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GPCR and diseases: mechanisms and therapeutic strategies

Research Project

Project/Area Number 19K08996
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Makita Noriko  東京大学, 医学部附属病院, 准教授 (60353455)

Co-Investigator(Kenkyū-buntansha) 佐藤 潤一郎  東京大学, 医学部附属病院, 助教 (50552890)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsGPCR / biased agonism / endocrine disease / Ca感知受容体 / β受容体 / βアドレナリン受容体 / arrestin / V2受容体
Outline of Research at the Start

Biased agonismを切り口としたGPCRシグナル異常による疾患メカニズムの解析と疾患制御の可能性を検討する。
①Ca感知受容体に対する機能選択的な自己抗体の作用機構/構造解析と、後天性低Ca尿性高Ca血症に対する特異的治療法の検討
②V2受容体変異体の機能解析と腎性尿崩症の新しい治療戦略の検討
③心不全・肥満症の治療戦略としてのβ1,2,3受容体に対するarrestin-biasの検証とその作用機構の解明

Outline of Final Research Achievements

Analysis of rare endocrine diseases caused by GPCR signaling disorder has revealed how GPCR signaling can be regulated specifically. In a patient diagnosed with acquired hypocalciuric hypercalcemia, we found unique autoantibodies working as biased allosteric modulators against CaSR and disclosed where they act. In vitro analysis, we found that cinacalcet can overcome the effect of the autoantibodies by working as a positive allosteric modulator, and succeeded in treating the patient with cinacalcet. To explore how biased signaling is constituted in this rare disease, we investigated mechanisms of G protein bias and tried cloning of unique monoclonal antibody against CaSR. These investigations may help us to reveal the unique structure of GPCR which activates a specific signaling and to create a novel drug which activates only a desired signaling.

Academic Significance and Societal Importance of the Research Achievements

本研究成果は、われわれのゲノムで最大のファミリーを形成し、創薬ターゲットの中心となってきたGタンパク質共役受容体(GPCR)の特異的な制御機構の解明に寄与することが期待される。そして、生理的な恒常性維持機構にも関与している可能性、さらには新たな創薬の基盤となる可能性を示唆する。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (57 results)

All 2022 2021 2020 2019

All Journal Article (21 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 21 results,  Open Access: 21 results) Presentation (23 results) (of which Int'l Joint Research: 1 results,  Invited: 20 results) Book (13 results)

  • [Journal Article] Identification of ENPP1 Haploinsufficiency in Patients With Diffuse Idiopathic Skeletal Hyperostosis and Early‐Onset Osteoporosis2022

    • Author(s)
      Kato Hajime、Ansh Anenya J、Lester Ethan R、Kinoshita Yuka、Hidaka Naoko、Hoshino Yoshitomo、Koga Minae、Taniguchi Yuki、Uchida Taisuke、Yamaguchi Hideki、Niida Yo、Nakazato Masamitsu、Nangaku Masaomi、Makita Noriko、Takamura Toshinari、Saito Taku、Braddock Demetrios T、Ito Nobuaki
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: - Issue: 6 Pages: 1125-1135

    • DOI

      10.1002/jbmr.4550

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of Serum Parathyroid Hormone Levels With All-Cause and Cause-Specific Mortality Among U.S. Adults2022

    • Author(s)
      Kato Hajime、Ito Nobuaki、Makita Noriko、Nangaku Masaomi、Leung Angela M.、Inoue Kosuke
    • Journal Title

      Endocrine Practice

      Volume: 28 Issue: 1 Pages: 70-76

    • DOI

      10.1016/j.eprac.2021.09.005

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Radiological evaluation of pseudofracture after the administration of asfotase alfa in an adult with benign prenatal hypophosphatasia: A case report2022

    • Author(s)
      Kato Hajime、Hidaka Naoko、Koga Minae、Kinoshita Yuka、Makita Noriko、Nangaku Masaomi、Ito Nobuaki
    • Journal Title

      Bone Reports

      Volume: 16 Pages: 101163-101163

    • DOI

      10.1016/j.bonr.2021.101163

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and efficacy of bexarotene for Japanese patients with cutaneous T-cell lymphoma: Real-world experience from post-marketing surveillance.2022

    • Author(s)
      Hamada T, Morita A, Suga H, Boki H, Fujimura T, Hirai Y, Shimauchi T, Tateishi C, Kiyohara E, Muto I, Nakajima H, Abe R, Fujii K, Nishigori C, Nakano E, Yonekura K, Funakoshi T, Amano M, Miyagaki T, Makita N, Manaka K, Shimoyama Y, Sugaya M.
    • Journal Title

      J Dermatol.

      Volume: 49 Issue: 2 Pages: 253-262

    • DOI

      10.1111/1346-8138.16201

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune checkpoint inhibitor combination therapies very frequently induce secondary adrenal insufficiency2021

    • Author(s)
      Manaka Katsunori、Sato Junichiro、Takeuchi Maki、Watanabe Kousuke、Kage Hidenori、Kawai Taketo、Sato Yusuke、Miyagawa Takuya、Yamada Daisuke、Kume Haruki、Sato Shinichi、Nagase Takahide、Iiri Taroh、Nangaku Masaomi、Makita Noriko
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 11617-11617

    • DOI

      10.1038/s41598-021-91032-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Position paper from the Japan Thyroid Association task force on the management of low-risk papillary thyroid microcarcinoma (T1aN0M0) in adults2021

    • Author(s)
      Kazuhiko Horiguchi, Yusaku Yoshida, Kenji Iwaku, Naoya Emoto, Toshihiko Kasahara, Junichiro Sato, Hiroki Shimura, Hisakazu Shindo, Satoru Suzuki, Hidekazu Nagano, Fumihiko Furuya, Noriko Makita, Fumihiko Matsumoto, Katsunori Manaka, Norisato Mitsutake, Megumi Miyakawa, Susumu Yokoya and Iwao Sugitani
    • Journal Title

      Endocrine Journal

      Volume: 68 Issue: 7 Pages: 763-780

    • DOI

      10.1507/endocrj.EJ20-0692

    • NAID

      130008068266

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Steroidogenic Activity in Unresected Adrenals Associated With Surgical Outcomes in Primary Aldosteronism2021

    • Author(s)
      Nakai Kazuki、Tsurutani Yuya、Inoue Kosuke、Matsui Seishi、Makita Kohzoh、Yamazaki Yuto、Sasano Hironobu、Makita Noriko、Nangaku Masaomi、Saito Jun、Omura Masao、Nishikawa Tetsuo
    • Journal Title

      Hypertension

      Volume: 77 Issue: 5 Pages: 1638-1646

    • DOI

      10.1161/hypertensionaha.120.16335

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of complications in 25 adult patients with X-linked hypophosphatemia.2021

    • Author(s)
      Kato H, Koga M, Kinoshita Y, Taniguchi Y, Kobayashi H, Fukumoto S, Nangaku M, Makita N, Ito N.
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: - Issue: 9 Pages: e3682-e3692

    • DOI

      10.1210/clinem/dgab282

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of FGF23-related hypophosphatemic osteomalacia by alcohol consumption2021

    • Author(s)
      Hidaka Naoko、Kato Hajime、Koga Minae、Katsura Masaki、Oyama Yuko、Kinoshita Yuka、Fukumoto Seiji、Makita Noriko、Nangaku Masaomi、Ito Nobuaki
    • Journal Title

      Bone Reports

      Volume: 15 Pages: 101144-101144

    • DOI

      10.1016/j.bonr.2021.101144

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered Thyroid Function Tests Observed in Hypophosphatasia Patients Treated with Asfotase Alfa2021

    • Author(s)
      Kato Hajime、Hidaka Naoko、Koga Minae、Kinoshita Yuka、Nangaku Masaomi、Makita Noriko、Ito Nobuaki
    • Journal Title

      International Journal of Endocrinology

      Volume: 2021 Pages: 1-5

    • DOI

      10.1155/2021/5492267

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Performance evaluation of the new chemiluminescent intact FGF23 assay relative to the existing assay system2021

    • Author(s)
      Kato Hajime、Hidaka Naoko、Koga Minae、Ogawa Noriyuki、Takahashi Shichihiro、Miyazaki Hiromi、Nangaku Masaomi、Makita Noriko、Ito Nobuaki
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 40 Issue: 1 Pages: 101-108

    • DOI

      10.1007/s00774-021-01258-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Massive calcification around large joints in a patient subsequently diagnosed with adult-onset hypophosphatasia2021

    • Author(s)
      Koga M.、Kinoshita Y.、Kato H.、Kobayashi H.、Shinoda Y.、Nangaku M.、Makita N.、Dahir K. M.、Ito N.
    • Journal Title

      Osteoporosis International

      Volume: 33 Issue: 2 Pages: 505-509

    • DOI

      10.1007/s00198-021-06145-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] V2 vasopressin receptor mutations2020

    • Author(s)
      Makita Noriko、Manaka Katsunori、Sato Junichiro、Iiri Taroh
    • Journal Title

      Vitam Horm.

      Volume: 113 Pages: 79-99

    • DOI

      10.1016/bs.vh.2019.08.012

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed postoperative hyponatremia following endoscopic transsphenoidal surgery for non-adenomatous parasellar tumors2020

    • Author(s)
      Hasegawa H, Shin M, Makita N, Shinya Y, Kondo K, Saito N.
    • Journal Title

      Cancers (Basel).

      Volume: 12 Issue: 12 Pages: 1

    • DOI

      10.3390/cancers12123849

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome with a novel frameshift variant in GATA3, p.W10Cfs40, lacks kidney malformation2020

    • Author(s)
      Kishi H, Jojima T, Kogai T, Iijima T, Ohira E, Tanuma D, Konno S, Kato K, Kezuka A, Akimoto K, Sakumoto J, Hishinuma A, Tomaru T, Makita N, Usui I, Aso Y.
    • Journal Title

      Clin Case Rep

      Volume: 8 Issue: 12 Pages: 2619-2624

    • DOI

      10.1002/ccr3.3186

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison between the clinical characteristics of patients with adrenal incidentalomas and those with hypertension-associated adrenal tumors in a single center in Japan2020

    • Author(s)
      Aoe Mari、Okada Akira、Usui Tomoko、Manaka Katsunori、Nangaku Masaomi、Makita Noriko
    • Journal Title

      Endocrine Journal

      Volume: 67 Issue: 6 Pages: 645-654

    • DOI

      10.1507/endocrj.EJ19-0262

    • NAID

      130007866176

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cinacalcet corrects biased allosteric modulation of CaSR by AHH autoantibody2019

    • Author(s)
      Noriko Makita, Takao Ando, Junichiro Sato, Katsunori Manaka, Koji Mitani, Yasuko Kikuchi, Takayoshi Niwa, Masanori Ootaki, Yuko Takeba,4 Naoki Matsumoto, Atsushi Kawakami, Toshihisa Ogawa, Masaomi Nangaku, and Taroh Iiri
    • Journal Title

      JCI Insight

      Volume: in press Issue: 8

    • DOI

      10.1172/jci.insight.126449

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bexarotene‐induced hypothyroidism: characteristics and therapeutic strategies2019

    • Author(s)
      Makita Noriko、Manaka Katsunori、Sato Junichiro、Mitani Koji、Nangaku Masaomi、Iiri Taroh
    • Journal Title

      Clinical Endocrinology

      Volume: 印刷中 Issue: 1 Pages: 195-200

    • DOI

      10.1111/cen.13975

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness and safety of cinacalcet for primary hyperparathyroidism: a single center experience2019

