A study on the treatment and transmission routes of Helicobacter cinedi infection.

• Project/Area Number: 19K08948
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: Tohoku University
• Principal Investigator: Nomura Kazuhiro 東北大学, 医学系研究科, 非常勤講師 (60466563)
• Co-Investigator(Kenkyū-buntansha): 香取 幸夫 東北大学, 医学系研究科, 教授 (20261620) ; 矢野 寿一 奈良県立医科大学, 医学部, 教授 (20374944) ; 角田 梨紗子 東北大学, 大学病院, 助教 (40596095)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ヘリコバクターシネディ / Helicobacter cinaedi

Outline of Research at the Start

Helicobacter cinaediは、培養による検出率が低いため、本菌による感染症の治療方針は確立していない。また、本菌はヒトや動物の消化管内に生息するとされるが、保菌状況やヒトへの感染経路は解明されていない。
本研究では、日本全国の無菌検体から検出されたH. cinaediを収集し、薬剤感受性測定と薬剤耐性遺伝子、病原因子の検出を行い、本菌による感染症の治療戦略を構築する。また、ヒトと動物の糞便の培養と遺伝子解析により本菌の保菌状況を明らかにする。さらにこれらの株を分子疫学的手法により型別し、本菌の伝播様式を解明する。本研究により、H. cinaedi感染症の実態を明らかにする。

Outline of Final Research Achievements

Helicobacter cinaedi strains developed in cultures of clinical specimens and H. cinaedi DNA was collected from tissues. These MLSTs showed diversity. All of the H. cinaedi strains detected in the clinical specimens showed amino acid substitutions that could be resistant to macrolides and quinolones. On the other hand, there were no amino acid substitutions that could be resistant to β-lactams. H. cinaedi was not detected in the feces of healthy individuals or animals collected in this study. Since this organism can be resistant to macrolides and quinolones, the use of these drugs should be avoided and the use of β-lactams should be considered in treatment.

Academic Significance and Societal Importance of the Research Achievements

本検討において、培養陰性の感染性動脈瘤の手術組織から多く H. cinaediが検出されていた。このことから、 H. cinaediは培養陰性の感染性大動脈瘤の重要な原因菌であることが明らかとなった。感染性大動脈瘤の場合、本菌を念頭に置き微好気培養や培養期間の延長をすべきである。また、本菌はマクロライド系およびキノロン系に耐性を示しうるため、治療の際はこれらの薬剤の使用を避け、βラクタム薬を使用する必要がある。以上のように本検討により、速やかに適切な治療を行わなければ致死的となりうる培養陰性の感染性大動脈瘤の抗菌薬選択についての知見を提唱することが可能となり、治療に直結すると考えられる。

Research Products

• [Journal Article] Endoscopic-assisted total maxillectomy with precise surgical margins. (2023)
  • Author(s): Nagaoka M, Omura K, Nomura K, Takeda T, Otori N, Kojima H.
  • Journal Title: Head Neck. Volume: 45 Issue: 2 Pages: 521-528
  • DOI: 10.1002/hed.27237
  • Peer Reviewed
• [Journal Article] Structural insights into the substrate specificity of IMP-6 and IMP-1 metallo-β-lactamases. (2023)
  • Author(s): Yamamoto K, Tanaka H, Kurisu G, Nakano R, Yano, H, Sakai H
  • Journal Title: J Biochem Volume: 173 Issue: 1 Pages: 21-30
  • DOI: 10.1093/jb/mvac080
  • Peer Reviewed / Open Access
• [Journal Article] Genetic relatedness of third-generation cephalosporin-resistant Escherichia coli among livestock, farmers, and patients in Japan (2023)
  • Author(s): Nakano Ryuichi、Nakano Akiyo、Nishisouzu Ryuji、Hikosaka Kenji、Suzuki Yuki、Kamoshida Go、Tansho-Nagakawa Shigeru、Endo Shiro、Kasahara Kei、Ono Yasuo、Yano Hisakazu
  • Journal Title: One Health Volume: 16 Pages: 100524-100524
  • DOI: 10.1016/j.onehlt.2023.100524
  • Peer Reviewed / Open Access
• [Journal Article] 耳鼻咽喉科頭頸部外科領域感染症における抗菌薬の適正使用の推進と新規抗菌薬開発 (2022)
  • Author(s): 保富 宗城, 伊藤 真人, 林 達哉, 河野 正充, 香山 智佳子, 角田 梨紗子, 櫛橋 幸民, 原渕 保明
  • Journal Title: Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo) Volume: 125 Issue: 11 Pages: 1563-1569
  • DOI: 10.3950/jibiinkotokeibu.125.11_1563
  • ISSN: 2436-5793, 2436-5866
  • Year and Date: 2022-11-20
  • Peer Reviewed
• [Journal Article] Clinical and Epidemiological Characteristics of Bloodstream Infections in Head and Neck Cancer Patients: A Decadal Observational Study (2022)
  • Author(s): Kitaya S, Kakuta R, Kanamori H, Ohkoshi A, Ishii R, Nomura K, Tokuda K, Katori Y.
