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The new method for long-term hypothermic lung preservation with continuous ventilation

Research Project

Project/Area Number 19K09040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionFujita Health University

Principal Investigator

Matsuda Yasushi  藤田医科大学, 医学部, 准教授 (00455833)

Co-Investigator(Kenkyū-buntansha) 佐渡 哲  東北大学, 大学病院, 講師 (20396485)
大石 久  東北大学, 大学病院, 講師 (60451580)
野田 雅史  東北大学, 加齢医学研究所, 准教授 (70400356)
平間 崇  東北大学, 大学病院, 助教 (80510338)
岡田 克典  東北大学, 加齢医学研究所, 教授 (90323104)
兼平 雅彦  山梨大学, 大学院総合研究部, 准教授 (90374941)
星川 康  藤田医科大学, 医学部, 教授 (90333814)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordslung transplantation / lung preservation / 肺移植 / 臓器保存 / 肺保存 / 持続換気保存 / 代謝 / 組織代謝 / 肺換気
Outline of Research at the Start

肺摘出後長時間臓器を保存するためには、摘出肺の代謝を維持しなければならない。低温肺保存中にも肺の細胞は代謝を行い、エネルギー(ATP:adenosine tri-phosphate)を産生し消費している。ドナー肺保存中には肺内の細胞は気道内の酸素を消費し、二酸化炭素を産生していると考えられる。長時間肺保存を行う場合には肺を構成する細胞が低酸素によるエネルギー不足にならないよう気道内に酸素を供給する目的で、低温保存中に摘出肺に人工呼吸を行う低温持続肺換気保存法(CVLP: continuous ventilated lung preservation)を開発し、その有効性を検討する。

Outline of Final Research Achievements

Results: The oxygen concentration in airway of isolated lungs was stable in ventilation group, however that was decreased in deflation group and inflation group. Moreover, the concentration of carbon dioxide in airway was significantly increased in deflation group and inflation group at the end of ischemic time. When we compared ATP in lung tissue between before and after lung preservation, the concentration of ATP in lung tissue was decreased in deflation group and inflation group, however that was stable in ventilation group. P/F ratio after left LTx was better in ventilation group compared to the other two groups. And also wet/dry ratio was the lowest in ventilation group in these groups.
Conclusion: Ventilation during preservation provides oxygen to isolated lung tissue and isolated lung could keep aerobic metabolism during preservation, therefore transplanted lung showed better condition than the conventional methods of lung preservation.

Academic Significance and Societal Importance of the Research Achievements

日本における肺移植は、まだ発展途上であり肺移植数は欧米に比較してまだ少ない。肺移植数は増加傾向にあり今後肺移植数が増加した時に、長時間保存できる方法が必要となる。Continuous ventilated lung preservation(CVLP)はドナー肺の長時間保存方法について新たな可能性を示したと言える。今後は、持続換気保存法が、DCDドナー(donor of cardiac death)などにも拡大されていくと考えられる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (19 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (17 results) (of which Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Donor management and extremely high donor lung utilization rate in Japan2024

    • Author(s)
      Hoshikawa Yasushi、Matsuda Yasushi、Ashikari Juntaro
    • Journal Title

      Journal of Thoracic Disease

      Volume: 16 Issue: 2 Pages: 1625-1631

    • DOI

      10.21037/jtd-23-290

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Effects of case volume on short- and long-term outcomes following cadaveric lung transplantation in Japan2024

    • Author(s)
      Chida M、Inoue T、Nakajima T、Okada Y、Oishi H、Nakajima J、Sato M、Yoshino I、Suzuki H、Nakajima D、Shintani Y、Kanou T、Toyooka S、Miyoshi K、Shiraishi T、Sato T、Matsumoto K、Nagayasu T、Hoshikawa Y、Matsuda Yasushi、Maeda S、Date H
    • Journal Title

      Journal of Thoracic Disease

      Volume: 16 Issue: 2 Pages: 1473-1479

    • DOI

      10.21037/jtd-23-90

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Prognostic factors for lung transplant recipients focusing on age and gender: the Japanese lung transplantation report 20222023

    • Author(s)
      Oishi H、Okada Y、Sato M、Nakajima J、Nakajima D、Shiraishi T、Sato T、Kanou T、Shintani Y、Miyoshi K、Toyooka S、Maeda S、Chida M、Matsumoto K、Nagayasu T、Suzuki H、Yoshino I、Matsuda Yasushi、Hoshikawa Y、Date H
    • Journal Title

      Surgery Today

      Volume: 53 Issue: 10 Pages: 1188-1198

    • DOI

      10.1007/s00595-023-02686-w

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Honeycomb lung is a major risk factor for preoperative radiological tumor size underestimation in patients with primary lung cancer2023

    • Author(s)
      Ishizawa Hisato、Matsuda Yasushi、Ohno Yoshiharu、Sakurai Eiko、Ota Atsuhiko、Hattori Hidekazu、Tsukamoto Tetsuya、Matsunaga Masaaki、Kawai Hiroshi、Suzuki Yamato、Nagano Hiromitsu、Negi Takahiro、Tochii Daisuke、Tochii Sachiko、Suda Takashi、Hoshikawa Yasushi
    • Journal Title

      Journal of Thoracic Disease

      Volume: 15 Issue: 2 Pages: 516-528

    • DOI

      10.21037/jtd-22-1115

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Bilateral lung transplant with pulmonary artery reconstruction using donor aorta for pulmonary hypertension with a giant pulmonary arterial aneurysm2023

    • Author(s)
      Watanabe Tatsuaki、Matsuo Satoshi、Watanabe Yui、Hirama Takashi、Matsuda Yasushi、Noda Masafumi、Niikawa Hiromichi、Oishi Hisashi、Suzuki Yamato、Ejima Yutaka、Toyama Hiroaki、Saiki Yoshikatsu、Okada Yoshinori
    • Journal Title

      European Journal of Cardio-Thoracic Surgery

      Volume: 63 Issue: 6 Pages: 1-13

    • DOI

      10.1093/ejcts/ezad234

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Malignant solitary fibrous tumors of the left atrial endocardium2022

    • Author(s)
      Suzuki Yamato、Matsuda Yasushi、Saito Ryoko、Adachi Osamu、Okada Yoshinori
    • Journal Title

      Asian Cardiovascular and Thoracic Annals

      Volume: 30 Issue: 2 Pages: 195-198

    • DOI

      10.1177/0218492321989206

    • Related Report
      2022 Research-status Report
  • [Journal Article] Changes in haemodynamics during single lung transplantation under venovenous extracorporeal membrane oxygenation2022

    • Author(s)
      Oishi Hisashi、Matsuda Yasushi、Ejima Yutaka、Toyama Hiroaki、Hirama Takashi、Watanabe Tatsuaki、Watanabe Yui、Niikawa Hiromichi、Noda Masafumi、Okada Yoshinori
    • Journal Title

      Interactive CardioVascular and Thoracic Surgery

      Volume: 35 Issue: 2 Pages: 1-9

    • DOI

      10.1093/icvts/ivac101

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tracheobronchial reconstruction by inverted Barclay’s method for tracheobronchial injury in an 8-year-old girl: a case report2022

    • Author(s)
      Suzuki Yamato、Ishizawa Hisato、Kawai Hiroshi、Matsuda Yasushi、Hoshikawa Yasushi
    • Journal Title

      Surgical Case Reports

      Volume: 8 Issue: 1 Pages: 1-4

    • DOI

      10.1186/s40792-022-01405-w

    • Related Report
      2022 Research-status Report
  • [Journal Article] Living Donor Lobar Lung Transplant for a Patient With Lung Disease Caused by ABCA3 Gene Mutations: A Case Report2022

    • Author(s)
      Kumata Sakiko、Matsuda Yasushi、Oishi Hisashi、Sado Tetsu、Niikawa Hiromichi、Watanabe Tatsuaki、Noda Masafumi、Hoshikawa Yasushi、Sakurada Akira、Saito-Koyama Ryoko、Niizuma Hidetaka、Kitazawa Hiroshi、Akiba Miki、Sasahara Yoji、Okada Yoshinori
    • Journal Title

      Transplantation Proceedings

      Volume: 54 Issue: 10 Pages: 2803-2806

    • DOI

      10.1016/j.transproceed.2022.07.020

    • Related Report
      2022 Research-status Report
  • [Journal Article] Outcomes of lung transplantation for idiopathic pleuroparenchymal fibroelastosis2021

    • Author(s)
      Shiiya Haruhiko、Nakajima Jun、Date Hiroshi、Chen-Yoshikawa Toyofumi Fengshi、Tanizawa Kiminobu、Handa Tomohiro、Oto Takahiro、Otani Shinji、Shiotani Toshio、Okada Yoshinori、Matsuda Yasushi、Shiraishi Takeshi、Moroga Toshihiko、Minami Masato、Funaki Soichiro、Chida Masayuki、Yoshino Ichiro他
    • Journal Title

      Surgery Today

      Volume: 未定 Issue: 8 Pages: 1276-1284

    • DOI

      10.1007/s00595-021-02232-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of CTLA4-Ig on Obliterative Bronchiolitis in a Mouse Intrapulmonary Tracheal Transplantation Model2021

    • Author(s)
      Suzuki Yamato、Oishi Hisashi、Kanehira Masahiko、Matsuda Yasushi、Hirama Takashi、Noda Masafumi、Okada Yoshinori
    • Journal Title

      Annals of Thoracic and Cardiovascular Surgery

      Volume: 27 Issue: 6 Pages: 355-365

    • DOI

      10.5761/atcs.oa.20-00398

    • NAID

      130008131277

    • ISSN
      1341-1098, 2186-1005
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous analysis of drugs administered to lung-transplanted patients using liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring2021

    • Author(s)
      Shinya Takasaki, Tensei Hirasawa, Yu Sato, Masamitsu Maekawa, Taku Tsukamoto, Masafumi Kikuchi, Jiro Ogura, Yoshihiro Hayakawa, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Okada, Hiroaki Yamaguchi, Nariyasu Mano
    • Journal Title

      Biomedical Chromatography

      Volume: 35 Issue: 6 Pages: 1-8

    • DOI

      10.1002/bmc.5067

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pneumonia With Scedosporium apiospermum and Lomentospora prolificans in a Patient After Bilateral Lung Transplantation for Pulmonary Hypertension: A Case Report2021

    • Author(s)
      Suzuki Yamato、Oishi Hisashi、Matsuda Yasushi、Noda Masafumi、Kumata Sakiko、Hayasaka Kazuki、Okada Yoshinori
    • Journal Title

      Transplantation Proceedings

      Volume: 53 Issue: 4 Pages: 1375-1378

    • DOI

      10.1016/j.transproceed.2021.02.002

    • Related Report
      2021 Research-status Report
  • [Journal Article] Plasma mycophenolic acid concentration and the clinical outcome after lung transplantation2020

    • Author(s)
      Yabuki Hiroshi、Matsuda Yasushi、Watanabe Tatsuaki、Eba Shunsuke、Hoshi Fumihiko、Hirama Takashi、Oishi Hisashi、Sado Tetsu、Noda Masafumi、Sakurada Akira、Kikuchi Masafumi、Yamaguchi Hiroaki、Mano Nariyasu、Okada Yoshinori
    • Journal Title

      Clinical Transplantation

      Volume: 34 Issue: 12 Pages: 1-9

    • DOI

      10.1111/ctr.14088

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a precise quantitative method for monitoring sirolimus in whole blood using LC/ESI?MS/MS2020

    • Author(s)
      Shigeta Kensuke、Kikuchi Masafumi、Tanaka Masaki、Takasaki Shinya、Oishi Hisashi、Sado Tetsu、Matsuda Yasushi、Noda Masafumi、Okada Yoshinori、Mano Nariyasu、Yamaguchi Hiroaki
    • Journal Title

      Biomedical Chromatography

      Volume: 34 Issue: 8 Pages: 1-8

    • DOI

      10.1002/bmc.4853

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Postoperative Continuous Renal Replacement Therapy in Lung Transplant Recipients2020

    • Author(s)
      Katahira Masato、Hirama Takashi、Eba Shunsuke、Suzuki Takaya、Notsuda Hirotsugu、Oishi Hisashi、Matsuda Yasushi、Sado Tetsu、Noda Masafumi、Sakurada Akira、Sidhu Aman、Okada Yoshinori
    • Journal Title

      Transplantation Direct

      Volume: 6 Issue: 6 Pages: e562-e562

    • DOI

      10.1097/txd.0000000000001013

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ex vivo lung CT findings may predict the outcome of the early phase after lung transplantation2020

    • Author(s)
      Oishi Hisashi、Noda Masafumi、Sado Tetsu、Matsuda Yasushi、Niikawa Hiromichi、Watanabe Tatsuaki、Sakurada Akira、Hoshikawa Yasushi、Okada Yoshinori
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 5 Pages: 1-16

    • DOI

      10.1371/journal.pone.0233804

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The new method for long-term hypothermic lung preservation with continuous ventilation2019

    • Author(s)
      Yasushi Matsuda
    • Organizer
      European Society of Transplantation
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Book] 臓器移植抗体陽性診療ガイドライン2023

    • Author(s)
      日本移植学会臓器移植抗体陽性ガイドライン策定委員会
    • Total Pages
      231
    • Publisher
      ぱーそん書房
    • ISBN
      9784907095802
    • Related Report
      2023 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

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