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Mechanism of eosinophilic esophagitis focusing on the immune response of the esophagus-skin interface via percutaneous sensitisation.

Research Project

Project/Area Number 19K08907
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54020:Connective tissue disease and allergy-related
Research InstitutionShimane University

Principal Investigator

Oshima Naoki  島根大学, 学術研究院医学・看護学系, 講師 (10403461)

Co-Investigator(Kenkyū-buntansha) 石原 俊治  島根大学, 学術研究院医学・看護学系, 教授 (80263531)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords好酸球性食道炎 / アレルギー / 経皮感作
Outline of Research at the Start

近年、アレルギー疾患の新たな感作経路として経皮感作が注目されている。好酸球性食道炎は食道に多数の好酸球が浸潤し、慢性炎症が起こる消化管のアレルギー疾患であるが、外来抗原の感作により発症に至る機序については未だ不明な点が多い。本研究では、皮膚における抗原感作は好酸球性食道炎発症の契機となるのか、また皮膚のバリア機構の破綻は好酸球性食道炎の病態形成の一因になり得るのかを明らかにすることを目的とする。

Outline of Final Research Achievements

In recent years, epicutaneous sensitisation has attracted attention as a new sensitisation route for allergic diseases. The aim of this study was to clarify whether antigen sensitisation in the skin triggers the development of eosinophilic esophagitis (EoE) and whether the disruption of the skin barrier mechanism can contribute to the pathogenesis of EoE. The results suggest that epicutaneous sensitisation with antigens induces eosinophilic inflammation in the esophageal mucosa and that ILC2 mediated by IL-33 may be involved in the pathogenesis of EoE. It was also found that disruption of the skin barrier exacerbates development of EoE.

Academic Significance and Societal Importance of the Research Achievements

本研究は“消化管粘膜”の好酸球性炎症でありながら、その病態解明の舞台を“皮膚”に移し、全く新しいアプローチからEoE発症の謎を解き明かそうとする学術的独自性を持った研究と考えられる。“アレルギーアーチ”の過程において、外来抗原の経皮暴露がEoE発症の一因になることが明らかになった。今回の成果を基に皮膚をターゲットとしたEoEの発症予防、経皮免疫療法といった新しい治療法の開発も期待でき、創造性も持ち合わせている。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (17 results)

All 2022 2021 2020 2019

All Journal Article (14 results) (of which Peer Reviewed: 12 results,  Open Access: 5 results) Presentation (3 results)

  • [Journal Article] Heterotopic Gastric Mucosa in Middle Esophagus Complicated with Esophageal Ulcers2022

    • Author(s)
      Kishimoto Kenichi、Shibagaki Kotaro、Nonomura Saya、Sumi Shohei、Fukuda Naoki、Takahashi Yusuke、Kotani Satoshi、Okimoto Eiko、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Ishihara Shunji
    • Journal Title

      Internal Medicine

      Volume: 61 Issue: 18 Pages: 2735-2740

    • DOI

      10.2169/internalmedicine.8705-21

    • NAID

      130008164558

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-09-15
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Simultaneous Onset of Pancreatitis and Colitis as Immune-related Adverse Events in a Patient Receiving Nivolumab Treatment for Renal Cell Carcinoma2022

    • Author(s)
      Yazaki Tomotaka、Moriyama Ichiro、Tobita Hiroshi、Sonoyama Hiroki、Okimoto Eiko、Oka Akihiko、Mishima Yoshiyuki、Oshima Naoki、Shibagaki Kotaro、Kawashima Kousaku、Ishimura Norihisa、Nagami Taichi、Maruyama Riruke、Shiina Hiroaki、Ishihara Shunji
    • Journal Title

      Internal Medicine

      Volume: 61 Issue: 10 Pages: 1485-1490

    • DOI

      10.2169/internalmedicine.7911-21

    • NAID

      130008114221

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-05-15
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-lasting renal dysfunction following tacrolimus induction therapy in ulcerative colitis patients2022