  • Journal Title: J Clin Med. Volume: 11 Issue: 16 Pages: 4820-4820
  • DOI: 10.3390/jcm11164820
  • Peer Reviewed / Open Access
• [Journal Article] Sinonasal Inverted Papilloma Showing a Misleading Finding on Magnetic Resonance Imaging (2022)
  • Author(s): Numano Y, Nomura K, Sugawara M, Hemmi T, Suzuki J, Kakuta R, Katori Y.
  • Journal Title: Ear Nose Throat J. Volume: - Pages: 014556132210956-014556132210956
  • DOI: 10.1177/01455613221095614
  • Peer Reviewed
• [Journal Article] Outcome of the 'waiting until spontaneous extrusion' strategy for long-term tympanostomy tube placement in children with cleft palate. (2022)
  • Author(s): Nomura Y, Oshima H, Nomura K, Kakuta R, Ikeda R, Hirano AK, Ota J, Kawase T, Katori Y.
  • Journal Title: Acta Otolaryngol. Volume: 142 Issue: 3-4 Pages: 248-253
  • DOI: 10.1080/00016489.2022.2041210
  • Peer Reviewed
• [Journal Article] Fibroepithelial Polyps Originating from the Posterior Nasal Septum: A Case Report (2022)
  • Author(s): Numano Y, Nomura K, Watanabe M, Sugawara M, Hemmi T, Suzuki J, Katori Y.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 257 Issue: 4 Pages: 333-336
  • DOI: 10.1620/tjem.2022.J047
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed
• [Journal Article] Chronic Maxillary Atelectasis without Obstruction of the Maxillary Ostium - A Case Report. (2022)
  • Author(s): Numano Y, Nomura K, Hemmi T, Suzuki J, Kakuta R, Sugawara M.
  • Journal Title: Ann Maxillofac Surg. Volume: 12 Issue: 2 Pages: 224-226
  • DOI: 10.4103/ams.ams_287_21
  • Peer Reviewed / Open Access
• [Journal Article] Effect of treatments for head and neck cancer on sinus shadow on computed tomography. (2022)
  • Author(s): Hemmi T, Suzuki J, Ishii R, Ikeda R, Kobayashi Y, Ikushima H, Nomura K, Sugawara M, Ohkoshi A, Katori Y.
