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Study on cellular immunity against Mycobacterium and development of new vaccine

Research Project

Project/Area Number 19K08939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54030:Infectious disease medicine-related
Research InstitutionNihon University

Principal Investigator

AIZAWA Shihoko  日本大学, 医学部, 准教授 (30513858)

Co-Investigator(Kenkyū-buntansha) 舛廣 善和  日本大学, 生物資源科学部, 准教授 (00336083)
早川 智  日本大学, 医学部, 教授 (30238084)
権 寧博  日本大学, 医学部, 教授 (80339316)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords抗酸菌 / BCG / 組換えBCG / 細胞性免疫 / 非結核性抗酸菌症 / 非結核性抗酸菌 / 感染防御 / ワクチン / 感染免疫
Outline of Research at the Start

近年増加傾向の非結核性抗酸菌(non-tuberculosis mycobacteria: NTM)症は結核と異なり空気感染しないが、結核よりも治りにくく有効なワクチンも存在しない。我々が作成した新規の結核の予防ワクチンである組換えBCG(rBCG-Mkan85B)は、既存のBCGよりも結核に対する免疫応答を強力に誘導することを明らかにしている。本研究ではNTM患者における細胞性免疫応答の解析から、rBCG-Mkan85BがNTMに対してもワクチンとして機能するかどうかを検討する。さらに、CD4とCD8のエピトープペプチドを用いて、ペプチドワクチンの開発を目指す。

Outline of Final Research Achievements

In this study, we aimed to analyze cellular immunity against NTM and to develop a new vaccine to protect against infection with non-tuberculous mycobacterial tuberculosis (NTM). We examined whether our rBCG Mkan85B/DNA vaccine (DNA-Mkan85B) system could be a novel vaccine against NTM in mice. rBCG Mkan85B/DNA-Mkan85B inoculated mice showed a significant decrease in the number of bacteria in the lungs after M. kansasii infection. The number of bacteria in the lungs of rBCG-Mkan85B/DNA-Mkan85B immunized mice was lower than that of mice in the control or BCG-vaccinated groups. In addition to antigen specific helper T cells, cytotoxic T cells could be induced. These result suggest that rBCG-Mkan85B/DNA Mkan85B may be an effective novel vaccine candidate against NTM.

Academic Significance and Societal Importance of the Research Achievements

rBCG-Mkan85B/DNA-Mkan85B接種はNTMに対する新たなワクチンとして有効である可能性が示唆された。NTM症はヒトからヒトへ感染することはないが、治療抵抗性である。本研究の成果は、世界的に患者数が増加傾向にあるNTM症に対する防御戦略開発において、新たな緒となりうる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2021 2020 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Recombinant BCG-Prime and DNA-Boost Immunization Confers Mice with Enhanced Protection against Mycobacterium kansasii2021

    • Author(s)
      Komine-Aizawa Shihoko、Mizuno Satoru、Matsuo Kazuhiro、Namiki Takahiro、Hayakawa Satoshi、Honda Mitsuo
    • Journal Title

      Vaccines

      Volume: 9 Issue: 11 Pages: 1260-1260

    • DOI

      10.3390/vaccines9111260

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Recombinant BCG over-expressed Mycobacterium antigens enhanced Ag85B-specific CD8+ T cells.2021

    • Author(s)
      Shihoko Komine-Aizawa, Satoru Mizuno, Satoshi Hayakawa, Kazuhiro Matsuo, Mitsuo Honda
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Recombinant BCG over-expressed Mycobacterium antigens enhanced Ag85B-specific CD8+ T cells2020

    • Author(s)
      Shihoko Komine-Aizawa, Satoru Mizuno, Satoshi Hayakawa, Kazuhiro Matsuo, Mitsuo Honda
    • Organizer
      The U.S.-Japan Cooperative Medical Sciences Program: The 54th Mycobacteria Panel Meeting(日米医学協力計画 抗酸菌症専門部会 第54 回日米合同会議)(新型コロナウイルス感染蔓延のため中止)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Recombinant BCG over-expressed Mycobacterium antigens enhanced Ag85B-specific CD8+ T cells2020

    • Author(s)
      Shihoko Komine-Aizawa
    • Organizer
      令和元年度日本大学学部連携研究推進シンポジウム 免疫と生殖の共進化 大野 乾 没後20年記念シンポジウム(新型コロナウイルス感染蔓延のため中止。誌上発表)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Recombinant BCG over-expressed Mycobacterium antigens enhanced Ag85B-specific CD8+ T cells.2019

    • Author(s)
      Shihoko Komine-Aizawa, Satoru Mizuno, Satoshi Hayakawa, Kazuhiro Matsuo, Mitsuo Honda
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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