    • Author(s)
      Cha Na、Oshima Naoki、Kishimoto Kenichi、Kotani Satoshi、Okimoto Eiko、Yazaki Tomotaka、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Shibagaki Kotaro、Tobita Hiroshi、Kawashima Kousaku、Ishimura Norihisa、Ishihara Shunji
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 70 Issue: 3 Pages: 297-303

    • DOI

      10.3164/jcbn.21-139

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low Fecal Calprotectin Predicts Histological Healing in Patients with Ulcerative Colitis with Endoscopic Remission and Leads to Prolonged Clinical Remission2022

    • Author(s)
      Kawashima Kousaku、Oshima Naoki、Kishimoto Kenichi、Kataoka Masatoshi、Fukunaga Mai、Kotani Satoshi、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Kazumori Hideaki、Ishikawa Noriyoshi、Araki Asuka、Ishihara Shunji
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 29 Issue: 3 Pages: 359-366

    • DOI

      10.1093/ibd/izac095

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary Extragastrointestinal Stromal Tumor of Greater Omentum with Intraperitoneal Bleeding2021

    • Author(s)
      Kataoka Masatoshi、Saitoh Tsukasa、Kawashima Kousaku、Yazaki Tomotaka、Sonoyama Hiroki、Okimoto Eiko、Oka Akihiko、Mishima Yoshiyuki、Mishiro Tsuyoshi、Oshima Naoki、Shibagaki Kotaro、Tobita Hiroshi、Moriyama Ichiro、Ishimura Norihisa、Nagase Mamiko、Hirahara Noriyuki、Tajima Yoshitsugu、Ishihara Shunji
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 21 Pages: 3413-3419

    • DOI

      10.2169/internalmedicine.6519-20

    • NAID

      130008110287

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-11-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of dapagliflozin and teneligliptin in nonalcoholic fatty liver disease patients without type 2 diabetes mellitus: a prospective randomized study2021

    • Author(s)
      Tobita Hiroshi、Yazaki Tomotaka、Kataoka Masatoshi、Kotani Satoshi、Oka Akihiko、Mishiro Tsuyoshi、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Naora Kohji、Sato Shuichi、Ishihara Shunji
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 68 Issue: 2 Pages: 173-180

    • DOI

      10.3164/jcbn.20-129

    • NAID

      130007993437

    • ISSN
      0912-0009, 1880-5086
    • Year and Date
      2021-03-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intermittent Purpura Development Associated with Leukocytoclastic Vasculitis Induced by Infliximab for Crohn's Disease2021

    • Author(s)
      Kishimoto Kenichi、Kawashima Kousaku、Fukunaga Mai、Kotani Satoshi、Sonoyama Hiroki、Oka Akihiko、Mishima Yoshiyuki、Oshima Naoki、Ishimura Norihisa、Ishikawa Noriyoshi、Maruyama Riruke、Ishihara Shunji
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 3 Pages: 385-389

    • DOI

      10.2169/internalmedicine.5340-20

    • NAID

      130007979732

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-02-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intestinal-type gastric dysplasia in Helicobacter pylori-na?ve patients2021

    • Author(s)
      Shibagaki Kotaro、Itawaki Ayako、Miyaoka Yoichi、Kishimoto Kenichi、Takahashi Yusuke、Kotani Satoshi、Mishiro Tsuyoshi、Oshima Naoki、Kawashima Kousaku、Ishimura Norihisa、Onuma Hideyuki、Nagasaki Makoto、Nagase Mamiko、Araki Asuka、Kadota Kyuichi、Kushima Ryoji、Ishihara Shunji
    • Journal Title

      Virchows Archiv

      Volume: 480 Issue: 4 Pages: 783-792

    • DOI

      10.1007/s00428-021-03237-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential gene expression analysis of dasatinib-induced colitis in a patient with chronic myeloid leukemia followed for 3?years: a case report2021