  • Journal Title: Auris Nasus Larynx. Volume: 49 Issue: 6 Pages: 1019-1026
  • DOI: 10.1016/j.anl.2022.03.020
  • Peer Reviewed
• [Journal Article] 東北大学病院耳鼻咽喉・頭頸部外科における新型コロナウイルススクリーニングPCR検査の現状調査 (2022)
  • Author(s): 角田 梨紗子, 金森 肇, 徳田 浩一, 北谷 栞, 香取幸夫
  • Journal Title: 日本耳鼻咽喉科免疫アレルギー感染症学会誌 Volume: 2 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Evaluation of NG-Test CARBA5 for the detection of carbapenemase-producing Gram-negative bacilli. (2022)
  • Author(s): Saito K, Mizuno S, Nakano R, Tanouchi A, Mizuno T, Nakano A, Suzuki Y, Kakuta N, Yano H
  • Journal Title: J Med Microbiol Volume: 71 Issue: 6 Pages: 0001557-0001557
  • DOI: 10.1099/jmm.0.001557
  • Peer Reviewed
• [Journal Article] Comamonas thiooxydans Expressing a Plasmid-Encoded IMP-1 Carbapenemase Isolated From Continuous Ambulatory Peritoneal Dialysis of an Inpatient in Japan (2022)
  • Author(s): Suzuki Y, Nakano R, Nakano A, Tasaki H, Asada T, Horiuchi S, Saito K, Watanabe M, Nomura Y, Kitagawa, D Lee ST, Ui K, Koizumi A, Nishihara Y, Sekine T, Sakata R, Ogawa M, Ohnishi M, Tsuruya K, Kasahara K, Yano H
  • Journal Title: Frontiers in Microbiology Volume: - Pages: 808993-808993
  • DOI: 10.3389/fmicb.2022.808993
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Emergence and Evolution of Unique Plasmids Harboring blaIMP-70 and blaCTX-M-253 in Multidrug-Resistant Providencia rettgeri. (2022)
  • Author(s): Watanabe M, Nakano R, Tanouchi A, Nakano A, Suzuki Y, Saito K, Sakata R, Ogawa M, Yano H
  • Journal Title: Microbiol Spectr Volume: 6 Issue: 4
  • DOI: 10.1128/spectrum.01204-22
  • Peer Reviewed / Open Access
• [Journal Article] Predominance of CTX-M-9 Group Among ESBL-Producing Escherichia coli Isolated from Healthy Individuals in Japan (2022)
  • Author(s): Masui T, Nakano R, Nakano A, Saito K, Suzuki Y, Kakuta N, Horiuchi S, Tsubaki K, Kitahara T, Yano H.
  • Journal Title: Microb Drug Resist. Volume: 28 Pages: 355-360
  • Peer Reviewed
• [Journal Article] The Role of nmcR, ampR, and ampD in the Regulation of the Class A Carbapenemase NmcA in Enterobacter ludwigii (2022)
  • Author(s): Nakano Ryuichi、Yamada Yuki、Nakano Akiyo、Suzuki Yuki、Saito Kai、Sakata Ryuji、Ogawa Miho、Narita Kazuya、Kuga Akio、Suwabe Akira、Yano Hisakazu
  • Journal Title: Frontiers in Microbiology Volume: 12 Pages: 794134-794134
  • DOI: 10.3389/fmicb.2021.794134
  • Peer Reviewed / Open Access
• [Journal Article] Optimal Multiple-Layered Anterior Skull Base Reconstruction Using a 360° Suturing Technique. (2022)
  • Author(s): Omura K, Nomura K, Mori R, Ishii Y, Aoki S, Takeda T, Tochigi K, Tanaka Y, Otori N, Kojima H.
  • Journal Title: Oper Neurosurg (Hagerstown). Volume: 22 Issue: 1 Pages: e1-e6
  • DOI: 10.1227/ons.0000000000000013
  • Peer Reviewed
• [Journal Article] The Development of Frontal and Sphenoid Sinuses After Full-House Endoscopic Sinus Surgery in a Child. (2022)
  • Author(s): Nomura K, Numano Y, Sugawara M.
  • Journal Title: J Craniofac Surg. Volume: 33 Issue: 1 Pages: e47-e49
  • DOI: 10.1097/scs.0000000000007907
  • Peer Reviewed
• [Journal Article] How I Do It: Inferior Turbinectomy: Modified Techniques for Submucosal Resection. (2021)
  • Author(s): Omura K, Nomura K, Takeda T, Yanagi N, Kuroyanagi H, Yanagihara T, Tanaka Y, Kojima H, Otori N.
  • Journal Title: Allergy Rhinol (Providence). Volume: 12
  • DOI: 10.1177/21526567211034736
  • Peer Reviewed
• [Journal Article] Preoperative Endovascular Embolization in an Easily Bleeding Respiratory Epithelial Adenomatoid Hamartoma of the Olfactory Cleft: A Case Report. (2021)
  • Author(s): Suzuki J, Tozuka H, Hemmi T, Ikushima H, Ishikawa T, Morishita Y, Nomura K, Sugawara M, Katori Y.
  • Journal Title: Tohoku J Exp Med. Volume: 254 Issue: 2 Pages: 107-110
  • DOI: 10.1620/tjem.254.107
  • NAID: 130008054173
  • Peer Reviewed
• [Journal Article] Clinical Factors Associated With the Outcomes of Long-Term Middle Ear Ventilation Tube Insertion in Pediatric Patients. (2021)
  • Author(s): Takai S, Nomura K, Oda K, Ozawa D, Irimada M, Ikeda R, Kakuta R, Katori Y, Ohyama K.
  • Journal Title: Ear Nose Throat J. Volume: 15 Issue: 10 Pages: NP511-NP517
  • DOI: 10.1177/01455613211026437
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Magnetic Resonance Imaging and Computed Tomography in the Evaluation of the Olfactory Cleft and Ethmoidal Cells. (2021)
  • Author(s): Hemmi T, Nomura K, Suzuki J, Kobayashi Y, Kakuta R, Sugawara M, Katori Y.
  • Journal Title: J Craniofac Surg. Volume: 32 Issue: 2 Pages: 541-545
  • DOI: 10.1097/scs.0000000000006849
  • Peer Reviewed
• [Journal Article] Prevalence and Relatedness of mcr-1-Mediated Colistin-Resistant Escherichia coli Isolated From Livestock and Farmers in Japan. (2021)
  • Author(s): Nakano A, Nakano R, Nishisouzu R, Suzuki Y, Horiuchi S, Kikuchi-Ueda T, Ubagai T, Ono Y, Yano H.
  • Journal Title: Front Microbiol. Volume: 12 Pages: 664931-664931
  • DOI: 10.3389/fmicb.2021.664931
  • Peer Reviewed / Open Access
• [Journal Article] First case of an invasive Bacteroides dorei infection detected in a patient with a mycotic aortic aneurysm-raising a rebellion of major indigenous bacteria in humans: a case report and review. (2021)
  • Author(s): Matsuoka T, Shimizu T, Minagawa T, Hiranuma W, Takeda M, Kakuta R, Kawamoto S.
  • Journal Title: BMC Infect Dis. Volume: 21 Issue: 1 Pages: 625-625
  • DOI: 10.1186/s12879-021-06345-8
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of aspiration pneumonia patients in acute care hospitals: A multicenter, retrospective survey in Northern Japan (2021)
  • Author(s): 1.Suzuki J, Okazaki T, Katori Y., et al.,
  • Journal Title: PLos One Volume: 16(7) Issue: 7 Pages: e0254261-e0254261
  • DOI: 10.1371/journal.pone.0254261
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of Helicobacter pylori among residents and their environments in the Nara prefecture, Japan. (2021)
  • Author(s): Horiuchi S, Nakano R, Nakano A, Hishiya N, Uno K, Suzuki Y, Kakuta N, Kakuta R, Tsubaki K, Jojima N, Yano H.
  • Journal Title: Journal of Infection and Public Health Volume: 14 Issue: 2 Pages: 271-275
  • DOI: 10.1016/j.jiph.2020.11.018
  • Peer Reviewed / Open Access
• [Journal Article] Genomic characteristics of listeria monocytogenes causing invasive listeriosis in Japan. (2021)
  • Author(s): Baba H, Kanamori H, Kakuta R, Sakurai H, Oshima K, Aoyagi T, Kaku M.
  • Journal Title: Diagn Microbiol Infect Dis. Volume: 99 Issue: 3 Pages: 115223-115223
  • DOI: 10.1016/j.diagmicrobio.2020.115233
  • Peer Reviewed
• [Journal Article] Effect of gauze placement soaked with adrenaline at suprabullar recess on hemostasis during endoscopic sinus surgery: A randomized controlled trial. (2020)
  • Author(s): Omura K, Hosokawa Y, Nomura K, Aoki S, Tochigi K, Miyashita K, Tanaka Y, Otori N, Kojima H.
  • Journal Title: Head & Neck. Volume: 42 Issue: 9 Pages: 2397-2404
  • DOI: 10.1002/hed.26243
  • Peer Reviewed
• [Journal Article] Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells. Respir Investig. (2020)
  • Author(s): Yamaya M, Nishimura H, Deng X, Sugawara M, Watanabe O, Nomura K, Shimotai Y, Momma H, Ichinose M, Kawase T.
  • Journal Title: Respir Investig. Volume: S2212-5345 Issue: 3 Pages: 30005-30008
  • DOI: 10.1016/j.resinv.2019.12.005
  • Peer Reviewed
• [Journal Article] Soft tissue reconstruction with anterior pedicled inferior turbinate flap in conjunction with palatal flap for standard inferior maxillectomy with hard palate resection. (2020)
  • Author(s): Omura K, Nomura K, Aoki S, Otori N, Tanaka Y.
  • Journal Title: Head & Neck. Volume: 42 Issue: 5 Pages: 1110-1114
  • DOI: 10.1002/hed.26091
  • Peer Reviewed
• [Journal Article] Resection of inverted papilloma in nasal cavity with transseptal access and crossing multiple incisions minimizes bleeding and reveals the tumor pedicle. (2020)
  • Author(s): Omura K, Nomura K, Aoki S, Hosokawa Y, Tanaka Y, Otori N, Kojima H.
  • Journal Title: Auris Nasus Larynx. Volume: 47 Issue: 3 Pages: 410-414
  • DOI: 10.1016/j.anl.2019.10.006
  • Peer Reviewed
• [Journal Article] Risk factors of post-tonsillectomy dysgeusia. (2020)
  • Author(s): Kitaya S, Kikuchi T, Yahata I, Ikeda R, Nomura K, Kawase T, Katori Y.
  • Journal Title: Auris Nasus Larynx. Volume: 47 Issue: 2 Pages: 238-241
  • DOI: 10.1016/j.anl.2019.07.005
  • NAID: 130008083319
  • Peer Reviewed
• [Journal Article] A Novel Mismatched PCR-Restriction Fragment Length Polymorphism Assay for Rapid Detection of gyrA and parC Mutations Associated With Fluoroquinolone Resistance in Acinetobacter baumannii (2020)
  • Author(s): Kakuta Naoki、Nakano Ryuichi、Nakano Akiyo、Suzuki Yuki、Tanouchi Ayako、Masui Takashi、Horiuchi Saori、Endo Shiro、Kakuta Risako、Ono Yasuo、Yano Hisakazu
  • Journal Title: Annals of Laboratory Medicine Volume: 40 Issue: 1 Pages: 27-27
  • DOI: 10.3343/alm.2020.40.1.27
  • Peer Reviewed / Open Access
• [Journal Article] Molecular characteristics of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Japan: Predominance of CTX-M-15 and emergence of hypervirulent clones. (2020)
  • Author(s): Kakuta N, Nakano R, Nakano A, Suzuki Y, Masui T, Horiuchi S, Kakuta R, Tsubaki K, Ogawa M, Yano H.
  • Journal Title: Int J Infect Dis. Volume: 98 Pages: 281-2886
  • DOI: 10.1016/j.ijid.2020.06.083
  • Peer Reviewed / Open Access
• [Journal Article] Inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by gaseous ozone treatment (2020)
  • Author(s): Yano H, Nakano R, Suzuki Y, Nakano A, Kasahara K, Hosoi H.
  • Journal Title: J Hosp Infect. Volume: 106 Issue: 4 Pages: 837-838
  • DOI: 10.1016/j.jhin.2020.10.004
  • Peer Reviewed
• [Journal Article] First Two Cases of Infected Aortic Aneurysm Caused by Non-Vaccine Streptococcus pneumoniae Serotype 23A. (2020)
  • Author(s): Kakuta R, Nakano R, Yano H, Ozawa D, Ohta N, Matsuoka T, Motoyoshi N, Kawamoto S, Saiki Y, Katori Y, Kaku M.
  • Journal Title: Ann Lab Med. Volume: 40 Issue: 3 Pages: 270-273
  • DOI: 10.3343/alm.2020.40.3.270
  • Peer Reviewed / Open Access
• [Journal Article] Abdominal Aortic Graft Infection Caused by <i>stG</i>485.0, ST29 <i>Streptococcus dysgalactiae</i> subsp. <i>equisimilis</i> (2020)
  • Author(s): Kakuta R, Shimizu T, Goto H, Endo S, Kanamori H, Ohta N, Nakano R, Yano H, Katori Y, Kaku M.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 73 Issue: 1 Pages: 65-67
  • DOI: 10.7883/yoken.JJID.2019.171
  • NAID: 130007789140
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed
• [Journal Article] Comparison between IMP carbapenemase-producing Enterobacteriaceae and non-carbapenemase-producing Enterobacteriaceae: a multicentre prospective study of the clinical and molecular epidemiology of carbapenem-resistant Enterobacteriaceae. (2020)
  • Author(s): Hayakawa K, Nakano R, Hase R, Shimatani M, Kato H, Hasumi J, Doi A, Sekiya N, Nei T, Okinaka K, Kasahara K, Kurai H, Nagashima M, Miyoshi-Akiyama T, Kakuta R, Yano H, Ohmagari N.
  • Journal Title: J Antimicrob Chemother. Volume: 75 Issue: 3 Pages: 697-708
  • DOI: 10.1093/jac/dkz501
  • Peer Reviewed
• [Journal Article] 難治性好酸球性副鼻腔炎に対する手術治療と薬物治療 (2020)
  • Author(s): 野村 和弘
  • Journal Title: 耳鼻咽喉科免疫アレルギー Volume: 37 Pages: 261-264
  • Peer Reviewed
• [Journal Article] Development of a loop-mediated isothermal amplification assay for rapid Helicobacter pylori detection. (2019)
  • Author(s): Horiuchi S, Nakano R, Nakano A, Hishiya N, Uno K, Suzuki Y, Tanouchi A, Kakuta N, Masui T, Jojima N, Yano H.
  • Journal Title: J Microbiol Methods. Volume: 163 Pages: 105653-105653
  • DOI: 10.1016/j.mimet.2019.105653
  • Peer Reviewed
• [Presentation] 最近14年間に東北大学病院耳鼻咽喉・頭頸部外科において検出されたインフルエンザ菌の薬剤感受性の現状 (2022)
  • Author(s): 北谷 栞, 角田 梨紗子, 香取 幸夫
  • Organizer: 第2回日本耳鼻咽喉科免疫アレルギー感染症学会
• [Presentation] 耳介血腫に対するOK-432局所注入療法 臨床効果と作用機序 (2022)
  • Author(s): 太田 伸男, 深瀬 滋, 白根 しおん, 野口 直哉, 舘田 豊, 角田 梨紗子, 北谷 栞, 佐藤 輝幸, 東海林 史
  • Organizer: 第2回日本耳鼻咽喉科免疫アレルギー感染症学会
• [Presentation] 中枢神経系感染症が疑われる患者に対するFilmArray髄膜炎脳炎パネルの臨床的影響力 (2022)
  • Author(s): 北川 大輔良県, 北野 泰斗, 鈴木 崇真, 古森 円香, 飯尾 祐衣, 三崎 晴輝, 飯尾 洋紀, 鈴木 由希, 中野 章代, 中野 竜一, 矢野 寿一
  • Organizer: 第 34 回日本臨床微生物学会総会
• [Presentation] IMP-34を産生する臨床分離Acinetobacter属の分子遺伝学的解析 (2022)
  • Author(s): 鈴木 由希， 中野 竜一, 中野 章代, 遠藤 史郎, 岡 健太郎, 宮本 健太郎, 堀内 沙央里, 朝田 智子, 高橋 志達, 賀来 満夫, 矢野 寿一
  • Organizer: 第 34 回日本臨床微生物学会総会
• [Presentation] 海外渡航者下痢症患者が保有していた薬剤耐性菌の分子遺伝学的解析 (2022)
  • Author(s): 堀内 沙央里, 中野 竜一, 中野 章代, 鈴木 由希, 中村 ふくみ[内山], 朝田 智子, 星野 ひとみ, 安藤 友規子, 城島 哲子, 矢野 寿一
  • Organizer: 第 34 回日本臨床微生物学会総会
• [Presentation] Genetic and moleculer characteristics of metallo-β-lactamase IMP-34 encoding plasmids of Acinetobacter spp. Isolated from inpatients in Japan. the 32nd International Congress of Antimicrobial Chemotherapy (ICC). November 27-30, 2022, Perth, Australia (2022)
  • Author(s): Suzuki Y, Endo S, Nakano R, Nakano A, Kaku M, Yano H
  • Organizer: the 32nd International Congress of Antimicrobial Chemotherapy (ICC).
  • Int'l Joint Research
• [Presentation] Carbapenem resistance mechanism of Enterobacter roggenkampii that simultaneously produces carbapenemases IMI-16 and IMI-18. (2022)
  • Author(s): Saito K, Suzuki Y, Nakano R, Nakano A, Watanabe M, Yano H
  • Organizer: the 32nd International Congress of Antimicrobial Chemotherapy (ICC).
  • Int'l Joint Research
• [Presentation] Molecular mechanism of Sed-1 β-lactamase expression in Citrobacter sedlakii. (2022)
  • Author(s): Watanabe M, Nakano R, Nakano A, Yamada Y, Suzuki Y, Saito K, Yagi S, Endo K, Suwabe A, Yano H
  • Organizer: the 32nd International Congress of Antimicrobial Chemotherapy (ICC).
  • Int'l Joint Research
• [Presentation] Molecular and epidemiological characteristics of carbapenemase-producing Enterobacterales clinical isolates in Nara, Japan. (2022)
  • Author(s): Kishi R, Nakano R, Nakano A, Suzuki Y, Horiuchi S, Saito K, Watanabe M, Morita R, Kawabe T, Yano H
  • Organizer: the 32nd International Congress of Antimicrobial Chemotherapy (ICC).
  • Int'l Joint Research
• [Presentation] Genetic relatedness of third-generation cephalosporin-resistant Escherichia coli among livestock, farmers, and patients in Japan. (2022)
  • Author(s): Nakano R, Nakano A, Nishisouzu R, Hikosaka K, Suzuki Y, Kamoshida G, Tansho-Nagakawa, Kasahara K, Ono Y, Yano H
  • Organizer: the 32nd International Congress of Antimicrobial Chemotherapy (ICC).
  • Int'l Joint Research
• [Presentation] PPredominance of CTX-M-15 β-lactamase-producing Escherichia coli isolated from wild deer inhabiting a tourist area in Japan (2022)
  • Author(s): Nakano A, Nakano R, Watanabe M, Suzuki Y, Horiuchi S, Saito K, Kishi R, Yano Hhabiting a tourist area in Japan
  • Organizer: the 32nd International Congress of Antimicrobial Chemotherapy (ICC).
  • Int'l Joint Research
• [Presentation] 海外から流入する可能性が高い耐性菌の特徴と検査面の対応 (2022)
  • Author(s): 矢野寿一
  • Organizer: 第34回日本臨床微生物学会総会・学術集会
  • Invited
• [Presentation] 東北大学病院耳鼻咽喉・頭頸部外科におけるSARS-CoV-2スクリーニングPCR検査の現状調査 (2021)
  • Author(s): 角田 梨紗子, 金森 肇, 北谷 栞, 香取 幸夫
  • Organizer: 第一回日本耳鼻咽喉科免疫アレルギー感染症学会
• [Presentation] 東北大学病院耳鼻咽喉・頭頸部外科における最近10年間の血液培養検査の現状 (2021)
  • Author(s): 北谷 栞, 角田 梨紗子, 金森 肇, 香取 幸夫
  • Organizer: 第一回日本耳鼻咽喉科免疫アレルギー感染症学会
• [Presentation] 奈良県におけるHelicobacter pyloriの蔓延実態と感染源の検討 (2021)
  • Author(s): 堀内 沙央里, 中野 竜一, 中野 章代, 菱矢 直邦, 宇野 健司, 鈴木 由希, 角田 梨紗子, 矢野 寿一
  • Organizer: 第95回日本感染症学会学術講演会／第69回日本化学療法学会総会 合同学会
• [Presentation] 本邦分離Citrobacter sedlakiiにおけるSed-1 β-ラクタマーゼの産生機構の解明 (2021)
  • Author(s): 渡邉 真子, 中野 竜一, 中野 章代, 山田 友紀, 鈴木 由希, 斉藤 開, 諏訪部 章, 矢野 寿一
  • Organizer: 第95回日本感染症学会学術講演会／第69回日本化学療法学会総会 合同学会
• [Presentation] 環境から分離された新規カルバペネマーゼIMI-18の遺伝学的特徴の解明 (2021)
  • Author(s): 斉藤 開, 鈴木 由希, 中野 竜一, 中野 章代, 渡邉 真子, 矢野 寿一
  • Organizer: 第95回日本感染症学会学術講演会／第69回日本化学療法学会総会 合同学会
• [Presentation] 観光地の鹿が保有する耐性菌の保有状況ならびにその特徴について (2021)
  • Author(s): 中野 章代, 渡邉 真子, 中野 竜一, 鈴木 由希, 堀内 沙央里, 斉藤 開, 矢野 寿一
  • Organizer: 第95回日本感染症学会学術講演会／第69回日本化学療法学会総会 合同学会
• [Presentation] 宮城県における侵襲性リステリア症の分子疫学的検討 (2020)
  • Author(s): 馬場 啓聡, 金森 肇, 角田 梨紗子, 桜井 博毅, 大島 謙吾, 青柳 哲史, 賀来 満夫
  • Organizer: 日本臨床腸内微生物学会総会・学術集会
• [Presentation] 環境中に分布するPseudomonas属が保有するカルバペネマーゼ遺伝子とその伝達性について (2020)
  • Author(s): 鈴木 由希, 中野 竜一, 中野 章代, 角田 梨紗子, 堀内 沙央里, 矢野 寿一, 角田 尚紀, 中島 一敏
  • Organizer: 日本化学療法学会雑誌
• [Presentation] 国内で分離されたCTX-M産生高病原性肺炎桿菌の細菌学的および分子遺伝学的特徴の解明 (2020)
  • Author(s): 角田 尚紀, 中野 竜一, 中野 章代, 鈴木 由希, 角田 梨紗子, 矢野 寿一, 小川 美保
  • Organizer: 日本感染症学会
• [Presentation] 異常行動で精神病が疑われ医療保護入院したCampylobacter fetusによる菌血症の1例 (2020)
  • Author(s): 吉原 真吾, 酒井 勇紀, 山口 尚希, 古川 龍太郎, 平位 暢康, 西村 知子, 大森 慶太郎, 小川 吉彦, 小川 拓, 笠原 敬, 角田 梨紗子, 中野 竜一, 矢野 寿一, 三笠 桂一
  • Organizer: 日本感染症学会
• [Presentation] 環境中に分布するカルバペネマーゼ産生Acinetobacter属における耐性遺伝子拡散の検討 (2019)
  • Author(s): 鈴木由希、角田梨紗子、矢野寿一、ほか
  • Organizer: 第31回日本臨床微生物学会総会・学術集会
• [Presentation] 奈良県におけるHelicobacter pyloriの感染源の検討 (2019)
  • Author(s): 堀内沙央里、角田梨紗子、矢野寿一、ほか
  • Organizer: 第31回日本臨床微生物学会総会・学術集会
• [Presentation] 国内で分離されたCTX-M型ESBL産生高病原性肺炎桿菌の分子遺伝学的特徴の解明 (2019)
  • Author(s): 角田尚紀、角田梨紗子、矢野寿一、ほか
  • Organizer: 第31回日本臨床微生物学会総会・学術集会
• [Presentation] 環境中に分布するカルバペネマーゼ産生Acinetobacter属およびPseudomonas属における耐性遺伝子拡散の検討 (2019)
  • Author(s): 鈴木由希、角田梨紗子、矢野寿一、ほか
  • Organizer: 第93回日本細菌学会
• [Book] 【重症化に注意!口腔・咽頭・喉頭の急性感染症】扁桃周囲膿瘍 扁桃周囲膿瘍の起炎菌と抗菌薬の選択 (2022)
  • Author(s): 矢野寿一
  • Total Pages: 3
  • Publisher: 東京医学社
  • ISBN: 9784885635618
• [Book] 【日常診療に活かそう!AMR対策】AMR対策を日常診療に活かす 感冒・インフルエンザ診療におけるAMR対策 (2021)
  • Author(s): 角田梨紗子
  • Total Pages: 116
  • Publisher: 東京医学社
  • ISBN: 9784885635465
• [Book] 【必読!!耳鼻咽喉科医が知っておくべきCOVID-19の知識】耳鼻咽喉科診療と新型コロナウイルス感染症対策 ネブライザー療法の可否 (2021)
  • Author(s): 角田 梨紗子, 香取 幸夫
  • Total Pages: 116
  • Publisher: 東京医学社
  • ISBN: 9784885635458