipulation resulting in decreased donor chondroitin sulfate mitigates GVHD in mice. (2021)
  • Author(s): Tamura S, Ushiki T, Suwabe T, Katagiri T, Ishiguro H, Fuse K, Shibasaki Y, Shindo T, Igarashi M, Sone H, Masuko M.
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] Dual Inhibition of the MEK/ERK and PI3K/AKT Pathways Prevents Pulmonary Graft-Versus-Host Disease through Suppression of Arteriovenous Inflammation and Bronchiolitis (2021)
  • Author(s): Hiroyuki Muranushi, Takero Shindo, Huong Thi Ngo, Fumiaki Gochi, Akihiko Yoshizawa, Toyofumi Fengshi Chen-Yoshikawa, and Akifumi Takaori-Kondo.
  • Organizer: The 63rd Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Impact of Human Leukocyte Antigen Epitope Matching on Outcomes after Unrelated Bone Marrow Transplantation (2021)
  • Author(s): Makoto Iwasaki, Junya Kanda, Hidenori Tanaka, Takero Shindo, Noriko Doki, Takahiro Fukuda, Yukiyasu Ozawa, Tetsuya Eto, Naoyuki Uchida, Yuta Katayama, Keisuke Kataoka, Makoto Onizuka, Yoshinobu Kanda, Tatsuo Ichinohe, Yoshiko Atsuta, and Satoko Morishima
  • Organizer: The 63rd Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] 肝移植後の抗体関連拒絶の新たな予防戦略：HLAエピトープ適合度によるde novo DSA発生予測 (2021)
  • Author(s): 平田真章、八木真太郎、進藤岳郎、伊藤孝司、川口淳、羽賀博典、波多野悦郎
  • Organizer: 第57回日本移植学会総会
  • Invited
• [Presentation] 血液悪性腫瘍に対する臍帯血移植におけるHLAエピトープミスマッチの意義 (2021)
  • Author(s): 森田真梨、進藤岳郎、家村知樹、新井康之、諌田淳也、近藤忠一、上田恭典、石川隆之、安齋尚之、米澤昭仁、今田和典、北野俊行、伊藤満、池田宇次、渡邊光正、髙折晃史
  • Organizer: 第29回日本組織適合性学会大会
• [Presentation] HLA class Iエピトープは非血縁者間骨髄移植後における重症急性GVHD発症の増加と関連する (2021)
  • Author(s): 岩﨑惇、諫田淳也、田中秀則、進藤岳郎、土岐典子、福田隆浩、小澤幸泰、衛藤徹也、内田直之、片山雄太、片岡圭亮、鬼塚真仁、神田善伸、一戸辰夫、熱田由子、森島聡子
  • Organizer: 第29回日本組織適合性学会大会
• [Presentation] High-dose thiotepa and busulfan with ASCT in CNS lymphoma -DSP1958 Expanded Access Program #3/4. (2020)
  • Author(s): Wada F, Nishikori M, Hishizawa M, Watanabe M, Aiba A, Kitano T, Shimazu Y, Shindo T, Kondo T, Takaori-Kondo A.
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] HLA polymorphisms is associated with treatment-free remission following TKI discontinuation. (2020)
  • Author(s): Ureshino H, Shindo T, Kimura S.
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] The impact of individual HLAs on survival after allo-HSCT from HLA-matched donors for ATL patients. (2020)
  • Author(s): Morishima S, Shindo T, Utsunomiya A, Ishida T, Fukuda T, Nakano N, Kawakita T, Eto T, Suehiro Y, Sawayama Y, Miyamoto T, Ichinohe T, Atsuta Y, Yoshimitsu M, Kato K.
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] The MEK inhibitor cobimetinib ameliorates bronchiolitis obliterans after hematopoietic stem cell transplantation. (2020)
  • Author(s): Muranushi H, Shindo T, Huong Ngo Thi, Gochi F, Yoshizawa A, Toyofumi Chen-Yoshikawa, Akifumi Takaori-Kondo.