    • Author(s)
      Oshima Naoki、Mishima Yoshiyuki、Shibagaki Kotaro、Kawashima Kousaku、Ishimura Norihisa、Ikejiri Fumiyoshi、Onishi Chie、Okada Takahiro、Inoue Masaya、Moriyama Ichiro、Suzumiya Junji、Kinoshita Yoshikazu、Ishihara Shunji
    • Journal Title

      BMC Gastroenterology

      Volume: 21 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s12876-020-01584-6

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective multicenter study of the esophageal triamcinolone acetonide‐filling method in patients with subcircumferential esophageal endoscopic submucosal dissection2020

    • Author(s)
      Shibagaki Kotaro、Yuki Takafumi、Taniguchi Hideaki、Aimi Masahito、Miyaoka Yoichi、Yuki Mika、Ishimura Norihisa、Oshima Naoki、Mishiro Tsuyoshi、Tamagawa Yuji、Mikami Hironobu、Izumi Daisuke、Yamashita Noritsugu、Sato Shuichi、Ishihara Shunji、Kinoshita Yoshikazu
    • Journal Title

      Digestive Endoscopy

      Volume: 32 Issue: 3 Pages: 355-363

    • DOI

      10.1111/den.13496

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence of functional dyspepsia-like symptoms in ulcerative colitis patients in clinical remission and overlap with irritable bowel syndrome-like symptoms2020

    • Author(s)
      Kotani Satoshi、Fukuba Nobuhiko、Kawashima Kousaku、Mishima Yoshiyuki、Sonoyama Hiroki、Okimoto Eiko、Tada Yasumasa、Oka Akihiko、Tamagawa Yuji、Oshima Naoki、Mishiro Tsuyoshi、Tobita Hiroshi、Shibagaki Kotaro、Moriyama Ichiro、Ishimura Norihisa、Kushiyama Yoshinori、Fujishiro Hirofumi、Ishihara Shunji
    • Journal Title

      Scandinavian Journal of Gastroenterology

      Volume: 55 Issue: 5 Pages: 560-564

    • DOI

      10.1080/00365521.2020.1761998

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comorbid irritable bowel syndrome symptoms and headache have greater association with anxiety than depression2020

    • Author(s)
      Kawashima Kousaku、Fukuba Nobuhiko、Uemura Yusuke、Ota Kuniko、Kazumori Hideaki、Sonoyama Hiroki、Oka Akihiko、Tada Yasumasa、Mishima Yoshiyuki、Oshima Naoki、Yuki Takafumi、Katsube Tomoko、Kinoshita Yoshikazu、Ishihara Shunji
    • Journal Title

      Medicine

      Volume: 99 Issue: 47 Pages: e23059-e23059

    • DOI

      10.1097/md.0000000000023059

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【炎症性腸疾患の新規治療とその適応】炎症性腸疾患における新規治療の現状2020

    • Author(s)
      石原 俊治,三島 義之,岡  明彦,大嶋 直樹,川島 耕作
    • Journal Title

      消化器・肝臓内科

      Volume: 8 Pages: 219-227

    • Related Report
      2020 Research-status Report
  • [Journal Article] 【何をしている好酸球?好酸球性消化管疾患のメカニズム】好酸球性胃腸炎の病態・診断・治療2020

    • Author(s)
      大嶋 直樹,石原 俊治
    • Journal Title

      消化器病サイエンス

      Volume: 4 Pages: 99-102

    • Related Report
      2020 Research-status Report
  • [Presentation] microRNAを用いた好酸球性食道炎の新規バイオマーカーの探索2022

    • Author(s)
      大嶋 直樹  石村 典久  石原 俊治
    • Organizer
      第108回日本消化器病学会総会(東京)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 好酸球性食道炎の治療後経過に関する検討2021

    • Author(s)
      石村 典久,沖本 英子,三代  剛,大嶋 直樹,川島 耕作,石原 俊治
    • Organizer
      第17回日本消化管学会総会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] microRNAの網羅的解析を用いた好酸球性食道炎のバイオマーカーの探索2019

    • Author(s)
      大嶋直樹、石村典久、石原俊治
    • Organizer
      第97回日本消化器内視鏡学会総会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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