    • Author(s)
      Manaka Katsunori、Sato Junichiro、Kinoshita Yuka、Ito Nobuaki、Fujita Megumi、Iiri Taroh、Nangaku Masaomi、Makita Noriko
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 8 Pages: 683-689

    • DOI

      10.1507/endocrj.EJ19-0034

    • NAID

      130007696450

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular analysis and literature-based hypothesis of an immunonegative prostate small cell carcinoma causing ectopic ACTH syndrome2019

    • Author(s)
      Takeuchi M, Sato J, Manaka K, Tanaka M, Matsui H, Sato Y, Kume H, Fukayama M, Iiri T, Nangaku M, Makita N
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 6 Pages: 547-554

    • DOI

      10.1507/endocrj.EJ18-0563

    • NAID

      130007668513

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of immune-related adverse events in endocrine organs induced by immune checkpoint inhibitors: clinical guidelines of the Japan Endocrine Society2019

    • Author(s)
      Arima Hiroshi、Iwama Shintaro、Inaba Hidefumi、Ariyasu Hiroyuki、Makita Noriko、Otsuki Michio、Kageyama Kazunori、Imagawa Akihisa、Akamizu Takashi
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 7 Pages: 581-586

    • DOI

      10.1507/endocrj.EJ19-0163

    • NAID

      130007684340

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 内分泌irAEをヒントに医薬連携を考える2022

    • Author(s)
      槙田 紀子
    • Organizer
      日本臨床腫瘍薬学会学術大会JASPO2022 3/13, 2022
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害薬による内分泌irAE2021

    • Author(s)
      槙田 紀子、間中 勝則、佐藤 潤一郎、竹内 牧、南学 正臣、飯利 太朗
    • Organizer
      第94回日本内分泌学会学術総会 教育講演19 2021年4月22日~5月30日
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 患者さんからいただいた「目からうろこ」2021

    • Author(s)
      槙田 紀子
    • Organizer
      第94回日本内分泌学会学術総会 目から鱗の専門医セミナー 4/24, 2021
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] PHPT非手術症例に対する薬物治療2021

    • Author(s)
      槙田 紀子
    • Organizer
      第54回日本内分泌外科学会学術総会 10/28, 2021
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] チロシンキナーゼ阻害薬(TKI)による甲状腺機能異常2020

    • Author(s)
      槙田紀子、間中勝則、竹内 牧、佐藤潤一郎、飯利太朗
    • Organizer
      第63回日本内分泌学会学術総会 シンポジウム21 薬剤性甲状腺機能障害 7/20~8/31, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Acromegalyに潜む遺伝子異常‐AIP、Carney Complex、GPR101、MEN12020

    • Author(s)
      槙田紀子
    • Organizer
      第93回日本内分泌学会学術総会 シンポジウム20 Genetic backgroundをもつ機能性下垂体腺腫の診断と治療 7/20~8/31, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 1型糖尿病とまれな内分泌疾患―症例を出発点として2020

    • Author(s)
      槙田紀子
    • Organizer
      第20回 日本内分泌学会九州支部学術集会 10/3, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 高リン血症の原因疾患と病態2020

    • Author(s)
      槙田紀子
    • Organizer
      第38回日本骨代謝学会学術集会 シンポジウム6ミネラル代謝異常症 骨をとりまくミネラル代謝 10/9~11, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 臨床と研究を結ぶ内分泌疾患2020

    • Author(s)
      槙田紀子
    • Organizer
      第21回日本内分泌学会近畿支部学術集会 JES We Can企画 11/7, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Update3 副甲状腺2020

    • Author(s)
      槙田紀子
    • Organizer
      第30回臨床内分泌代謝Update 11/13~14, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害薬による内分泌irAE2020

    • Author(s)
      槙田紀子、間中勝則、佐藤潤一郎、竹内牧、南学正臣、飯利太朗
    • Organizer
      第63回日本甲状腺学会学術集会 専門医教育セミナー 11/19~12/15, 2020
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害薬による内分泌irAE2020

    • Author(s)
      槙田紀子、間中勝則、佐藤潤一郎、竹内牧、南学正臣、飯利太朗、
    • Organizer
      第94回日本内分泌学会学術総会 教育講演19 2021年4/22~5/30
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 患者さんからいただいた「目からうろこ」2020

    • Author(s)
      槙田紀子
    • Organizer
      第49回日本内分泌学会学術総会 目から鱗の専門医セミナー 4/24, 2021
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 先天性腎性尿崩症の原因となる変異V2受容体をターゲットとした特異的治療法の開発2020

    • Author(s)
      槙田 紀子, 間中 勝則, 佐藤 潤一郎, 中井 一貴, 竹内 牧, 三谷 康二, 南学 正臣, 飯利 太朗
    • Organizer
      第93回日本内分泌学会学術総会 7/20-8/31, 2020
    • Related Report
      2020 Research-status Report
  • [Presentation] まれな疾患からみえてくる新しい世界2019

    • Author(s)
      槙田紀子、間中勝則、佐藤潤一郎、南学正臣、飯利太朗
    • Organizer
      第29回臨床内分泌代謝Update 11/29, 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 薬剤性甲状腺機能障害2019

    • Author(s)
      槙田紀子、間中勝則、佐藤潤一郎、竹内牧、南学正臣、飯利太朗
    • Organizer
      第62回日本甲状腺学会学術集会 10/11, 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Ca、P、Mg異常を考える2019

    • Author(s)
      槙田紀子
    • Organizer
      第20回日本内分泌学会関東甲信越支部学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] これでわかる内分泌臨床の新たな知見:The JCEM 2018-2019から2019

    • Author(s)
      槙田紀子
    • Organizer
      第19回日本内分泌学会九州支部学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] わたしが何ものでもなかったころのこと2019

    • Author(s)
      槙田紀子
    • Organizer
      第1回九州内分泌・代謝「若手の会」9/6, 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] まれな内分泌疾患の解析から生まれる新しいコンセプト2019

    • Author(s)
      槙田紀子
    • Organizer
      第37回内分泌代謝学サマーセミナー 7/5, 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 内科医の考える甲状腺の手術適応2019

    • Author(s)
      槙田紀子、間中勝則、佐藤潤一郎、竹内牧、飯利太朗、南学正臣
    • Organizer
      第31回日本内分泌外科学会総会 6/14, 2019
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] The Influence of Aldosterone Values in the Tributary Veins of Unresected Adrenal Gland on Primary Aldosteronism Surgical Outcomes.2019

    • Author(s)
      Kazuki Nakai, Yuya Tsurutani, Tomoko Takiguchi, Seishi Matsui, Kouzou Makita, Jun Inoue, Maki Nagata, Noriko Makita, Masaomi Nangaku, Jun Saito, Masao Omura, Tetsuo Nishikawa
    • Organizer
      ENDO 2019, New Orleans, 3/23-26, 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 後天性低カルシウム尿性高カルシウム血症(AHH)で見出されたカルシウム感知受容体抗体の機能解析2019

    • Author(s)
      槙田紀子、佐藤潤一郎、間中勝則、江田真紀子、安藤隆雄、山崎肇、矢島隆寛、伊藤崇浩、赤羽貴美子、中井一貴、三谷康二、大石篤郎、 南学正臣、飯利太朗
    • Organizer
      第92日本内分泌学会学術総会 仙台国際センター 5/9, 2019
    • Related Report
      2019 Research-status Report
  • [Book] 内科学 第12版2022

    • Author(s)
      槙田紀子(ホルモンの生合成・分泌・代謝/ホルモンの作用機序/内分泌疾患の診断/ホルモン受容体異常症)(総編集 矢﨑 義雄、小室 一成)
    • Total Pages
      12
    • Publisher
      朝倉書店
    • ISBN
      9784254322804
    • Related Report
      2021 Annual Research Report
  • [Book] 今日の治療指針 2022年版[ポケット判]2022

    • Author(s)
      槙田紀子(原発性副甲状腺機能亢進症)(編集 福井 次矢、高木 誠、小室 一成)
    • Total Pages
      2
    • Publisher
      医学書院
    • ISBN
      9784260047777
    • Related Report
      2021 Annual Research Report
  • [Book] なんで使うの? そのくすり2022

    • Author(s)
      三谷康二、槙田紀子(チラーヂンS)(編集 村川裕二、高山和郎)
    • Publisher
      南江堂
    • ISBN
      9784524227761
    • Related Report
      2021 Annual Research Report
  • [Book] むかしの頭で診ていませんか?総合内科診療をスッキリまとめました2021

    • Author(s)
      槙田紀子(甲状腺機能亢進症を見逃さない/甲状腺腫を発見したら)(編集 髙橋重人、村川裕二)
    • Total Pages
      7
    • Publisher
      南江堂
    • ISBN
      9784524228539
    • Related Report
      2021 Annual Research Report
  • [Book] 標準的医療説明2021

    • Author(s)
      槙田紀子(副腎クリーゼ)(編集 一般社団法人 内科系学会社会保険連合)
    • Total Pages
      4
    • Publisher
      医学書院
    • ISBN
      9784260047388
    • Related Report
      2021 Annual Research Report
  • [Book] 最新ガイドラインに基づく 代謝・内分泌疾患 診療指針 2021-’222021

    • Author(s)
      槙田紀子(副甲状腺機能低下症)(編集 門脇 孝、下村伊一郎)
    • Total Pages
      8
    • Publisher
      総合医学社
    • ISBN
      9784883787388
    • Related Report
      2021 Annual Research Report
  • [Book] プロフェッショナル腎臓病学2020

    • Author(s)
      間中勝則、槙田紀子
    • Total Pages
      8
    • Publisher
      中外医学社
    • ISBN
      9784498224629
    • Related Report
      2020 Research-status Report
  • [Book] 今日の疾患辞典(デジタル版)2020

    • Author(s)
      槙田紀子
    • Publisher
      プレシジョン
    • Related Report
      2020 Research-status Report
  • [Book] 内分泌・糖尿病・代謝内科2020

    • Author(s)
      槙田紀子(企画編集)
    • Total Pages
      76
    • Publisher
      科学評論社
    • Related Report
      2020 Research-status Report
  • [Book] 低カルシウム血症(今日の診断指針 ポケット判 第8版)2020

    • Author(s)
      槙田紀子(永井 良三 総編集)
    • Total Pages
      4
    • Publisher
      医学書院
    • Related Report
      2019 Research-status Report
  • [Book] CaSRの歴史:GPCR研究の古典的常識への挑戦の歴史(透析療法ネクストXXVI)2020

    • Author(s)
      槙田紀子、飯利太朗(秋葉隆、秋澤忠男 編集)
    • Total Pages
      10
    • Publisher
      医学図書出版
    • Related Report
      2019 Research-status Report
  • [Book] 家族性低カルシウム尿性高カルシウム血症(FHH)と後天性低カルシウム尿性高カルシウム血症(AHH) (副甲状腺・骨代謝疾患診療マニュアル 改訂第2版)2019

    • Author(s)
      槙田紀子、飯利太朗(平田結喜緒 監修)
    • Total Pages
      5
    • Publisher
      診断と治療社
    • Related Report
      2019 Research-status Report
  • [Book] 内分泌Up To Date(臨床雑誌 内科)2019

    • Author(s)
      槙田紀子(企画編集)
    • Total Pages
      146
    • Publisher
      南江堂
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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