  • Organizer: 第12回日本血液疾患免疫療法学会学術集会
• [Presentation] 生体肝移植後GVHDにおけるDonor dominant one-way HLA matchingの意義：京都大学における1,759例の後方視的解析から (2020)
  • Author(s): 平田真章、八木真太郎、進藤岳郎、万木紀美子、菱田理恵、海道利実、上本伸二
  • Organizer: 第38回肝移植学会学術集会
• [Presentation] The MEK Inhibitor Trametinib Enhances Diverse T Cell Reconstitution with Suppressing Xenogeneic Graft-Versus-Host-Disease (2019)
  • Author(s): Hidekazu Itamura, Hiroyuki Muranushi, Takero Shindo, Kazutaka Kitaura, Seiji Okada, Tadasu Shin-I, Ryuji Suzuki, Akifumi Takaori-Kondo, Shinya Kimura
  • Organizer: The 62nd Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Graft-Versus-Host Disease-Free, Relapse-Free Survival in Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia/Lymphoma Provides a Novel Donor Selection Paradigm (2019)
  • Author(s): Hiroyuki Muranushi, Takero Shindo, Masakatsu Hishizawa, Masahito Tokunaga, Atsushi Wake, Nobuaki Nakano, Tetsuya Eto, Michihiro Hidaka, Ilseung Choi, Toshihiro Miyamoto, Naoyuki Uchida, Yukiyoshi Moriuchi, Yasuhiko Miyazaki, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Koji Kato
  • Organizer: The 62nd Annual Meeting of the American Society of Hematology
  • Int'l Joint Research
• [Presentation] Allelic polymorphisms of KIRs and HLAs predict favorable responses to tyrosine kinase inhibitors in CML (2019)
  • Author(s): Takero Shindo, Hiroshi Ureshino, Shinya Kimura
  • Organizer: The 78th Annual Meeting of the Japanese Cancer Association
  • Invited
• [Presentation] MEK inhibitor trametinib enhances diverse T cell reconstitution with suppressing xenogeneic GVHD (2019)
  • Author(s): Hiroyuki Muranushi, Hidekazu Itamura, Takero Shindo, Kazutaka Kitaura, Seiji Okada, Tadasu Shin-I, Ryuji Suzuki, Akifumi Takaori-Kondo, Shinya Kimura
  • Organizer: The 81st Annual Meeting of the Japanese Society of Hematology
• [Presentation] Mogamulizumb投与後にもT細胞再構築が得られずEBV関連中枢神経原発B細胞リンパ腫を発症したATL (2019)
  • Author(s): 蒲池和晴、進藤岳郎、宮原正晴、北浦一孝、明石道昭、新井理、鈴木隆二、大島孝一、木村晋也
  • Organizer: 第6回日本HTLV-1学会
• [Book] EBM血液疾患の治療2021-2022 (2020)
  • Author(s): 金倉譲 監修、木崎昌弘 編集、鈴木律朗 編集、神田善伸 編集、大森司 編集、山崎宏人 編集
  • Total Pages: 660
  • Publisher: 中外医学社
  • ISBN: 9784498225244
• [Remarks] 京都大学医学部附属病院血液内科・移植免疫研究室
  • URL: https://hematol.kuhp.kyoto-u.ac.jp/research/transplantation.html
• [Remarks] 妊婦健診で抗HTLV-1抗体陽性と言われた方へ
  • URL: https://www.start2be.org/patient-support/7819/
• [Remarks] 京都大学医学部附属病院血液内科・移植免疫研究室
  • URL: https://www.kuhp.kyoto-u.ac.jp/~hemonc/research/transplantation.html
• [Remarks] 京都大学大学院医学研究科 血液・腫瘍内科学講座 移植免疫研究室
  • URL: https://www.kuhp.kyoto-u.ac.jp/~hemonc/research/transplantation.html
• [Patent(Industrial Property Rights)] 造血幹細胞移植後の合併症リスクの検出方法 (2020)
  • Inventor(s): 岡村浩史、中前博久、進藤岳郎、大塚泰史
  • Industrial Property Rights Holder: 大阪市立大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2020-015285
  • Filing Date: 2020
• [Patent(Industrial Property Rights)] 免疫再構築促進剤、及び移植片対宿主病（GVHD）治療剤 (2019)
  • Inventor(s): 進藤岳郎、板村英和、村主啓行
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-157710
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] 慢性移植肺機能不全の改善又は予防薬 (2019)
  • Inventor(s): 進藤岳郎、芳川豊史、高萩亮宏、伊達洋至
  • Industrial Property Rights Holder: 京都大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas